Category: 1467-84-1

Electric Literature of 1467-84-1, Adding some certain compound to certain chemical reactions, such as: 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1467-84-1.

To a mixture of (4-aminocyclohexyl)methanol (6.62 g, 40 mmol) and K2C03 (11.04 g, 80 mmol) was in MeCN (60 mL) at 0 C was added Mel (5.6 g, 40 mmol) dropwise, the reaction mixture was stirred at rt for 7 h, filtered, and the filtrate was concentrated to afford the crude title compound. ESI-MS m/z 144 (MH)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1467-84-1, (trans-4-Aminocyclohexyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VENATORX PHARMACEUTICALS, INC.; BURNS, Christopher, J.; CHU, Guo-Hua; HAMRICK, Jodie; BOYD, Steven, A.; CONDON, Stephen, M.; (0 pag.)WO2019/232053; (2019); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

PREPARATION 50 2-((1r,4r)-4-Aminocyclohexyl)acetonitrile a) tert-Butyl (1 r,4r)-4-(hydroxymethyl)cyclohexylcarbamate Di-tert-butyl dicarbonate (3.04 g, 13.9 mmol) was added to a stirred solution of ((1r,4r)-4-aminocyclohexyl)methanol (1.50 g, 11.6 mmol) in tetrahydrofuran (20 mL). After stirring overnight at room temperature, the mixture was evaporated and partitioned between ethyl acetate and water. The organic layer was washed with water, brine, dried (MgSO4) and evaporated. The residue was treated with hexanes and the suspension was filtered to give the title compound (2.11 g, 79%) as a white solid. LRMS (m/z): 228 (M-H)+.1H NMR (300 MHz, DMSO-d6) delta ppm 0.84 – 0.95 (m, 2H), 1.05 – 1.18 (m, 2H), 1.20 – 1.29 (m, 2H), 1.40 (s, 9H), 1.71 -1.80 (m, 3H), 3.14 (m, 1H), 3.21 (t, 2H), 4.41 (t, 1H), 6.73 (d, 1H).

The synthetic route of 1467-84-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; GOMEZ CASTILLO, Elena; BACH TANA, Jordi; WO2011/157397; (2011); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1467-84-1

REFERENCE SYNTHETIC EXAMPLE 19 4-{[trans-4-(Hydroxymethyl)cyclohexyl]amino}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide To a solution of 4-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (680 mg, 2.09 mol) obtained in Reference Synthetic Example 7 in N,N-dimethylacetamide (1.1 mL), N,N-diisopropylethylamine (1.1 mL) and (trans-4-aminocyclohexyl)methanol (945 mg, 7.31 mmol) obtained in Reference Synthetic Example 12 were added, and the mixture was stirred at 130C for 3 hours. The reaction mixture was allowed to cool to room temperature, mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=5/1) (v/v)) to obtain the title compound as a white solid (781 mg, yield: 89%).

With the rapid development of chemical substances, we look forward to future research findings about 1467-84-1.

Reference:
Patent; Nissan Chemical Industries, Ltd.; TAKAHASHI, Keiji; WATANABE, Tsuneo; HAYASHI, Keishi; KURIHARA, Kazunori; NAKAMURA, Takanori; YAMAMOTO, Akio; NISHIMURA, Takuya; KAMIYAMA, Toshihiko; HIDAKA, Yuuki; EP2955181; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, molecular formula is C7H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (trans-4-Aminocyclohexyl)methanol

To a stirred solution of 2,4-dichloro-5-nitropyrimidine (0.6 g, 3 mmol) in THF (10 mL) was added DIPEA (0.4 g, 3 mmol) dropwise followed by ((1R,4R)-4-aminocyclohexyl)methanol (0.4 g, 3 mmol) at ambient temperature. The reaction mixture was stirred at ambient temperature for 4 h. Completion of the reaction was confirmed by UPLC. The product was isolated to afford ((1R, 4R)-4-((2-chloro-5-nitropyrimidin-4-yl)amino)cyclohexyl)methanol (0.3 g, 33%) as a yellow solid. MS (ESI) m/z 287 [M+1]+.

With the rapid development of chemical substances, we look forward to future research findings about 1467-84-1.

Reference:
Patent; Celgene Corporation; CANAN, Stacie S.; HAWRYLUK, Natalie Anne; WITTY, Michael John; (74 pag.)US2017/348315; (2017); A1;,
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Reference of 1467-84-1, Adding some certain compound to certain chemical reactions, such as: 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1467-84-1.

The reference gathers the precedent 14 of the resulting 1 – (4-chloro-1 – {[ 2 – (trimethyl silicon alkyl) ethoxy] methyl} – 1H-pyrrolo [2,3-b] pyridine-5-yl) prop-2-en-1-one (35.3g, 105mmol) add in order to Japan International disclosed in paragraph 2013/024895 of the recorded reference gathers the precedentb 122 the method obtained (trans-4-amino-cyclohexyl) methanol (16.4g, 126mmol), potassium phosphate (44.7g, 210mmol) and dimethyl sulfoxide (175 ml), in 100-110 C stirring 2 hours 30 minutes. Subsequently, to the cold-discharge 50 C rear, for adding water in the reaction mixture. Filter the resulting solid, after washing with ethyl acetate, dried under reduced pressure, the title compound is obtained as light yellow solid (32.1g, yield 71%).

According to the analysis of related databases, 1467-84-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; WATANABE, TSUNEO; TAKAHASHI, KEIJI; HAYASHI, KEISHI; NAKAMURA, TAKANORI; MINAMI, MASATAKA; KURIHARA, KAZUNORI; YAMAMOTO, AKIO; NISHIMURA, TAKUYA; UNI, MIYUKI; KAMIYAMA, TOSHIHIKO; IWAMOTO, SHUNSUKE; (96 pag.)TW2016/7947; (2016); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

To a solution of trans-4-aminocyclohexyl)methanol (CXXXIV) (1.0 g, 6.04 mmol) and HATU (2.78 g, 7.30 mmol) in DMF (15 mL) was added DIPEA (4.03 mL, 23.07 mmol) and the mixture was stirred for 10 min. Then, 5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carboxylic acid (LII) (2.5 g, 7.69 mmol) was added and the mixture was stirred at room temperature for 18 h. The LC-MS of mixture showed near completion of the starting material. The solvents were concentrated in vacuo, the residue partitioned between EtOAc and saturated aqueous NaHCO3, organic layer was separated, washed with water and brine. The organic layer was dried over anhydrous Na2SO4, solvents removed in vacuo and the crude product was purified by column chromatography using (90-100% EtOAc/hexanes) to obtain 5-bromo-N-trans-4-(hydroxymethyl)cyclohexyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carboxamide (CXXXV) as a white solid (2.06 g, 4.72 mmol, 61.4% yield). ESIMS found for C20H26BrN3O3 m/z 438.1 (M+H).

The synthetic route of 1467-84-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Mittapalli, Gopi Kumar; Hofilena, Brian Joseph; Eastman, Brian Walter; Cao, Jianguo; Chiruta, Chandramouli; Bollu, Venkataiah; (145 pag.)US2019/263821; (2019); A1;,
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