Category: 1475-13-4

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1475-13-4, name is 1-(2,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, molecular weight is 191.0545, as common compound, the synthetic route is as follows.Computed Properties of C8H8Cl2O

Example 121 5-(2-Piperidino-ethyl)-2-methyl-1H-indole-3-carboxylic Acid-1-(2,4-dichlorophenyl)-ethyl Ester The procedure for Example 65 was followed, substituting 1-(2,4-dichlorophenyl)ethanol for (S)-phenylethanol, and substituting piperidine for diethylamine. ESI+MS m/z 459 (M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1475-13-4, 1-(2,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2003/64991; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1475-13-4 ,Some common heterocyclic compound, 1475-13-4, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 4-chloro-2-trichloromethylquinazoline 1 (0.2 g, 0.71 mmol), DMAP (26 mg, 0.21 mmol, 0.3 equiv) and adequate alcohol derivative (0.85 mmol, 1.2 equiv) in toluene (3 mL) was introduced in miniaturized sealed reactor (5mL). The reaction mixture was irradiated in a monomode microwave oven, for 1 h at 130C. After removal of the toluene under reduced pressure, the residue was purified by silica gel column chromatography and recrystallized from appropriate solvent. 4.1.16 4-(1-(2,4-Dichlorophenyl)ethoxy)-2-(trichloromethyl)quinazoline (14) Yield 69%. Brown powder. Mp 123 C, (isopropanol). 1H NMR (200 MHz, CDCl3) delta = 8.31 (d, J = 8 Hz, 1H), 8.07 (d, J = 8 Hz, 1H), 7.96-7.87 (m, 1H), 7.69 (t, J = 7 Hz, 1H), 7.49-7.39 (m, 2H), 7.20 (dd, J = 2 Hz; 8 Hz, 1H), 6.78 (q, J = 7 Hz, 1H), 1.81 (d, J = 7 Hz, 3H) . 13C NMR (50 MHz, CDCl3) delta = 165.3, 159.2, 150.8, 135.3, 131.6, 130.8 129.4, 129.3, 129.0, 128.6, 123.4, 115.4, 96.9, 72.7, 21.0. LC-MS (ESI+) tR 6.02 min, m/z [M + H]+ 434.74/436.86/438.81. MW: 436.55 g/mol. Anal. Calcd for C17H11Cl5N2O: C, 46.77; H, 2.54; N, 6.42. Found: C, 46.41; H, 2.52; N, 6.51.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1475-13-4, its application will become more common.

Reference:
Article; Gellis, Armand; Primas, Nicolas; Hutter, Sebastien; Lanzada, Gilles; Remusat, Vincent; Verhaeghe, Pierre; Vanelle, Patrice; Azas, Nadine; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 34 – 44;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1475-13-4, name is 1-(2,4-Dichlorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H8Cl2O

General procedure: The above secondary alcohol was dissolved in acetonitrile (30mL). Molecular sieve (1.5g), silica gel (1.5g) and activated MnO2 (3.5g, 40mmol) were added, and the mixture was stirred at 70C for 8h. upon completion of the oxidation, the resulting suspension was filtered through diatomite, and the filtrate was concentrated by rotary evaporation. Purification of the residue by column chromatography (petroleum ethrt/EtOAc, 15:1) afforded ketone 13.

With the rapid development of chemical substances, we look forward to future research findings about 1475-13-4.

Reference:
Article; Bi, Fangchao; Song, Di; Zhang, Nan; Liu, Zhiyang; Gu, Xinjie; Hu, Chaoyu; Cai, Xiaokang; Venter, Henrietta; Ma, Shutao; European Journal of Medicinal Chemistry; vol. 159; (2018); p. 90 – 103;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1475-13-4, name is 1-(2,4-Dichlorophenyl)ethanol. A new synthetic method of this compound is introduced below., Computed Properties of C8H8Cl2O

General procedure: A mixture of 2 mmol of substrate, and 4 mL ethylene glycol was stirred for 5 min, and then 2.4 mmol of DBDMH or 4.6 mmol of NBS was added by 5 times in one hour, and the mixture was stirred 24 h at room temperature. Afterward, the mixture was extracted with ether (10 mL × 3). The combined organic layer was washed twice by water (20 mL), and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure, and the residual was treated with alumina chromatography (Petroleum ether/AcOEt=20/1,V/V) to generate the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1475-13-4, 1-(2,4-Dichlorophenyl)ethanol.

Reference:
Article; Han, Bingbing; Zheng, Zubiao; Wu, Fang; Wang, Aidong; Synthetic Communications; vol. 47; 24; (2017); p. 2387 – 2394;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts