Category: 148-51-6

Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochlorideIn 1975, Yamashita, Junko published 《Action site of antagonists of vitamin B6 in the central nervous system of frogs and cockroaches》. 《Journal of Nutritional Science and Vitaminology》published the findings. The article contains the following contents:

Treatment with thiosemicarbazide [79-19-6], semicarbazide-HCl [563-41-7], isoniazide [54-85-3], DL-penicillamine [52-66-4], or toxopyrimidine [73-67-6] induced wild leaping or jumping behavior, and tonic or clonic convulsions in the frog (Rana nigromaculata) in which the nervous parts posterior to the optic lobe inclusive remained intact. No convulsions were induced by castrix [535-89-7] or 4-deoxypyridoxine-HCl [148-51-6] in frogs in which the nervous parts anterior to the diencephalon inclusive had been removed. Excessive restlessness and convulsions were induced by thiosemicarbazide in cockroaches (Periplaneta americana) in which the central nerve cord was severed between the subesophageal and prothoracic ganglia. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochlorideIn 1975, Yamashita, Junko published 《Action site of antagonists of vitamin B6 in the central nervous system of frogs and cockroaches》. 《Journal of Nutritional Science and Vitaminology》published the findings. The article contains the following contents:

Treatment with thiosemicarbazide [79-19-6], semicarbazide-HCl [563-41-7], isoniazide [54-85-3], DL-penicillamine [52-66-4], or toxopyrimidine [73-67-6] induced wild leaping or jumping behavior, and tonic or clonic convulsions in the frog (Rana nigromaculata) in which the nervous parts posterior to the optic lobe inclusive remained intact. No convulsions were induced by castrix [535-89-7] or 4-deoxypyridoxine-HCl [148-51-6] in frogs in which the nervous parts anterior to the diencephalon inclusive had been removed. Excessive restlessness and convulsions were induced by thiosemicarbazide in cockroaches (Periplaneta americana) in which the central nerve cord was severed between the subesophageal and prothoracic ganglia. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Meldrum, B. S. published 《Convulsive effects of 4-deoxypyridoxine in photosensitive baboons》 in 1971. The article was appeared in 《British Journal of Pharmacology》. They have made some progress in their research.Synthetic Route of C8H12ClNO2 The article mentions the following:

In baboons (Papio papio) which when exposed to intermittent light stimulation (ILS) showed myoclonus and electroencephalographic signs of epilepsy, deoxypyridoxine-HCl (I) (10-20 mg/kg, i.v.) did not modify the responses, while 15 min-2 hr after 40-60 mg I/kg, the myoclonic responses to ILS were enhanced. Animals normally giving transient myoclonic responses showed rhythmic myoclonus of the eyelids and face continuing for several sec after the end of ILS. In 4 out of 6 baboons after 80-100 mg I/kg this self-sustaining myoclonus developed into a full tonic-clonic seizure at least once 45-180 min after the drug injection. The injection of 105-150 mg I/kg not only enhanced myoclonic responses to ILS but also led to the appearance after 46-67 min of spontaneous seizures. These recurred every 10-15 min, were often only partial, and commonly originated in, and were sometimes confined to, the occipital cortex. An excess of pyridoxine, given i.v. a few minutes before and after the I, blocked both the enhancement of photosensitivity produced by 100 mg I/kg and spontaneous seizures produced by 150 mg/kg. I may produce these convulsive effects by interfering with the formation or action of pyridoxal phosphate. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Synthetic Route of C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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LaBrecque, G. C.;Gouck, H. K. published 《Compounds affecting fertility in adult houseflies》. The research results were published in《Journal of Economic Entomology》 in 1963.Computed Properties of C8H12ClNO2 The article conveys some information:

Of 1100 compounds that were tested, 20 caused sterility in adult Musca domestica when given in the food. P,P-Bis(1-aziridinyl)-N-(p-methoxyphenyl)phosphinic amide, 5-fluoroorotic acid, and 1,4-piperazinediylbis[bis(1-aziridinyl)phosphinic oxide] induced sterility without apparent toxic effect over the broadest range of concentrations, from 5% to 0.1% or 0.25%. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Computed Properties of C8H12ClNO2) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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COA of Formula: C8H12ClNO2《Effect of pyridoxal phosphate on toxicity and antitumor activity of mitomycin C and 4-deoxypyridoxine hydrochloride in rats. Preliminary observations》 was published in 1966. The authors were Fujimoto, Shigeru, and the article was included in《Cancer Chemotherapy Rept.》. The author mentioned the following in the article:

In rats bearing ascites hepatoma, combined therapy with mitomycin C and vitamin B₆ arrested leukopenia, but failed to alleviate liver dysfunction and anemia. The growth of subcutaneous tumors was not stimulated by vitamin B₆. Tumor growth was inhibited for 2 weeks after administration of 4-deoxypyridoxine-HCl, an antagonist of vitamin B₆, to rats fed a diet free of vitamin B₆. The administration of vitamin B₆ did not lessen the effect of mitomycin C on subcutaneous tumors in rats. Vitamin B₆ might counteract leukopenia, a side effect of antitumor agents, by an improvement in metabolism of proteins. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 COA of Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Taborsky, Robert G. published 《Preparation of 5-hydroxy-4,6-dimethyl-3-pyridinemethanol (4-deoxypyridoxine) by the use of hydrazine》. The research results were published in《Journal of Organic Chemistry》 in 1961.Related Products of 148-51-6 The article conveys some information:

2-Methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (10 g.) and 50 ml. 95% N₂H₄ refluxed 18 hrs., most of the N₂H₄ removed in vacuo, and the residue extracted with 60 ml. refluxing MeOH yielded N₂H₄.HCl, m. 91-2°. The volume of the filtrate reduced to 20 ml., 15 ml. 11.2% MeOH-HCl added, the precipitate isolated, and 50 ml. Et₂O added gave a further precipitate The total yield was 8.1 g. 2-methyl-3-hydroxy-4-methyl-5-hydroxymethylpyridine-HCl (I), m. 273° (decomposition). All conditions and isolation procedures were as above except that instead of the 4-Me ether, 5 g. pyridoxine-HCl and 25 ml. 95% N₂H₄ were used to give 98% I. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Related Products of 148-51-6) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Reeves, Richard E.;Meleney, Henry E.;Frye, William W. published 《Cultivation of Entamoeba histolytica with penicillin-inhibited Bacteroides symbiosus cells. I. Pyridoxine requirement》. The research results were published in《American Journal of Hygiene》 in 1959.SDS of cas: 148-51-6 The article conveys some information:

In a modified Shaffer-Frye culture system it was found that the multiplication of Entamoeba histolytica is strongly inhibited by low concentrations of deoxypyridoxol. The effect of this substance is reversed by the addition of pyridoxal, pyridoxylamine, pyridoxol or pyridoxal phosphate. The last substance was shown to be more effective than pyridoxol in reversing the action of desoxypyridoxol. Conditions were found which allowed the determination of the concentrations of desoxypyridoxol required to reduce to half-maximum the multiplication of E. histolytica. These half-maximum concentrations were reproducible for given stains of amebae, but significant differences were found among 5 strains examined. The F-22 and a newly isolated strain (JH) were more sensitive, the DKB, 200 and K-9 strains were less sensitive to the anti-metabolite. Neither the F-22 nor the DKB strain developed the ability to tolerate larger amounts of anti-metabolite upon continued cultivation in media containing it. Desoxypyridoxol was also effective in preventing the growth of E. histolytica in Cleveland-Collier cultures in the presence of a multiplying mixed-bacterial flora. These results show that there is a pyriodoxine requirement for the multiplication of E. histolytica in the MS-F system. It is not definitely established whether the action of the anti-metabolite is directly on the ameba or upon some phase of the residual metabolism of the accompanying penicillin-inhibited bacterial cells.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 SDS of cas: 148-51-6) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Recommanded Product: 148-51-6In 1969, Sanders, L. B.;Cetorelli, J. J.;Winefordner, James D. published 《Phosphorescence characteristics of several antimetabolites》. 《Talanta》published the findings. The article contains the following contents:

Phosphorescence excitation and emission wavelength peaks, lifetimes, limits of detection, and concentration ranges of anal. usefulness of 37 antimetabolites in rigid (77°K.) ethanolic solution were determined Seventeen of the metabolites produced anal. useful phosphorescence, whereas the remaining 20 were of limited or no anal. use. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Recommanded Product: 148-51-6) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride《Convulsive effects of 4-deoxypyridoxine and of bicuculline in photosensitive baboons (Papio papio) and in rhesus monkeys (Macaca mulatta)》 was published in 1971. The authors were Meldrum, B. S.;Horton, R. W., and the article was included in《Brain Research》. The author mentioned the following in the article:

4-Deoxypyridoxine HCl (I) [148-51-6] administered i.v. at 40-100 mg/kg enhanced the natural syndrome of photosynthetic epilepsy in baboons and increased the severity of photically-induced myoclonus so that it progressed to a tonic-clonic seizure. In subconvulsive doses I provoked epileptic afterdischarges in the occipital cortex of monkeys exposed to photic stimulation. In both species I at 100-150 mg/kg induced spontaneous seizures which originated unilaterally in the occipital cortex and began with a horizontal nystagmus. When the occipital discharges no longer generalized, the animals had a normal electroencephalogram. A 4:1 excess of pyridoxine [65-23-6] in baboons blocked the increase in photically-induced responses and drug-induced seizures. Bicuculline (II) [485-49-4] administered i.v. at 0.1-0.4 mg/kg induced generalized seizures in both species, and at 0.3-0.6 mg/kg induced prolonged (150-300 min) seizures characterized by sustained myoclonic activity and relative absence of episodes of postictal silence in baboons. At 0.1-0.3 mg/kg II sometimes caused a brief myoclonic jerk associated with frontorolandic spikes and waves. There seem to be 2 inhibitory systems which differ in their pharmacol. responsiveness but both probably involve γ-aminobutyric acid [56-12-2] as the neurotransmitter. One system seems to be intracortical and its functional failure causes occipital discharges and spontaneous seizures after administration of the pyridoxine antagonists. The other is probably a collateral inhibitory system within the pathways afferent to the somatomotor cortex. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Reference:
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Kosower, Nechama S.;Rock, Rica A. published 《Seizures in experimental porphyria》. The research results were published in《Nature (London, United Kingdom)》 in 1968.Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article conveys some information:

Rats made porphyric by allylisopropylacetamide (I) are susceptible to induced convulsions. Female Sprague-Dawley rats (150-160 g.) were injected daily with 400 mg. I/kg. in 0.15M NaCl for 8-10 days. Controls received NaCl. Twenty-four hrs. after the last injection, control and exptl. animals were injected with isonicotinoylhydrazide (II) or 4-methoxymethylpyridoxol-HCl (III) at pH 7, or deoxypyridoxol-HCl (IV) at pH 7. Other animals were given pyridoxal-HCl (V) 15 min. prior to injection of the compounds At 0.75 millimoles II/kg., clonic-tonic convulsions occurred in 60% of porphyric rats and in none of the controls; at 1.12 millimoles/kg., 90% of the porphyric rats convulsed, and 20% of controls. At 0.5-2 millimoles/kg., V did not alter the convulsions induced by II. Following III at 0.25 millimoles/kg., 70% of porphyric rats convulsed, and all convulsed at 0.75 millimoles/kg. (but no controls convulsed). No difference was noted between controls and animals injected with IV. These compounds may act by interfering with pyridoxal 5-phosphate in the nervous system.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts