Category: 15833-00-8

Application of 15833-00-8, Adding some certain compound to certain chemical reactions, such as: 15833-00-8, name is 2-(2-Aminophenyl)propan-2-ol,molecular formula is C9H13NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15833-00-8.

2-(2-aminophenyl)propan-2-ol (1.19 g, 7.87 mmol) was suspend in dioxane (10 mL) and added carbonyldiimidazole (1.53 g, 9.44 mmol) and stirred for 2 h at room temperature. Aqueous HCl (I N, 15 mL) was added and the reaction was extracted with ethyl acetate (3×20 mL). The combined organic layers were washed with IN HCl and brine, dried and concentrated to give 4,4-dimethyl-lH-3,l-benzoxazin-2-one as a pale solid (1.34 g, 7.56 mmol, 96%). The product was used as such without further purification in the next step LCMS: 0.70 min; ES+ 178 ( M+H+); lH NMR (CHLOROFORM-d, 400MHz): delta (ppm) 9.08 (br s, 1H), 7.24 (t, 1H), 7.14 (d, 1H), 7.07 (t, 1H), 6.89 (d, 1H), 1.73 (s, Step 3: 6-bromo-4.4-dimethyl-lH-3.1-benzoxazin-2-one

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15833-00-8, 2-(2-Aminophenyl)propan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; SYNGENTA PARTICIPATIONS AG; CUTLER, Sean, R.; LACHIA, Mathilde, Denise; WENDEBORN, Sebastian, Volker; GODFREY, Christopher, Richard Ayles; SABBADIN, Davide; (82 pag.)WO2018/17490; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 15833-00-8, 2-(2-Aminophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(2-Aminophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(2-Aminophenyl)propan-2-ol

EXAMPLE 4; 1-{3-[2-hydroxy-2-(6-hydroxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-ethylamino]-3-methyl-butyl}-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one; a) 4,4-dimethyl-1,4-dihydro-benzo[1,3]oxazin-2-one; 112 g (1.13 mol) phosgene are piped into 500 mL THF. Then a solution of 52 g (0.34 mol) 2-(2-amino-phenyl)-propan-2-ol, prepared from 2-aminoacetophenone and methylmagnesium iodide, in 300 mL THF is added. The reaction mixture is left to stand overnight, evaporated down and combined with 500 ml pyridine. After the pyridine has been distilled off water is added and the mixture is extracted with diethyl ether. The organic phases are washed successively with 2 N hydrochloric acid, sodium hydroxide solution and water, dried with sodium sulphate and evaporated down. The residue remaining (46 g) is further reacted directly without any more purification.

The synthetic route of 15833-00-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2005/227975; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 15833-00-8 , The common heterocyclic compound, 15833-00-8, name is 2-(2-Aminophenyl)propan-2-ol, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

112 g (1.13 mol) phosgene are piped into 500 mL THF. Then a solution of 52 g (0.34 mol) 2-(2-amino-phenyl)-propan-2-ol, prepared from 2-aminoacetophenone and methylmagnesium iodide, in 300 mL THF is added. The reaction mixture is left to stand overnight, concentrated by evaporation and combined with 500 ml of pyridine. After the pyridine has been distilled off the remainder is combined with water and extracted with diethyl ether. The organic phases are washed successively with 2 N hydrochloric acid, sodium hydroxide solution and water, dried with sodium sulphate and concentrated by evaporation. The residue remaining (46 g) is further reacted directly, without any more purification. M.p. (toluene/petroleum ether)=109-110 C.

The synthetic route of 15833-00-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2007/37781; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts