Category: 1562-00-1

Electric Literature of 1562-00-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1562-00-1, name is Sodium isethionate. A new synthetic method of this compound is introduced below.

An electrically-heated, mechanically stirred 1 liter autoclave was fitted with an vent valve connected in turn to a condenser and receiver assembly, a bottom valve, a thermowell, a pressure gauge, an inlet line for feeding of reagents, and a pressure-relief valve. The receiver was placed on a balance to facilitate continuous determination of the amount of distillate collected in the receiver. The amine starting material, aqueous sodium 2-hydroxyethanesulfonate, and aqueous 50 percent sodium hydroxide were charged to the autoclave. With the isolation valve open, the reaction mixture was rapidly heated with stirring until condensate was detected in the condenser/receiver. The mixture was further heated with continuous removal of water until the targeted amount of distillate had been removed. An analysis of the collected aqueous distillate was performed by UV spectroscopy to determine the amount of amine which co-distilled with the water. The isolation valve was then closed and the reaction mixture further heated to a target temperature in the range of 140-200 C. for 2-17 hours as specified in Examples 1-8. The reaction mixture was then cooled until the pressure dropped to 0 psig (ca. 110 C.) whereupon dilution water was added to dilute the concentrated reaction product. The resulting solution was then cooled to room temperature and drained from the reactor. Analysis of the product mixture was then performed by various chromatographic and spectroscopic procedures as indicated in the specific examples.; Procedure C A magnetically-stirred 70-mL fluoropolymer-lined steel autoclave was fitted with an internal thermocouple capable of determining the temperature of the liquid phase contained in the vessel, a pressure gauge, a pressure-relief valve, and a vent valve. The amine starting material, anhydrous or aqueous sodium 2-hydroxyethanesulfonate, and anhydrous or aqueous sodium hydroxide were charged to the open autoclave, which was then assembled and immersed in an electrically heated oil bath. With the vent valve closed, the stirred reaction mixture was rapidly heated to the reaction temperature and held at that temperature for the times specified in Examples 9, 10, and 13 below. The reaction mixture was then cooled to ambient temperature, the reactor opened, and the reaction product taken up in sufficient water to dissolve all solids.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Reference:
Patent; Carroll, Glenn T.; Smith, Gary S.; Stringer, Gary E.; US2006/89509; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1562-00-1, Adding some certain compound to certain chemical reactions, such as: 1562-00-1, name is Sodium isethionate,molecular formula is C2H5NaO4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1562-00-1.

Example 4; Preparation of [C2dmim][ise]; [C2dmim][ise] is an IL comprised of 1-ethyl-2,3-dimethylimidazolium as the cation, and isethionate (ise) as the anion. A 250-mL round bottom flask was charged with [C2dmim]2[SO4] (7.331 g, 21 mmol) and 2:1 alcohol-water (24 mL). This mixture was stirred until forming a clear, colorless solution, whereupon a prepared solution of sodium isethionate (6.267 g, 42 mmol) was added to the mixture in one portion with stirring. A fine precipitate formed soon thereafter. The resulting slurry was stirred for about 2 h, whereupon it was suction filtered, and the filtrate was concentrated as far as feasible by rotary evaporation. The residue was taken up in methanol (25 mL) and loaded onto an about 20-g column of 230-400 mesh silica gel previously packed in methanol.As in Example 3, the methanolic solution of crude [C2dmim][ise] was pushed down to the level of the top of the silica gel bed with air pressure while the column issue was collected in a 250-mL round bottom flask; the flask previously containing the crude product was rinsed with methanol (25 mL) and the rinse methanol was similarly loaded and pressed down while the column issue was collected on top of the first fraction. The rinsing process was repeated once before the silica gel column was washed down with fresh methanol (100 mL), all the while collecting the column issue on top of the accumulated methanol solution. The combined methanolic fractions were concentrated by rotary evaporation to produce purified [C2dmim][ise] (10.713 g, 43 mmol, 101%) as an ionic liquid. The ionic liquid of Example 4 was liquid at ambient conditions.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FLUIDIC, INC.; US2012/321967; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1562-00-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1562-00-1 as follows.

Example A; 31 g of (E)-10-pentafluorosulfanyldec-9-enecarbonyl chloride, prepared as in Example 1, are dissolved in 100 g of THF, 2-hydroxyethanesulfonic acid Na salt (15 g) and triethylamine (10 g) are added, and the mixture is stirred at 30 C. for 6 hrs.In order to isolate the product, the mixture is added to ice/methyl tert-butyl ether, the water phase is extracted with this solvent, and all org. phases are evaporated. Ethanol and then 1.2 equivalents of sodium hydroxide are added. The mixture is warmed briefly, and, after cooling, the crystals formed are isolated and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; US2009/264525; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1562-00-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1562-00-1 as follows.

Example A; 31 g of (E)-10-pentafluorosulfanyldec-9-enecarbonyl chloride, prepared as in Example 1, are dissolved in 100 g of THF, 2-hydroxyethanesulfonic acid Na salt (15 g) and triethylamine (10 g) are added, and the mixture is stirred at 30 C. for 6 hrs.In order to isolate the product, the mixture is added to ice/methyl tert-butyl ether, the water phase is extracted with this solvent, and all org. phases are evaporated. Ethanol and then 1.2 equivalents of sodium hydroxide are added. The mixture is warmed briefly, and, after cooling, the crystals formed are isolated and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1562-00-1, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; US2009/264525; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 1562-00-1 , The common heterocyclic compound, 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To 20 g of CH3CN was added 2-hydroxyethanesulfonic acid sodium (27) 4.7 g, 2.9 g of triethylamine, 4-dimethylaminopyridine24 mg were dissolved,(24) obtained in the above (Synthesis Example 1-1-3)Was dissolved in 20 g of CH3CN dropwise at 20 or lower, The mixture was stirred at 25 for 2 hours to obtain a sulfonic acid salt (25). 20 g of CH2Cl2 and 34 g of an aqueous solution of triphenylsulfonium chloride were added, And stirred for 30 minutes. After separating the organic layer,The aqueous layer was extracted with CH2Cl2,The combined organic layers were washed three times with H2O.The solvent was distilled off under reduced pressure,8.4 g of the target compound (PAG-1) was obtained (yield of 57% in three steps).

The synthetic route of 1562-00-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shin-Etsu Chemical Co., Ltd.; Domon, Daisuke; Masnaga, Keiichi; Sakehashi, Masayoshi; Watanabe, Satoshi; (33 pag.)KR2015/71677; (2015); A;,
Alcohol – Wikipedia,
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Synthetic Route of 1562-00-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, molecular weight is 148.1135, as common compound, the synthetic route is as follows.

EXAMPLE 1 14.8 g Isethionic acid-Na and 150 mg NaOH and 100 ml of benzyl alcohol were reacted in a 250 ml round bottom flask with a distillation bridge and heated slowly at 180 to 200 C for about 3 hours. At this temperature, about 1.8 g of water was distilled off. (0049) The reaction product was allowed to cool, forming crystals, and then filtered under suction. The very fine precipitate was dried. 18.7 g of a white substance at 78.6 % yield was recovered. IR confirmed that the reaction product was 99% pure.

Statistics shows that 1562-00-1 is playing an increasingly important role. we look forward to future research findings about Sodium isethionate.

Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (16 pag.)WO2017/175177; (2017); A1;,
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Alcohols – Chemistry LibreTexts

Related Products of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.

N-[(3S,4S)-6-Acetyl-3-hydroxy-2,2-di methyl-3,4-di hydro-2H- 1 -benzopyran-4-yl]-3-chloro-4- fluorobenzamide (3.92g, 10.Ommol) and pyridine (2.5mL) were dissolved in DCM (125mL) and triphosgene (980mg, 3.33mmol) was added. The reaction mixture was stirred for 2h. Sodium isethionate (1.48g, 10.Ommol) was added and the reaction mixture was stirred overnight. The rection mixture was diluted with DCM (50mL) and EtOAc (100mL) and washed with brine, dried (Mg504) and concentrated in vacuo. The residue was dissolved in EtOAc (50mL), filtered and passed through a plug of silica. The residue was triturated from diisopropyl ether then hexane to give the title compound (133mg, 2.3%) as a cream solid.LCMS (ESj: 544.0 [MH].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1562-00-1, Sodium isethionate.

Reference:
Patent; PROXIMAGEN LIMITED; SAVORY, Edward; HILL, Daniel; KOCIAN, Oldrich; WO2014/140510; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1562-00-1

Approximately 1.7 g of Compound A was added to a bottle and dissolved in 34 mL of acetone, concentration of 50 mg/mL. 400 pL (20 mg of freebase) of the stock solution was then dispensed into 84 vials and the acetone allowed to evaporate. 1M stock solutions of each counterion were prepared in either THF, ethanol or water, where appropriate as outlined in Table 27. L-aspartic acid was added as neat counterion due to low solubility. 1.05 equivalents of each counterion was added at room temperature and observations made. 2-hydroxy ethanesulfonic acid was supplied as a sodium salt and had 1.05 equivalents of HC1 added after counterion addition. All samples were then temperature cycled using the following procedure: a) Heat to 40 C, hold for 1 hour; b) Cooled to room temperature, hold for 3 hours; c) Heat to 40 C, hold for 1 hour; and d) Samples were held at 5 C overnight.All samples displaying solutions had the lids removed from the vials and were allowed to evaporate at ambient temperature. Samples with solid material had the mother liquor removed and the solids analyzed by XRPD. The mother liquor was transferred to a new sample vial and stored at 5 C to allow for further precipitation. The analyzed solids on the XRPD plate were exposed to 40 C/75 % RH conditions for 6 hours before analysis by XRPD. Table 27. Solvents Used to make Acid Stock Solutions

With the rapid development of chemical substances, we look forward to future research findings about 1562-00-1.

Reference:
Patent; ALDEYRA THERAPEUTICS, INC.; MACHATHA, Stephen, Gitu; LOUGHREY, Jonathan, James; MCLACHLAN, Hannah, Ruth; SNEDDON, Gregor; (194 pag.)WO2020/33344; (2020); A1;,
Alcohol – Wikipedia,
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Application of 1562-00-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reaction product V, [C1impd]2[SO4] (3.166 g, 8.74 mmol) was dissolved in 2:1 alcohol-water (30 mL), whereupon a prepared solution of sodium isethionate (2.592 g, 17.50 mmol) in 2:1 alcohol-water (18 mL) was added to it with stirring. The resulting slurry was stirred for about 2 h, whereupon it was suction filtered, and the filtrate was concentrated as far as feasible by rotary evaporation. The residue was taken up in methanol (25 mL) and loaded onto an about 12-g column of 230-400 mesh silica gel previously packed in methanol.As in Example 3, the methanolic solution of crude [C1impd][ise] was pushed down to the level of the top of the silica gel bed with air pressure while the column issue was collected in a 250-mL round bottom flask; the flask previously containing the crude product was rinsed with methanol (25 mL) and the rinse methanol was similarly loaded and pressed down while the column issue was collected on top of the first fraction. The rinsing process was repeated once before the silica gel column was washed down with fresh methanol (125 mL), all the while collecting the column issue on top of the accumulated methanol solution. The combined methanolic fractions were concentrated by rotary evaporation to produce purified [C1impd][ise] (4.122 g, 15.96 mmol, 91%) as an ionic liquid. The ionic liquid of Example 11 slowly solidified at ambient conditions. Specifically, it was freely liquid when contained in a flask immersed in an 80 C. water bath; it remained liquid for several hours after it was removed from the water bath. Thereafter, several regions of the liquid began to slowly solidify independently of each other, and after about 1 day, the IL had turned thoroughly solid under ambient conditions.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FLUIDIC, INC.; US2012/321967; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1562-00-1, Sodium isethionate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C2H5NaO4S, blongs to alcohols-buliding-blocks compound. COA of Formula: C2H5NaO4S

Example 9; Preparation of N-Methyl vinyl sulfonamide; PART A: A mixture of isethionic acid sodium salt (0.250 Kg, 1689 mmol) was taken inDMF (0.32L) and dichloromethae (0.3L). To this mixture thionyl chloride (0.375L, 5186mmol) was added dropwise at 20-30C. The reaction mixture was heated slowly from 30-60 “C. After completion of the reaction 3.5 lit of chilled water was added. The reaction mixture was extracted with 3×0.5L dichloromethane. Then dichloromethane was distilled out from the reaction mixture to get an oil. [ Yield 0.250Kg, 90%] which was distilled under vacuum to get pure chloroethane sulfonyl chloride. (0.225kg, 90%).

The synthetic route of 1562-00-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; USV LIMITED; WO2009/118753; (2009); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts