Reference of 135241-08-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 135241-08-6 as follows.
the above-mentioned 4-chloro-1-hydroxy-naphthalene carboxylic acid methyl ester 32g of triflic anhydride 68g were dissolved and stirred at room temperature for 6 hours in 400ml of pyridine. 500ml After adding water, using a separatory funnel, and extracted with toluene 500ml. 3333 Further organic layer was washed with pure water three times, the use of dilute aqueous hydrochloric acid The organic layer was washed three times using aqueous sodium bicarbonate The organic layer was washed three times, then the organic layer was washed with pure water three times. The organic layer was collected and dried over anhydrous magnesium sulfate. After filtration over anhydrous magnesium sulfate, and concentrated using a rotary evaporator to obtain a crude product. 4–1-(((20g( 40% ) The crude product with heptane were recrystallized, thereby obtaining the following 4-chloro-1 – (((trifluoromethyl) sulfonyl) hydroxy) naphthalene carboxylate 20g (yield: 40%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,135241-08-6, its application will become more common.
Reference:
Patent; JNC Co., Ltd.; Kageyama, Akiko; (341 pag.)KR2015/74015; (2015); A;,
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