Category: 15852-73-0

Application of 15852-73-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15852-73-0, name is (3-Bromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(d) 3-(3-HydroxymethyIphenyl)-5-/i’o-butyl-Lambdar-fer?’-butylthiophene-2-sulfonamide; A mixture of m-bromobenzyl alcohol (1.05 g, 5.80 mmol), 5-iso-butyl-2-(iV-tert- butylaminosulfonyl)thiophene-3-boronic acid (2.41 g, 7.55 mmol; see step (c))5 Pd(PPh3)4 (270 mg5 0.235 mmol), NaOH (19.1 mL, 1.5 M aq5 28.6 mmol), EtOH (5.0 mL) and toluene (30 mL) was stirred under N2 at 900C for about 4 h. After cooling, water (10 mL) was added to the reaction mixture and this was then extracted with ethyl acetate. The combined organic phase was dried and concentrated in vacuo. The crude product was purified on column EPO chromatography (EtOAc/hexane, 30:70) to give sub-title compound as a colourless syrup in 57percent yield (1.26 g, 3.31 mmol).1H NMR delta (CDCl3): 0.96 (d, J = 6.6 Hz, 6H), 0.98 (s, 9H), 1.82-2.00 (m, IH), 2.66 (d, J= 7.1 Hz, 2H)5 3.28 (br s, IH), 4.67 (s, 2H), 4.81 (br s, IH), 6.76 (s, IH), 7.30-7.50 (m, 3H)5 7.64 (s, IH).13C NMR delta (CDCl3): 22.1, 29.4, 30.4, 39.1, 54.4, 64.6, 127.1, 127.8, 128.5, 129.0, 134.9, 136.2, 141.2, 143.2, 148.2. MS (ESI) m/z: 382(M+1)+.IRv (neat, cm”1): 3498, 3286, 2958, 2870, 1465, 1313. Anal. Calcd. for C19H27NO3S2: C, 59.81; H, 7.13; N, 3.67. Found: C, 60.05; H, 7.31; N, 3.90.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VICORE PHARMA AB; WO2006/109048; (2006); A1;,
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Application of 15852-73-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15852-73-0, name is (3-Bromophenyl)methanol. A new synthetic method of this compound is introduced below.

Preparation of [ (3-BROMOBENZYL) OXYL (TERT- butyl) dimethylsilane 232 mg (1.24 mmol) of 3-bromo-benzylalcohol was dissolved in 50 ml of methylene chloride, and 126 mg (1.85 mmol) of imidazole and 224 mg (1.49 mmol) of tert-butyldimethylsilyl chloride were added thereto, followed by stirring at room temperature. After 2 hours, a resulting white solid was filtered off, and the remaining organic layer was washed with 20 ml of 1 N aqueous hydrochloric acid and 20 ml of saturated aqueous NaCl, then dried over anhydrous MGS04. Removal of solvent in vacuo provided 306 mg (1.02 mmol) of the title compound at 82.3% yield. 1H NMR (CDCL3, PPM) ; 6 7.37 (1H, s), 7.26 (1H, d), 7.13 (1H, d), 7.08 (1H, q) FAB MS (m/e) = 302 [M+1]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15852-73-0, (3-Bromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; LG LIFE SCIENCES LTD.; WO2004/80979; (2004); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15852-73-0, name is (3-Bromophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 15852-73-0

Example 50 {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane TBSCl (18.7 g, 124.3 mmol), Et3N (14.08 g, 139.2 mmol) and DMAP (194.3 mg, 8.9 mmol) were dissolved in CH2Cl2 (120 mL) and the solution was cooled to 0-5 C. (3-Bromophenyl)methanol (18.5 g, 99.4 mmol) was added dropwise to the solution. After the addition of the (3-bromophenyl)methanol, the mixture was warmed to room temperature and stirred for 2 h. 5% HCl was added to the reaction mixture to adjust the pH=4-5. Then the organic phase was separated and the aqueous layer was extracted with CH2Cl2 (50 mL*2). The combined organic phases were washed with water and dried over Na2SO4. After removing the solvent, 28.5 g of {[(3-bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane was obtained (Yield: 95.1%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15852-73-0, (3-Bromophenyl)methanol.

Reference:
Patent; Glaxo Group Limited; US2009/203677; (2009); A1;,
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Application of 15852-73-0, Adding some certain compound to certain chemical reactions, such as: 15852-73-0, name is (3-Bromophenyl)methanol,molecular formula is C7H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15852-73-0.

General procedure: 1 mmol of the substrate (alcohol, phenol or amine) wasadded to a mixture of RHA/TiO2(30percent) (20 mg) and aceticanhydride (1.5 mmol per OH/NH2 group) and the resulting mixture was stirred at room temperature. After completionof the reaction (mentioned by TLC), dichloromethane(20 mL) was added and the catalyst was separated byfiltration. The organic phase was washed with 10percent aqueoussolution of sodium bicarbonate (2 20 mL) and dried overNa2SO4. The solvent was removed under reduced pressureto afford the desired product in good to high yields. Thespectral (IR, 1H and 13C NMR) data of new compounds arepresented below:

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Seddighi, Mohadeseh; Shirini, Farhad; Goli-Jolodar, Omid; Comptes Rendus Chimie; vol. 19; 8; (2016); p. 1003 – 1010;,
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Related Products of 15852-73-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 15852-73-0 as follows.

General procedure: OMS-2-SH-B (20 mg, 10 mol%), benzyl alcohol (0.3 mmol) and benzamidine (0.5 mmol) were added into a Schlenk tube. Then, air was removed and toluene (1 mL) was added by a syringe under O2 atmosphere. If substituted benzyl alcohol was liquid, it was added with toluene under O2 balloon protection. If methyl benzene was used as substrate instead of benzyl alcohol, it was added as solvent (1 mL) into the reaction tube by syringe under O2 atmosphere. The mixture was stirred for required time at certain temperature for 20 h. The resulting mixture was cooled down, filtered and washed with EtOAc, and concentrated under reduced pressure to give the crude product. Finally, the product was purified by silica gel chromatography to yield the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15852-73-0, its application will become more common.

Reference:
Article; Shen, Jian; Meng, Xu; Catalysis Communications; vol. 127; (2019); p. 58 – 63;,
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Adding a certain compound to certain chemical reactions, such as: 15852-73-0, (3-Bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 15852-73-0, blongs to alcohols-buliding-blocks compound. Formula: C7H7BrO

To a solution of 3-bromobenzyl alcohol (3.00 g, 16.0 mmol) and triethylamine (2.91 mL, 20.9 mmol) indichloromethane (50 mL) at 0 °C was added methanesulfonyl chloride drop-wise. After 2 h, the reaction mixture was washed with saturated aqueous sodium bicarbonate solution and water. The organic layer was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound as a light yellow oil.Yield: 4.3 g, 16 mmol, 100percent. 1H NMR (400 MHz, CDCI3) oe 2.99 (5, 3H), 5.21 (5, 2H),7.30 (dd, J=7.8, 7.7 Hz, 1 H), 7.34-7.38 (m, 1 H), 7.52-7.56 (m, 1 H), 7.57-7.59 (m, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15852-73-0, its application will become more common.

Reference:
Patent; PFIZER INC.; PETTERSSON, Martin Youngjin; JOHNSON, Douglas Scott; SUBRAMANYAM, Chakrapani; O’DONNELL, Christopher John; AM ENDE, Christopher William; GREEN, Michael Eric; PATEL, Nandini Chaturbhai; STIFF, Cory Michael; TRAN, Tuan Phong; KAUFFMAN, Gregory Wayne; STEPAN, Antonia Friederike; VERHOEST, Patrick Robert; WO2015/49616; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H7BrO

Step 1 c’: Synthesis of (4′-(Trifluoromethyl)-[1 ,1 ‘-biphenyl]-3-yl)methanol To a solution of 3-bromo benzyl alcohol (0.1 g, 0.53 mM) and 4- (trifluoromethyl)phenyl)boronic acid (0.121 g, 0.64 mM), DMF/water (8:1 ), Na2C03 (0.142 g, 1 .33 mM) and PdCI2(PPh3)2 (0.010 mM) were added. The reaction mixture was heated in a microwave at 1 10 ¡ãC for 6 min. The reaction mixture was quenched with water and extracted with ethyl acetate (3×10 ml). The organic layer was washed with brine, dried over Na2S04 and concentrated to obtain a crude product, which was purified by column chromatography (silica gel, 100-200 mesh, eluted with 15percent ethyl acetate in petroleum ether) to afford the title compound (4’-(trifluoromethyl)-[1 ,1 ‘- biphenyl]-3-yl)methanol as a colorless oil. Yield: 0.108 g( 80percent);1H NMR (DMSO-d6, 300 MHz): delta 7.91 (d, J=8.1 Hz, 2 H), 7.84-7.82 (m, 3 H), 7.70 (m, 1 H), 7.50-7.48 (m, 2H), 5.30 (t, J = 5.7Hz, 1 H, OH), 4.60 (d, J=5.7 Hz, 2 H); MS: m/z 275 (M+Na).

With the rapid development of chemical substances, we look forward to future research findings about 15852-73-0.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; MAHAJAN, Vishal, Ashok; SAWARGAVE, Sangameshwar, Prabhakar; WO2013/128378; (2013); A1;,
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Synthetic Route of 15852-73-0, Adding some certain compound to certain chemical reactions, such as: 15852-73-0, name is (3-Bromophenyl)methanol,molecular formula is C7H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15852-73-0.

General procedure: A mixture of alcohol (0.75 mmol), and catalyst Mo1 (13 mg,3.0 mol%) taken in 0.5 mL of water was stirred at 100 C under oxygenatmosphere (O2 bladder) and the stirring was continued for16-24 h as per requirement. The progress of reaction was monitoredby TLC. After completion of the reaction, ethyl acetate was added to the mixture. The aqueous phase was extracted with ethyl acetate 2-3 times. Then the combined organic extracts were driedover anhydrous sodium sulfate and the solvent was removed under reduced pressure. The crude product so obtained was purified by column chromatography using hexane-ethyl acetate as eluent. While the known products were characterized by spectroscopic techniques and compared with reported data and the new products 22b and 36b were characterized completely. The characterization detail is provided in supporting information section.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Thiruvengetam, Prabaharan; Chakravarthy, Rajan Deepan; Chand, Dillip Kumar; Journal of Catalysis; vol. 376; (2019); p. 123 – 133;,
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Related Products of 15852-73-0 ,Some common heterocyclic compound, 15852-73-0, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 50 {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane TBSCl (18.7 g, 124.3 mmol), Et3N (14.08 g, 139.2 mmol) and DMAP (194.3 mg, 8.9 mmol) were dissolved in CH2Cl2 (120 mL) and the solution was cooled to 0-5 C. (3-Bromophenyl)methanol (18.5 g, 99.4 mmol) was added dropwise to the solution. After the addition of the (3-Bromophenyl)methanol, the mixture was warmed to room temperature and stirred for 2 h. 5% HCl was added to the reaction mixture to adjust the pH=4-5. Then the organic phase was separated and the aqueous layer was extracted with CH2Cl2 (50 mL*2). The combined organic phases were washed with water and dried over Na2SO4. After removing the solvent, 28.5 g of {[(3-bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane was obtained (Yield: 95.1%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15852-73-0, (3-Bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Glaxo Group Limited; US2009/203657; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 15852-73-0 ,Some common heterocyclic compound, 15852-73-0, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 51a: 1-Bromo-3-(methoxymethyl)benzene (Compound 0601-139)[0412]To a solution of m-bromobenzyl alcohol (1.0 g, 5.3 mmol) in THF (10 mL) was added NaH (0.26 g, 10.6 mmol) at 0¡ã C., stirred for 10 minutes, followed by addition of iodomethane (1.1 g, 7.9 mmol). The resulting reaction mixture was stirred for 1 hour. To the mixture ethyl acetate (30 mL) was added, washed with water, brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the title compound 0601-139 (1.0 g, 93percent) as an oil. 1H NMR (400 MHz, DMSO-d6) delta 3.30 (s, 3H), 4.41 (s, 2H), 7.29 (t, J=8.0 Hz, 1H), 7.40 (t, J=7.6 Hz, 1H), 7.47 (d, J=8.0 Hz, 1H), 7.64 (d, J=8.0 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15852-73-0, (3-Bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng; US2013/102595; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts