Category: 153599-45-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.153599-45-2, name is Methyl 3-(2-hydroxyethyl)benzoate, molecular formula is C10H12O3, molecular weight is 180.2, as common compound, the synthetic route is as follows.Computed Properties of C10H12O3

To a stirred solution of methyl 3- (2-hydroxyethyl) benzoate (10 g) in anhydrous dichloromethane (90 mL) at 0 C was added methanesulfonyl chloride (34 g, 299 mmol) And triethylamine (12 g, 118 mmol).The reaction was stirred at 0 C for 1 hour, quenched with water (50 ml)And extracted with ethyl acetate (100 ml x 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: 10% ethyl acetate in petroleum ether)To give 2.7 g of methyl 3- (2 – ((methylsulfonyl) oxy) ethyl) benzoate as a colorless oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,153599-45-2, Methyl 3-(2-hydroxyethyl)benzoate, and friends who are interested can also refer to it.

Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; DING, ZHAO ZHONG; WU, HAO; SUN, FEI; WU, LI FANG; YANG, LING; (97 pag.)TWI558709; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153599-45-2, name is Methyl 3-(2-hydroxyethyl)benzoate, the common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 3-(2-hydroxyethyl)benzoate

3- (2-HYDROXYETHYL)- benzoic acid methyl ester (50 mg, 0.28 mmol) was dissolved in methanol (1 ml). 1N NaOH aqueous solution (1 ml) was added therein. The reaction mixture was stirred at room temperature for 1 hour to give 43 mg (yield: 95%, white solid) of the target compound. 1H NMR (400MHZ, CDC13) ; 52. 32 (br, 1H), 2.89 (t, J=6. 4Hz, 2H), 3.85 (t, J=6. 4Hz, 2H), 7.36 (t, J=7. 6Hz, 1H), 7.42 (D, J=5. 6Hz, 1H), 7.88 (d, J=8. 8Hz, 1H), 7.89 (s, 1H)

The synthetic route of 153599-45-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JE IL PHARMACEUTICAL CO., LTD.; WO2004/113281; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts