Category: 156-87-6

Yoneyama, Tohru; Hatakeyama, Shingo; Sutoh-Yoneyama, Mihoko; Yoshiya, Taku; Uemura, Tsuyoshi; Ishizu, Takehiro; Suzuki, Minoru; Hachinohe, Shingo; Ishiyama, Shintaro; Nonaka, Motohiro; Fukuda, Michiko N.; Ohyama, Chikara published their research in BMC Cancer in 2021. The article was titled 《Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy》.Formula: C3H9NO The article contains the following contents:

P-Boronophenylalanine (10BPA) is a powerful 10B drug used in current clin. trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of 10BPA must be administered over a few hours. Here, we report BNCT efficacy after rapid, ultralow-dose administration of either tumor vasculature-specific annexin A1-targeting IFLLWQR (IF7)-conjugated 10BPA or borocaptate sodium (10BSH). (1) IF7 conjugates of either 10B drugs i.v. injected into MBT2 bladder tumor-bearing mice and biodistribution of 10B in tumors and normal organs analyzed by prompt gamma-ray anal. (2) Therapeutic effect of IF7-10B drug-mediated BNCT was assessed by either MBT2 bladder tumor bearing C3H/He mice and YTS-1 tumor bearing nude mice. I.v. injection of IF7C conjugates of either 10B drugs into MBT2 bladder tumor-bearing mice promoted rapid 10B accumulation in tumor and suppressed tumor growth. Moreover, multiple treatments at ultralow (10-20 mg/kg) doses of IF7-10B drug-mediated BNCT significantly suppressed tumor growth in a mouse model of human YTS-1 bladder cancer, with increased Anxa1 expression in tumors and infiltration by CD8-pos. lymphocytes. We conclude that IF7 serves as an efficient 10B delivery vehicle by targeting tumor tissues via the tumor vasculature and could serve as a relevant vehicle for BNCT drugs. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C3H9NO

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In 2019,Green Chemistry included an article by Hu, Wenkang; Zhang, Yilin; Zhu, Haiyan; Ye, Dongdong; Wang, Dawei. Safety of 3-Aminopropan-1-ol. The article was titled 《Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water》. The information in the text is summarized as follows:

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Safety of 3-Aminopropan-1-ol

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《Organic functionalized graphene oxide behavior in waterã€?was written by Kim, Changwoo; Lee, Junseok; Wang, Will; Fortner, John. Application of 156-87-6 And the article was included in Nanomaterials in 2020. The article conveys some information:

Surface modified graphene oxide (GO) has received broad interest as a potential platform material for sensors, membranes, and sorbents, among other environmental applications. However, compared to parent (unmodified) GO, there is a dearth of information regarding the behavior of subsequently (secondary) modified GO, other than bulk natural organic matter (NOM) coating(s). Here, we systematically explore the critical role of organic functionalization with respect to GO stability in water. Specifically, we synthesized a matrix of GO-based materials considering a carefully chosen range of bound organic mols. (hydrophobic coatings: propylamine, tert-octylamine, and 1-adamantylamine; hydrophilic coatings: 3-amino-1-propanol and 3-amino-1-adamantanol), so that chem. structures and functional groups could be directly compared. GO (without organic functionalization) with varying oxidation extent(s) was also included for comparison. The material matrix was evaluated for aqueous stability by comparing critical coagulation concentration (CCC) as a function of varied ionic strength and type (NaCl, CaCl2, MgCl2, and MgSO4) at pH 7.0. Without surface derivatization (i.e., pristine GO), increased stability was observed with an increase in the GO oxidation state, which is supported by plate-plate Derjaguin, Landau, Verwey and Overbeek (DLVO) energy interaction analyses. For derivatized GO, we observed that hydrophilic additions (phi-GO) are relatively more stable than hydrophobic organic coated GO (pho-GO). We further explored this by altering a single OH group in the adamantane-x structure (3-amino-1-adamantanol vs. 1-adamantylamine). As expected, Ca2+ and monovalent co-ions play an important role in the aggregation of highly oxidized GO(HGO) and phi-GO,while the effects of divalent cations and co-ions were less significant for pho-GO. Taken together, this work provides new insight into the intricate dynamics of GO-based material stability in water as it relates to surface functionalization (surface energies) and ionic conditions including type of co- and counter-ion, valence, and concentration The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Application of 156-87-6

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�-(3-Hydroxypropyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde Methyl Hemiacetal�was written by Cordaro, Massimiliano. Recommanded Product: 156-87-6This research focused onuracil aldehyde methyl hemiacetal preparation. The article conveys some information:

The synthesis of 3-(3-hydroxypropyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde as a stable Me hemiacetal through a convenient 3-step procedure is reported. The mol. is multifunctional as it contains a formyl group, a hydroxyl group and the imide moiety. Each of these groups can play a role in specific transformations or uses. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 156-87-6

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Nowosielski, Bartosz; Jamrogiewicz, Marzena; Luczak, Justyna; Warminska, Dorota published an article in 2022. The article was titled 《Novel Binary Mixtures of Alkanolamine Based Deep Eutectic Solvents with Water-Thermodynamic Calculation and Correlation of Crucial Physicochemical Propertiesã€? and you may find the article in Molecules.Reference of 3-Aminopropan-1-ol The information in the text is summarized as follows:

This paper demonstrates the assessment of physicochem. and thermodn. properties of aqueous solutions of novel deep eutectic solvent (DES) built of tetrabutylammonium chloride and 3-amino-1-propanol or tetrabutylammonium bromide and 3-amino-1-propanol or 2-(methylamino)ethanol or 2-(butylamino)ethanol. Densities, speeds of sound, refractive indexes, and viscosities for both pure and aqueous mixtures of DES were investigated over the entire range of compositions at atm. pressure and T = (293.15 – 313.15) K. It was concluded that the exptl. data were successfully fitted using the Jouyban-Acree model with respect to the concentration Obtained results showed that this math. equation is an accurate correlation for the prediction of aqueous DES properties. Key physicochem. properties of the mixtures-such as excess molar volumes, excess isentropic compressibilities, deviations in viscosity, and deviations in refractive indexes-were calculated and correlated by the Redlich-Kister equation with temperature-dependent parameters. The non-ideal behavior of the studied systems were also evaluated by using the Prigogine-Flory-Patterson theory and the results were interpreted in terms of interactions between the mixture components. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of 3-Aminopropan-1-ol

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《Eco-Friendly Sustainable Poly(benzoxazine-co-urethane) with Room-Temperature-Assisted Self-Healing Based on Supramolecular Interactions》 was published in ACS Omega in 2020. These research results belong to Sriharshitha, Salendra; Krishnadevi, Krishnamoorthy; Devaraju, Subramani; Srinivasadesikan, Venkatesan; Lee, Shyi-Long. Application of 156-87-6 The article mentions the following:

This work is an attempt to develop bio-based eco-friendly poly(benzoxazine-co-urethane) [poly(U-co-CDL-aee)] materials using cardanol-based benzoxazines (CDL) and hexamethylene diisocyanate (HMDI) to check their self-healing ability and thermal properties. CDL monomers were synthesized using cardanol, amino ethoxyethanol (aee) or 3-aminopropanol (3-ap), and paraformaldehyde through the Mannich reaction. Later, CDL-aee or CDL-3-ap monomers were copolymerized with a urethane precursor (HMDI), followed by ring-opening polymerization through thermal curing. The thermal properties of poly(U-co-CDL) were evaluated by differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA). The self-healing behavior of the bio-based poly(U-co-CDL) was checked by applying a mild external pressure. The results revealed that the developed poly(U-co-CDL) showed repeatable self-healing ability due to supramol. hydrogen-bonding interactions. Further, the self-healing ability of poly(U-co-CDL) was studied using d. functional theory (DFT). From the above results, the developed material with superior self-healing ability can be used in the form of self-healing coatings and composites for various applications with extended shelf-life and reliability. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application of 156-87-6

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《Protein cation exchangers derived by charge reversal from poly(ethylenimine)-Sepharose FF: Comparisons between two derivatization routes》 was written by Xu, Rui; Li, Xianxiu; Dong, Xiaoyan; Sun, Yan. COA of Formula: C3H9NO And the article was included in Journal of Chromatography A in 2020. The article conveys some information:

It has been known that anion exchangers prepared by grafting poly(ethyleneimine) (PEI) onto Sepharose FF (PEI-Sepharose) at ionic capacities (IC) over 600 mmol/L show both high protein adsorption capacity and uptake kinetics, and charge reversal of PEI-Sepharose by modification with succinic anhydride can produce protein cation exchangers of high capacity and uptake rate. Previously, a Charge Reversal-then-Reduction procedure (route A) was studied for preparation of cation exchangers of different IC values from PEI-Sepharose. In this work, we proposed a new route, i.e., Charge Reduction-then-Reversal route (route B), to develop cation exchangers of different IC values from PEI-Sepharose FF with an IC of 700 mmol/L (FF-PEI-L700) as the starting resin. The two kinds of cation exchangers (route A, PEI-L700-CRn; route B, PEI-Rm-Cn) are compared for lysozyme (Lys) adsorption and chromatog. The two modification routes result in the difference in the ligand structures that significantly affect protein adsorption equilibrium and kinetics. Route A introduces long electroneutral groups that hinder protein adsorption and reduce equilibrium capacity. Moreover, charge reversal by reaction with succinic anhydride could cause diamide formation, which reduces remaining carboxyl groups or the IC. In the charge-reduced FF-PEI-Rm resins of the lowest IC (394 mmol/L) prepared in route B, the diamide formation was little due to the lack of primary and secondary amine groups, so its charge reversal makes a higher-IC cation exchanger. This makes PEI-Rm-Cn show a higher IC (589 mmol/L) than PEI-L700-CRn (463 mmol/L) in which De/D0 jumps about four times. The differences in the adsorption equilibrium and kinetics make the two kinds of resins behave distinctly in dynamic adsorption and chromatog. Namely, PEI-Rm-Cn resins display obviously higher dynamic binding capacities than PEI-L700-CRn resins in the IC range studied. For instance, the DBC (at 10% breakthrough) of PEI-R590-C680 (192 mg/mL) is 33% higher than that of PEI-L700-CR680 (144 mg/mL). This is proved by the purification of Lys from chicken egg white solution, in which the PEI-R590-C680 column purified Lys with a recovery yield 14% higher than the PEI-L700-CR680 column. This research thus demonstrated that Charge Reduction-then-Reversal route is superior over Charge Reversal-then-Reduction route in fabricating a high-capacity cation exchanger from PEI-Sepharose. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6COA of Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.COA of Formula: C3H9NO

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《Enthalpies of dilution of amino alcohols in aqueous solutions at 298.15 K》 was published in Thermochimica Acta in 2020. These research results belong to Romero, Carmen M.; Cruz, Yadhi P.; Perez-Casas, Silvia. Quality Control of 3-Aminopropan-1-ol The article mentions the following:

The enthalpies of dilution of aqueous solutions of the amino alcs.: 3-amino-1-propanol, (RS)-1-amino-2-propanol, (RS)-3-amino-1,2-propanediol, and 1,3-diamino-2-propanol were measured as a function of concentration at 298.15 K using a thermal activity monitor (TAM). The results of the exptl. measurements were treated according to the McMillan-Mayer theory, to obtain the enthalpic homogeneous interaction coefficients The pair interaction coefficient hxx shows a clear dependence on the position and number of polar groups. The enthalpic coefficients are discussed in terms of the mol. interaction between solvated solute mols. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Quality Control of 3-Aminopropan-1-ol

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The author of 《Scalable Synthesis of Sequence-Defined Oligomers via Photoflow Chemistry》 were Van De Walle, Matthias; De Bruycker, Kevin; Junkers, Tanja; Blinco, James P.; Barner-Kowollik, Christopher. And the article was published in ChemPhotoChem in 2019. Application of 156-87-6 The author mentioned the following in the article:

The development of practical routes that enable the synthesis of unimol. non-natural macromols. on multi-gram scales remains a key challenge in polymer chem. Herein, we present a continuous flow setup employing the light-induced chem. based on photocaged dienes as a controlled ligation system to establish a new platform for scalable monodisperse macromol. synthesis. 800 Mg of sequence-defined linear chains with 8 repeating units were obtained in a sequential protecting group based 2-step process. The current study demonstrates that photoflow synthesis is a viable approach to generate large quantities of monodisperse oligomers. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 156-87-6

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In 2019,Inorganica Chimica Acta included an article by Elmas, Gamze; Okumus, Aytug; Hokelek, Tuncer; Kilic, Zeynel. Related Products of 156-87-6. The article was titled 《Phosphorus-nitrogen compounds. Part 52. The reactions of octachlorocyclotetraphosphazene with sodium 3-(N-ferrocenylmethylamino)-1-propanoxide: Investigations of spectroscopic, crystallographic and stereogenic properties》. The information in the text is summarized as follows:

The reaction of octachlorocyclotetraphosphazene (tetramer, N4P4Cl8, 1) with two mole equivalent of Na 3-(N-ferrocenylmethylamino)-1-propanoxide (2) gave the novel ansa-spiro (3), 2-trans-6-dispiro (4), 2-cis-6-dispiro (5), 2-trans-4-dispiro (6) and 2-cis-4-dispiro (7) cyclotetraphosphazenes. However, when the reaction was carried out with 1 and three mole equivalent of 2, seven products observed with respect to the 31P NMR spectrum of the reaction mixture Five of these products were identified as 3, 4, 5, 6 and 7, and the other two products are expected to be 2-trans-4-trans-6-trispiro (8) derived from 4 and/or 6, and 2-trans-4-cis-6-trispiro (9) derived from 5 and/or 7. Both of the trispiro products (8 and 9) were not isolated using column chromatog. Besides, when the reaction was made with 1 and excess amount of 2, the tetraspiro products were not observed by TLC and 31P NMR spectrum of the reaction mixture The structures of cyclotetraphosphazene derivatives were verified by ESI-MS, FTIR, 1H, 13C and 31P NMR spectral data. The mol. and solid state structures of 3, 5 and 6 were established by x-ray diffraction method. The x-ray crystallog. data indicate that compounds 3 and 6 have three-different and two equivalent chiral P centers, resp. The absolute configurations of 3 and 6 also are as SS’S” and RR. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Related Products of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 156-87-6

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