Category: 144284-25-3

Reference of 144284-25-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 144284-25-3 as follows.

4.2 2,4,5-Trifluorobenzyliodide 3 2,4,5-Trifluorobenzylalcohol (2.26 g, 14 mmol) was dissolved in dry 1,4-dioxane (30 mL) and to that BF3·Et2O (1.98 g, 14 mmol) and KI (2.32 g, 14 mmol) were added and the resulting mixture was stirred for 48 h at room temperature. The reaction mixture was poured into cold water and extracted with diethyl ether. The combined organic layer was washed with water, brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography eluting with 10% ethyl acetate in hexane to give 3 (3.35 g, 88%) as a brown liquid. 1H NMR (400 MHz, CDCl3) delta 4.34 (s, 2H), 6.93-6.86 (m, 1H), 7.21-7.14 (m, 1H); 13C NMR (100 MHz, CDCl3) delta -5.78, 106.0, 106.2, 106.2, 106.4, 118.3, 118.5, 123.1, 145.7, 148.1, 148.7, 151.2, 154.2, 156.6.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144284-25-3, its application will become more common.

Reference:
Article; Subbaiah; Haq, Wahajul; Tetrahedron Asymmetry; vol. 25; 13-14; (2014); p. 1026 – 1030;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 144284-25-3, 2,4,5-Trifluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 144284-25-3, blongs to alcohols-buliding-blocks compound. Computed Properties of C7H5F3O

General procedure: Triphenylphosphonium salts 49 and 50 were obtained by treating alcohols 47 and 48 (4.5 mmol) in MeCN/THF (1:1, 10 mL) with Ph3P.HBr (3.12 g, 9 mmol). The resulting reaction mixture was heated at 80 C to complete the reaction (as indicated by TLC). The solvents were evaporated and the oily residues were triturated with Et2O. After overnight refrigeration and filtration of the precipitates, the corresponding salts were obtained and used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144284-25-3, its application will become more common.

Reference:
Article; Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George; European Journal of Medicinal Chemistry; vol. 46; 2; (2011); p. 721 – 737;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 144284-25-3, Adding some certain compound to certain chemical reactions, such as: 144284-25-3, name is 2,4,5-Trifluorobenzyl alcohol,molecular formula is C7H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144284-25-3.

To 25mL sealed tube were added norcantharidin 4 (1.0mmol, 168mg), 4-DMAP (1.0mmol, 244mg), after argon replacement three times, then added DCM 2.5mL, 2,4,5-trifluoro Benzyl alcohol 5 (2.0mmol, 232muL) was reacted at 60 for 14h. After the reaction was completed, it was cooled to room temperature, washed three times with HCl (1 mol/L) and saturated brine, and the organic phases were combined. After the organic phases were dried over anhydrous sodium sulfate, flash column chromatography gave a white solid product 6-3, yield 37.9%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144284-25-3, 2,4,5-Trifluorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zunyi Medical University; Jia Jia; He Chunyang; Zhu Erlin; Wang Le; Li Xiaofei; Zhang Jianyong; (9 pag.)CN111253415; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts