Category: 156453-53-1

Xue, Da-quan published the artcileSynthesis of dapoxetine hydrochloride, Product Details of C19H18O2, the publication is Hecheng Huaxue (2010), 18(5), 647-649, database is CAplus.

Dapoxetine hydrochloride was synthesized from 3-chloropropiophenone by catalytic asym. reduction, alkylation, O-methylsulfonylation, and dimethylamination, as well as salt formation in an overall yield of 39.9%.

Hecheng Huaxue published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C10H15ClO3S, Product Details of C19H18O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sasikumar, M. published the artcileSimple and efficient synthesis of (S)-dapoxetine, Related Products of alcohols-buliding-blocks, the publication is Synthetic Communications (2012), 42(20), 3061-3067, database is CAplus.

A refinement in the synthetic strategy for (S)-dapoxetine was described. The key features of synthetic strategy include (a) a Sharpless asym. epoxidation and regioselective reductive ring opening of a 2,3-epoxy alc. to elaborate the hydroxy-bearing stereogenic center at the benzylic position; (b) regioselective functionalization of the 1-naphthol and the amine functionality through Mitsunobu procedures; and (c) Eschweiler-Clarke reductive methylation to access the target mol.

Synthetic Communications published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rapolu, Rajesh Kumar published the artcileShort enantioselective routes to (S)-Dapoxetine, Formula: C19H18O2, the publication is Chemistry & Biology Interface (2013), 3(1), 50-60, database is CAplus.

Two enantioselective approaches involving a stereoselective conjugate addition of a homochiral lithium amide based on (R)-N-(1-phenylethyl)benzylamine and a stereoselective ketone reduction of a prochiral ketone were employed for a chiral synthesis of (S)-dapoxetine. Both routes employ readily and com. viable starting materials and reagents, and suitable for process synthesis of (αS)-N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine (Dapoxetine hydrochloride) (I). The synthesis of the target compound was achieved using 3-chloro-1-phenyl-1-propanone as a starting material.

Chemistry & Biology Interface published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Formula: C19H18O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yafeng published the artcileEnantioselective β-hydroxy thioesters formation via decarboxylative aldol reactions of malonic acid half thioesters with aldehydes promoted by chloramphenicol derived sulfonamides¹, Computed Properties of 156453-53-1, the publication is Tetrahedron (2017), 73(34), 5055-5062, database is CAplus.

A highly enantioselective synthesis of chiral β-hydroxy thioesters that uses a decarboxylative aldol reaction of malonic acid half thioesters and aldehydes catalyzed by a chloramphenicol base-derived bifunctional organocatalyst is reported. The resulting chiral β-hydroxy thioesters were obtained in high yields (up to 82%) with good to excellent enantioselectivities (up to 94% ee). The synthetic application of the methodol. is illustrated by the asym. synthesis of the selective serotonin reuptake inhibitor dapoxetine.

Tetrahedron published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C15H20O6, Computed Properties of 156453-53-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mahale, Rajendra D. published the artcileCorey-Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates, Related Products of alcohols-buliding-blocks, the publication is Organic Process Research & Development (2012), 16(4), 710-713, database is CAplus.

A safe and inexpensive procedure for asym. reduction of ketones using in situ prepared N,N-diethylaniline borane (DEANB) and oxazaborolidine catalyst from sodium borohydride, N,N-diethylaniline hydrochloride and (S)-α,α-diphenylprolinol is described. This protocol is demonstrated successfully to manufacture enantiopure dapoxetine at the plant scale.

Organic Process Research & Development published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts