Category: 13726-17-5

Related Products of 13726-17-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13726-17-5, name is (4-Chloro-3-methoxyphenyl)methanol, molecular formula is C8H9ClO2, molecular weight is 172.61, as common compound, the synthetic route is as follows.

[00154] Step 2. A suspension of pyridinium chlorochromate (1.37 g, 6.34 mmol) in dichloromethane (35 mL) was treated with Celite (2.0 g) and stirred at rt. A solution of (4-chloro-3-methoxyphenyl)methanol (730 mg, 4.23 mmol) in dichloromethane (5 mL) was added in one portion, and the resulting mixture was stirred at rt for 3 h. After this time, the mixture was diluted with diethyl ether, and stirred vigorously. The mixture was then filtered through a pad of silica gel and the collected solids were rinsed with additional diethyl ether. The combined filtrates were concentrated under vacuum to provide 4-chloro-3-methoxybenzaldehyde as a pale tan-yellow solid (630 mg, 87%). 1H NMR (400 MHz, CDCl3) delta ppm 3.98 (s, 3 H) 7.41 (dd, J=I.9, 1.8 Hz, 1 H) 7.45 (d, J=2.0 Hz, 1 H) 7.55 (d, J=7.6 Hz, 1 H) 9.95 (s, I H).

The chemical industry reduces the impact on the environment during synthesis 13726-17-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BATT, Douglas, G.; WO2010/9069; (2010); A1;,
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Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13726-17-5, name is (4-Chloro-3-methoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9ClO2

D. Synthesis of 4-chloro-3-methoxybenzaldehyde To a solution of (4-chloro-3-methoxyphenyl)methan-1-ol (5.08 g, 29.4 mmol) in benzene (120 mL) was added MnO2 (5.65 g, 65 mmol). The reaction mixture was refluxed for 17 hr, chilled, and filtered through Celite, washing the cake with CH2Cl2 (300 mL). The filtrate was concentrated in vacuo to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89%).

The synthetic route of 13726-17-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Portola Pharmaceuticals, Inc.; US6906063; (2005); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 13726-17-5, (4-Chloro-3-methoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9ClO2, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9ClO2

D. Synthesis of 4-chloro-3-methoxybenzaldehyde (0202) To a solution of (4-chloro-3-methoxyphenyl)methan-1-ol (5.08 g, 29.4 mmol) in benzene (120 mL) was added MnO2 (5.65 g, 65 mmol). The reaction mixture was refluxed for 17 hr, chilled, and filtered through Celite, washing the cake with CH2Cl2 (300mL). The filtrate was concentrated in vacuo to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13726-17-5, (4-Chloro-3-methoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Portola Pharmaceuticals, Inc.; Scarborough, Robert; Jantzen, Hans-Michael; Huang, Wolin; Sedlock, David; Marlowe, Charles; Kane-Maguire, Kim; (200 pag.)EP2314593; (2016); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts