Category: 153759-59-2

Sashidhara, Koneni V.; Kumar, Manoj; Khedgikar, Vikram; Kushwaha, Priyanka; Modukuri, Ram K.; Kumar, Abdhesh; Gautam, Jyoti; Singh, Divya; Sridhar, Balasubramaniam; Trivedi, Ritu published an article on January 10 ,2013. The article was titled 《Discovery of Coumarin-Dihydropyridine Hybrids as Bone Anabolic Agents》, and you may find the article in Journal of Medicinal Chemistry.SDS of cas: 153759-59-2 The information in the text is summarized as follows:

The concept of mol. hybridization led us to discover a novel series of coumarin-dihydropyridine hybrids that have potent osteoblastic bone formation in vitro and that prevent ovariectomy-induced bone loss in vivo. In this context, among all the compounds screened for alk. phosphatase activity, four compounds 10, 14, 18, and 22 showed significant activity at picomolar concentrations A series of other in vitro data strongly suggested compound 18 as the most promising bone anabolic agent, which was further evaluated for in vivo studies. From these studies compound 18 proved to be useful, which at low oral dose of 1 (mg/kg)/day body weight increased bone mass d. and volume, expression of osteogenic genes (RUNX2, BMP-2, and ColI), bone formation rate (BFR), and mineral apposition rate (MAR), improved the trabecular microarchitecture, and decreased bone turn over markers in an ovariectomized rodent model for postmenopausal osteoporosis. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2SDS of cas: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.SDS of cas: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksOn June 1, 2018, Gupta, Sampa; Adhikary, Sulekha; Modukuri, Ram K.; Choudhary, Dharmendra; Trivedi, Ritu; Sashidhara, Koneni V. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Benzofuran-pyran hybrids: A new class of potential bone anabolic agents》. The article mentions the following:

Benzofuran moiety is an important pharmacophore showing pos. effects on bone health. In the present study, sixteen benzofuran-pyran hybrids were synthesized and were evaluated for their osteogenic effects on primary osteoblast cells isolated from calvaria. Compounds 22 and 24 were found potent in stimulating osteoblast differentiation as assessed by the alk. phosphatase activity. These compounds were also found to be nontoxic to osteoblast cells as compared to the control cells in MTT assay. Further, Alizarin Red-S staining for visualization of calcium nodules demonstrated compounds 22 and 34 as active in enhancing mineralization in osteoblast cells. Addnl., transcriptional anal. of these compounds on osteoblast cells revealed that compound 22 up-regulated the expression of osteogenic genes RUNX2, BMP-2, COL-1, thus substantiating that compound 22 having two geminal Me groups in its R3 position is a potent osteogenic agent. Addnl., compound 22 enhanced the ability of bone marrow stromal cells to differentiate towards osteoblast lineage and therefore can be further studied in vivo in bone loss model. In the experiment, the researchers used many compounds, for example, 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Category: alcohols-buliding-blocks)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Category: alcohols-buliding-blocksDeprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Rao, K. Bhaskara; Kushwaha, Pragati; Modukuri, Ram K.; Singh, Pratiksha; Soni, Isha; Shukla, P. K.; Chopra, Sidharth; Pasupuleti, Mukesh published an article in ACS Medicinal Chemistry Letters. The title of the article was 《Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus》.Electric Literature of C12H14O3 The author mentioned the following in the article:

A series of novel hybrids I [R = t-Bu, iso-Pr, n-propyl; R1 = 4-Me-C6H4, 4-MeO-C6H4, furan-2-yl, thiophene-2-yl; R2 = CO2Et, 4-MeO-C6H4, 3,4-dimethoxyphenyl.] possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against Staphylococcus aureus, and in particular, compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] was nonhemolytic and nontoxic to mammalian cells. The in vivo studies utilizing a S. aureus septicemia model demonstrated that compound I [R = t-Bu, R1 = 4-Me-C6H4, R2 = 3,4-dimethoxyphenyl.] was as potent as vancomycin. The results of antibacterial activities underscore the potential of this scaffold that can be utilized for developing a new class of novel antibiotics. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Electric Literature of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kushwaha, Pragati; Tripathi, Ashish Kumar; Gupta, Sampa; Kothari, Priyanka; Upadhyay, Akanksha; Ahmad, Naseer; Sharma, Tanuj; Siddiqi, M. I.; Trivedi, Ritu; Sashidhara, Koneni V. published their research in European Journal of Medicinal Chemistry on August 5 ,2018. The article was titled 《Synthesis and study of benzofuran-pyran analogs as BMP-2 targeted osteogenic agents》.Application of 153759-59-2 The article contains the following contents:

Twenty-four novel benzofuran-pyran derivatives were synthesized and evaluated for their anti-osteoporotic activity in primary cultures of rat calvarial osteoblasts in vitro. Among all the compounds screened for the alk. phosphatase activity, three compounds 9-(2-(4-fluorobenzoyl)-7-methylbenzofuran-5-yl)3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione , 9-(7-Ethyl-2-(4-fluorobenzoyl)benzofuran-5-yl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione and 9-(7-Ethyl-2-(4-fluorobenzoyl)benzofuran-5-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione showed potent activity at picomolar concentrations in osteoblast differentiating stimulation. Addnl., these compounds were found effective in mineralization, assessed by alizarin red-S staining assay. Compounds were again validated through a series of other in vitro experiments Moreover, mol. dynamics simulations demonstrated that both benzofuran and pyran moieties are requisite to fit into the active site of BMP-2 receptor, a key target of the osteogenic agents. The obtained results strongly convey that compound 9-(2-(4-fluorobenzoyl)-7-methylbenzofuran-5-yl)3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione is a potential bone anabolic agent among synthesized series, which can be further explored as a drug lead for treating osteoporosis. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Application of 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Application of 153759-59-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C12H14O3On May 25, 2018, Singh, L. Ravithej; Kumar, Ajeet; Upadhyay, Akanksha; Gupta, Sampa; Palanati, Gopala Reddy; Sikka, Kamakshi; Siddiqi, Mohammad Imran; Yadav, Prem N.; Sashidhara, Koneni V. published an article in European Journal of Medicinal Chemistry. The article was 《Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy》. The article mentions the following:

Rational designing and synthesis of coumarin-dihydroquinazolinone conjugates such as I [R1 = Me, i-Pr, s-Bu, etc.; R2 = H, 2-thienyl, 3,4-(MeO)2, etc.] to evaluate their agonist activity at GPR109a receptor was presented. Among the synthesized small mol. library, compound I [R1 = Me, R2 = 4-MeO] displayed robust agonist action at GPR109a with EC50 < 11nM. Homol. model of human GPR109a protein was generated to realize the binding interaction of the active mol. with the active site of GPR109a. Further, the efficacy of active compound I [R1 = Me, R2 = 4-MeO] was supported by in-vivo experiments which showed reduced body weight in diet induced obese mice model. Interestingly, compound I [R1 = Me, R2 = 4-MeO] reduced leptin in blood plasma and total serum cholesterol. These results suggested that the coumarin-dihydroquinazolinone conjugate is a suitable scaffold to further expand the chem. diversity and make them potential niacin receptor 1 agonist. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Electric Literature of C12H14O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 153759-59-2On October 20, 2015 ,《Designing, synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: In vitro validation and docking studies》 was published in European Journal of Medicinal Chemistry. The article was written by Sashidhara, Koneni V.; Avula, Srinivasa Rao; Doharey, Pawan Kumar; Singh, L. Ravithej; Balaramnavar, Vishal M.; Gupta, Jyoti; Misra-Bhattacharya, Shailja; Rathaur, Sushma; Saxena, Anil K.; Saxena, Jitendra Kumar. The article contains the following contents:

In our continuing search for safe and efficacious antifilarials, a series of novel chalcone-benzothiazole hybrids have been synthesized and evaluated for their Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition activity. Their selectivity towards BmTMK was studied and compared to the human TMK (HsTMK) by an in silico method. Out of seventeen derivatives, compounds I and II showed higher interactions with the BmTMK active site. MolDock docking model revealed the interactions of these two derivatives and the results corroborated well with their in vitro antifilarial activities. Our studies suggest that these hybrids are selective towards the BmTMK enzyme and may serve as potential therapeutic agents against filariasis. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2HPLC of Formula: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.HPLC of Formula: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 153759-59-2On October 31, 2013 ,《Hybrid benzofuran-bisindole derivatives: New prototypes with promising anti-hyperlipidemic activities》 appeared in European Journal of Medicinal Chemistry. The author of the article were Sashidhara, Koneni V.; Modukuri, Ram K.; Sonkar, Ravi; Rao, K. Bhaskara; Bhatia, Gitika. The article conveys some information:

A series of different benzofuran-bisindole hybrids I [R = Me, Cl, t-Bu, etc.; R1 = Cl, MeO, NC; R3 = H, HO, MeO, O2N] were synthesized and evaluated in vitro for their antioxidant and in vivo for antidyslipidemic activity in triton WR-1339 induced hyperlipidemic rats. four compounds showed significant decrease in plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) followed by increase in postheparin lipolytic activity (PHLA). In addition, the active hybrids possessed moderate antioxidant properties and increased the plasma lecithin cholesterol acyltransferase (LCAT) activity, which plays a key role in lipoprotein metabolism contributing to an increased level of HDL-C in serum. These results indicate that these hybrids constitute novel prototypes for the management of dyslipidemia. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Related Products of 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Related Products of 153759-59-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Avula, Srinivasa Rao; Sharma, Komal; Palnati, Gopala Reddy; Bathula, Surendar Reddy published an article on February 28 ,2013. The article was titled 《Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C12H14O3 The information in the text is summarized as follows:

Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (pos. and neg.) breast cancers is a very challenging task. The concept of mol. hybridization led the authors to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Computed Properties of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Computed Properties of C12H14O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Modukuri, Ram K.; Choudhary, Dharmendra; Bhaskara Rao, K.; Kumar, Manoj; Khedgikar, Vikram; Trivedi, Ritu published their research in European Journal of Medicinal Chemistry on December 31 ,2013. The article was titled 《Synthesis and evaluation of new coumarin-pyridine hybrids with promising anti-osteoporotic activities》.Electric Literature of C12H14O3 The article contains the following contents:

Anti-osteoporotic effects of the newly synthesized coumarin-pyridine hybrids were evaluated in primary cultures of rat calvarial osteoblasts in vitro. Four of these compounds were potent in stimulating osteoblast differentiation and mineralization as assessed by the alk. phosphatase production and alizarin red-S staining assay, resp. These compounds were also found to be nontoxic in osteoblast cells as compared to the control group in an MTT assay. Furthermore, the effect of these compounds on the transcript levels of osteogenic genes revealed that the compound I robustly enhanced mineralization of the osteogenic genes in calvarial osteoblasts. In this context, compound I was selected as a potential lead for further structural optimization in the development of new anti-osteoporotic agents. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Electric Literature of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Electric Literature of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Palnati, Gopala Reddy; Sonkar, Ravi; Avula, Srinivasa Rao; Awasthi, Chetan; Bhatia, Gitika published an article in European Journal of Medicinal Chemistry. The title of the article was 《Coumarin chalcone fibrates: A new structural class of lipid lowering agents》.Computed Properties of C12H14O3 The author mentioned the following in the article:

In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% resp. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Computed Properties of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Computed Properties of C12H14O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts