Category: 13651-14-4

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13651-14-4, name is (2,3-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 13651-14-4

To a dichloromethane solution (0.2 M) of (2,3-dimethylphenyl)methanol (1 eq.) from the previous step was added triethylamine (1.2 eq.) and then methanesulfonyl chloride (1.1 eq.) at 0 0C. The reaction mixture was stirred at 0 0C for 20 min before it was quenched with sat. aq. NaHCO3. The aqueous layer was separated and back-extracted with dichloromethane. The combined organic extracts were then dried over Na2SO4, filtered and the filtrate concentrated in vacuo to furnish the title compound as a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 13651-14-4.

Reference:
Patent; MERCK FROSST CANADA LTD.; CHIH-YU CHEN, Austin; LALIBERTE, Sebastien; LAROUCHE, Guillaume; HAN, Yongxin; MCKAY, Daniel; WO2011/20193; (2011); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13651-14-4, name is (2,3-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2,3-Dimethylphenyl)methanol

In a fixed-bed reactor having an inner diameter of 10 mm, 1 g of the Cu5wt%-Pd4wt%-K5wt%/Al203 catalyst prepared in Example 1 was charged in a constant temperature zone of the reaction tube, and both ends were filled with quartz sand and quartz wool to ensure the reaction. The airflow was stable and evenly distributed. The sealing device was reductively activated with hydrogen (25 ml/min) at 350 C for 7 hours. Then change the carrier gas to argon and the argon flow was adjusted to 200ml/h and pressure to 3.5MPa. Then the temperature was adjusted to 150C; The reaction was started by continuously feeding o-nitroaniline:fatty alcohol:distilled water according to a mass ratio of 1:12:10 with a high pressure pump. The feed flow of o-nitroaniline, fatty alcohol, and distilled water was 0.7 g/liter/h. After the reaction product was cooled by the condenser and then entered the gas-liquid separator, the liquid product was collected. The results of the experiments with different fatty alcohols are shown in Table 2.

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Reference:
Patent; Zhejiang University of Technology; Zhang Qunfeng; Cheng Zheng; Feng Feng; Xu Xiaoliang; Ma Lei; Lu Chunshan; Li Xiaonian; (12 pag.)CN105037274; (2018); B;,
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Synthetic Route of 13651-14-4, Adding some certain compound to certain chemical reactions, such as: 13651-14-4, name is (2,3-Dimethylphenyl)methanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13651-14-4.

Compound M (0.040 g) obtained in Reference Example 13 and 2,3-dimethylbenzyl alcohol (0.11 g) were dissolved in tetrahydrofuran (0.50 mL). Triphenylphosphine (0.21 g) and diethyl azodicarboxylate (0.12 mL) were added thereto under ice-cooling, followed by stirring at room temperature for 12 hours. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel preparative thin layer chromatography (hexane:ethyl acetate_triethylamine=5:10:1) to give Compound 14 (0.016 g, 32%) as a pale yellow oily substance. [0315] 1H NMR (270 MHz, CDCl3) delta7.50-7.38 (2H, m), 7.30-6.94 (5H, m), 4.96 (1H, septet), 4.86-4.66 (2H, m), 3.88-3.50 (6H, m), 3.38-3.22 (2H, m), 2.52 (4H, m), 2.46-2.30 (2H, m), 2.29 (3H, s), 2.17 (3H, s), 1.68 (4H, m), 1.49 (2H, m), 1.07 (6H, d). [0316] MASS (m/e) 539 [(M+H)+]

According to the analysis of related databases, 13651-14-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US2003/225288; (2003); A1;,
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Electric Literature of 13651-14-4 , The common heterocyclic compound, 13651-14-4, name is (2,3-Dimethylphenyl)methanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture containing benzyl alcohol(1 mmol), beta-naphthol (1 mmol), 4-hydroxycoumarin(1 mmol), 4 mmol % of [BDBDMIm]Br, and 0.05 g of CAN was stirred at room temperature for the requiredreaction times. Progress of the reaction was monitoredby TLC (EtOAc : petroleum ether, 1 : 3). Uponcompletion of the process the product was extractedwith CHCl3/H2O. The organic phases was separatedand the solvent evaporated. Crystallization of theresidue gave the pure product. The aqueous phase wasconcentrated under reduced pressure, washed withEt2O, and evaporated under reduced pressure torecover the ionic liquid for subsequent use.

The synthetic route of 13651-14-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gharib; Nikpassand; Russian Journal of General Chemistry; vol. 86; 12; (2016); p. 2759 – 2767; Zh. Obshch. Khim.; vol. 86; (2016); p. 2759 – 2767,9;,
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