Category: 15484-46-5

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, molecular formula is C5H8O3, molecular weight is 116.12, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: Under N2 atmosphere and at 0 C, to a stirred solution of MBHalcohols 1 (0.3 mmol) and PPh3 (0.6 mmol) in EtOAc orCH2Cl2 (2 mL) in a Schlenk tube (25 mL) was slowly addedazodicarboxylates 2 (0.6 mmol) over 5 minutes by the means ofa microsyringe. The resulting reaction mixture was allowed towarm up to room temperature and stirred until the MBH alcohols1 were completely consumed, as monitored by TLC. Thesolvent was removed under reduced pressure and the residuewas purified by column chromatography on silica gel (gradienteluant: petroleum ether/ethyl acetate 9:1-3:1) to afford thehydrazines 3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.

Reference:
Article; Xu, Silong; Shang, Jian; Zhang, Junjie; Tang, Yuhai; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 990 – 995;,
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Reference of 15484-46-5 ,Some common heterocyclic compound, 15484-46-5, molecular formula is C5H8O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound la (3.48 g, 30 mmol) was dissolved in 50 mL of dry THF with imidazole (2.250 g, 33 mmol). TBDPSCI (9.070 g, 33 mmol) was added to the solution dropwise at 0 C. The reaction was stirred overnight at room temperature. Then, precipitate was removed by filtration to achieve clear solution which was further extracted with saturated sodium bicarbonate solution, water and brine. The organic layers were combined and dried over anhydrous sodium sulfate. (0396) The solution was collected, concentrated and subjected to flash chromatography to afford compound 8a. Yield, 6.99 g, 66%. -NMR (400 MHz, CDCl3): 5(ppm) 7.64-7.69 (m, 4H), 7.34-7.47 (m, 6H), 6.33(q, J= 1.9 Hz, 1H), 6.1 l(q, J=l.9 Hz, 1H), 4.42 (t, J=2. l Hz, 2H), 3.70 (s, 3H), 1.08 (s, 9H). 13C-NMR (100 MHz, CDCb): 5(ppm) 166.25, 139.33, 135.46, 133.24, 129.78, 127.77, 124.09, 62.21, 51.63, 26.82, 19.30. MS (m/z): [M]+ calcd. for C2, H2(,(LSI. 354.17; found, 377.1 for [M+Na]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15484-46-5, Methyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF MASSACHUSETTS; THAYUMANAVAN, Sankaran; VACHET, Richard, W.; ZHUANG, Jiaming; ZHAO, Bo; (0 pag.)WO2020/6340; (2020); A1;,
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Adding a certain compound to certain chemical reactions, such as: 15484-46-5, Methyl 2-(hydroxymethyl)acrylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 15484-46-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 15484-46-5

Trifluoromethanesulfonic anhydride (25.0 g) and dichloromethane (80.0 ml) were put into a reaction vessel and cooled to 0 C. Compound (T-8) (10.3 g) and a dichloromethane (160 ml) solution containing trimethylamine (8.97 g) were slowly added dropwise thereto. The obtained solution was poured into 1,6-hexanediol (314 g) and the mixture was stirred at room temperature for 12 hours. The reaction mixture was poured into water, and an aqueous layer was extracted with dichloromethane. The obtained organic layer was washed with water and dried with anhydrous magnesium sulfate. This solution was concentrated under a reduced pressure, and the residue was purified through silica gel chromatography (volume ratio, heptane:ethyl acetate=3:2), and thereby Compound (T-9) (11.3 g; 59%) was obtained.

The synthetic route of 15484-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; TANAKA, Hiroyuki; (95 pag.)US2019/390115; (2019); A1;,
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Related Products of 15484-46-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below.

Briefly, compound la (2.0 g, 17.23 mmol) was dissolved in 20 mL of dry DCM and cooled to 0 C in ice bath. PBr3 (2.332 g, 8.615 mmol) was added slowly to the solution. Then the reaction mixture was stirred at room temperature. The completion of reaction was monitored by TLC. The reaction was then quenched by the addition of ice. The reaction solution was neutralized by sodium bicarbonate solution and then extracted with DCM three times. Organic layers were collected and dried over anhydrous sodium sulfate, then concentrated. Compound lb was obtained by flash chromatography. Yield: 2.52 g, 82%. -NMR (400 MHz, CDCl3): d 6.34 (s, 1H), 5.96 (s, 1H), 4.18 (s, 2H), 3.82(s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF MASSACHUSETTS; THAYUMANAVAN, Sankaran; VACHET, Richard, W.; ZHUANG, Jiaming; ZHAO, Bo; (0 pag.)WO2020/6340; (2020); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, the common compound, a new synthetic route is introduced below. SDS of cas: 15484-46-5

Example 54; Acetic anhydride (87 g) as a derivatizing agent was added dropwise over a period of 1 hour to 371 g of the reaction mixture obtained in Example 53, and the mixture was stirred for 2 hours at 50C. The amount of methyl alpha-(hydroxyethyl) acrylate in 458 g of this reaction mixture was 2 g. The reaction mixture was then washed with water to remove the catalyst, following which purification was carried out by distillation using a distillation apparatus (theoretical number of plates, 13) and under reduced pressure (operating pressure, 2 kPa). The amount of reaction mixture prior to distillation was 450 g, and included 256 g of methyl alpha-(allyloxymethyl) acrylate, 1 g of methyl alpha-(hydroxymethyl) acrylate and 30 g of methyl alpha-(acetoxymethyl) acrylate. Following distillation, 192 g of product containing 99.3 wt% of methyl alpha-(allyloxymethyl) acrylate and 0.2 wt% of methyl alpha-(hydroxymethyl) acrylate was obtained.

The synthetic route of 15484-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Shokubai Co., Ltd.; EP2415751; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., Recommanded Product: 15484-46-5

General procedure: Into a round bottom flask charged with a magnetic stirbar was added 1 equiv. MBH adduct, followed by 3 equiv. 33wt % HBr (in HOAc). The solution was vigorously stirred until judged complete by TLC, then was poured into a 1 : 1 (volumetric) mixture of deionized water and CH2Cl2. The organic layer was separated, then the residual product was extracted from the aqueous layer with an additional portion of CH2Cl2. The combined organic layers were washed with deionized water then brine, then were dried with Na2SO4, filtered, concentrated, and purified via column chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15484-46-5, Methyl 2-(hydroxymethyl)acrylate.

Reference:
Article; Nicponski, Daniel R.; Tetrahedron Letters; vol. 55; 13; (2014); p. 2075 – 2077;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, molecular formula is C5H8O3, molecular weight is 116.12, as common compound, the synthetic route is as follows.Product Details of 15484-46-5

MgI2 (683 mg, 2.45 mmol) was added to anhydrous CH2Cl2 (6 mL), and the mixture was stirred at normal temperature for 45 min. The mixture was cooled to -78 C., and then methyl 2-(hydroxymethyl)acrylate dissolved in anhydrous CH2Cl2 (8 mL) was added thereto. The mixture was further stirred at -78 C. for 30 min, and then isopropyl iodide (417 mg, 24.5 mmol), Bu3SnH (2.57 mg, 8.84 mmol) and Et3B (8.84 mL, 8.84 mmol, 1.0 M/hexane solution) in sequence were slowly added thereto. Immediately after all were added thereto, air (20 mL) was slowly added thereto through a syringe. After the mixture was stirred for 2 hr and 30 min, the reactant was diluted in diethyl ether (120 mL). Silica gel (10 g) was added thereto, and then the resulting mixture was evaporated under reduced pressure. The powder obtained was washed with hexane (500 mL) and extracted with diethyl ether (300 mL), evaporation was performed under reduced pressure, and then column chromatography was used to obtain 150 mg (yield 78%) of the title compound. 1H NMR (300 MHz, CDCl3) d 0.87 (d, J=6.0 Hz, 3H), 0.88 (d, J=5.4 Hz, 3H), 1.32-1.38 (m, 1H), 1.41-1.76 (m, 2H), 2.34 (s, 1H), 2.45-2.86 (m, 1H), 3.68-3.70 (m, 2H), 3.68 (s, 3H); 13C NMR (75 MHz, CDCl3) d 22.16, 22.43, 25.78, 37.86, 45.45, 51.89, 63.38, 162.18, 176.11.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.

Reference:
Patent; Korea Institute of Science and Technology; MIN, Sun Joon; Cho, Yong Seo; Lee, Jae Kyun; Pae, Ae Nim; Son, Young Wook; US2013/197227; (2013); A1;,
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