Category: 155310-11-5

Adding a certain compound to certain chemical reactions, such as: 155310-11-5, 3-Amino-2,2-difluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 155310-11-5, blongs to alcohols-buliding-blocks compound. SDS of cas: 155310-11-5

Into a 40-mL round-bottom flask, was placed 3-amino-2, 2-difluoropropan-l-ol (1 g, 9.002 mmol, 1 equiv), DCM (10 mL), Et3N (1.37 g, 13.539 mmol, 1.50 equiv), TsCl (1.72 g, 9.002 mmol, 1.0 equiv). The resulting solution was stirred for overnight at room temperature. The resulting mixture was concentrated. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (0: 1- 1:2). This resulted in 600 mg (25.13%) of N-(2,2-difluoro- 3-hydroxypropyl)-4-methylbenzene-l-sulfonamide as a white solid. 1H-NMR- 1(300 MHz, CDCl3, ppm) d 7.76- 7.73 (d, J = 9.0 Hz, 2H), 7.35 – 7.32 (d, J = 9.0 Hz, 2H), 5.04- 5.00 (m, 1H), 3.91 – 3.83 (m, 2H), 3.46 – 3.35 (m, 2H), 2.45 (s, 3H).

The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; (475 pag.)WO2020/41406; (2020); A1;,
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Application of 155310-11-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, molecular formula is C3H7F2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 4-chloro-1-fluoro-2-nitro-benzene (2.6 mmol)and amine (2.6 mmol), K2CO3 (5.2 mmol) in DMF (10 mL) wasadded TEA (5.2 mmol). The mixture was then stirred at 100 C for2 h. After the reaction was complete, the mixture was poured intowater (30 mL) and extracted with EtOAc (30 mL) three times. Thecombined organic layer was washed with brine (20 mL), dried overNa2SO4 and then concentrated in vacuo. The residue was thenpurified by column chromatography on silica gel to give 4-chloro-N(R2)-2-nitro-aniline. To a solution of 4-chloro-N(R2)-2-nitro-aniline (2.2 mmol) andhydrazine hydrate (1 mL) in the mixed solvent of MeOH (5 mL) andTHF (5 mL) was added Raney Ni (5%e10% loading). The mixturewasthen stirred at room temperature for 1-2 h. LC-MS showed completeconversion of start material. The mixture was then filteredand the filtrate was concentrated in vacuo to give the crude of 4-chloro-N1(R2)-benzene-1,2-diamine, which was used in the nextstep without further purification. A mixture of 4-chloro-N1(R2)-benzene-1,2-diamine (1 mmol)and sodium chloroacetate (130 mg, 1.1 mmol) in 4N HCl was heatedto 100 C overnight. After the reaction was complete, the mixturewas concentrated in vacuo to remove the solvent and the residuewas dissolved in DCM (100 mL). The solutionwas thenwashed withsat NaHCO3 (50 mL), brine, dried over MgSO4 and concentrated invacuo. The residue was purified by column chromatography onsilica gel (DCM/EA 3/1) to give 5-chloro-2-(chloromethyl)-1-R2-benzimidazole.To a mixture of 3-methylsulfonyl-1H-pyrazolo[3,4-c]pyridine(0.89 mmol) and 5-chloro-2-(chloromethyl)-1-R2-benzimidazole(0.74 mmol) in DMF (5 mL) was added K2CO3 (204 mg,1.48 mmol) and the mixture was stirred at rt overnight. After thereaction was completed, the mixture was filtered and the filtratewas purified by preparative HPLC to give final product. To a mixture of 3-methylsulfonyl-1H-pyrazolo[3,4-c]pyridine(0.89 mmol) and 5-chloro-2-(chloromethyl)-1-R2-benzimidazole(0.74 mmol) in DMF (5 mL) was added K2CO3 (204 mg,1.48 mmol) and the mixture was stirred at rt overnight. After thereaction was completed, the mixture was filtered and the filtratewas purified by preparative HPLC to give final product.

According to the analysis of related databases, 155310-11-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Feng, Song; Li, Chao; Chen, Dongdong; Zheng, Xiufang; Yun, Hongying; Gao, Lu; Shen, Hong C.; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 1147 – 1157;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 3-Amino-2,2-difluoropropan-1-ol

EXAMPLE 28; Preparation of Compound 79; Step 1 & Step 2; Into the solution of 2,2-difluoro-3-aminopropionic acid (2 g, 14.4 mmol) in 40 mL of THF, was added 2N LAH solution in THF at 0 C. The mixture was heated to reflux for 3 h. After cooling to 0 C., 1.75 mL of 5N KOH water solution was added and the mixture was filtered. The solid was washed with 40 ml of THF. The combined filtrates were dried with MgSO4. After removal of the solvent in vacuo, 525 mg of the desired compound 73 was obtained.To the crude compound 73 in 100 mL of toluene, was added TEA (552 mg, 5.46 mmol) and phthalic anhydrite (740 mg, 5 mmol). After azeotroping for 3 h, the toluene was removed in vacuo and the residue was purified by preparative flash chromatography (silica gel, ethyl acetate/hexane, 1:4) to afford the desired product 74 (358 mg): 1H NMR (CDCl3); 7.92 (2H, m), 7.8 (2H, m), 4.21(2H, t), 3.74 (2H, m) 3.23(1H, br; OH) MS [M+H]=241.89

The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gilead Sciences, Inc.; US2010/22508; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C3H7F2NO

To a solution of 3-amino-2,2-difluoro-propan-1-ol (2.00 g, 18.0 mmol, CAS155310-11-5) in a mixed solvents of THF (75 mL) and H2O (75 mL) was added Boc2O (3.93 g, 18.0 mmol) slowly at 0 C. The reaction mixture was stirred at 25 C. for 16 hours. On completion, the reaction mixture was diluted with 1.0 M aq.HCl (100 mL) and extracted with EA (2×150 mL). The combined organic phase was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (3.76 g, 98% yield) as white solid. 1H NMR (400 MHz, CDCl3) delta 5.04 (s, 1H), 4.10-3.87 (m, 1H), 3.76-3.63 (m, 2H), 3.60-3.54 (m, 2H), 1.48 (s, 9H).

The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
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Application of 155310-11-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, molecular formula is C3H7F2NO, molecular weight is 111.0906, as common compound, the synthetic route is as follows.

50 mL of THF was added to 50 mL of aqueous solution of the compound 41, and then reacted with 1.13 g (1.0 eq., 5.17 mmol) of Boc2O at 0 C. It was then stirred overnight. After confirming by TLC the disappearance of the reacting materials, THF was removed by using an evaporator. The residual liquid was added with ethyl acetate, and liquid fractionation extraction was performed 3 times. The collected organic layer was washed with a saturated aqueous solution of NaCl. After drying over magnesium sulfate, it was concentrated under reduced pressure by using an evaporator in water bath at 40 C. As a result, the solids are obtained, which were then washed with hexane to obtain 1.08 g of the desired compound 42 (2 step yield of 99% from the compound 18). 1H-NMR signal assignment is given in the following. 1H-NMR (500 MHz, CDCl3) delta1.46 (9H, s), 3.54 (2H, ddd), 3.67 (2H, ddd), 3.95 (1H, m), 4.98 (1H, br).

The chemical industry reduces the impact on the environment during synthesis 155310-11-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Seikagaku Corporation; Miyamoto, Kenji; Yasuda, Yosuke; Takeuchi, Hisayuki; Yoshioka, Keiji; (69 pag.)US2016/151506; (2016); A1;,
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