Didier, Eric; Loubinoux, Bernard; Ramos Tombo, Gerardo M.; Rihs, Grety published an article in Tetrahedron. The title of the article was ãChemo-enzymatic synthesis of 1,2- and 1,3-amino alcohols and their use in the enantioselective reduction of acetophenone and anti-acetophenone oxime methyl ether with boraneã?Related Products of 135969-66-3 The author mentioned the following in the article:
New chiral amino alcs. were enantioselectively synthesized using biotransformations as the key steps. Thus, the Bakers yeast reduction of the β-keto ester I gave hydroxy ester II (R = CO2Et) in 34% yield with high enantio- and diastereoselectivity. Saponification of the ester gave acid II (R = CO2H), which was converted to oxazolidinone III by a modified reaction with diphenylphosphorazide. Hydrolysis of III with KOH gave amino alc. II (R = NH2). The new chiral amino alcs. were used as ligand in the enantioselective borane reduction of acetophenone and of the corresponding anti-oxime Me ether. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-2-(Methylamino)cyclopentan-1-ol(cas: 135969-66-3Related Products of 135969-66-3)
(1S,2R)-2-(Methylamino)cyclopentan-1-ol(cas: 135969-66-3) is a member of cyclopentanes. Although cyclopentane itself doesn’t have a single highly favoured conformation, a substituent on the cyclopentane ring can upset the balance of strains thereby favouring either the envelope or the half-chair.Related Products of 135969-66-3
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