Category: 14426-21-2

Reference of 14426-21-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14426-21-2, name is Diethanolamine hydrochloride, molecular formula is C4H12ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirring solution of 57 (500 mg, 3.33 mmol) in DCM (100 mL) was added CSI (290 tL, 471 mg, 3.33 mmol). After 20 mi Et3N (1.4 mL, 1.0 g, 10 mmol) and a solution of diethanolamine.HC1 (571 mg, 4.0 mmol) in DMF (5 mL) were added subsequently. After an additional 45 mm., the reaction mixture was concentrated under reduced pressure and the residue was purified by gradient column chromatography (0 -* 15% MeOH in DCM).Product 66 was obtained as colorless thick oil (767 mg, 2.13 mmol, 64%). ?H NIVIR (400IVIFIz, CDC13) (ppm) 4.26 (d, J= 8.2 Hz, 2H), 3.87 (t, J= 4.9 Hz, 4H), 3.55 (t, J = 4.9Hz, 4H), 2.37-2.16 (m, 6H), 1.65-1.45 (m, 2H), 1.39 (quintet, J = 8.6 Hz, 1H), 1.05-0.92 (m, 2H)

According to the analysis of related databases, 14426-21-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; WIJDEVEN, Maria Antonia; VAN DE SANDE, Petrus Josephus Jacobus Maria; VAN BERKEL, Sander Sebastiaan; VAN DELFT, Floris Louis; (150 pag.)WO2016/53107; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 14426-21-2 ,Some common heterocyclic compound, 14426-21-2, molecular formula is C4H12ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into a reaction flask equipped with a stirrer, a condenser and a thermometer, 4.84 g (0.01 mol) of intermediate III-2 was added, 30mL dichloromethane to dissolve, add DCC 4. lg, stirring for some time after adding DMAP. After stirring for a period of time, bis (2-hydroxyethyl) amine hydrochloride l.lg (O.Olmol) was added to the reaction system in batches, and the reaction was continued for 2 hours. The filtrate was washed with 3 X 40 mL of water, the dichloromethane layer was separated, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness under reduced pressure. Column chromatography [eluent: nu (petroleum ether) Nu (ethyl acetate) = 90: 10] to give a white solid product of 3.818 (yield 99.8%), yield 66.8%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14426-21-2, its application will become more common.

Reference:
Patent; Tianjin Pharmaceuticals Research Institute Co., Ltd.; Liu, Ying; Liu, DengKe; Jie, xiaoshuai; Qi, haofei; Wang, jingyang; (13 pag.)CN102838652; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14426-21-2, name is Diethanolamine hydrochloride. A new synthetic method of this compound is introduced below., SDS of cas: 14426-21-2

EXAMPLE 6 N,N-di-[2-(3,4,5-trimethoxybenzoyloxy)ethyl]taurine A mixture of 14 g of diethanolamine hydrochloride, 200 ml of dimethoxyethane and 47 g of 3,4,5-trimethoxybenzoyl chloride was left at ambient temperature for one night under agitation. The excess HCl was removed with a current of nitrogen, and the solution then evaporated under reduced pressure and taken up in 300 ml of anhydrous ethyl alcohol. 14 G of sodium ethoxide in 200 ml of absolute alcohol was added under cooling, then 21 g of sodium bromoethanesulphonate and 1.7 g of potassium iodide. After 120 hours at ambient temperature, the inorganic salts were filtered off and the solution concentrated under reduced pressure to a small volume. The mixture was then left to stand for one night, then filtered and crystallized from methanol. The product had a melting point of 179-182 C. and was identical to that obtained in Example 2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14426-21-2, Diethanolamine hydrochloride.

Reference:
Patent; Laboratorio Chimico Farmaceutico CAUSYTH S.p.A.; US4259332; (1981); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 14426-21-2 ,Some common heterocyclic compound, 14426-21-2, molecular formula is C4H12ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into a reaction flask equipped with a stirrer, a condenser and a thermometer, 4.84 g (0.01 mol) of intermediate III-2 was added, 30mL dichloromethane to dissolve, add DCC 4. lg, stirring for some time after adding DMAP. After stirring for a period of time, bis (2-hydroxyethyl) amine hydrochloride l.lg (O.Olmol) was added to the reaction system in batches, and the reaction was continued for 2 hours. The filtrate was washed with 3 X 40 mL of water, the dichloromethane layer was separated, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness under reduced pressure. Column chromatography [eluent: nu (petroleum ether) Nu (ethyl acetate) = 90: 10] to give a white solid product of 3.818 (yield 99.8%), yield 66.8%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14426-21-2, its application will become more common.

Reference:
Patent; Tianjin Pharmaceuticals Research Institute Co., Ltd.; Liu, Ying; Liu, DengKe; Jie, xiaoshuai; Qi, haofei; Wang, jingyang; (13 pag.)CN102838652; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts