Category: 140373-17-7

Related Products of 140373-17-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 140373-17-7 as follows.

To a solution of 6-(naphthalen-2-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylic acid (Intermediate 3A, 100 mg, 328 pmol) and N,N-diisopropylethylamine (170 pi, 980 pmol) in DMF (5.0 ml) were added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (69.1 mg, 360 pmol) and 1-hydroxy-7-azabenzotriazole (22.3 mg, 164 pmol). The mixture was stirred at RT for 1H. Then, 2-amino-2-(4-fluorophenyl)ethanol (50.8 mg, 328 pmol) was added, and stirring was continued overnight at RT, followed by heating to 50C for 5 h. After cooling to RT, the mixture was poured into water, and the precipitate was collected by filtration, washed with water and dried to afford the title compound. Yield: 66.1 mg (44% of theory). LC/MS [Method 7]: Rt = 0.90 min; MS (ESIpos): m/z = 443 [M+H]+. 1H-NMR (400 MHz, DMSO-d6): d [ppm] = 11.88 (br. s, 1H), 8.64 (d, 1H), 8.39 (s, 1H), 8.23 (s, 1H), 8.04 (d, 1H), 8.01-7.96 (m, 2H), 7.89 (dd, 1H), 7.64-7.57 (m, 2H), 7.48-7.39 (m, 3H), 7.20-7.12 (m, 2H), 5.11-5.01 (m, 2H), 3.79-3.67 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; MUeLLER, Steffen; SCHOHE-LOOP, Rudolf; ORTEGA, HERNANDEZ, Nuria; SUeSSMEIER, Frank; JIMENEZ NUNEZ, Eloisa; BRUMBY, Thomas; LINDNER, Niels; GERDES, Christoph; POOK, Elisabeth; BUCHMUeLLER, Anja; GAUGAZ, Fabienne, Zdenka; LANG, Dieter; ZIMMERMANN, Stefanie; EHRMANN, Alexander, Helmut, Michael; GERISCH, Michael; LEHMANN, Lutz; TIMMERMANN, Andreas; SCHAeFER, Martina; SCHMIDT, Georg; SCHLEMMER, Karl-Heinz; FOLLMANN, Markus; KERSTEN, Elisabeth; WANG, Vivian; GAO, Xiang; WANG, Yafeng; (801 pag.)WO2019/219517; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 140373-17-7, 2-Amino-2-(4-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 140373-17-7, blongs to alcohols-buliding-blocks compound. Formula: C8H10FNO

Step 1 4-(4-Fluorophenyl)oxazolidin-2-one 600 mg of 2-amino-2-(4-fluorophenyl)ethan-1-ol and 80 mg of potassium carbonate were suspended in 914 mg of diethyl carbonate, and the mixture was stirred at 130 C. for 2.5 hours, and further stirred at 100 C. for 2.5 hours while removing the ethanol that was generated. The reaction solution was diluted with ethyl acetate. The solution was washed in turn with water and brine and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 610 mg of the objective compound as pale yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.

Reference:
Patent; NIPPON SHINYAKU CO., LTD.; US2011/288065; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 140373-17-7 , The common heterocyclic compound, 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Method E, Step 5Compound E5 will be reacted with E6 and EDCI in DMF to give compound E7 after purification.

The synthetic route of 140373-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2009/61699; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 140373-17-7, 2-Amino-2-(4-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 140373-17-7, blongs to alcohols-buliding-blocks compound. name: 2-Amino-2-(4-fluorophenyl)ethanol

step 1 4- (4-fluorophenyl) oxazolidin-2-one2-amino-2- (4-fluorophenyl) ethan-1-ol 600mg and diethyl carbonate 914mg potassium carbonate 80mg It was suspended in, and stirred for 2.5 hours at 130 , further stirred for 2.5 hours at 100 , except for the ethanol to produce.The reaction mixture was diluted with ethyl acetate, washed successively with water and saturated brine, and dried with magnesium sulfate.Under reduced pressure, the solvent was distilled off, to give the title compound 610mg as a pale yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.

Reference:
Patent; NIPPON SHINYAKU COMPANY LIMITED; FUJIHARA, HIDETAKA; ASAKI, TETSUO; HORI, KATSUTOSHI; NAITO, HARUNA; (146 pag.)JP5668756; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 140373-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4,6-dichloropyrimidine (240 mg, 1.61 mmol) and 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol (250.00 mg, 1.61 mmol) in isopropanol (3 mL) was added DIPEA (0.84 mL, 4.83 mmol). The solution was stirred for 5 h at 50 C. H2O (50 mL) was added to the cooled solution and extracted with 10% IPA/DCM (3×50 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated in vacuo to afford 2-((6-chloropyrimidin-4-yl)amino)-2-(4-fluorophenyl)ethan-1-ol compound 18 (365 mg, 85%) as thick yellow liquid. MS (ESI): Calcd. for C12H11ClFN3O: 267, found 268 (MH+).

According to the analysis of related databases, 140373-17-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346450; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 140373-17-7 , The common heterocyclic compound, 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 47: Preparation of 2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-(4-fluoro- phenyl)-ethanol Under an Ar atmosphere, a mixture of 2-chloro-6-(3-chloro-phenyl)-pyrazine (112.5 mg, 0.5 mmol) and 2-amino-2-(4-fluoro-phenyl)-ethanol (230 mg, 1.5 mmol) was exposed to microwave irradiation at 180 C for 1 hour. After the reaction was completed as monitored by LC-MS, the residue was partitioned between EtOAc and brine. The aqueous layer was separated and then extracted with EtOAc. The combined organic layers were concentrated, and then the residue was purified by Prep-HPLC to give 2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-(4- fluoro-phenyl)-ethanol (10 mg).

The synthetic route of 140373-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; WANG, Jianhua; WANG, Min; YANG, Song; ZHOU, Chengang; WO2014/106606; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts