Category: 147034-01-3

Electric Literature of 147034-01-3 , The common heterocyclic compound, 147034-01-3, name is (2,5-Dibromophenyl)methanol, molecular formula is C7H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of (2,5-dibromo-phenyl)-methanol (40 g, 150 mmol) and triphenylpho spine (59 g, 230 mmol) in THF (1000 mL) at 0 C is added carbon tetrabromide (75 g, 230 mmol) slowly. The reaction mixture is stirred at room temperature for 2 hr and the solvent is removed to give the crude product. Purification by flash column chromatography affords 40 g of 1,4- dibromo-2-bromomethyl -benzene.

The synthetic route of 147034-01-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; COGAN, Derek; GUO, Xin; MARSHALL, Daniel Richard; MEYERS, Kenneth Michael; ZHANG, Yunlong; (130 pag.)WO2016/89800; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.147034-01-3, name is (2,5-Dibromophenyl)methanol, molecular formula is C7H6Br2O, molecular weight is 265.93, as common compound, the synthetic route is as follows.Computed Properties of C7H6Br2O

To a stirred solution of (2,5-dibromo-phenyl)-methanol (45 g, 170 mmol) in THF (1000 mL) is added 60% NaH in mineral oil (10 g, 250 mmol) at 0 C. The mixture is stirred for 30 min and allyl bromide (25 g, 203 mmol) is added. Then the mixture is warmed up to room temperature for 12 hrs. The reaction is quenched with ice and the mixture is extracted with EtOAc. The organic layers are combined, dried and concentrated to give the crude product. Purification by flash column chromatography affords 45 g of 2-allyloxymethyl-l,4-dibromo-benzene.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147034-01-3, (2,5-Dibromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; COGAN, Derek; GUO, Xin; MARSHALL, Daniel Richard; MEYERS, Kenneth Michael; ZHANG, Yunlong; (130 pag.)WO2016/89800; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts