Category: 1333264-06-4

On August 14, 2014, Jorand-Lebrun, Catherine; Kulkarni, Santosh; Christmann-Franck, Serge published a patent.Computed Properties of 1333264-06-4 The title of the patent was Macrocyclic pyridazinone derivatives as IRAK inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I, and their use in the prophylaxis and treatment of diseases. Compounds of formula I wherein R1 and R3 are independently H, (CH2)0-2CONH2 and derivatives, OH and derivatives, halo, etc.; R2 is H, (un)substituted (un)branched C1-3 alkyl; R4 is H and (un)substituted (un)branched C1-10 alkyl where one or two methylene units may be replaced with O; Z is absent, arylenediene and heterocyclenediene; L is (CH2)1-6 wherein one or two methylene units may be replaced by O and CH=CH; and their pharmaceutically usable tautomers, solvates, salts, stereoisomers, and mixtures in all ratios, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their IRAK inhibitory activity. From the assay it was determined that compound II exhibited IC50 values of < 0.1 μM towards both IRAK1 and IRAK4. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Computed Properties of 1333264-06-4

The Article related to macrocyclic pyridazinone preparation irak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Computed Properties of 1333264-06-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 9, 2011, Layton, Mark E.; Kelly, Michael J.; Hartingh, Timothy J. published a patent.Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol The title of the patent was Preparation of benzothiadiazole and thiadiazolopyridine dioxides as positive allosteric modulators of mGluR2. And the patent contained the following:

The present invention is directed to 5-substituted 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and 1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2,-dioxide derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurol. and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The compounds of the invention have general formula I, wherein X is C or N; Y is C1-6 alkyl; R1 is (un)substituted benzyl, (un)substituted C2-8 alkyl, etc.; each R2 is independently halo, OH, C1-4 alkyl, etc.; A is (un)substituted aryl or (un)substituted heteroaryl. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. Synthetic procedures for preparing I are exemplified. Example compound II, prepared in a 5-step synthesis that culminated in reaction of III with 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, potentiated mGluR2 activity in a FLIPR assay with an EC50 of 5.0 nM. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

The Article related to benzothiadiazole thiadiazolopyridine dioxide preparation allosteric mglur2 modulator therapy, neurol psychiatric disorder treatment benzothiadiazole thiadiazolopyridine dioxide and other aspects.Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chung, Sheng-Hsuan; Lin, Ting-Ju; Hu, Qian-Yu; Tsai, Chia-Hua; Pan, Po-Shen published an article in 2013, the title of the article was Synthesis of boron-containing primary amines.Product Details of 1333264-06-4 And the article contains the following content:

B-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the 1st step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters, e.g., p-(pinB)C6H4CH2NH2 (Bpin = 4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl), in good to excellent yields. These compounds were further used to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a Pd-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Product Details of 1333264-06-4

The Article related to aminomethylphenyl boronate ester preparation ugi four component reaction, peptoid boronate ester preparation suzuki coupling aryl heteroaryl chloride, hydroxymethylphenyl boronate ester preparation condensation phthalimide salt and other aspects.Product Details of 1333264-06-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts