Category: 148043-73-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,4,5,5,5-Pentafluoropentan-1-ol

4,4,5,5,5-pentafluoropentanol (10 g) and methylene chloride (100 ml) is added to the reaction flask. Add triethylamine (11.3 g). Under ice bath, drop methanesulfonyl chloride (6.72 g). The completion of the dropping. Restoration to room temperature react for 2 hours. Water to wash the excess triethylamine and methyl chloride, dried with anhydrous sodium sulfate, turns on lathe does, get 14.14 g 4,4,5,5,5-pentafluoropentyl methanesulfonate.

With the rapid development of chemical substances, we look forward to future research findings about 148043-73-6.

Reference:
Patent; Tianjin Fuyin Biotechnology Development Co., Ltd.; Liu, Wenjuan; Mo, Lan; (9 pag.)CN104447447; (2017); B;,
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Synthetic Route of 148043-73-6 , The common heterocyclic compound, 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol, molecular formula is C5H7F5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step-6.1: Synthesis of 4,4,5,5,5-pentafluoropentyl methanesulfonate To a stirred solution of 4,4,5,5,5-pentafluoropentan-l-ol (7.5 g, 42.13 mmol) in dichloromethane (100 mL) at 0 C was added triethylamine (7.1 mL, 50.56 mmol) and methane sulfonyl chloride (3.53 mL, 46.34 mmol). The reaction mixture was stirred for 1 h at RT and diluted with dichloromethane. The organic layer was washed with water, brine, dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 4,4,5,5,5- pentafluoropentyl methanesulfonate (6.0 g, 56%) as a brown colour liquid.

The synthetic route of 148043-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; HAO, Ming-Hong; KORPAL, Manav; NYAVANANDI, Vijay Kumar; PUYANG, Xiaoling; SAMAJDAR, Susanta; SMITH, Peter Gerard; WANG, John; ZHENG, Guo Zhu; ZHU, Ping; (161 pag.)WO2016/196342; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 148043-73-6, blongs to alcohols-buliding-blocks compound. Recommanded Product: 148043-73-6

4-Bromo-3-methylbenzylalcohol (4) A solution of methyl 4-bromo-3-methylbenzoate (2.0 g, 8.7 mmol) in dry THF (10 mL) was added to an ice-cooled suspension of lithium aluminiumhydride (400 mg, 10.4 mmol) in dry THF (30 mL). After addition, the mixture was warmed to room temperature and then stirred for 3 h. The excess lithium aluminiumhydride was quenched by successive addition of water (0.4 mL), 15percent NaOHaq (0.4 mL), and water (1.2 mL) under ice cooling. The insoluble material appeared was removed by filtration (celite), and the precipitate was washed by AcOEt (20 mL*5). The combined filtrates were washed with brine (50 mL) and then dried over Na2SO4. The solvent was evaporated, and the obtained product (1.6 g, 100percent) was used for next step without further purification. 1H-NMR (CDCl3, 400 MHz): delta7.53 (1H, d, J=8.1 Hz), 7.26 (1H, d, J=1.5 Hz), 6.40 (1H, dd, J=8.1, 1.5 Hz), 4.68 (2H, s), 2.44 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,148043-73-6, its application will become more common.

Reference:
Patent; CHANG, Christopher J.; VAN DE BITTNER, Genevieve V.; HIRAYAMA, Tasuku; CHAN, Jefferson; US2014/51863; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H7F5O

Into a reactor (internal capacity: 200 mL, made of glass) equipped with a stirrer and a dropping funnel, C2F5CH2CH2CH2OH (23.6 g), triethylamine (16.1 g) and acetone (80 mL) were put and stirred. Then, by an ice bath, the inner temperature of the reactor was adjusted to be at most 10 C., and in a nitrogen atmosphere, a solution of 4-(chloromethyl)benzoic acid chloride (25.0 g) in acetone (15 mL) was dropwise added. Further, the temperature was returned to room temperature, and stirring was continued for 2 hours. (0156) The obtained reaction crude liquid was transferred to a separating funnel, AK-225 (100 mL) was added, followed by washing three times with distilled water (100 mL), and the solvent in the AK-225 phase was distilled off to obtain 40.2 g of a compound (A-2) (pale yellow liquid) represented by the following structural formula (A-2) and classified into the above compound (A). The yield was 93%. (0157) (0158) The measured results of 1H-NMR and 19F-NMR of the obtained fluorinated compound (A-2) are shown below. 1H-NMR (solvent:CDCl3) delta(ppm): 2.05-2.31 (4H, m, -CH2[CH2CH2]CF2-), 4.41 (2H, t, -OCH2-), 4.62 (2H, s, ClCH2-), 7.48 (2H, d, Ph), 8.03 (2H, d, Ph). 19F-NMR (solvent:CDCl3) delta(ppm): -85.9 (3F, s, -CF3), -118.7 (2F, t, -CF2-). (0161) Into a reactor (internal capacity: 50 mL, made of glass) equipped with a stirrer and a dropping funnel, methacrylic acid (2.73 g), potassium carbonate (5.02 g) and DMF (20 mL) were put and stirred. Then, heating was carried out so that the inner temperature of the reactor became 50 C., and a solution of the compound (A-2) (10.0 g) in DMF (10 mL) was dropwise added. The dropping funnel was replaced with a Dimroth condenser, and the reactor was heated to 80 C. and stirred for 2 hours. (0162) The obtained reaction crude liquid was transferred to a separating funnel, AK-225 (50 mL) was added, followed by washing three times with distilled water (50 mL), and the solvent in the AK-225 phase was distilled off to obtain 11.1 g of a fluorinated compound (I-5) of the present invention (pale yellow liquid) represented by the following structural formula (I-5). The yield was 97%. The measured results of 1H-NMR and 19F-NMR of the obtained fluorinated compound (I-5) of the present invention are shown below. 1H-NMR (solvent:CDCl3) delta(ppm): 1.99 (3H, s, -CH3), 2.05-2.31 (4H, m, -CH2[CH2CH2]CF2-), 4.40 (2H, t, -COO[CH2]CH2-), 5.26 (2H, s, -COO[CH2]Ph-), 5.63 (1H, s,transC?CH2), 6.19 (1H, s,cisC?CH2), 7.46 (2H, d, Ph), 8.04 (2H, d, Ph). (0166) 19F-NMR (solvent:CDCl3) delta(ppm): -85.9 (3F, s, -CF3), -118.8 (2F, t, -CF2-).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; Asahi Glass Company, Limited; Hoshino, Taiki; US8471056; (2013); B2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. A new synthetic method of this compound is introduced below., Safety of 4,4,5,5,5-Pentafluoropentan-1-ol

4,4,5,5,5-Pentafluoropentan-1-al (or related compounds) has already been described in the literature [see, for example,iii oriv]. Here, 4,4,5,5,5-pentafluoropentan-1-al was prepared by oxidizing 4,4,5,5,5-pentafluoropentan-1-ol under standard conditions (a dichloromethane solution was prepared by reacting with pyridinium dichromate or else by a TEMPO oxidation [see, for example,v]-the dichloromethane solution of the 4,4,5,5,5-pentafluoropentan-1-al was used directly in the Wittig reaction owing to the low boiling point). A Swern oxidation of pentafluoropentanol is problematic [vi].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; SANDER, Michael; Grossbach, Danja; Dinter, Christian; Hassfeld, Jorma; Voigtlaender, David; US2009/62558; (2009); A1;,
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Electric Literature of 148043-73-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol, molecular formula is C5H7F5O, molecular weight is 178.1, as common compound, the synthetic route is as follows.

General procedure: 10653] General Procedure 12 for the preparation of 12 with exclusion of moisture: 1 molar equivalent of alcohol was dissolved in 5 molar equivalents of pyridine, and 1.1 molar equivalents of tosyl chloride were added at 0-5 C. The mix- tare was then stirred at 00 C. for 2.5 hours and at room temperature for 1-2 hours or overnight. The reaction mixture was stirred into a mixture of ice-water and concentrated sulphuric acid (10 ml: 1 ml). Here, per 10 ml of pyridine 29-53 ml of water were used as base. The mixture was extracted three times with diethyl ether, and the combined organic phases were washed once with water and with saturated sodium chloride solution, dried over sodium sulphate ormagnesium sulphate and concentrated.4,4,5,5,5-Pentafluoropentyl 4-methylbenzenesulphonate 40 g (224.6 mmol) of 4,4,5,5,5-pentafluorpentan-1-ol were reacted with 47.04 g of tosyl chloride according to General Procedure 12. 39.5 g (53% of theory) of product were obtained. 1H NMR (400 MHz, chloroform-d1): delta=1.90-2.00 (m, 2H), 2.01-2.17 (m, 2H), 2.46 (s, 3H), 4.10 (t, 2H), 7.37 (d, 2H), 7.80 (d, 2H).

The chemical industry reduces the impact on the environment during synthesis 148043-73-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Wintermantel, Tim; Moeller, Carsten; Bothe, Ulrich; Nubbemeyer, Reinhard; Zorn, Ludwig; Ter Laak, Antonius; Bohlmann, Rolf; Wortmann, Lars; US2015/80438; (2015); A1;,
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Synthetic Route of 148043-73-6, Adding some certain compound to certain chemical reactions, such as: 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol,molecular formula is C5H7F5O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 148043-73-6.

EXAMPLE 1 Into a 1L hastelloy C autoclave, pentafluoropentanol (C2F5(CH2)3OH, 519 g) and trifluoromethane sulfonic acid (20 g) were charged and stirred at 175C for 14 hours. The reactor pressure at that time was 0.7 MPa (gage pressure). After the reaction, the obtained crude liquid was subjected to liquid separation, and the organic phase was washed twice with water (50 ml) and dried over magnesium sulfate, followed by filtration to obtain a crude liquid. The conversion by the reaction was 75.7% as measured by gas chromatography (hereinafter referred to simply as GC). By distillation under reduced pressure, the desired following compound (I-1) (172 g) was obtained as a fraction of (60 to 61C)/1.4 kPa (absolute pressure). The GC purity was 99.9%. By the NMR analysis, formation of the following compound (I-1) was confirmed. Compound (I-1) : C2F5(CH2)3O(CH2)3C2F5.1HNMR (300.4MHz, CDCl3, TMS) delta (ppm) : 1.87 (m, 2H), 2.12 (m, 2H), 3.48 (m, 2H).19FNMR (282.7MHz, CDCl3, CFCl3) delta (ppm) : -86.1 (3F), -118.8(2F).

According to the analysis of related databases, 148043-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASAHI GLASS COMPANY LTD.; EP1577284; (2005); A1;,
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Alcohols – Chemistry LibreTexts

Related Products of 148043-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. A new synthetic method of this compound is introduced below.

Synthesis of compound 17 A 250 ml flask containing a solution of compound 18 (20 g, 1 12.3 mmol) in 50 ml of dry acetonitrile under inert nitrogen atmosphere. Triethylamine (19.9 ml, 142.6 mmol) and a solution of Methanesulfonyl chloride (9.9 ml, 128 mmol) in 35 ml ACN were slowly added at a temperature below 20 C. The mixture was stirred at room temperature 4 h. The mixture was concentrated by evaporating most of the ACN and extracted with CH2CI2. The organic phase was washed with saturated NaCI solution, dried over anhydrous MgS04, filtered and evaporated to dryness. 24.45 g of a yellow liquid was obtained (122% by mass).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; CRYSTAL PHARMA, S.A.U.; PEREZ ENCABO, Alfonso; TURIEL HERNANDEZ, Jose Angel; GALLO NIETO, Francisco Javier; LORENTE BONDE-LARSEN, Antonio; GARCIA ESCUDERO, Luis Angel; WO2015/181116; (2015); A1;,
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Related Products of 148043-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol, molecular formula is C5H7F5O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

,4,5,5,5-pentafluoropentanol (10 g) and dichloromethane (100 mL) were added to the reaction flask, Triethylamine (11.3 g) was added and the mixture was added dropwise under ice-cooling Methylsulfonyl chloride (6.72 g) was added dropwise and the reaction was resumed at room temperature for 2 hours. Excess triethylamine and methylsulfonyl chloride were washed with water, dried over anhydrous sodium sulfate and spin dried to give 14.14 g 4,4,5,5,5-pentafluoropentanol methanesulfonate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; Tianjin Pharmaceutical Innovation Co., Ltd.; LIU, WENJUAN; MO, LAN; (14 pag.)CN103965280; (2016); B;,
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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ramadoss, Govindarajan, once mentioned the application of 148043-73-6, Name is 4,4,5,5,5-Pentafluoropentan-1-ol, molecular formula is C5H7F5O, molecular weight is 178.1, MDL number is MFCD00153224, category is alcohols-buliding-blocks. Now introduce a scientific discovery about this category, Category: alcohols-buliding-blocks.

Mesoporous ferromagnetic manganese ferrite nanoparticles for enhanced visible light mineralization of azoic dye into nontoxic by-products

In this study, a one pot facile synthesis of ferromagnetic manganese ferrite nanoparticles (MnFe2O4) was carried out using chemical co-precipitation method for mineralization of azo dye (Congo red (CR)) in aqueous solution under visible light irradiation. The synthesized MnFe2O4 nanoparticles were highly crystalline and showed face-centred cubic (FCC) structure with average particle size of 58 +/- 4 nm. The BET analysis of the MnFe2O4 nanoparticles revealed the mesoporous distribution of material with high surface area can provide large electro active sites and short diffusion paths for the transport of ions which plays a vital role in the photocatalytic degradation of CR. The point of zero charge (pHPZC) was observed to be 6.7 indicating favourable condition for materialanionic dye interaction. The XPS studies revealed that the large amounts of oxygen vacancies were produced due to the defects in the lattice oxygen. The MnFe2O4 nanoparticlesmineralised 98.3 +/- 0.2% of 50mg/L CRwithin 30 min when tested in photocatalytic reactor under 565 nm. The particles were recoverable under the influence of an external magnet after the photocatalytic reaction and were reusable. The recovered nanoparticles showed 96% of CR degradation efficiency even after five cycles of reuse. The by-product analysis with GC-MS indicated mineralization of CR into simple alcohols and acids. The aqueous solution containing mineralised CR was nontoxic to Trigonella foenumgraecum and Vignamungo seeds and favoured increased germination, plumule and radicle length when compared to untreated CR. (C) 2020 Elsevier B.V. All rights reserved.

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