Category: 157142-48-8

Xu, Xianjun; Feng, Huangdi; Zhang, Xiaoyong; Song, Liangliang; Van Meervelt, Luc; Van der Eycken, Johan; Harvey, Jeremy N.; Van der Eycken, Erik V. published an article on February 11 ,2022. The article was titled 《Pd-Catalyzed Ring Restructuring of Oxazolidines with Alkenes Leading to Fused Polycyclic Indolizines》, and you may find the article in Organic Letters.Product Details of 157142-48-8 The information in the text is summarized as follows:

A palladium-catalyzed reaction of N-propargyl oxazolidines with alkenes for the synthesis of indolizidines has been developed. Through a sequential 6-exo-dig cyclization/proton transfer/[3+2] cycloaddition/cycloreversion/aromatization process, a series of fused polycyclic indolizines are obtained in moderate to good yields with high functional group tolerance. Exptl. and theor. studies suggest that the [3+2] cycloaddition/cycloreversion of the oxazolidine ring probably involves C-C and C-O bond cleavage, providing a new ring restructuring approach for the synthesis of heterocycles. The experimental process involved the reaction of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Product Details of 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 157142-48-8

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《Direct Access to 4-Substituted Isoquinolones via a Sequential Pd-Catalyzed Cyclization/Base-Promoted Aromatization/Ring-Opening of N-Propargyl-1,3-oxazolidines》 was written by Xu, Xianjun; Song, Liangliang; Feng, Huangdi; Van der Eycken, Erik V.. Recommanded Product: 157142-48-8 And the article was included in Molecular Catalysis on April 30 ,2022. The article conveys some information:

Herein, a practical Pd-catalyzed cyclization/base-promoted aromatization/ring-opening protocol of N-propargyl-1,3-oxazolidines with carboxylic acids was disclosed. In the current domino reaction, a series of ester-functionalized isoquinolones I [R1 = Ph, 4-MeC6H4, 2-FC6H4, etc.; R2 = H, 6-Me, 7-MeO, etc.; R3 = Ph, 4-MeC6H4, 4-ClC6H4; R4 = Me, t-Bu, Ph, etc.] was obtained in moderate to good yields via C-O bond cleavage, which features a broad functional group tolerance. After reading the article, we found that the author used 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Recommanded Product: 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 157142-48-8

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The author of 《Highly Efficient and Robust Enantioselective Liquid-Liquid Extraction of 1,2-Amino Alcohols utilizing VAPOL- and VANOL-based Phosphoric Acid Hosts》 were Pinxterhuis, Erik B.; Gualtierotti, Jean-Baptiste; Wezenberg, Sander J.; de Vries, Johannes G.; Feringa, Ben L.. And the article was published in ChemSusChem in 2018. Synthetic Route of C9H13NO The author mentioned the following in the article:

The large-scale production of enantiopure compounds in a cost-effective and environmentally friendly manner remains one of the major challenges of modern-day chem. The resolution of racemates through enantioselective liquid-liquid extraction was developed as a suitable solution but has remained largely underused, owing to a lack of highly efficient and robust chiral hosts to mediate the process. This paucity of hosts can in part be attributed to a poor understanding of the underlying principles behind these processes hindering the design of more efficient selectors. A previously untested class of hosts, VAPOL and VANOL derived phosphoric acids, was studied in depth for the efficient enantioselective liquid-liquid extraction of 1,2-amino alcs. A systematic investigation of extraction parameters was conducted, revealing many key interactions and DFT calculations illustrate the binding modes for the 1:1 complexes that are involved in chiral recognition. The resulting, now-optimized, procedures are highly robust and easy to implement. They are also easily scalable, as demonstrated by U-tube experiments In the experiment, the researchers used 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Synthetic Route of C9H13NO)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Synthetic Route of C9H13NO

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Barlow, Thomas; Dipple, Anthony published an article on January 31 ,1998. The article was titled 《Aralkylation of Guanosine with p-Substituted Styrene Oxides》, and you may find the article in Chemical Research in Toxicology.Product Details of 157142-48-8 The information in the text is summarized as follows:

To probe mechanisms of nucleoside aralkylation, product distributions and product stereochemistries were determined in reactions of optically active p-methyl- and p-bromo-styrene oxide with guanosine. The proportion of 7-, N2- and O6-substituted guanosine products was 0.32:0.62:0.06 in neutral, aqueous reactions of the (R) p-methylstyrene oxide and 0.85:0.09:0.04 in reactions with the (R) p-bromostyrene oxide. The exocyclic positions opened The epoxide at the α-carbon. Epoxide ring-opening by the nitrogen at the 7-position showed little preference for the α- or β-carbons in reactions with p-methylstyrene oxide. However, the p-bromostyrene oxide favored reaction at the β-carbon almost 4-fold over reaction at the α-carbon. Almost total inversion of stereochem. was found to occur in reactions at the 7-position. In contrast, the ratio of inversion to retention of configuration in N- and O-substituted products was 2:1 and 1:1 for reactions with the p-methylstyrene oxide and 6:1 and 3:1 for reactions with p-bromostyrene oxide, resp. These experiments suggest that an SN2 mechanism is in effect with reactions at the 7-position, whereas substrates of an increasingly ionic nature are involved in reactions at the N2- and O6- positions, resp. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Product Details of 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 157142-48-8

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In 2017,Beilstein Journal of Organic Chemistry included an article by Liu, Xinyun; Phan, Johnny H.; Haugeberg, Benjamin J.; Londhe, Shrikant S.; Clift, Michael D.. Synthetic Route of C9H13NO. The article was titled 《Quinone-catalyzed oxidative deformylation: synthesis of imines from amino alcohols》. The information in the text is summarized as follows:

A new method for imine synthesis by way of quinone-catalyzed oxidative deformylation of 1,2-amino alcs. is reported. A wide range of readily accessible amino alcs. and primary amines can be reacted to provide N-protected imine products. The methodol. presented provides a novel organocatalytic approach for imine synthesis and demonstrates the synthetic versatility of quinone-catalyzed oxidative C-C bond cleavage. The results came from multiple reactions, including the reaction of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Synthetic Route of C9H13NO)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C9H13NO

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Computed Properties of C9H13NOOn November 2, 2020 ,《Site-Specific C(sp3)-H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions》 appeared in Angewandte Chemie, International Edition. The author of the article were Zhao, Rong; Fu, Kang; Fang, Yuanding; Zhou, Jia; Shi, Lei. The article conveys some information:

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C-N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive mols. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, ESR spectroscopy, and d. functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N-H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Computed Properties of C9H13NO)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Computed Properties of C9H13NO

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《Design, Synthesis, Acaricidal Activity, and Mechanism of Oxazoline Derivatives Containing an Oxime Ether Moiety》 was written by Li, Yongqiang; Li, Chaojie; Zheng, Yanlong; Wei, Xingcun; Ma, Qiaoqiao; Wei, Peng; Liu, Yuxiu; Qin, Yaoguo; Yang, Na; Sun, Yufeng; Ling, Yun; Yang, Xinling; Wang, Qingmin. Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol And the article was included in Journal of Agricultural and Food Chemistry on April 9 ,2014. The article conveys some information:

Two series of novel 2,4-diphenyl-1,3-oxazolines containing an oxime ether moiety were designed and synthesized via the key intermediate N-(2-chloro-1-(p-tolyl)ethyl)-2,6-difluorobenzamide. The bioassay results showed that the target compounds with an oxime ether substituent at the para position of 4-Ph exhibited excellent acaricidal activity against Tetranychus cinnabarinus in the laboratory Moreover, all of the target compounds had much higher activities than etoxazole, as the ovicidal and larvicidal activities of the target compounds I-a-I-l and II-a-II-n against T. cinnabarinus were all over 90% at 0.001 mg L-1, but etoxazole gave only 30% and 40% resp. at the same concentration The activity order of compounds with regard to acaricidal activity in vivo was almost consistent with their affinity activity with sulfonylurea receptor (SUR) of Blattella germanica in vitro, hence, it was supposed that the acaricidal mechanism of action of the target compounds was that they can bind with the site of SUR and therefore inhibit chitin synthesis. Moreover, the eminent effect of the compound II-l, [2-(trifluoromethyl)benzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime], against Panonychus citri and T. cinnabarinus in the field indicated that II-l exhibited a promising application prospect as a new candicate for controlling spider mites in the field. In the experiment, the researchers used 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol

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Related Products of 157142-48-8On November 15, 2002 ,《The role of nucleation inhibition in optical resolutions with families of resolving agents》 appeared in Angewandte Chemie, International Edition. The author of the article were Nieuwenhuijzen, Jose W.; Grimbergen, Reinier F. P.; Koopman, Carla; Kellogg, Richard M.; Vries, Ton R.; Pouwer, Kees; van Echten, Erik; Kaptein, Bernard; Hulshof, Lumbertus A.; Broxterman, Quirinius B.. The article conveys some information:

The role of nucleation inhibition during Dutch resolution (DR) of several compounds in the presence of various additives is investigated. Significant improvements in the diastereomeric excesses (de values) of the salt products are observed The overall results indicated that the nucleation inhibition and associated kinetic effects can play a role in DR leading to a second generation of DR, namely the use of small amounts of a certain family member of the resolving agent as an additive. In the experiment, the researchers used many compounds, for example, 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Related Products of 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Related Products of 157142-48-8

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