Category: 144-19-4

Related Products of 144-19-4, Adding some certain compound to certain chemical reactions, such as: 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol,molecular formula is C8H18O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144-19-4.

238. 5g of 2, 2, 4-trimethyl-1, 3-pentanediol was placed (TMPD, 1.631 mol) in a 2-13- neck round-bottom flask. To this was added 205.7g DMC (2.283 mol, 40% excess) and 2.2g zinc stearate. The reaction flask was equipped with a thermocouple temperature probe, magnetic stirbar, and a 1″wide, 10″long vacuum-jacketed, silvered column packed with HastelloyG) B, atop which was placed a variable reflux K-head and condenser. The system was purged by bubbling nitrogen into the reaction mixture for 45 minutes prior to being heated. While under an atmosphere of nitrogen, the mixture was heated slowly to 100- 105C. After 30 minutes of heating, the boiling mixture began to reflux at an overhead temperature of 62-64C. The methanol byproduct/DMC azeotrope (typically a 70/30 wt/wt mixture of methanol/DMC) was removed at a reflux to takeoff ratio of between 3: 1 and 8: 1. After 2 hours of continuous heating, the temperature of the reaction mixture slowly began to rise, reaching 150-155C over the course of the next 15.5 hours as methanol was removed from the system. At this point, 37.9g DMC and 79.2g methanol (75.9% of total expected) had been removed from the reaction. The reaction mixture was then cooled to 60C and a vacuum was slowly introduced in order to remove unreacted DMC and additional methanol by-product. During this time, the temperature of the mixture was slowly increased. After 3 hours, the reaction mixture had been warmed to 90-95C and the system pressure had been reduced to 1.0-2. 0 mmHg. The system pressure was then further reduced to 0.5-1. 0 mmHg and the temperature of the mixture increased to 130C. Unreacted TMPD was preferentially removed from the reaction at an overhead temperature of 80-95C followed by distillation of the carbonate product 4-isopropyl-5, 5-dimethyl-1, 3-dioxan-2-one at an overhead temperature of 95-110C. Several cuts were taken during the distillation and analyzed by GC with the following results; Based on the above results (assuming actual wt. % is approximately equal to GC area %), reaction yield = 73.5%.

According to the analysis of related databases, 144-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HUNTSMAN PETROCHEMICAL CORPORATION; WO2003/89424; (2003); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H18O2

EXAMPLE 5 1,3-bis-(4-nitrophenoxy)-2,2,4-trimethylpentane 146 g (1 mol) 2,2,4-trimethyl-1,3-dihydroxypentane, 346.5 g (2.2 mols) 4-nitrochlorobenzene and 140 g powdered sodium hydroxide were reacted using the same procedure described in Example 1 in 600 ml DMSO. Yield: 265 g (68.3% of the theoretical) Mp.: 95-96 C. (beige powder)

With the rapid development of chemical substances, we look forward to future research findings about 144-19-4.

Reference:
Patent; Bayer Aktiengesellschaft; US4820866; (1989); A;,
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Electric Literature of 144-19-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol, molecular formula is C8H18O2, molecular weight is 146.2273, as common compound, the synthetic route is as follows.

EXAMPLE 1 Preparation of 1-(2-methyl-2-propenyloxy)-2,2,4-trimethylpentan-3-ol: To a 1L flask equipped with a reflux condenser and a thermometer, was added 292.5 g (2.0 mol) of 2,2,4-trimethylpentan-1,3-diol, 352.0 g (4.4 mol) of 50% aqueous NaOH, and 6.45 g (20 mmol) of tetrabutyl ammonium bromide.This mixture was heated in an oil bath and when the reaction mixture reached 50 C., 199.2 g (2.2 mol) of methallyl chloride was added drop-wise over 50 minutes.During the addition, the oil bath temperature was gradually raised to 100 C. and the reaction was continued for an additional 3 hours at 100 C. The reaction mixture was cooled, quenched with 400 ml of water, and extracted twice with 100 ml of toluene.The combined organic layers were washed with 50 ml of saturated ammonium chloride and 50 ml of saturated sodium chloride and evaporated to give 408 g of crude 1-(2-methyl-2-propenyloxy)-2,2,4-trimethylpentan-3-ol.After reduced pressure distillation (71-80 C., 3 MmHg), 377.1 g (yield 94.1%) of 1-(2-methyl-2-propenyloxy)-2,2,4-trimethylpentan-3-ol was obtained. 1H-NMR (500 MHz, CDCl3, delta) ppm: 0.93 (d, J=6.8 Hz, 3H), 0.95 (s, 3H), 0.96 (s, 3H), 1.02 (d, J=6.9 Hz, 3H), 1.74 (s, 3H), 1.85-1.94 (m, 1H), 3.13 (d, J=3.8 Hz, 1H), 3.19 (d, J=8.7 Hz, 1H), 3.38-3.43 (m, 2H), 3.85 (s, 2H), 4.88 (s, 1H), 4.91 (s, 1H). IR (film) cm-1: 3501, 3077, 2961, 2873, 1657, 1472, 1455, 1414, 1369, 1259, 1171, 1093, 1032, 992, 899. [0042] MS (m/e): 200 (M+), 183, 167, 157, 145, 128, 110, 95, 85, 83, 73, 55, 43, 29.

Statistics shows that 144-19-4 is playing an increasingly important role. we look forward to future research findings about 2,2,4-Trimethyl-1,3-pentanediol.

Reference:
Patent; Takasago International Corporation; US2004/14633; (2004); A1;,
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Application of 144-19-4 ,Some common heterocyclic compound, 144-19-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 3.8 liter jacketed vessel, 424 grams of 2,2,4-trimethyl-1,3-pentanediol (TMPD Glycol) were charged and heated to a nominal temperature of 150 C. When the TMPD Glycol began to melt, the agitator was switched on to a speed of 400 rpm. In a separate vessel, 1674 grams of 2-ethylhexanoic acid (2-EH) was heated. When the temperature of the 2-EH reached 175 C., it was added to the TMPD Glycol forming a clear solution. The solution was heated until it reached 240 C. The temperature of the vessel contents was controlled by manipulating the temperature of the fluid in the vessel jacket. A sparge of nitrogen was established through a small pipe that discharged 50 cc/min of nitrogen to the base of the vessel under the impeller. Nitrogen purging was discontinued after 1 hours of operation. The pressure of the vessel was atmospheric (760 mmHg). A condenser located in the line between the vessel and the vacuum pump condensed any vapors in the gas and was collected in a receiver vessel where it separated into an aqueous and water layer. The organic layer comprising mainly 2-EH was returned to the vessel while the water layer was removed from the system. During the experiment, samples of the solution were taken at discrete intervals to monitor the progress of the reaction. The results of this experiment are shown in Table 10.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144-19-4, 2,2,4-Trimethyl-1,3-pentanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eastman Chemical Company; US7674931; (2010); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 144-19-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: EXAMPLE 7-1 Oxidation of 2,2-Dimethyl-5-phenylpentane-1,3-diol A sodium chlorite aqueous solution (81.0 mg, 0.717 mmol in H2O (0.4 ml)), and a sodium hypochlorite aqueous solution (0.0146 M, 0.16 ml) were separately and slowly dropped onto an acetonitrile (1.2 ml)-pH 6.8 phosphate buffer (1 M, 0.8 ml) of 2,2-dimethyl-5-phenylpentane-1,3-diol (49.7 mg, 0.239 mmol) and DMN-AZADO (3.97 mg, 0.024 mmol) at room temperature. The mixture was stirred at 25 C. for 1 h, and a pH 2.3 phosphate buffer was added until the mixture was brought to pH 4 or less. The aqueous layer was then saturated with a common salt, and extracted with dichloromethane. The organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in a diethyl ether solution, and treated with an excess amount of a diazomethane diethyl ether solution to produce a methyl ester product. After evaporating the solvent under reduced pressure, the product was purified by silica gel column chromatography to give a hydroxy ester compound (51.0 mg, 90%)

According to the analysis of related databases, 144-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOHOKU UNIVERSITY; Iwabuchi, Yoshiharu; Shibuya, Masatoshi; Doi, Ryusuke; US9114390; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 144-19-4 , The common heterocyclic compound, 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 4 Synthesis of 7-Isopropyl-8,8-dimethyl-8,9-dihydro-7H-6,10-dioxabenzocyclononene-5,11-dione in a More Dilute Solution, Without the Addition of a Catalyst. A solution of 114.82 g (0.10 mole) of phthalic anhydride and 16.31 g (0.11 mole) of 2,2,4-trimethyl-1,3-pentanediol (TMPD) in 250 mL of xylene was heated for 96 hr as described in Examples 1-3. Xylene was removed on a rotary evaporator at 20 torr, at a base temperature of 68 C. The residue (30.0 g) was diluted with 30 mL of methanol and the resulting slurry cooled to 1 C., filtered, and washed with methanol which had been chilled to -20 C. to give 15.9 g (58% yield) of 7-Isopropyl-8,8-dimethyl-8,9-dihydro-7H-6,10-dioxabenzocyclononene-5,11-dione, which was 99.9% pure by vapor phase chromatography (vpc).

The synthetic route of 144-19-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eastman Chemical Company; US5990321; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts