Category: 156-87-6

In 2019,Molecules included an article by Shao, Yu; Chen, Jia; Ren, Xiang-Kui; Zhang, Xinlin; Yin, Guang-Zhong; Li, Xiaopeng; Wang, Jing; Wesdemiotis, Chrys; Zhang, Wen-Bin; Yang, Shuguang; Sun, Bin; Zhu, Meifang. Safety of 3-Aminopropan-1-ol. The article was titled 《Synthesis, self-assembly and characterization of tandem triblock BPOSS-PDI-X shape amphiphiles》. The information in the text is summarized as follows:

The authors report the facile synthesis, self-assembly, and characterization of shape amphiphiles (BPOSS-PDI-X) based on isobutyl-functionalized polyhedral oligomeric silsesquioxane (BPOSS), perylene tetracarboxylic diimide (PDI), and (60)fullerene (C60) moieties. Firstly, an asym. functionalized diblock shape amphiphile precursor (BPOSS-PDI-OH) was obtained through the 1-pot reaction between perylene-3,4,9,10-tetracarboxylic dianhydride and two different amines, BPOSS-NH2 and 3-amino-1-propanol. It was further conjugated with C60-COOH to give a tri-block shape amphiphile (BPOSS-PDI-C60). Their chem. structures were thoroughly characterized by NMR, IR and MALDI-TOF MS spectrometry. To gain insights on the structure-property relation, their self-assembly in gas phase, in solution, and in solid state were characterized using traveling wave ion mobility mass spectrometry (TWIM-MS), UV/visible absorption, fluorescence emission spectrophotometer, and TEM, resp. BPOSS-PDI-OH formed more complicated dimers than BPOSS-PDI-C60. Both samples showed unique aggregation behaviors in solution with increasing concentration, which could be attributed neither to H- nor to J-type and might be related to the discrete dimers. While BPOSS-PDI-C60 could hardly crystallize into ordered structures, BPOSS-PDI-OH could form nanobelt-shaped single crystals, which may hold potential applications in microelectronics. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Safety of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Tuning Hot Carrier Cooling Dynamics by Dielectric Confinement in Two-Dimensional Hybrid Perovskite Crystals》 were Yin, Jun; Maity, Partha; Naphade, Rounak; Cheng, Bin; He, Jr-Hau; Bakr, Osman M.; Bredas, Jean-Luc; Mohammed, Omar F.. And the article was published in ACS Nano in 2019. Application of 156-87-6 The author mentioned the following in the article:

Hot carrier (Hc) cooling is a critical photophys. process that significantly influences the optoelectronic performance of hybrid perovskite-based devices. The hot carrier extraction at the device interface is very challenging because of its ultrashort lifetime. Ultrafast transient reflectance spectroscopy measurements and time-domain ab initio calculations show how the dielec. constant of the organic spacers can control and slow the Hc cooling dynamics in single-crystal 2D Ruddlesden-Popper hybrid perovskites. (EA)2PbI4 (EA = HOC2H4NH3+) that correspond to a high dielec. constant organic spacer has a longer Hc cooling time compared to that of (AP)2PbI4 (AP = HOC3H6NH3+) and (PEA)2PbI4 (PEA = C6H5C2H4NH3+). The slow Hc relaxation process in the former case can be ascribed to a stronger screening of the Coulomb interactions, a small nonradiative internal conversion within the conduction bands, as well as a weak electron-phonon coupling. The findings provide a strategy to prolong the hot carrier cooling time in low-dimensional hybrid perovskite materials by using organic spacers with reduced dielec. confinement. Crystallog. data are given. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Nanoscale included an article by Zhou, Yiqun; Liyanage, Piumi Y.; Devadoss, Dinesh; Rios Guevara, Linda Rebeca; Cheng, Ling; Graham, Regina M.; Chand, Hitendra S.; Al-Youbi, Abdulrahman O.; Bashammakh, Abdulaziz S.; El-Shahawi, Mohammad S.; Leblanc, Roger M.. SDS of cas: 156-87-6. The article was titled 《Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood-brain barrier and inhibitors of β-amyloid》. The information in the text is summarized as follows:

The blood-brain barrier (BBB) is a main obstacle for drug delivery targeting the CNS and treating Alzheimer’s disease (AD). In order to enhance the efficiency of drug delivery without harming the BBB integrity, nanoparticle-mediated drug delivery has become a popular therapeutic strategy. Carbon dots (CDs) are one of the most promising and novel nanocarriers. In this study, amphiphilic yellow-emissive CDs (Y-CDs) were synthesized with an ultrasonication-mediated methodol. using citric acid and o-phenylenediamine with a size of 3 nm that emit an excitation-independent yellow photoluminescence (PL). The content of primary amine and carboxyl groups on CDs was measured as 6.12 x 10-5 and 8.13 x 10-3 mmol mg-1, resp., indicating the potential for small-mol. drug loading through bioconjugation. Confocal image analyses revealed that Y-CDs crossed the BBB of 5-day old wild-type zebrafish, most probably by passive diffusion due to the amphiphilicity of Y-CDs. And the amphiphilicity and BBB penetration ability didn’t change when Y-CDs were coated with different hydrophilic mols. Furthermore, Y-CDs were observed to enter cells to inhibit the overexpression of human APP and β-amyloid (Aβ) which is a major factor responsible for AD pathol. Therefore, data suggest that Y-CDs have a great potential as nontoxic nanocarriers for drug delivery towards the CNS as well as a promising inhibiting agent of Aβ-related pathol. of the AD. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Podjed, Nina; Modec, Barbara published an article in Molecules. The title of the article was 《Hydrogen Bonding and Polymorphism of Amino Alcohol Salts with Quinaldinate: Structural Study》.Synthetic Route of C3H9NO The author mentioned the following in the article:

Three amino alcs., 3-amino-1-propanol, 2-amino-1-butanol and 2-amino-2-methyl-1-propanol were reacted with quinoline-2-carboxylic acid, known as quinaldinic acid. This combination yielded three salts, I [R = 3-hydroxypropylammonium, 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium]. The 2-amino-1-butanol and 2-amino-2-methyl-1-propanol systems produced two polymorphs each, labeled as salts I [R = 1-hydroxymethyl propylammonium, 2-hydroxy-1,1-dimethyl-Et ammonium] resp. The compounds were characterized by X-ray structure anal. on single-crystal. The crystal structures of all consisted of protonated amino alcs. with NH3+ moiety and quinaldinate anions with carboxylate moiety. The used amino alcs. contained one OH and one NH2 functional group, both proned to participate in hydrogen bonding. Therefore, similar connectivity patterns were expected. This proved to be true to some extent as all structures contained the NH3+•••-OOC heterosynthon. Nevertheless, different hydrogen bonding and π•••π stacking interactions were observed, leading to distinct connectivity motifs. The largest difference in hydrogen bonding occurred between polymorphs , I [R = 2-hydroxy-1,1-dimethyl-Et ammonium] as they had only one heterosynton in common. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Synthetic Route of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ACS Omega included an article by Xie, Jingwei; Ellebracht, Nathan C.; Jones, Christopher W.. Recommanded Product: 3-Aminopropan-1-ol. The article was titled 《Inter- and Intramolecular Cooperativity Effects in Alkanolamine-Based Acid-Base Heterogeneous Organocatalysts》. The information in the text is summarized as follows:

Intramol. cooperativity in heterogeneous organocatalysts is investigated using alkanolamine-functionalized silica acid-base catalysts for the aldol condensation reaction of 4-nitrobenzaldehyde and acetone. Two series of catalysts, one with and one without silanol-capping, are synthesized with varied alkyl linker lengths (two to five) connecting secondary amine and terminal hydroxyl functionalities. The reactivity of these catalysts is assessed to determine the relative potential for intermol. (silane amine-surface silanol) vs. intramol. (amine-hydroxyl within a single silane) cooperativity, the impact of inhibitory surface-silane interactions, and the role of alkyl linker length and flexibility. For the array of catalysts tested, those with longer linker lengths generally give increased catalytic activity, although the turnover frequency (TOF) trends differ between catalysts with and without surface silanol capping. Catalysts with alkyl substituted amines lacking a terminal hydroxyl demonstrate an adverse effect of chain length, where the larger alkyl substituent on the amine provides steric hindrance depressing catalytic activity, while giving addnl. evidence for improved rates afforded by intramol. cooperativity in the alkanolamine materials. The silanol-capped alkanolamine catalyst with the longest alkyl linker is found to be the most active alkanolamine catalyst due to its hydrophobized surface, which removes hypothesized silanol-alkanolamine inhibitory interactions, with the sufficient length and flexibility of its amine-hydroxyl linker allowing for favorable conformations for cooperativity. This study demonstrates the feasibility of and important factors affecting intramol. cooperative activity in acid-base heterogeneous organocatalysis. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Nguyen, Ngoc The; Bui, Quynh Anh; Nguyen, Hoang Huong Nhu; Nguyen, Tien Thanh; Ly, Khanh Linh; Tran, Ha Le Bao; Doan, Vu Nguyen; Nhi, Tran Thi Yen; Nguyen, Ngoc Hoa; Nguyen, Ngoc Hao; Tran, Ngoc Quyen; Nguyen, Dinh Trung published an article in Gels. The title of the article was 《Curcuminoid Co-Loading Platinum Heparin-Poloxamer P403 Nanogel Increasing Effectiveness in Antitumor Activity》.SDS of cas: 156-87-6 The author mentioned the following in the article:

Nanosized multi-drug delivery systems provide synergistic effects between drugs and bioactive compounds, resulting in increased overall efficiency and restricted side effects compared to conventional single-drug chemotherapy. In this study, we develop an amphiphilic heparin-poloxamer P403 (HP403) nanogel that could effectively co-load curcuminoid (Cur) and cisplatin hydrate (CisOH) (HP403@CisOH@Cur) via two loading mechanisms. The HP403 nanogels and HP403@CisOH@Cur nanogels were closely analyzed with 1H-NMR spectroscopy, FT-IR spectroscopy, TEM, and DLS, exhibiting high stability in spherical forms. In drug release profiles, accelerated behavior of Cur and CisOH at pH 5.5 compared with neutral pH was observed, suggesting effective delivery of the compounds in tumor sites. In vitro studies showed high antitumor activity of HP403@CisOH@Cur nanogels, while in vivo assays showed that the dual-drug platform prolonged the survival time of mice and prevented tail necrosis. In summary, HP403@CisOH@Cur offers an intriguing strategy to achieve the cisplatin and curcumin synergistic effect in a well-designed delivery platform that increases antitumor effectiveness and overcomes undesired consequences caused by cisplatin in breast cancer treatment. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C3H9NOIn 2019 ,《Experimental evaluation of highly efficient primary and secondary amines with lower energy by a novel method for post-combustion CO2 capture》 appeared in Applied Energy. The author of the article were Liu, Sen; Gao, Hongxia; He, Chuan; Liang, Zhiwu. The article conveys some information:

In this work, a novel method in terms of reaction energy was proposed to evaluate the potential amine absorbents for post-combustion CO2 capture, including two key parameters, i.e. the molar Gibbs energy change (ΔrGm) of proton combination with amine and the molar reaction enthalpy (ΔrHm) of protonated amine dissociation into amine and proton, which are calculated by the Van’t Hoff equation. Firstly, the equilibrium acid dissociation constant (Ka) of seven primary and secondary amines were exptl. determined at 293-323 K. The calculated ΔrGm and ΔrHm values obtained by the novel method indicated that the 2-(ethylamino)ethanol (EAE) and 2-(methylamino)ethanol (MAE) were the alternative promising absorbents among the seven tested amines, with a relatively low ΔrGm of about -57.0 kJ/mol and ΔrHm of 49.7 kJ/mol. In addition, seven amine solutions with molar concentration of 2.5 M and 5.0 M were investigated by the rate-based fast screening method to validate the reliability and applicability of the novel method. The comprehensive comparison of the absorption rate, desorption rate, CO2 equilibrium solubility and cyclic capacity, also demonstrated the same conclusion that EAE and MAE solutions presented good CO2 capture performances. The 2.5 M and 5.0 M EAE solutions obtain the highest energy efficiency for CO2 capture with the highest cyclic capacity, which is about 52.9% and 32.3% higher than those of Monoethanolamine (MEA) solution, resp. Addnl., the structure-activity anal. of seven amines suggested that the addition of hydroxyl group can obviously decrease the absorption rate and energy consumption of amine solution for CO2 removal, the alkyl group addition on or close to amino group with steric hindrance is favorable for the CO2 capture performance, while the addition of Me group on amine mol. without steric hindrance can reduce the CO2 cyclic capacity. What’s more, four tertiary amines were also investigated by using these two approaches, and the compared results further validated the accuracy and applicability of the proposed novel method. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《New approach for the one-pot synthesis of 1,3,5-triazine derivatives: Application of Cu(I) supported on a weakly acidic cation-exchanger resin in a comparative study》 was written by Havrankova, Eva; Csollei, Jozef; Pazdera, Pavel. Related Products of 156-87-6This research focused ontriazine preparation one pot synthesis copper acidic resin catalyst; 1,3,5-triazine; Ullmann reaction; one-pot synthesis; supported Cu(I) catalyst. The article conveys some information:

An efficient and simple methodol. for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and nucleophiles is reported. Cations Cu(I)-supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of the substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted s-triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new s-triazine derivatives with potential biol. activity were prepared and characterized. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Related Products of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3-Aminopropan-1-olIn 2020 ,《Carbon utilization based on post-treatment of desalinated reject brine and effect of structural properties of amines for CaCO3 polymorphs control》 appeared in Desalination. The author of the article were Yoo, Yunsung; Kang, Dongwoo; Park, Sangwon; Park, Jinwon. The article conveys some information:

This study proposed simultaneous disposal and utilization process of desalinated reject brine and CO2, or brine-based carbon capture and utilization (CCU). Using metal cations in desalinated reject brine, the feasibility of amines with different structural properties as crystallization inhibitors, morphol. controller of calcium carbonate formation was investigated in this study. Ca2+ ions were separated from desalinated reject brine in a salt refining plant by using a pH swing method and used for CaCO3 formation. Through this process, disposal of the large amount of metal cations in the desalinated reject brine was achieved. CO2 was selectively captured by alkanolamine, alkylamine, and multi-amine CO2 carriers with numerous amino groups and carried into the separated Ca(OH)2 to generate CaCO3. X-ray diffraction (XRD), SEM (SEM), and Fourier-transform IR spectroscopy (FT-IR) were used to investigate crystal shape and polymorph of the product. Addnl., thermogravimetric/derivative thermogravimetric anal. (TG/DTG) was used for purity anal. The results demonstrated that crystallization inhibition depending on structural properties of amines was possible, leading to successful CaCO3 polymorph control. The results of this research can be applied to process where the industrial production of metal carbonates based on inorganic CCU and disposal of the desalinated reject brine were involved. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Reference of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Reactions of Criegee Intermediates are Enhanced by Hydrogen-Atom Relay Through Molecular Design》 was published in ChemPhysChem in 2020. These research results belong to Kuo, Mei-Tsan; Takahashi, Kaito; Lin, Jim Jr-Min. Formula: C3H9NO The article mentions the following:

We report a type of highly efficient double hydrogen atom transfer (DHAT) reaction. The reactivities of 3-aminopropanol and 2-aminoethanol towards Criegee intermediates (syn- and anti-CH3CHOO) were found to be much higher than those of n-propanol and propylamine. Quantum chem. calculation has confirmed that the main mechanism of these very rapid reactions is DHAT, in which the nucleophilic attack of the NH2 group is catalyzed by the OH group which acts as a bridge of HAT. Typical gas-phase DHAT reactions are termol. reactions involving two hydrogen bonding mols.; these reactions are typically slow due to the substantial entropy reduction of bringing three mols. together. Putting the reactive and catalytic groups in one mol. circumvents the problem of entropy reduction and allows us to observe the DHAT reactions even at low reactant concentrations This idea can be applied to improve theor. predictions for atmospherically relevant DHAT reactions. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts