Category: 14703-69-6

Ma, Yuan published the artcileTheoretical study on the formation mechanisms, dynamics and the effective catalysis of the nitrophenols, Category: alcohols-buliding-blocks, the publication is ChemistrySelect (2018), 3(36), 10188-10197, database is CAplus.

The hydrogen abstraction reactions of mono-substituted phenols and nitrogen dioxide may be the sources of HONO and phenoxy radical. Further addition reaction of NO₂ and phenoxy radical can form 2-nitrophenol (2-NP) and 4-nitrophenol (4-NP). The specific formation mechanisms and dynamics of NPs have drawn significant attention in recent days. The promoted reaction mechanisms by water, phenol and intermediate have also been studied. Compared with the naked reaction, the catalytic pathways can reduce the energy barrier from 48.40 kcal/mol to 18.23, 23.03 and 18.87 kcal/mol to form 2-NP, resp. Water mols. are the most effective catalysts, and the energy barrier could be further reduced to 8.20 kcal/mol when three water mols. are participating in the reaction. Water mols. can not only promote the formation of 4-NP, but also simplify the reaction steps. In general, the water mols. serve as catalysts in the formation of NPs. The rate constants of 2-NP and its hydrates have been predicted. The results are listed as follows: k_2-NP =3.82×10^-13; k_2-NP-1W =2.43×10^-7; k_2-NP-2W =3.39×10^-4 cm³mol.^-1s^-1. The rate constants of mono-substituted phenols (methylamino phenol, aminophenol and hydroquinone) and NO₂ are also predicted by the traditional transitional state theory and variational transition state theory using the B3LYP/6-311++G(3df,3pd)//6-311++G(d). For the most dominant path, the rate constants for o/m/p-methylaminophenol are 1.91×10^-14, 4.28×10^-20 and 8.78×10^-15 cm³mol.^-1s^-1, resp.

ChemistrySelect published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sandanayake, K. R. A. Samankumara published the artcileMolecular fluorescence sensor for saccharides based on amino coumarin, Name: 3-(Methylamino)phenol, the publication is Chemistry Letters (1995), 139-40, database is CAplus.

The intramol. neighboring group interaction of the amino group of the 7-aminocoumarin moiety with phenylboronic acid gave fluorescence intensity and spectral changes upon saccharide binding which could be used in fluorescence mapping of saccharides in biol. cells.

Chemistry Letters published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Name: 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Xiao published the artcileEngineering of reversible luminescent probes for real-time intravital imaging of liver injury and repair, Related Products of alcohols-buliding-blocks, the publication is CCS Chemistry (2022), 4(1), 356-368, database is CAplus.

As the major organ for drug metabolism and detoxification, the liver is prone to damage and severely impaired functionality. The treatment of liver diseases is based on a clear understanding of the process underlying liver injury and repair. However, intravital real-time imaging of liver injury and repair is still limited due to the lack of in vivo reversible visualization methods. To this end, we proposed a rational design strategy for the development of a reversible upconversion luminescence nanoprobe that allows real-time and in vivo imaging of liver injury and repair processes. As a proof of concept, we first developed a small mol. probe NB3 which can reversibly respond to related analytes of early liver injury [peroxynitrite (ONOO^–)] and liver repair [glutathione (GSH)]. The small mol. probe was then integrated with a core-shell upconversion nanoparticle to form a sophisticated nanoprobe. Compared with traditional small mol. probes, this nanoprobe exhibited a higher selectivity to ONOO^–, longer retention time in liver, and wider dynamic response range to GSH after oxidation by ONOO^–. The novel nanoprobe facilitated the successful monitoring and discrimination among the different degrees of liver injury and repair in a mouse model.

CCS Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gomola, Kinga published the artcileAn optically uniaxial antiferroelectric smectic phase in asymmetrical bent-core compounds containing a 3-aminophenol central unit, Formula: C7H9NO, the publication is Journal of Materials Chemistry (2010), 20(37), 7944-7952, database is CAplus.

Two series of asym. bent-core compounds possessing 3-aminophenol and its N-Me derivative have been synthesized. The asymmetry arose from the different linkages between the central unit and the chem. chains of the substituents, and in two cases also from different lateral substituents. The mesomorphic properties were investigated by differential scanning calorimetry, polarizing optical microscopy, switching current and electro-optical measurements, X-ray anal., and second-harmonic generation. All materials possessing 3-aminophenol as a central unit showed liquid crystalline properties, and two of them exhibited the orthogonal smectic phase (SmA family phase) and very stable columnar phases, while the N-Me analogs exhibited no mesophase. Because of the optically uniaxial nature, double switching current peaks, and SHG activity associated with a distinct threshold elec. field, this orthogonal smectic phase was assigned to a novel type, which has a short-range antiferroelec. order with a long-range randomized polar plane (SmAP_AR).

Journal of Materials Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Formula: C7H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Denisov, E. T. published the artcileKinetic parameters for the forward and reverse reactions of the tert-butoxyl radical with phenols, Computed Properties of 14703-69-6, the publication is Kinetika i Kataliz (1993), 34(3), 424-9, database is CAplus.

Parameters of the parabolic transition state model (2 intersecting unperturbed potential energy curves) for H-abstraction reaction of Me₃CO^• with phenols were evaluated from exptl. kinetic data reported in the literature. Constancy of the br_e parameter for classes of sterically hindered and nonhindered phenols permitted calculation of forward and reverse rate constants of 99 phenols with Me₃CO^• at 333 K.

Kinetika i Kataliz published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Computed Properties of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Uddin, Jashim Md. published the artcileDesign, Synthesis, and Structure-Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents, Computed Properties of 14703-69-6, the publication is Bioconjugate Chemistry (2013), 24(4), 712-723, database is CAplus and MEDLINE.

Cyclooxygenase-2 (COX-2) is an attractive target for mol. imaging because it is an inducible enzyme that is expressed in response to inflammatory and proliferative stimuli. Recently, the authors reported that conjugation of indomethacin with carboxy-X-rhodamine dyes results in the formation of effective, targeted, optical imaging agents able to detect COX-2 in inflammatory tissues and premalignant and malignant tumors. The present paper summarizes the details of the structure-activity relationship (SAR) studies performed for lead optimization of these dyes. A wide range of fluorescent conjugates were designed and synthesized, and each of them was tested for the ability to selectively inhibit COX-2 as the purified protein and in human cancer cells. The SAR study revealed that indomethacin conjugates are the best COX-2-targeted agents compared to the other carboxylic acid-containing nonsteroidal anti-inflammatory drugs (NSAIDs) or COX-2-selective inhibitors (COXIBs). An n-butyldiamide linker is optimal for tethering bulky fluorescent functionalities onto the NSAID or COXIB cores. The activity of conjugates also depends on the size, shape, and electronic properties of the organic fluorophores. These reagents are taken up by COX-2-expressing cells in culture, and the uptake is blocked by pretreatment with a COX inhibitor. In in vivo settings, these reagents become highly enriched in COX-2-expressing tumors compared to surrounding normal tissue, and they accumulate selectively in COX-2-expressing tumors as compared with COX-2-neg. tumors grown in mice. Thus, COX-2-targeted fluorescent inhibitors are useful for preclin. and clin. detection of lesions containing elevated levels of COX-2.

Bioconjugate Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C4H5NS2, Computed Properties of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Amery, G. W. published the artcileSynthesis and identification of some N-methylated aminonitrophenols, Application In Synthesis of 14703-69-6, the publication is Journal of the Chemical Society [Section] C: Organic (1967), 1053-7, database is CAplus.

The synthesis of a number of new N-methyl and N,N-dimethylaminonitrophenols is described. Spectroscopy assisted in deducing the orientation of these compounds In particular, the position of the nitro group, relative to the OH group, can be clearly discerned by comparison of the spectrum of the hydroxynitroanilinium ion with those of the 3 nitrophenols. 26 references.

Journal of the Chemical Society [Section] C: Organic published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Application In Synthesis of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Newton, Rebecca published the artcileThe discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity, Quality Control of 14703-69-6, the publication is European Journal of Medicinal Chemistry (2016), 20-32, database is CAplus and MEDLINE.

Deregulation of the receptor tyrosine kinase RET has been implicated in medullary thyroid cancer, a small percentage of lung adenocarcinomas, endocrine-resistant breast cancer and pancreatic cancer. There are several clin. approved multi-kinase inhibitors that target RET as a secondary pharmacol. but addnl. activities, most notably inhibition of KDR, lead to dose-limiting toxicities. There is, therefore, a clin. need for more specific RET kinase inhibitors. Herein we report our efforts towards identifying a potent and selective RET inhibitor using vandetanib 1 as the starting point for structure-based drug design. Phenolic anilinoquinazolines exemplified by 6 showed improved affinities towards RET but, unsurprisingly, suffered from high metabolic clearance. Efforts to mitigate the metabolic liability of the phenol led to the discovery that a flanking substituent not only improved the hepatocyte stability, but could also impart a significant gain in selectivity. This culminated in the identification of 36; a potent RET inhibitor with much improved selectivity against KDR.

European Journal of Medicinal Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Quality Control of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Honing, Maarten published the artcileAdduct ion formation by aromatic amines in thermospray mass spectrometry, Product Details of C7H9NO, the publication is Journal of Mass Spectrometry (1996), 31(5), 527-536, database is CAplus.

The formation of solvent adduct ions in thermospray and ionspray mass spectrometry was studied for twelve aromatic amines: aniline, N-methylaniline, N,N-dimethylaniline, 3-aminophenol, 3-(methylamino)phenol, 3-(dimethylamino)phenol, 2-aminopyridine, 2-(methylamino)pyridine, 2-(dimethylamino)pyridine, 2-amino-5,6-dimethyl-4-hydroxypyrimidine, 2-(methylamino)-5,6-dimethyl-4-hydroxypyrimidine, and 2-(dimethylamino)-5,6-dimethyl-4-hydroxypyrimidine. For all compounds, adduct ions, [M + H + A_n]⁺, with A being methanol or acetonitrile, were observed in the thermospray mass spectra; water adduct ions were observed for a few compounds No adduct ions with ammonia were formed when ammonium acetate was added to the liquid chromatog. carrier stream. These observations cannot be explained on the basis of gas-phase ion-mol. reactions of the neutral analyte and protonated solvent or solvent additive mols. Comparative experiments, changing the pH of the carrier stream in both thermospray and ionspray ionization, showed that the solvent adduct ions present in the thermospray mass spectra are not likely to be formed by ion evaporation processes. Incomplete evaporation of droplets or cluster ions is proposed to be responsible for the observations. With this hypothesis, both the absence of ammonium adduct ions and the dependence of the adduct ion abundances on N-methylation can be related to the adduct-analyte bond strengths.

Journal of Mass Spectrometry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Product Details of C7H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mao, Di published the artcileA Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures, Recommanded Product: 3-(Methylamino)phenol, the publication is Angewandte Chemie, International Edition (2017), 56(7), 1765-1770, database is CAplus and MEDLINE.

A major hurdle in stem cell therapy is the tumorigenic risk of residual undifferentiated stem cells. This report describes the design and evaluation of synthetic hybrid mols. that efficiently reduce the number of human induced pluripotent stem cells (hiPSCs) in cell mixtures The design takes advantage of Kyoto probe 1 (KP-1), a fluorescent chem. probe for hiPSCs, and clin. used anticancer drugs. Among the KP-1-drug conjugates we synthesized, we found an exceptionally selective, chem. tractable mol. that induced the death of hiPSCs. Mechanistic anal. suggested that the high selectivity originates from the synergistic combination of transporter-mediated efflux and the cytotoxicity mode of action. The present study offers a chem. and mechanistic rationale for designing selective, safe, and simple reagents for the preparation of non-tumorigenic clin. samples.

Angewandte Chemie, International Edition published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Recommanded Product: 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts