Category: 13826-35-2

Synthetic Route of 13826-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The liquid phase oxidative methylesterification of various substrates was carried out in a 15 mL glass vial equipped with a magneticstirrer. In a general procedure, 1 mmol of the substrate wasadded to the reaction vial containing 3 mL of dimethyl sulfoxide(DMSO), 1 mL of distilled water and 10 mg of the catalyst. To theresulting mixture, 70% aqueous TBHP (4 mmol 12 mmol) wasadded dropwise under continuous stirring. The addition of TBHPwas exothermic. The reaction vial was sealed with a Teflon septumfitted aluminium cap and immersed in an oil bath maintained at100 C. The reaction was continued for 20 h. After the reaction,the catalyst was isolated by centrifugation and the filtrate wasmixed with 100 mL of water in a 250 mL separating funnel. Theorganic compounds were extracted from the aqueous mixtureusing ethyl acetate (50 mL 2 times). The organic portion wascombined and dried over Na2SO4 and evaporated under vacuumusing a rotator evaporator to obtain the crude product. The crudeproducts were purified by column chromatography using silicagel (100-200 mesh) and a mixture of petroleum ether and ethylacetate. The products were initially identified by GC-MS andfinally confirmed by NMR spectroscopy.

According to the analysis of related databases, 13826-35-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gupta, Shyam Sunder R.; Kantam, Mannepalli Lakshmi; Vinu, Ajayan; Journal of Catalysis; vol. 389; (2020); p. 259 – 269;,
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Reference of 13826-35-2 ,Some common heterocyclic compound, 13826-35-2, molecular formula is C13H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a. 3-Phenoxybenzaldehyde Chromium trioxide (3.00 g.) was added to a stirred solution of pyridine (4.75 g.) in dry methalene chloride (75 ml.), and stirring was continued for a further 15 minutes. 3-Phenoxybenzyl alcohol (1 g.) in methylene chloride (5 ml.) was added, the mixture stirred for a further 15 minutes, decanted and the residue washed with diethyl ether (100 ml.). The filtrate was washed with 55 sodium hydroxide solution (3 * 50 ml), 2.5 NHCl (50 ml.) and 5% sodium carbonate solution (50 ml.) and dried over Na2 SO4 to give 3-phenoxy-benzaldehyde. Alternatively the alcohol can be oxidized using Jones’ reagent, a similar yield of aldehyde being obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; National Research Development Corporation; US4024163; (1977); A;,
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Related Products of 13826-35-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13826-35-2, name is (3-Phenoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 35-1-1 1-Chloromethyl-3-phenoxy-benzene; To a solution of (3-phenoxy-phenyl)-methanol (2.00 g, 10.0 mmol) in carbon tetrachloride (40 mL) was added triphenylphosphine (3.15 g, 12.0 mmol) at room temperature. The reaction solution was stirred under nitrogen atmosphere for 5 hours and 40 minutes under reflux. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (2.05 g, 94%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.37 (2H, s), 6.94-6.97 (1H, m), 7.00-7.03 (2H, m), 7.05-7.06 (1H, m), 7.13-7.20 (3H, m), 7.37-7.41 (2H, m).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13826-35-2, (3-Phenoxyphenyl)methanol.

Reference:
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
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Related Products of 13826-35-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13826-35-2, name is (3-Phenoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: All the reactions were carried out in a multi-reactor (Carousel 12 station, RADLEYS). Typically, 0.5 mmol morpholine (43 mg), 1.0 mmol benzyl alcohol (108 mg), 50 mg Au/HT (1.9 mol % Au), and 5 mL o-xylene were added to a 40 mL glass vessel. Then, the reaction mixture was stirred (310 rpm) at 90 C under argon. After 24 h, it was cooled down to room temperature. ?20 mL ethyl acetate was added to dissolve the reaction mixture and filtrated with celite to remove the solids. Then the ethyl acetate and solvent were removed under vacuum and a yellow liquid was obtained. It was further purified using column chromatography (ethyl acetate / petroleum ether = 2/3, v/v; Silica Gel: 200-300 mesh; Rf = 0.17) to obtain the pure product as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13826-35-2, (3-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Zhu, Jiangling; Zhang, Yan; Shi, Feng; Deng, Youquan; Tetrahedron Letters; vol. 53; 25; (2012); p. 3178 – 3180;,
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13826-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To an oven-dried 20 cm3 test tube with a ground-in stopperequipped with a stir bar were added anthranilamide (1.0 mmol), benzyl alcohol (1.0 mmol), KOH (2.0 mmol),and 4 cm3 toluene. The test tube was put in an oil bath potpreheated at 90 C and the mixture was stirred for 20 h at90 C. After cooling to room temperature, the reactionmixture was added about 5 g silica gel and directly condensedon a rotator under vacuum. The resulting residualwas transferred to a silica gel chromatography column andeluted with a solution of petroleum ether and ethyl acetate[4/1 (v/v)] to give a white solid 2-phenyl-4(3H)-quinazolinone.For some products (3f, 3g, 3n, and 3t) onlysparingly soluble in ethyl acetate, the reaction mixtureswere condensed in vacuo on a rotary evaporator. Theresiduals were washed three times with water and oncewith ethyl acetate, and then dried in an infrared oven togive the desired products pure enough for NMR analysis.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Qiu, Dezhi; Wang, Yanyan; Lu, Dongming; Zhou, Lihong; Zeng, Qingle; Monatshefte fur Chemie; vol. 146; 8; (2015); p. 1343 – 1347;,
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13826-35-2, Adding a certain compound to certain chemical reactions, such as: 13826-35-2, (3-Phenoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13826-35-2, blongs to alcohols-buliding-blocks compound.

General procedure: To a screw tube in a glovebox was added In(Oi-Pr)3 (29.2 mg, 0.1 mmol). The tube was then sealed and removed from the glovebox, and CHCl3 (1 mL), alcohol (0.5 mmol), and pivalaldehyde (280 muL, 2.5 mmol) were added under N2 in this order. After stirring the mixture at r.t. for 3 h, H2O (1.0 mL) was added to the reaction mixture, which was then extracted with EtOAc. The organic phase was dried (Na2SO4), and evaporated under reduced pressure. The crude material was purified by silica gel column chromatography (Table 2 and Scheme 2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13826-35-2, its application will become more common.

Reference:
Article; Ogiwara, Yohei; Ono, Yuji; Sakai, Norio; Synthesis; vol. 48; 23; (2016); p. 4143 – 4148;,
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13826-35-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13826-35-2 as follows.

(3-Phenoxy-phenyl)-methanol (Intermediate 46, 5 g, 25 mmol) was dissolved in DCM (50 mL), cooled to 0 C, and thionyl chloride (4 ml, 50 mmol) was added dropwise followed by a drop of DMF. The reaction mixtre was stirred at room temperature for 12 h and concentrated under reduced pressure to remove solvent. To the resulting residue was added ice and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate, concentrated under reduced pressure and purified by column chromatography (95%, 5.2 g). NMR: 400 MHz, DMSO- d6: delta 7.36-7.43 (m, 3H), 7.13-7.20 (m, 2H), 6.95-7.07 (m, 4H), 4.73 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 13826-35-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian; BRUGGER, Nadia; WO2015/130905; (2015); A1;,
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13826-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13826-35-2, name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 16 (3-Phenoxyphenyl)methyl 3-[(Z)-2-chloro-3,3,3-trifluoro-prop-1-enyl]-2,2-dimethyl-cyclopropanecarboxylate 13 A solution of 3-[(Z)-2-chloro-3,3,3-trifluoro-prop-1-enyl]-2,2-dimethyl-cyclopropanecarbonyl chloride (242 mg, 1.1 eq) in toluene (6 mL) was added dropwise to a solution of (3-phenoxyphenyl)methanol (170 mg, 1 eq) and pyridine (68 muL, 1 eq) in toluene (6 mL). The reaction mixture was stirred overnight at room temperature after which time TLC analysis showed the reaction had gone to completion. The reaction mixture was diluted with ethyl acetate (15 mL) and washed with water (2*10 mL) and brine (10 mL) before being dried over MgSO4 and the solvent removed in vacuo. The residue was purified by flash chromatography (solvent 9:1 hexane/ethyl acetate) to afford the product as a clear oil (262 mg, 73%). 1H NMR deltaH (CDCl3, 300 MHz): 7.25 (m, 4H), 6.93 (m, 6H), 5.00 (dd, J=15.6, 3.3 Hz, 2H), 2.10 (t, J=8.4 Hz, 1H), 1.95 (d, J=8.4 Hz, 1H), 1.22 (s, 3H), 1.20 (s, 3H); ESI-MS 447.1 [MNa]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Thompson, William; Jackson, Peter; Lindsay, Derek; Screen, Thomas; Moulton, Benjamin; Urch, Christopher; US2015/94474; (2015); A1;,
Alcohol – Wikipedia,
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