Synthetic Route of 15149-10-7, Adding some certain compound to certain chemical reactions, such as: 15149-10-7, name is 2-(p-Tolyloxy)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15149-10-7.
General procedure: A mixture of 3 (46.1 mmol) and NaH (138.2 mmol) inanhydrous THF (100 ml) was stirred under a nitrogen atmosphere at rt. After 1h, epichlorohydrin (230.5 mmol) in the THF (10 ml) was added dropwise into themixture. Then, the mixture was hold at reflux for 10 h. The mixture was pouredinto ice water (300 ml) and extracted with Et2O (2 ¡Á 200 ml). The Et2Oextracts were combined and dried over anhydrous MgSO4. After thesolvent was evaporated, the residue was purified by column chromatography(petroleum ether : ethyl acetate = 8 : 1) to afford 4 in 65% yield. Yield 65%. White solid, mp 87-88 oC.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15149-10-7, 2-(p-Tolyloxy)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jia, Jian-Min; Liu, Fang; Xu, Xiao-Li; Guo, Xiao-Ke; Jiang, Fen; Cherfaoui, Bahidja; Sun, Hao-Peng; You, Qi-Dong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1557 – 1561;,
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