Category: 13807-89-1

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13807-89-1, name is 2-((4-Methoxybenzyl)oxy)ethanol, molecular formula is C10H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-((4-Methoxybenzyl)oxy)ethanol

Dissolve 3.7ml of oxalyl chloride in dichloromethane (75ml) and control the temperature to -70 C.Dissolve dimethyl sulfoxide (6.4 ml) in dichloromethane (10 ml) and slowly dropwise.After completion of the dropwise addition, the reaction was performed for 1 hour.6 g (33.0 mmol) of 2- (4-methoxybenzyloxy) ethanol was dissolved in dichloromethane (5 ml) and slowly added. After two hours of reaction, triethylamine (12.5 ml) was slowly added dropwise.After 30 minutes of reaction, the temperature reduction device was removed and the temperature was raised to zero degrees.3N HCl was added slowly, extracted, and the organic layers were combined. With 1N HCl,Saturated sodium bicarbonate solution, washed with saturated brine, dried,The organic solvent was spin-dried to obtain 5 g of product.

With the rapid development of chemical substances, we look forward to future research findings about 13807-89-1.

Reference:
Patent; Nanjing Gurui Biological Technology Co., Ltd.; Mei Yan; (56 pag.)CN110734456; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 13807-89-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13807-89-1, name is 2-((4-Methoxybenzyl)oxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Methanesulfonic acid 2-(4-methoxybenzyloxy) ethyl ester A solution of 2-(4-methoxybenzyloxy)ethanol (Intermediate 18) (2.26g, 12.4mmol) and diisopropylethylamine (6.7ml, 37.2mmol) in 15mL dry DCM, cooled to O0C under a nitrogen atmosphere, was treated dropwise with a solution of methanesulfonyl chloride (1.5ml_, 18.6mmol) in 1OmL DCM. The reaction mixture was stirred at RT for 16h, then water was added. The organic layer was separated, dried (MgSO4) and concentrated. Purification by chromatography (Redisep cartridge) eluting with ethyl acetate/cyclohexane afforded the title compound as an oil. Yield: 2.5g (77%) LC-MS (Method 4): Rt 2.81 mins, molecular ion not observed

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13807-89-1, 2-((4-Methoxybenzyl)oxy)ethanol.

Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2008/96093; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13807-89-1, name is 2-((4-Methoxybenzyl)oxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-((4-Methoxybenzyl)oxy)ethanol

(1) Synthesis of ethylene glycol protected by azidochlorobenzyl group and methoxybenzyl group: synthesis of 1-azido-2-chloro-4-(4-methoxybenzyloxyethoxymethyl)benzene. 2-(4-Methoxybenzyloxy)ethanol (500 mg, 2.75 mmol) was dissolved in DMF (10 ml), and sodium hydride (60% in oil, 132 mg, 3.30 mmol) was added at 0 C., which was followed by stirring for 30 min. Then 4-azido-3-chlorobenzyl bromide (813 mg, 3.30 mmol) was added portionwise. The resulting mixture was stirred at 0 C. for 30 min and at room temperature for 2 hr. Ice-water was added and the mixture was extracted with ether. The ether layer was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (eluent; hexane:ethyl acetate=10:1) to give the title compound as a yellow oil (805 mg, yield 84%). 1 H-NMR (270 MHz, CDCl3) delta: 7.39(d,1H), 7.30-7.24(m,3H), 7.13(d,1H), 6.90-6.85(m,2H), 4.51(s,4H), 3.80(s,3H), 3.64(s,4H)

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Reference:
Patent; Wako Pure Chemical Industries, Ltd.; US5998595; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts