Category: 13325-10-5

In 2019,European Journal of Organic Chemistry included an article by Yokoyama, Soichi; Shibauchi, Hiroshi; Asahara, Haruyasu; Nishiwaki, Nagatoshi. SDS of cas: 13325-10-5. The article was titled 《Metal-Free O-Selective Direct Acylation of Amino Alcohols Through Pseudo-Intramolecular Process》. The information in the text is summarized as follows:

Efficient α-aryl-β-keto ester acylation of amine accompanied by the elimination of Et phenylacetate was achieved owing to the pseudo-intramol. process. The eliminated Et phenylacetate could be recycled by conversion into an α-aryl-β-keto ester upon treatment with an acyl chloride in the presence of lithium bis(trimethylsilyl)amide, by which the atom economy considerably increased. Acylation using an α-aryl-β-keto ester is highly sensitive to the bulkiness of the nucleophile, which facilitated the regioselective-acylation of the less hindered amino group in diamine without protecting the other. The transacylation of α-aryl-β-keto ester with N-alkylamino alc. resulted in chemoselective O-acylation without protecting the amino group because the hydroxy group was attracted to the reaction site of the keto ester by forming an ammonium salt. Transacylation is a practically useful tool for organic synthesis because this protocol can be conducted under mild conditions with simple manipulations in the absence of any additives such as metal catalyst and base. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

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In 2022,Xu, Haiting; Luo, Ruifeng; Dong, Lingling; Pu, Xiulan; Chen, Qiyan; Ye, Naijing; Qi, Shanshan; Han, Xiaoqin; Nie, Wenbiao; Fu, Chaomei; Hu, Yichen; Zhang, Jinming; Gao, Fei published an article in Nanomedicine (New York, NY, United States). The title of the article was 《pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis》.Formula: C4H11NO The author mentioned the following in the article:

An oral nanoparticle (NPs) encapsulated in chitosan/alginate hydrogel (CA-Gel) with dual-sensitive in pH and reactive oxygen species (ROS) was developed to load curcumin (CUR) based on the intracellular-specific characteristics of macrophages. Chondroitin sulfate (CS) wrapped PBAE-SA-PAPE with intracellular pH/ROS dual-sensitive characteristics and CUR via a simple nanopptn. method to form NPs (CS-CUR-NPs), and mixed CA-Gel to acquire the final preparation (CS-CUR-NPs-Gel). CS-CUR-NPs displayed an ideal average particle size (179.19 ± 5.61 nm) and high encapsulating efficiency (94.74 ± 1.15%). CS showed a good targeting ability on macrophages and the CA-Gel contribution in protecting NPs from being destroyed in the upper gastrointestinal tract. As expected, CS-CUR-NPs-Gel could significantly alleviate inflammation in DSS-induced UC mice via TLR4-MAPK/NF-ΚB pathway. This study is the first to attempt to design a novel pH/ROS dual-stimulated release strategy in helping intracellular CUR delivery and anticipated for efficient anti-UC therapy. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

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Verevkin, Sergey P.; Andreeva, Irina V.; Konnova, Maria E.; Portnova, Svetlana V.; Zherikova, Kseniya V.; Pimerzin, Aleksey A. published their research in Journal of Chemical Thermodynamics in 2021. The article was titled 《Paving the way to the sustainable hydrogen storage: Thermochemistry of amino-alcohols as precursors for liquid organic hydrogen carriers》.Recommanded Product: 4-Aminobutan-1-ol The article contains the following contents:

The absolute vapor pressures of four amino-alcs. were measured using the transpiration method. A consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. The averaged values of vaporization enthalpies are recommended as reliable benchmark properties for thermochem. calculations of the energetics of chem. reactions including synthesis of alkyl-substituted pyrazines, compounds considered as seminal liquid organic hydrogen carriers (LOHC). In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

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Alcohol – Wikipedia,
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《Direct Catalytic Decarboxylative Amination of Aryl Acetic Acids》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Kong, Duanyang; Moon, Patrick J.; Bsharat, Odey; Lundgren, Rylan J.. Recommanded Product: 4-Aminobutan-1-ol The article mentions the following:

The decarboxylative coupling of a carboxylic acid with an amine nucleophile provides an alternative to the substitution of traditional organohalide coupling partners. Benzoic and alkynyl acids may be directly aminated by oxidative catalysis. In contrast, methods for intermol. alkyl carboxylic acid to amine conversion, including amidate rearrangements and photoredox-promoted approaches, require stoichiometric activation of the acid unit to generate isocyanate or radical intermediates. Reported here is a process for the direct chemoselective decarboxylative amination of electron-poor arylacetates by oxidative Cu catalysis. The reaction proceeds at (or near) room temperature, uses native carboxylic acid starting materials, and is compatible with protic, electrophilic, and other potentially complicating functionality. Mechanistic studies support a pathway in which ionic decarboxylation of the acid generates a benzylic nucleophile which is aminated in a Chan-Evans-Lam-type process. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

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Referemce:
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Hatefi, Nayyereh; Smith, William R. published an article in 2021. The article was titled 《Ideal-gas thermochemical properties for alkanolamine and related species involved in carbon-capture applications》, and you may find the article in Journal of Chemical & Engineering Data.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

We calculated ideal-gas thermochem. properties (molar enthalpy, entropy, Gibbs energy, and heat capacity, Cp) for 30 primary and 12 secondary alkanolamines and their neutral, protonated, and carbamate forms, and for 7 tertiary alkanolamines and their protonated forms. The data, provided in a spreadsheet format in the Supporting Information document, are useful for the construction of both macroscopic and mol.-based thermodn. models of CO2-capture processes involving the indicated species. The calculations were implemented using a combination of Spartan18 and Gaussian16 electronic structure software using two typical high-order methods, G4 and G3B3, and for comparison, we also calculated results from the commonly used and less computationally expensive B3LYP/aug-cc-pVTZ method. Our calculation methodol. is validated by comparing results for a set of mols. for which literature data are available. The thermochem. data for each species over the temperature range 200-1500 K is given as a function of temperature in the form of NASA seven-term polynomial expressions, permitting the properties to be calculated over this temperature range. The accuracy of the G3B3 and G4 results is estimated to be 6 kJ·mol-1 for the species formation enthalpies, and the B3LYP/aug-cc-pVTZ results are generally of inferior quality. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

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Referemce:
Alcohol – Wikipedia,
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《Screening of a Planococcus bacterium producing a cold-adapted protease and its application in low-salt fish sauce fermentation》 was written by Gao, Ruichang; Zhou, Jing; Leng, Weijun; Shi, Tong; Jin, Wengang; Yuan, Li. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Journal of Food Processing and Preservation in 2020. The article conveys some information:

A strain of bacteria isolated from a traditional fermented shrimp paste showed high protease activity at low-temperature (15°C). The strain was identified as Planococcus maritimus and named Planococcus maritimus XJ2. P. maritimus XJ2 grows well in a low-temperature, low-salt, and alk. environment. The protease produced by P. maritimus XJ2 exhibited the highest enzyme activity at 40°C, pH 9.0 and showed salt tolerance. The amino acid nitrogen content of low-salt fish sauce inoculated with P. maritimus XJ2 was 1.28 ± 0.04 g/100 mL, which was significantly higher than that of the control without P. maritimus XJ2 (0.89 ± 0.02 g/100 mL, p < .01). The amounts of key desirable volatiles, such as alcs., ketones, acids, esters, and pyrazine were higher in P. maritimus XJ2 than in the control (p < .05). P. maritimus XJ2 could be used as a starter culture for low-salt fish sauce incubated at 21°C. Practical applications : The bacteria identified in this study has a good capacity to ferment the fish for good quality of fish sauce. A new method for the rapid fermentation of low-salt fish sauce and the improvement of its flavor by using Planococcus maritimus XJ2 is established. The procedure can help people to produce fish sauce in a shorter time, which will promote the development of fish sauce industry. Therefore, the starter and the method have good practical application in fish sauce produce. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

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Electric Literature of C4H11NOIn 2021 ,《Recent progress in production of amino acid-derived chemicals using Corynebacterium glutamicum》 appeared in World Journal of Microbiology & Biotechnology. The author of the article were Tsuge, Yota; Matsuzawa, Hiroki. The article conveys some information:

A review. Green chem. production by microbial processes is critical for the development of a sustainable society in the twenty-first century. Among the important industrial microorganisms, the gram-pos. bacterium Corynebacterium glutamicum has been utilized for amino acid fermentation, which is one of the largest microbial-based industries. To date, several amino acids, including L-glutamic acid, L-lysine, and L-threonine, have been produced by C. glutamicum. The capability to produce substantial amounts of amino acids has gained immense attention because the amino acids can be used as a precursor to produce other high-value-added chems. Recent developments in metabolic engineering and synthetic biol. technologies have enabled the extension of metabolic pathways from amino acids. The present review provides an overview of the recent progress in the microbial production of amino acid-derived bio-based monomers such as 1,4-diaminobutane, 1,5-diaminopentane, glutaric acid, 5-aminolevulinic acid, L-pipecolic acid, 4-amino-1-butanol, and 5-aminolevulinic acid, as well as building blocks for healthcare products and pharmaceuticals such as ectoine, L-theanine, and gamma-aminobutyric acid by metabolically engineered C. glutamicum. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

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Name: 4-Aminobutan-1-olIn 2020 ,《Efficiency of Cytosolic Delivery with Poly(β-amino ester) Nanoparticles is Dependent on the Effective pKa of the Polymer》 appeared in ACS Biomaterials Science & Engineering. The author of the article were Routkevitch, Denis; Sudhakar, Deepti; Conge, Marranne; Varanasi, Mahita; Tzeng, Stephany Y.; Wilson, David R.; Green, Jordan J.. The article conveys some information:

The mechanism by which cationic polymers containing titratable amines mediate effective endosomal escape and cytosolic delivery of nucleic acids is not well understood despite the decades of research devoted to these materials. Here, we utilize multiple assays investigating the endosomal escape step associated with plasmid delivery by polyethylenimine (PEI) and poly(β-amino esters) (PBAEs) to improve the understanding of how these cationic polymers enable gene delivery. To probe the role of these materials in facilitating endosomal escape, we utilized vesicle membrane leakage and extracellular pH modulation assays to demonstrate the influence of polymer buffering capacity and effective pKa on the delivery of the plasmid DNA. Our results demonstrate that transfection with PBAEs is highly sensitive to the effective pKa of the overall polymer, which has broad implications for transfection. In more acidic environments, PBAE-mediated transfection was inhibited, while PEI was relatively unaffected. In neutral to basic environments, PBAEs have high buffering capacities that led to dramatically improved transfection efficacy. The cellular uptake of polymeric nanoparticles overall was unchanged as a function of pH, indicating that microenvironmental acidity was important for downstream intracellular delivery efficiency. Overall, this study motivates the use of polymer chem. characteristics, such as effective pKa values, to more efficiently evaluate new polymeric materials for enhanced intracellular delivery characteristics. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

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The author of 《Compounds based on 5-(perylen-3-ylethynyl)uracil scaffold: High activity against tick-borne encephalitis virus and non-specific activity against enterovirus A》 were Chistov, Alexey A.; Orlov, Alexey A.; Streshnev, Philipp P.; Slesarchuk, Nikita A.; Aparin, Ilya O.; Rathi, Brijesh; Brylev, Vladimir A.; Kutyakov, Sergey V.; Mikhura, Irina V.; Ustinov, Alexey V.; Westman, Gunnar; Palyulin, Vladimir A.; Jain, Nidhi; Osolodkin, Dmitry I.; Kozlovskaya, Liubov I.; Korshun, Vladimir A.. And the article was published in European Journal of Medicinal Chemistry in 2019. HPLC of Formula: 13325-10-5 The author mentioned the following in the article:

Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogs of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid and its amides I (R = Bu, CH2CH(OH)CMe2CH2OH, (CH2)2OH, etc.; R1 = H, (CH2)2OH) were synthesized using combined protection group strategy and those compounds appeared to have low toxicity on porcine embryo kidney (PEK) or rhabdomiosarcoma (RD) cells together with remarkable activity against enveloped tick-borne encephalitis virus (TBEV): EC50 values vary from 0.077 μM to subnanomolar range. Surprisingly, 3-pivaloyloxymethyl (Pom) protected 5-(perylen-3-ylethynyl)uracil-1-acetic acid precursors showed even more pronounced activity. All the compounds showed no activity against several non-enveloped enteroviruses, except 4-hydroxybutylamides I (R = (CH2)4OH; R1 = H) and (R= CH2CH(OH)CMe2CH2OH; R1 = H), which inhibited the reproduction of enterovirus A71 with EC50 50-100 μM, with a non-specific mode of action. The results suggest that the carbohydrate moiety of RAFI nucleosides does not play a crucial role in their antiviral action, and biol. activity of the 5-(perylen-3-ylethynyl)uracil scaffold can be effectively modulated by substituents in positions 1 and 3. The high antiviral activity of these new compounds, coupled with low toxicity advocate their potential role in antiviral therapy. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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In 2022,Hashimoto, Hisashi; Ueda, Yoshihiro; Takasu, Kiyosei; Kawabata, Takeo published an article in Angewandte Chemie, International Edition. The title of the article was 《Catalytic Substrate-Selective Silylation of Primary Alcohols via Remote Functional-Group Discrimination》.COA of Formula: C4H11NO The author mentioned the following in the article:

Silylation of alcs. has generally been known to take place at the sterically most accessible less-hindered hydroxy group. Herein, the catalyst-controlled substrate-selective silylation of primary alcs., in which the selectivity was controlled independently of the innate reactivity of the hydroxy group, based on the steric environment, is reported. The chain-length-selective silylation of 1,n-amino alc. derivatives was achieved and 1,5-amino alc. derivatives showed outstandingly high reactivity in the presence of analogs with a shorter or longer chain length under catalyst-controlled conditions. A highly substrate-selective catalytic silylation of pentanol analogs was also developed, in which the remote functionality at C(5) from the reacting hydroxy groups was effectively discriminated on silylation.4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts