Category: 156-87-6

《Etherification of phenols by amines via transient diazonium intermediates》 was written by Reynard, Guillaume; Mayrand, Hugo; Lebel, Helene. Reference of 3-Aminopropan-1-ol And the article was included in Canadian Journal of Chemistry in 2020. The article conveys some information:

The synthesis of alkyl aryl ethers from electron poor phenols and amines using 1,3-propanedinitrite was described. Due to the mild conditions, functionalized primary, secondary and tertiary alkyl groups were successfully introduced, denoting a highly tolerant process that allowed for unprotected alcs. and acetals. The reaction was thought to proceeded through the formation of a diazonium intermediate that undergoes subsequent SN2> or SN1 reactions. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of 3-Aminopropan-1-ol

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《In silico evaluation of the antibacterial and modulatory activity of lapachol and nor-lapachol derivates》 was written by Figueredo, Fernando Gomes; Ramos, Ingrid T. L.; Paz, Josinete A.; Silva, Tania M. S.; Camara, Celso A.; Oliveira-Tintino, Cicera Datiane de Morais; Relison Tintino, Saulo; Maia de Farias, Pablo Antonio; Coutinho, Henrique Douglas Melo; Fonteles, Marta Maria de F.. Category: alcohols-buliding-blocks And the article was included in Microbial Pathogenesis in 2020. The article conveys some information:

To investigate pharmacol. properties of 2-(2-hydroxyethylamine)-3-(3-methyl-2-butenyl)-1,4-dihydro-1,4-naphthalenedione, 2-(2-hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone and 2-(3-hydroxy-propylamine)-3-(3-methyl-2-butenyl)-[1,4]naphthoquinone using computational prediction models, in addition to evaluating the in vitro antibacterial and modulatory activity of these compounds against bacterial ATCC strains and clin. isolates. The substances were synthesized from 2-hydroxy-quinones, lapachol and nor-lapachol obtaining the corresponding 2-methoxylated derivatives via di-Me sulfate alkylation in a basic medium, these then reacted chemoselectively with 2-ethanolamine and 3-propanolamine to form the corresponding amino alcs. The antibacterial activity and modulatory activity of the substances were assayed by broth microdilution method to determine MIC. The mol. structures were analyzed using the ChEMBL database to predict possible pharmacol. targets, which pointed to the mol. 2- (2-hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone as a probable antibacterial agent for the proteins Replicative DNA helicase and RecA. The compounds had low mol. weight and a small number of rotatable bonds. The MICs of the substances were not clin. significant, however, the association with gentamicin and amikacin reduced MICs of these antibiotics. Combination of these substances with aminoglycosides may be therapeutic alternative to bacterial resistance and reduction of side effects. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: alcohols-buliding-blocks

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Name: 3-Aminopropan-1-olIn 2022 ,《Synthesis and characterization of new spiro cyclotriphosphazene derivatives》 was published in Inorganic Chemistry Communications. The article was written by Begec, Saliha. The article contains the following contents:

Reactions of spiro-N,N-diisopropylpropane-1,3-diamino-2,2-4,4 tetrachlorocyclotriphosphazatriene (1) with 2,2′-dihydroxybiphenyl (2), and 3-amino-1-propanol (3) were studied. Dispiro (4,6) and trispiro (5) phosphazene derivatives were obtained from these reactions. New spirocyclotriphosphazenes (4-6) were characterized by elemental anal., 1H, 13C and 31P NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Name: 3-Aminopropan-1-ol

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Vaughan, Hannah J.; Zamboni, Camila G.; Radant, Nicholas P.; Bhardwaj, Pranshu; Revai Lechtich, Esther; Hassan, Laboni F.; Shah, Khalid; Green, Jordan J. published an article in 2021. The article was titled 《Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer》, and you may find the article in Molecular Therapy–Oncolytics.Recommanded Product: 156-87-6 The information in the text is summarized as follows:

Despite initial promise, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based approaches to cancer treatment have yet to yield a clin. approved therapy, due to delivery challenges, a lack of potency, and drug resistance. To address these challenges, we have developed poly(beta-amino ester) (PBAE) nanoparticles (NPs), as well as an engineered cDNA sequence encoding a secretable TRAIL (sTRAIL) protein, to enable reprogramming of liver cancer cells to locally secrete TRAIL protein. We show that sTRAIL initiates apoptosis in transfected cells and has a bystander effect to non-transfected cells. To address TRAIL resistance, NP treatment is combined with histone deacetylase inhibitors, resulting in >80% TRAIL-mediated cell death in target cancer cells and significantly slowed xenograft tumor growth. This anti-cancer effect is specific to liver cancer cells, with up to 40-fold higher cell death in HepG2 cancer cells over human hepatocytes. By combining cancer-specific TRAIL NPs with small-mol.-sensitizing drugs, this strategy addresses multiple challenges associated with TRAIL therapy and offers a new potential approach for cancer treatment. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 156-87-6

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《Experimental and predicted physicochemical properties of monopropanolamine-based deep eutectic solvents》 was written by Nowosielski, Bartosz; Jamrogiewicz, Marzena; Luczak, Justyna; Smiechowski, Maciej; Warminska, Dorota. Electric Literature of C3H9NO And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

In this work, the novel deep eutectic solvents (DESs) based on 3-amino-1-propanol (AP) as hydrogen bond donor (HBD) and tetrabutylammonium bromide (TBAB) or tetrabutylammonium chloride (TBAC) or tetraethylammonium chloride (TEAC) as hydrogen bond acceptors (HBAs) were synthesized with different molar ratios of 1: 4, 1: 6 and 1: 8 salt to AP. Fourier Transform IR Spectroscopy measurements were performed to provide an evidence of any chem. structure changes. Phys. properties of the prepared DESs including densities, viscosities, refractive indexes and sound velocities were measured within the temperature range of 293.15-333.15 K at the pressure of 0.1 MPa. They were analyzed in terms of estimating the effect of HBA to HBD molar ratio, anion and length of alkyl chain in a salt, and their temperature dependences were fitted by empirical equations. Thermal expansion coefficients and activation energies for viscous flow were obtained accordingly. Moreover, exptl. values of d. and refractive index were compared with predicted ones. For prediction of d., Rackett equation modified by Spencer and Danner and the mass connectivity index-based method were used, while refractive index was estimated by the at. contribution method.3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C3H9NO

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In 2019,Journal of Controlled Release included an article by Luebtow, Michael M.; Nelke, Lena C.; Seifert, Julia; Kuehnemundt, Johanna; Sahay, Gaurav; Dandekar, Gudrun; Nietzer, Sarah L.; Luxenhofer, Robert. Product Details of 156-87-6. The article was titled 《Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models》. The information in the text is summarized as follows:

Here, we report on a novel nanoformulation of CUR that enables CUR concentrations in water of at least 50 g/L with relative drug loadings of >50 wt% and high dose efficacy testing in 3D tumor models. Despite this high loading and concentration, the CUR nanoformulation comprises polymer-drug aggregates with a size <50 nm. Most interestingly, this is achieved using an amphiphilic block copolymer, that by itself does not form micelles due to its limited hydrophilic/lipophilic contrast. The ultra-high loaded nanoformulations exhibit a very good stability, reproducibility and redispersibility. In order to test effects of CUR in conditions closer to an in vivo situation, we utilized a 3D tumor test system based on a biol. de-cellularized tissue matrix that better correlates to clin. results concerning drug testing. We found that in comparison to 2D culture, the invasively growing breast cancer cell line MDA-MB-231 requires high concentrations of CUR for tumor cell eradication in 3D. In addition, we supplemented a 3D colorectal cancer model of the malignant cell line SW480 with fibroblasts and observed also in this invasive tumor model with stroma components a decreased tumor cell growth after CUR application accompanied by a loss of cell-cell contacts within tumor cell clusters. In a flow bioreactor simulating cancer cell dissemination, nanoformulated CUR prevented SW480 cells from adhering to a collagen scaffold, suggesting an anti-metastatic potential of CUR. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Product Details of 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 156-87-6

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Eshimbetov, Alisher; Adizov, Shahobiddin; Kaur, Inderpreet; Reymov, Akhmed published an article in 2021. The article was titled 《Is it possible to differentiate between 2-phenylaminodihydro-1,3-thiazine from 2-phenyliminotetrahydro-1,3-thiazine by spectral methods New glance to the old problem》, and you may find the article in European Journal of Chemistry.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

Several studies have reported the presence of amine and imine tautomeric forms for hydrogenated 1,3-thiazine derivatives However, identification of their tautomeric forms by UV, FTIR and mass-spectral methods does not yield expected results. Here, we report the synthesis of 2-phenylaminodihydro-1,3-thiazine and 2-phenyliminotetrahydro-1,3-thiazine and the anal. of their UV, FTIR and NMR (1H and 13C) spectral data. An identical picture of UV spectra was recorded for both compounds However, distinctive characteristics were found in the FTIR, 1H and 13C NMR spectra. The C=N band of amine form was observed in higher frequency region relative to imine form. The signal of C2 carbon of amine form in 13C NMR spectrum was occurred in more downfield (δ 165.3 ppm) relative to C2 signal of imine form (δ 152.1 ppm). In addition, the difference between C2 and C8 carbon signals of amine form was very high (Δδ = 30.6 ppm) relative to imine form (δ 5.4 ppm). The position of C2 and C8 signals and the difference between them in 13C NMR spectrum was found to be more promising in identification of tautomeric forms in case of hydrogenated 1,3-thiazine derivatives In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Category: alcohols-buliding-blocks

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《A flexible paper-based chemosensor for colorimetric and ratiometric fluorescence detection of toxic oxalyl chloride》 was written by Chen, Tianhong; Jiang, Lirong; Yuan, Hou-Qun; Zhang, Yue; Su, Dongdong; Bao, Guang-Ming. Category: alcohols-buliding-blocks And the article was included in Sensors and Actuators, B: Chemical in 2020. The article conveys some information:

The screening of highly toxic chem. vapor is critical for environmental monitoring and human health maintenance. Herein, we reported a chemosensor (AC-HPD) for rapid and specific detection of highly toxic oxalyl chloride vapor, which adopted anthracene carboxyimide as a fluorophore and 3-aminopropanol as the reaction site. Upon coupling of oxalyl chloride with NH and OH groups, AC-HPD exhibited remarkable colorimetric and ratiometric fluorescence dual-mode responses towards oxalyl chloride via the intramol. charge transfer effect. AC-HPD could determine oxalyl chloride with features of rapid response, excellent specificity, low detection limit (95 nM), as well as obvious color and fluorescence change. Furthermore, AC-HPD-embedded test strip was successfully fabricated and used as a flexible sensing device for rapid, sensitive and visible monitoring oxalyl chloride vapor. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

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Safety of 3-Aminopropan-1-olIn 2020 ,《Tunable Structural Color Patterns Based on the Visible-Light-Responsive Dynamic Diselenide Metathesis》 was published in Advanced Materials (Weinheim, Germany). The article was written by Liu, Cheng; Fan, Zhiyuan; Tan, Yizheng; Fan, Fuqiang; Xu, Huaping. The article contains the following contents:

Structural color materials with reversible stimuli-responsiveness to external environment have been widely used in sensors, encryption, display, and other fields. Compared with other stimuli, visible light is highly controllable both temporally and spatially with less damage to materials, which is more suitable for structural color patterning. Herein, a new diselenide-containing shape memory material is prepared and used for creating patterns via visible light stimulus. In this system, the structural color originates from birefringence of stretched materials, whose shapes can be fixed while maintaining the mech. stress. The fixed stress can be released by diselenide metathesis under visible light irradiation By regulating the wavelength or irradiation time with a com. projector, the pattern with tunable structural colors is realized and the structural color pattern can be erased and rewritten arbitrarily. During the patterning process, the optical signal is first stored as mech. signal and then transformed back to optical signal. It is a new method for preparing visible-light-responsive structural color material and has great potential in display devices, anticounterfeiting labels, and data storage. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Safety of 3-Aminopropan-1-ol

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The author of 《pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury》 were Zhang, Can Yang; Lin, Wenjing; Gao, Jin; Shi, Xutong; Davaritouchaee, Maryam; Nielsen, Amy E.; Mancini, Rock J.; Wang, Zhenjia. And the article was published in ACS Applied Materials & Interfaces in 2019. Electric Literature of C3H9NO The author mentioned the following in the article:

Dysregulated vascular inflammation is the underlying cause of acute lung inflammation/injury (ALI). Bacterial infections and trauma cause ALI that may rapidly lead to acute respiratory distress syndrome (ARDS). There are no pharmacol. therapies available to patients with ALI/ARDS, partially as drugs cannot specifically target the lungs. Herein, we developed a stimuli-responsive nanoparticle (NP) to target inflammatory lungs for ALI therapies. The NP is composed of a sharp acid-sensitive segment poly(β-amino esters) as a core for drug loading and controlled release and a polyethylene glycol-biotin on the particle surface available for bioconjugation, enabling lung targeting and extended circulation. The studies on dissipative particle dynamics simulation and characteristics of NPs suggest that anti-ICAM-1 antibodies can be coated to the particle surface and this coating is required to enhance lung targeting of NPs. A model drug of anti-inflammatory agent TPCA-1 is encapsulated in NPs with a high drug-loading content at 24% (weight/weight). In the mouse ALI model, our TPCA-1-loaded NPs coated with anti-ICAM-1 can target inflamed lungs after i.v. injection, followed by drug release triggered by the acid environment, thus mitigating lung inflammation and injury. Our studies reveal the rational design of nanotherapeutics for improved therapy of ALI, which may be applied to treating a wide range of vascular inflammation. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H9NO

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