Category: 13330-96-6

Adding a certain compound to certain chemical reactions, such as: 13330-96-6, 4-(Dimethylamino)butan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13330-96-6, blongs to alcohols-buliding-blocks compound. Product Details of 13330-96-6

Example 8 Synthesis of MC4 Ether MC4 Ether (Compound 15) having the structure shown below was synthesized as described below. A 50 mL RBF with stir-bar were flushed with nitrogen, and NaH (220 mg, 9 mmol), dimethylaminobutanol (1.05 g, 9 mmol) and anh. benzene (10 mL) added. After effervescence subsided, Compound 14 (440 mg, 0.75 mmol) was added and RM refluxed overnight at 90 C. TLC indicated some product formation. The reaction was diluted to 40 mL with benzene, and quenched with ethanol (25 mL). It was then washed with water (40 mL), dried and concentrated. The crude product was purified to yield product as a pale yellow oil, 145 mg, 31%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13330-96-6, its application will become more common.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS INC; Heyes, James; Wood, Mark; Martin, Alan; Lee, Amy C.H.; Judge, Adam; Robbins, Marjorie; MacLachlan, Ian; US2013/123339; (2013); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13330-96-6, name is 4-(Dimethylamino)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-(Dimethylamino)butan-1-ol

Example S. Synthesis of MC4 Ether.[0294] MC4 Ether (Compound 15) having the structure shown below was synthesized as described below.Chemical Fotmuta: Omicron^Eta,, OmicronExact Mass: 627.6Molecular Wteirjit 628.1Bemena And sis: C.8222; K 13.00; N, 2.23; 0.2.55MC4 Ether[0295] A 50 mL RBF with stir-bar were flushed with nitrogen, and NaH (220 mg, 9 mmol), dimethylaminobutanol (1.05g, 9 mmol) and anh. benzene (10 mL) added. Aftereffervescence subsided, Compound 14 (440 mg, 0.75 mmol) was added and RM refluxed overnight at 90C. TLC indicated some product formation. The reaction was diluted to 40 mL with benzene, and quenched with ethanol (25 mL). It was then washed with water (40 mL), dried and concentrated. The crude product was purified to yield product as a pale yellow oil, 145 mg, 31%.

With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS, INC.; HEYES, James; WOOD, Mark; MARTIN, Alan; WO2011/141705; (2011); A1;,
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Reference of 13330-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, molecular weight is 117.19, as common compound, the synthetic route is as follows.

(R)-3-[N’-(5-Acetyl-2H-pyrazole-3-carbonyl)-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-hydrazino]-2-hydroxypropionic Acid 4-dimethylaminobutyl Ester (R)-3-[N’-(5-Acetyl-2H-pyrazole-3-carbonyl)-N-(5′-chloro-2′-fluorobiphenyl-4-ylmethyl)-hydrazino]-2-hydr oxypropionic acid (10.0 mg, 21 mumol) was combined with HOBt (17.1 mg, 126 mumol) and EDC (22 muL, 130 mumol) in DCM (0.2 mL, 3 mmol) and stirred for 10 minutes. 4-Dimethylamino-1-butanol (22.4 muL, 168 mumol) was added and the resulting mixture was stirred at room temperature and monitored for completion (?4 hours). The mixture was concentrated by rotary evaporation and the residue was purified by preparative HPLC to yield the title compound as a TFA salt (4.2 mg). MS m/z [M+H]+ calc’d for C28H33ClFN5O5, 574.22. found 574.1.

The chemical industry reduces the impact on the environment during synthesis 13330-96-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hughes, Adam D.; Fleury, Melissa; US2013/330365; (2013); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-(Dimethylamino)butan-1-ol

100 mg of intermediate compound 5 and 86 mg of triphosgene were dissolved in 10 ml of anhydrous dichloromethane, replaced with nitrogen three times, 0.12 ml of triethylamine was added under ice bath, and after 5 minutes, 0.12 ml of N,N-dimethylbutanol was dissolved in 10 ml of anhydrous dichloromethane, and added to the reaction solution, and reacted at room temperature overnight and TLC showed that the substrate completely disappeared. The reaction mixture was quenched and the reaction mixture was cooled to room temperature, the reaction mixture was extracted with ethyl acetate, the organic layer was washed with water three times, dried over anhydrous sodium sulfate, and concentrated, and subjected to column chromatography to obtain of 90 mg of yellow crystals (compound 1-1) (yield 64%).

With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Zuo Jianping; Lu Dong; Tong Xiankun; Zhang Yunzhe; Tang Wei; Ren Wenming; He Peilan; Chen Wuhong; Yang Xiaoqian; Zeng Limin; Yang Li; Liu Jianan; (61 pag.)CN109384727; (2019); A;,
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Reference of 13330-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, molecular weight is 117.19, as common compound, the synthetic route is as follows.

General procedure: 12 (100 mg, 0.35 mmol) was dissolved in the mixture of 1,4-dioxane (10 mL) and H2O (2.00 mL) and then added with boronicacid (2.80 mmol), Pd(dppf)2Cl2 (28 mg, 0.035 mmol) and Cs2CO3(228 mg, 0.70 mmol). The reaction was heated at 100 C underargon atmosphere. After 12 h, the reaction mixture was cooled toroom temperature and was concentrated in vacuo. Then themixture was diluted with water and extracted with ethyl acetate.The combined organic layer was washed by saturated sodiumchloride solution for three times, dried over anhydrous Na2SO4 andconcentrated under reduced pressure. The residue was purified bysilica gel chromatography to give 13.To a stirred solution of 13 and triphosgene (100 mg, 0.34 mmol)in anhydrous dichloromethane (5 mL) was added triethylamine(104 mg, 1.02 mmol) at 0 C under nitrogen atmosphere. After5 min, a solution of 4-(dimethylamino)butan-1-ol (1.02 mmol) indichloromethane (5.00 mL) was added and then the mixture wasstirred at room temperature for overnight. The reactionwas dilutedwith dichloromethane (15 mL) and washed with water (3 20 mL).The organic phases were dried over anhydrous Na2SO4 andconcentrated in vacuo. The residue was purified by using columnchromatography to afford the corresponding product.

The chemical industry reduces the impact on the environment during synthesis 13330-96-6, I believe this compound will play a more active role in future production and life.

Reference:
Article; Lu, Dong; Liu, Jianan; Zhang, Yunzhe; Liu, Feifei; Zeng, Limin; Peng, Runze; Yang, Li; Ying, Huazhou; Tang, Wei; Chen, Wuhong; Zuo, Jianping; Tong, Xiankun; Liu, Tao; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 328 – 337;,
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Adding a certain compound to certain chemical reactions, such as: 13330-96-6, 4-(Dimethylamino)butan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-(Dimethylamino)butan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 4-(Dimethylamino)butan-1-ol

General procedure: To a solution of 6-substituted pyridazinone 9 (0.5 mmol) in DMF (10 mL) was added Cs2CO3 (0.55 mmol). An appropriately substituted nitro benzyl chloride (0.52 mmol) was added and the resulting mixture was stirred at 40-50 C for 3 h, the solvent was removed under reduced pressure and the residue was dissolved in EtOAc (30 mL), which was then washed with brine (3 ¡Á 10 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The crude product, 2-nitrobenzyl-6-substituted-pyridazin-3(2H)-one (10), was used in the next step without further purification. To a solution of 10 in 95 % ethanol (50 mL) was added acetic acid (10 mmol) followed by slow addition of iron powder (2 mmol). The resulting mixture was stirred for 5 h at 100 C. The mixture was then filtered through celite and the filter cake was washed with 95 % ethanol (3 ¡Á 15 mL). The combined ethanol filtrates were evaporated in vacuo and the residue was re-dissolved in ethyl acetate (30 mL). The organic layer was washed with brine (3 ¡Á 10 mL) and 2 M NaOH (10 mL) sequentially. The organic layer was dried over anhydrous Na2SO4, evaporated in vacuo to afford 2-aminobenzyl-6-substituted-pyridazin-3(2H)-one (11) as a yellow solid, which was used without further purification. To a stirred solution of 11 and triphosgene (1 mmol) in dry dichloromethane (5 mL) was added triethylamine (2 mmol) under nitrogen atmosphere. A solution of the corresponding alcohol (1 mmol) in dichloromethane (5 mL) was added 5-10 min later and the mixture was stirred at room temperature overnight, diluted with dichloromethane (15 mL) and washed with water (3 ¡Á 20 mL). The organic phases were separated, combined, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by using column chromatography to afford the corresponding product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13330-96-6, 4-(Dimethylamino)butan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Xing, Weiqiang; Ai, Jing; Jin, Shiyu; Shi, Zhangxing; Peng, Xia; Wang, Lang; Ji, Yinchun; Lu, Dong; Liu, Yang; Geng, Meiyu; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 302 – 312;,
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