Category: 153759-59-2

Sashidhara, Koneni V.; Rao, K. Bhaskara; Kushwaha, Vikas; Modukuri, Ram K.; Verma, Richa; Murthy, P. K. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi》.COA of Formula: C12H14O3 The author mentioned the following in the article:

Here we report the synthesis of novel chalcone-thiazole compounds and their antifilarial activity. The antifilarial properties of these hybrids were assessed against microfilariae as well as adult worms of Brugia malayi. Among all the synthesized compounds, only two compounds, namely (E,E)-I (R = iPr, R1 = 2-furyl; R = tBu, R1 = 2-thienyl) were identified to be promising in vitro. These active compounds were tested in B. malayi-jird (Meriones unguiculatus) and B. malayi-Mastomys coucha models. Compound (E,E)-I (R = tBu, R1 = 2-thienyl) showed 100% embryostatic effect and 49% macrofilaricidal in jird and M. coucha models, resp. This study provides a new structural clue for the development of novel antifilarial lead mols. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.COA of Formula: C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Recommanded Product: 153759-59-2On October 15, 2014 ,《Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Sashidhara, Koneni V.; Rao, K. Bhaskara; Singh, Seema; Modukuri, Ram K.; Aruna Teja, G.; Chandasana, Hardik; Shukla, Shubha; Bhatta, Rabi S.. The article contains the following contents:

A series of amine substituted 3-phenylcoumarin derivatives was designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model to screen antidepressant activity in rodents. Among the series, compounds I and II potentially decreased the immobility time by 73.4% and 79.7% at a low dose of 0.5 mg/kg as compared to standard drug fluoxetine (FXT) which reduced the immobility time by 74% at a dose of 20 mg/kg, i.p. Addnl., these active compounds also exhibited significant efficacy in tail suspension test (TST) (another model to screen antidepressant compounds). Interestingly, rotarod and locomotor activity tests confirmed that these two compounds do not have any motor impairment effect and neurotoxicity in mice. Our studies demonstrate that the new 3-phenylcoumarin derivatives may serve as a promising antidepressant lead and hence pave the way for further investigation. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Modukuri, Ram K.; Singh, Seema; Bhaskara Rao, K.; Aruna Teja, G.; Gupta, Sampa; Shukla, Shubha published an article on January 15 ,2015. The article was titled 《Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Related Products of 153759-59-2 The information in the text is summarized as follows:

A new series of coumarin based aminopyran derivatives I [ R1 = Me, iso-Pr, sec-Bu, tert-Bu; R2 = H, OMe; R3 = OMe; R4 = H, OMe; R5 = H, Me] were designed, synthesized and evaluated for their preclin. antidepressant effect on Swiss albino mice. Among the series, compounds I [ R1 = iso-Pr, R2 = R4 = H, R3 = OMe, R5 = Me; R1 = iso-Pr, R2 = R4 = = R5 = H, R3 = OMe; R1 = iso-Pr, R2 = R5 = H, R3 = R4= OMe; R1 = iso-Pr, R2 = H, R3 = R4= OMe, R5 = Me; R1 = sec-Bu, R2 = R4 = H, R3 = OMe, R5 = Me; R1 = sec-Bu, R2 = H, R3 = R4= OMe, R5 = Me] exhibited significant activity profile in forced swimming test (FST). Compound I [R1 = iso-Pr, R2 = H, R3 = R4= OMe, R5 = Me] was most efficacious, which at a very low dose of 0.5 mg/kg reduced the time of immobility by 86.5% as compared to the standard drug fluoxetine (FXT) which reduced the immobility time by 69.8% at the dose of 20 mg/kg, i.p. In addition, all active compounds were screened in dose dependent manner (at doses of 0.25, 0.5, 1 mg/kg i.p.) in FST and tail suspension test (TST). Interestingly, all active compounds did not caused any significant alteration of locomotor activity in mice as compared to control, indicating that the hybrids did not produce any motor impairment effects. The results indicate that coumarin-aminopyran derivatives may have potential therapeutic value for the management of mental depression. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Related Products of 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Related Products of 153759-59-2

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Jaiswal, Anil Kumar; Rao, K. Bhaskara; Kushwaha, Pragati; Rawat, Keerti; Modukuri, Ram K.; Khare, Prashant; Joshi, Sumit; Mishra, Shikha; Rai, Ambak; Sashidhara, Koneni V.; Dube, Anuradha published their research in International Journal of Antimicrobial Agents on December 31 ,2016. The article was titled 《Development of Leishmania donovani stably expressing DsRed for flow cytometry-based drug screening using chalcone thiazolyl-hydrazone as a new antileishmanial target》.COA of Formula: C12H14O3 The article contains the following contents:

Green fluorescent protein produces significant fluorescence and is extremely stable, however its excitation maximum is close to the UV range and thus can damage living cells. Hence, Leishmania donovani stably expressing DsRed were developed and their suitability for flow cytometry-based antileishmanial screening was assessed by evaluating the efficacies of standard drugs as well as newly synthesized chalcone thiazolyl-hydrazone compounds The DsRed gene was successfully integrated at the 18S rRNA locus of L. donovani and transfectants (LdDsRed) were selected using hygromycin B. Enhanced expression of DsRed and a high level of infectivity to J774A.1 macrophages were achieved, which was confirmed by fluorescence microscopy and flow cytometry. Furthermore, these LdDsRed transfectants were utilized for development of an in vitro screening assay using the standard antileishmanial drugs miltefosine, amphotericin B, pentamidine and paromomycin. The response of transfectants to standard drugs correlated well with previous reports. Subsequently, the suitability of this system was further assessed by screening a series of 18 newly synthesized chalcone thiazolyl-hydrazone compounds in vitro for their antileishmanial activity, wherein 8 compounds showed moderate antileishmanial activity. The most active compound I, with ∼73% splenic parasite reduction, exerted its activity via generating nitric oxide and reactive oxygen species and inducing apoptosis in LdDsRed-infected macrophages. Thus, these observations established the applicability of LdDsRed transfectants for flow cytometry-based antileishmanial screening. Further efforts aimed at establishing a high-throughput screening assay and determining the in vivo screening of potential antileishmanial leads are required. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).COA of Formula: C12H14O3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Intramolecular hydrogen bonding as a synthetic tool to induce chemical selectivity in acid catalyzed porphyrin synthesis》 were Megiatto, Jackson D.; Patterson, Dustin; Sherman, Benjamin D.; Moore, Thomas A.; Gust, Devens; Moore, Ana L.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2012. COA of Formula: C12H14O3 The author mentioned the following in the article:

A straightforward procedure based on the formation of intramol. hydrogen bonds to impart selectivity in the preparation of multi-functionalized porphyrins has been developed. To illustrate the concept, the synthesis of a biomimetic artificial photosynthetic model able to undergo electron and proton transfer reactions upon irradiation is reported. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).COA of Formula: C12H14O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Salen-porphyrin-based conjugated microporous polymer supported Pd nanoparticles: highly efficient heterogeneous catalysts for aqueous C-C coupling reactions》 was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. These research results belong to Ju, Pengyao; Wu, Shujie; Su, Qing; Li, Xiaodong; Liu, Ziqian; Li, Guanghua; Wu, Qiaolin. Computed Properties of C12H14O3 The article mentions the following:

The salen-porphyrin based conjugated microporous polymer (SP-CMP) was first constructed by polycondensation reaction of a salen-dialdehyde derivative and pyrrole. Due to the outstanding chem. and thermal stability, abundant micropores with a reasonable pore size, and ordered salen-porphyrin arrays in the A4B4-type polymer framework, the functional CMP was further applied as a Pd nanoparticle support by the coordinate interactions between the polydentate chelating sites with Pd(OAc)2 and subsequent reduction with NaBH4. The as-synthesized composite material (Pd@SP-CMP) was fully characterized by powder X-ray diffraction (PXRD), thermogravimetric anal. (TGA), Fourier transform IR (FT-IR) spectroscopy, XPS, and solid-state 13C NMR (NMR). The porous property of Pd@SP-CMP was also characterized by N2 adsorption/desorption isotherms and the obtained material exhibited a Brunauer-Emmett-Teller (BET) surface area of 266 m2 g-1, together with a pore volume of 0.192 cm3 g-1. The microscopic morphol. of Pd@SP-CMP was further evaluated by SEM (SEM) and transmission electron microscopy (TEM). The Pd@SP-CMP material with highly dispersed Pd nanoparticles exhibited excellent catalytic activity towards Suzuki-Miyaura and Heck-Mizoroki coupling reactions in water or in the dioxane/water mixture In addition, Pd@SP-CMP also displayed outstanding stability and recyclability, and it can be reused without loss of activity in ten successive reactions. More importantly, the salen-porphyrin based CMPs could be the promising candidates for developing high-performance heterogeneous catalysts. In the experimental materials used by the author, we found 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Computed Properties of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Computed Properties of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 5-(tert-Butyl)-4-hydroxyisophthalaldehydeOn September 25, 2012 ,《Mimicking the electron transfer chain in photosystem II with a molecular triad thermodynamically capable of water oxidation》 was published in Proceedings of the National Academy of Sciences of the United States of America. The article was written by Megiatto, Jackson D. Jr.; Antoniuk-Pablant, Antaeres; Sherman, Benjamin D.; Kodis, Gerdenis; Gervaldo, Miguel; Moore, Thomas A.; Moore, Ana L.; Gust, Devens. The article contains the following contents:

In the photosynthetic photosystem II, electrons are transferred from the manganese-containing oxygen evolving complex (OEC) to the oxidized primary electron-donor chlorophyll P680•+ by a proton-coupled electron transfer process involving a tyrosine-histidine pair. Proton transfer from the tyrosine phenolic group to a histidine nitrogen positions the redox potential of the tyrosine between those of P680•+ and the OEC. We report the synthesis and time-resolved spectroscopic study of a mol. triad that models this electron transfer. The triad consists of a high-potential porphyrin bearing two pentafluorophenyl groups (PF10), a tetracyanoporphyrin electron acceptor (TCNP), and a benzimidazole-phenol secondary electron-donor (Bi-PhOH). Excitation of PF10 in benzonitrile is followed by singlet energy transfer to TCNP (r = 41 ps), whose excited state decays by photoinduced electron transfer (r = 830 ps) to yield Bi-PhOH-PF10•+-TCNP•-. A second electron transfer reaction follows (T < 12 ps), giving a final state postulated as BiH+-PhO•-PF10-TCNP•-, in which the phenolic proton now resides on benzimidazole. This final state decays with a time constant of 3.8 ps. The triad thus functionally mimics the electron transfers involving the tyrosine-histidine pair in PSII. The final charge-separated state is thermodynamically capable of water oxidation, and its long lifetime suggests the possibility of coupling systems such as this system to water oxidation catalysts for use in artificial photosynthetic fuel production The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Quality Control of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Quality Control of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts