Category: 13325-10-5

In 2019,Angewandte Chemie, International Edition included an article by Silva, Siguara B. L.; Oberhaensli, Francois; Tribalat, Marie-Aude; Genta-Jouve, Gregory; Teyssie, Jean-Louis; Dechraoui-Bottein, Marie-Yasmine; Gallard, Jean-Francois; Evanno, Laurent; Poupon, Erwan; Thomas, Olivier P.. Product Details of 13325-10-5. The article was titled 《Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges》. The information in the text is summarized as follows:

Among the outstanding chem. diversity found in marine sponges, cyclic guanidine alkaloids, present in species of the family Crambeidae, are particularly attractive, not only because of their unique chem. features, but also due to a broad range of biol. activities. Despite a growing interest in these natural products as therapeutic agents, their metabolic pathway has not been exptl. investigated. Ex situ feeding experiments using radiolabeled precursors performed on the Mediterranean sponge Crambe crambe suggest arginine and fatty acids as precursors in the metabolic pathway of crambescins. A subsequent bio-inspired approach supported the change of paradigm in the metabolic pathway of cyclic guanidine alkaloids. A large part of the chem. diversity of this family would therefore originate from a tethered Biginelli-like reaction between C-2/C-3 activated fatty acids and a central guanidinylated pyrrolinium. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

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HPLC of Formula: 13325-10-5In 2019 ,《Aggregation of Ag(0) nanoparticles to unexpected stable chain-like assemblies mediated by 2,2′-bipyridine decorated peptoids》 was published in Journal of Colloid and Interface Science. The article was written by Tigger-Zaborov, Hagar; Maayan, Galia. The article contains the following contents:

We report a unique example of Ag(0) nanoparticles (NPs)-assemblies stabilized by 2,2-bipyridine (BP), via the incorporation of BP at the N-terminus of a peptoid heptamer bearing phenylethyl groups in the other positions. We show that this peptoid mediates the aggregation of the Ag(0) NPs into nanochain-like assemblies. Transmission electron microscopy, supported by UV-Vis spectroscopy anal., revealed pre-assembly of the BP-peptoid oligomers into elongated pearl-like morphol., which serve as a template for the NPs. The fact that completely synthetic biomimetic oligomers can template and control the assembly of metal NPs, and specifically Ag(0), represents a conceptual mimic of the interaction between biomols. and minerals for the production of nanostructured inorganic materials with complex morphologies.4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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《Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction》 was written by Slesarchuk, Nikita A.; Khvatov, Evgeny V.; Chistov, Alexey A.; Proskurin, Gleb V.; Nikitin, Timofei D.; Lazarevich, Anastasiya I.; Ulanovskaya, Angelina A.; Ulashchik, Egor A.; Orlov, Alexey A.; Jegorov, Artjom V.; Ustinov, Alexey V.; Tyurin, Anton P.; Shmanai, Vadim V.; Ishmukhametov, Aydar A.; Korshun, Vladimir A.; Osolodkin, Dmitry I.; Kozlovskaya, Liubov I.; Aralov, Andrey V.. HPLC of Formula: 13325-10-5 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxylic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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《Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol》 was written by Prabowo, Cindy Pricilia Surya; Shin, Jae Ho; Cho, Jae Sung; Chae, Tong Un; Lee, Sang Yup. Formula: C4H11NO And the article was included in Biotechnology and Bioengineering in 2020. The article conveys some information:

4-Amino-1-butanol (4AB) serves as an important intermediate compound for drugs and a precursor of biodegradable polymers used for gene delivery. Here, we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase(encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7 g/L of 4AB. The strategies reported here should be useful for the microbial production of primary amino alcs. from renewable resources. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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Zhang, Qingchun; Feng, Shufan; Zhao, Yulian; Jin, Bo; Peng, Rufang published an article in 2021. The article was titled 《Design and synthesis of N-hydroxyalkyl substituted deferiprone: a kind of iron chelating agents for Parkinson′s disease chelation therapy strategy》, and you may find the article in JBIC, Journal of Biological Inorganic Chemistry.Computed Properties of C4H11NO The information in the text is summarized as follows:

The blood-brain barrier (BBB) permeability of mols. needs to meet stringent requirements of Lipinski′s rule, which pose a difficulty for the rational design of efficient chelating agents for Parkinson′s disease chelation therapy. Therefore, the iron chelators employed N-aliphatic alcs. modification of deferiprone were reasonably designed in this work. The chelators not only meet Lipinski′s rule for BBB permeability, but also ensure the iron affinity. The results of solution thermodn. demonstrated that the pFe3+ value of N-hydroxyalkyl substituted deferiprone is between 19.20 and 19.36, which is comparable to that of clin. deferiprone. The results of 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays indicated that the N-hydroxyalkyl substituted deferiprone also possesses similar radical scavenging ability in comparison to deferiprone. Meanwhile, the Cell Counting Kit-8 assays of neuron-like rat pheochromocytoma cell-line demonstrated that the N-hydroxyalkyl substituted deferiprone exhibits extremely low cytotoxicity and excellent H2O2-induced oxidative stress protection effect. These results indicated that N-hydroxyalkyl substituted deferiprone has potential application prospects as chelating agents for Parkinson′s disease chelation therapy strategy. Graphic abstract: [graphic not available: see fulltext] The experimental part of the paper was very detailed, including the reaction process of 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

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《Palladium-Catalyzed Aminocarbonylation Reaction to Access 1,2,3-Triazole-5-carboxamides Using Dimethyl Carbonate as Sustainable Solvent》 was written by de Albuquerque, Danilo Yano; de Moraes, Juliana R.; Schwab, Ricardo S.. Name: 4-Aminobutan-1-olThis research focused ontriazole carboxamide preparation; amine iodotriazole formic acid carbonylative coupling. The article conveys some information:

A simple and direct palladium-catalyzed aminocarbonylation of 5-iodo-1,2,3-triazoles backbone for the incorporation of an amide functional group was presented. The approach was based on the palladium catalyzed carbonylative coupling reaction of iodo-triazole with different amines employing formic acid and sulfuric acid as CO source (Morgan’s reaction) to provide the 1,2,3-triazole-5-carboxamides I [R = Bn, 4-OMeC6H4, C10H21, etc.; R1 = H, n-Bu, Ph, etc.] in good to excellent yields. The important features of this methodol. included short reaction time, high yields, the use of di-Me carbonate as a sustainable solvent and the use of efficient alternative source of carbon monoxide, avoiding pressurized cylinder. The methodol. described herein for the synthesis of 1,4,5-trisubstituted 1,2,3-triazole-5-carboxamides I, could offer an alternative path for functionalization of other heterocycles. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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In 2022,Wang, Chenfei; Huang, Xiaobei; Sun, Litao; Li, Qiuxia; Li, Zhili; Yong, Haiyang; Che, Delu; Yan, Cong; Geng, Songmei; Wang, Wenxin; Zhou, Dezhong published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization》.COA of Formula: C4H11NO The author mentioned the following in the article:

Topol. structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

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《Protecting-group-free synthesis of hydroxyesters from amino alcohols》 was written by Reynard, Guillaume; Joseph-Valcin, Eve-Marline; Lebel, Helene. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The synthesis of hydroxyesters such as RCOOCH2(CH)nOH [R = MeC≡C, 2-furyl, Ph, etc.; n = 1,2,3,4,7] from carboxylic acids RCOOH and unprotected amino alcs. H2NCH2(CH)nOH in both continuous flow and batch processes was reported. The formation of a transient diazonium species with a dinitrite reagent was key in this transformation. The reaction conditions were compatible with a variety of functional groups. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

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Takahashi, Kaito published an article in 2022. The article was titled 《Theoretical analysis on reactions between syn-methyl Criegee intermediate and amino alcohols》, and you may find the article in Journal of the Chinese Chemical Society (Weinheim, Germany).SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Due to their strong zwitterionic character, Criegee intermediates can interact strongly with hydrogen bonding mols. in the atm., such as water vapor, alcs., acids, amines, and thiols. To gain a phys. understanding of the reactivity of Criegee intermediates toward these mols., we theor. studied the reaction of syn-CH3CHOO with linear n-amino alc. and branched amino alcs. that contain three carbon atoms. We found that the interaction contribution is the determining factor for the increase in reactivity when we elongate the alkyl chain length and when we place a Me group in the amino group. This finding was rationalized by evaluating the electron-donating ability of the amino alc. Consistent with the increase in reactivity for NH(CH3)C2H4OH and NH2C4H8OH compared to NH2C2H4OH, we found that these two amino alcs. have vertical ionization energies ∼0.5 eV smaller than NH2C2H4OH. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

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Quality Control of 4-Aminobutan-1-olIn 2022 ,《Axial-ligand-cleavable silicon phthalocyanines triggered by near-infrared light toward design of photosensitizers for photoimmunotherapy》 was published in Journal of Photochemistry and Photobiology, A: Chemistry. The article was written by Takakura, Hideo; Matsuhiro, Shino; Kobayashi, Masato; Goto, Yuto; Harada, Mei; Taketsugu, Tetsuya; Ogawa, Mikako. The article contains the following contents:

Near-IR photoimmunotherapy (NIR-PIT) is a novel phototherapy for the treatment of cancer that uses NIR light and conjugates of antibody-IR700, a silicon phthalocyanine photosensitizer. A key feature of NIR-PIT is light-induced axial ligand cleavage of IR700, which finally causes cytotoxicity. Here, we focused on protonation of the axial ligand on the IR700 anion radical during the photochem. process. The Gibbs energy in the protonation reaction of IR700 derivatives with different axial ligands was calculated These calculations suggested the order of the cleavage efficiency corresponds to the basicity of the axial ligand (i.e. alkoxy > siloxy (IR700) > phenoxy > oxycarbonyl), which was confirmed by the photoirradiation experiments with synthesized compounds Thus, axial ligand cleavage is significantly dependent on the basicity of the axial ligand. Our findings suggest that PIT reagent with an IR700 derivative bearing alkoxy group would show better efficacy than IR700. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

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