Category: 13325-10-5

In 2019,Polymers for Advanced Technologies included an article by Kekec, Nur Cicek; Akolpoglu, Mukrime Birgul; Bozuyuk, Ugur; Kizilel, Seda; Nugay, Nihan; Nugay, Turgut; Kennedy, Joseph P.. COA of Formula: C4H11NO. The article was titled 《Calcification resistance of polyisobutylene and polyisobutylene-based materials》. The information in the text is summarized as follows:

Calcification of implanted biomaterials is highly undesirable and limits clin. applicability. Experiments were carried out to assess the calcification resistance of polyisobutylene (PIB), PIB-based polyurethane (PIB-PU), PIB-PU reinforced with (CH3)3N+CH2CH2CH2NH2 I–modified montmorillonite (PIB-PU/nc), PIB-based polyurethane urea (PIB-PUU), PIB-PU containing S atoms (PIBS-PU), PIBS-PU reinforced with (CH3)3N+CH2CH2CH2NH2 I–modified montmorillonite (PIBS-PU/nc), and poly(isobutylene-b-styrene-b-isobutylene) (SIBS), relative to that of a clin. widely implanted polydimethylsiloxane (PDMS)-based PU, Elast-Eon (the “”control””). Samples were incubated in simulated body fluid for 28 days at 37°C, and the extent of surface calcification was analyzed by SEM (SEM), at. force microscopy (AFM), energy-dispersive X-ray spectroscopy (EDX), XPS, and Fourier-transform-IR (FT-IR) spectroscopy. Whereas the PDMS-based PU showed extensive calcification, PIB and PIB-PU containing 72.5% PIB, ie, a polyurethane whose surface is covered with PIB, were free of calcification. PIBS-PU and PIB-PUU, ie, polyurethanes that contain S or urea groups, resp., were slightly calcified. The amine-modified montmorillonite-reinforcing agent reduced the extent of calcification. SIBS was found slightly calcified. Evidently, PIB and materials fully coated with PIB are calcification resistant.4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

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Politano, Fabrizio; Sandoval, Arturo Leon; Uranga, Jorge G.; Bujan, Elba I.; Leadbeater, Nicholas E. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Using experimental and computational approaches to probe an unusual carbon-carbon bond cleavage observed in the synthesis of benzimidazole N-oxides》.Formula: C4H11NO The article contains the following contents:

Exptl. and computational studies was performed in order to investigate an unusual carbon-carbon bond cleavage that occurs in the preparation of certain benzimidazole N-oxides from anilines. The key factor determining the outcome of the reaction was found to be the substituents on the amine functionality of the aniline. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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《Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model》 was written by Kim, Jayoung; Mondal, Sujan K.; Tzeng, Stephany Y.; Rui, Yuan; Al-kharboosh, Rawan; Kozielski, Kristen K.; Bhargav, Adip G.; Garcia, Cesar A.; Quinones-Hinojosa, Alfredo; Green, Jordan J.. Related Products of 13325-10-5 And the article was included in ACS Biomaterials Science & Engineering in 2020. The article conveys some information:

Glioblastoma (GBM) is the most devastating brain cancer, and cures remain elusive with currently available neurosurgical, pharmacol., and radiation approaches. While retrovirus- and adenovirus-mediated suicide gene therapy using DNA encoding herpes simplex virus-thymidine kinase (HSV-tk) and prodrug ganciclovir has been suggested as a promising strategy, a nonviral approach for treatment in an orthotopic human primary brain tumor model has not previously been demonstrated. Delivery challenges include nanoparticle penetration through brain tumors, efficient cancer cell uptake, endosomal escape to the cytosol, and biodegradability. To meet these challenges, we synthesized poly(ethylene glycol)-modified poly(beta-amino ester) (PEG-PBAE) polymers to improve extracellular delivery and coencapsulated plasmid DNA with end-modified poly(beta-amino ester) (ePBAE) polymers to improve intracellular delivery as well. We created and evaluated a library of PEG-PBAE/ePBAE nanoparticles (NPs) for effective gene therapy against two independent primary human stem-like brain tumor initiating cells, a putative target to prevent GBM recurrence. The optimally engineered PEG-PBAE/ePBAE NP formulation demonstrated 54 and 82% transfection efficacies in GBM1A and BTIC375 cells resp., in comparison to 37 and 66% for optimized PBAE NPs without PEG. The leading PEG-PBAE NP formulation also maintained sub-250 nm particle size up to 5 h, while PBAE NPs without PEG showed aggregation over time to micrometer-sized complexes. The comparative advantage demonstrated in vitro successfully translated into improved in vivo diffusion, with a higher amount of PEG-PBAE NPs penetrating to a distance of 2 mm from the injection site. A significant increase in median survival from 53.5 to 67 days by PEG-PBAE/pHSV-tk NP and systemic ganciclovir treatment compared to a control group in orthotopic murine model of human glioblastoma demonstrates the potential of PEG-PBAE-based NPs as an effective gene therapy platform for the treatment of human brain tumors. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

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In 2019,Beilstein Journal of Organic Chemistry included an article by Ke, Yuan-Zhen; Huang, Shou-Ling; Lai, Guoqiao; Luh, Tien-Yau. Electric Literature of C4H11NO. The article was titled 《Selective ring-opening metathesis polymerization (ROMP) of cyclobutenes. Unsymmetrical ladderphane containing polycyclobutene and polynorbornene strands》. The information in the text is summarized as follows:

At 0 °C in THF in the presence of Grubbs first generation catalyst, cyclobutene derivatives undergo ROMP readily, whereas norbornene derivatives remain intact. When the substrate contains both cyclobutene and norbornene moieties, the conditions using THF as the solvent at 0 °C offer a useful protocol for the selective ROMP of cyclobutene to give norbornene-appended polycyclobutene. Unsym. ladderphane having polycyclobutene and polynorbornene as two strands is obtained by further ROMP of the norbornene appended polycyclobutene in the presence of Grubbs first generation catalyst in DCM at ambient temperature Methanolysis of this unsym. ladderphane gives polycyclobutene Me ester and insoluble polynorbornene-amide-alc. The latter is converted into the corresponding soluble acetate. Both polymers are well characterized by spectroscopic means. No norbornene moiety is found to be incorporated into polycyclobutene strand at all. The double bonds in the polycyclobutene strand are mainly in cis configuration (ca 70%), whereas the E/Z ratio for polynorbornene strand is 8:1. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Electric Literature of C4H11NO

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Category: alcohols-buliding-blocksIn 2021 ,《Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions》 appeared in European Journal of Medicinal Chemistry. The author of the article were Huang, Guang; Solano, Claribel Murillo; Melendez, Joel; Yu-Alfonzo, Sabrina; Boonhok, Rachasak; Min, Hui; Miao, Jun; Chakrabarti, Debopam; Yuan, Yu. The article conveys some information:

The identity of fast-acting, multistage antimalarial agents, a series of pyridylvinylquinoline-triazole analogs I (R = pyrrolidin-1-yl, diethylamino, 4-methylpiperazin-1-yl, 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl, etc.) and II (R1 = piperidin-1-yl, 2-(piperazin-1-yl)ethan-1-ol, 1H-pyrazol-1-yl, (5Z)-2,4-dioxo-5-(phenylmethylidene)-1,3-thiazolidin-3-yl, etc.; n = 1, 2) have been synthesized via CuAAC. Most of the compounds display significant inhibitory effect on the drug-resistant malarial Dd2 strain at low submicromolar concentrations Among the tested analogs, compound II (R1 = piperidin-1-yl; n = 2) is the most potent mol. with an EC50 value of 0.04 ± 0.01 mM. This study indicates that compound II (R1 = piperidin-1-yl; n = 2) is a fast-acting antimalarial compound and it demonstrates stage specific action at the trophozoite phase in the P. falciparum asexual life cycle. In addition, compound II (R1 = piperidin-1-yl; n = 2) is active against both early and late stage P. falciparum gametocytes. From a mechanistic perspective, compound II (R1 = piperidin-1-yl; n = 2) shows good activity as an inhibitor of β-hematin formation. Collectively, the findings suggest that fast-acting agent II (R1 = piperidin-1-yl; n = 2) targets dual life stages of the malarial parasites and warrant further investigation of pyridylvinylquinoline hybrids as new antimalarials. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Category: alcohols-buliding-blocks

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Xiong, Jinfeng; Tan, Songwei; Yu, Long; Shen, Hui; Qu, Shen; Zhang, Chong; Ren, Ci; Zhu, Da; Wang, Hui published an article in 2021. The article was titled 《E7-Targeted Nanotherapeutics for Key HPV Afflicted Cervical Lesions by Employing CRISPR/Cas9 and Poly (Beta-Amino Ester)》, and you may find the article in International Journal of Nanomedicine.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Persistent HR-HPV (high-risk human papillomavirus) infection is the main cause of cervical cancer. The HPV oncogene E7 plays a key role in HPV tumorigenesis. At present, HPV preventive vaccines are not effective for patients who already have a cervical disease, and implementation of the recommended regular cervical screening is difficult in countries and regions lacking medical resources. Therefore, patients need medications to treat existing HPV infections and thus block the progression of cervical disease. In this study, we developed nanoparticles (NPs) composed of the non-viral vector PBAE546 and a CRISPR/Cas9 recombinant plasmid targeting HPV16 E7 as a vaginal treatment for HPV infection and related cervical malignancies. Our NPs showed low toxicity and high biol. safety both in vitro (cell line viability) and in vivo (various important organs of mice). Our NPs significantly inhibited the growth of xenograft tumors derived from cervical cancer cell lines in nude mice and significantly reversed the cervical epithelial malignant phenotype of HPV16 transgenic mice. Our NPs have great potential to be developed as a drug for the treatment of HPV-related cervical cancer and precancerous lesions. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

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The author of 《Skeletal Diversity in Catalytic Synthesis of (1,3-Oxazacycloalk-3-ylmethyl)-Substituted Pyrroles》 were Akhmetova, V. R.; Bikbulatova, E. M.; Kunakova, R. V.; Ameta, K. L.; Ibragimov, A. G.. And the article was published in Russian Journal of General Chemistry in 2019. Recommanded Product: 4-Aminobutan-1-ol The author mentioned the following in the article:

A series of bi- and trinuclear pyrrole derivatives was prepared by the 5 mol% ZrOCl2·8H2O-catalyzed CH-sp2-aminomethylation reaction of pyrrole with bis(1,3-oxazacycloalk-3-yl)methanes. The reaction proceeds at the positions 2,5 or 2 of pyrrole depending on the amount of aminomethylating reagents obtained from formaldehyde and α,ω-amino alcs. (2-aminoethan-1-ol, 3-aminopropan-1-ol, 4-aminobutan-1-ol). The aminomethylation reaction of indole with bis(1,3-oxazolidin-3-yl)methane proceeds at the position 3. In the case of carbazole, N-aminomethylation proceeds under these conditions at the N9 atom.4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol) was used in this study.

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《Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies》 was published in Nanomedicine (New York, NY, United States) in 2020. These research results belong to Choi, John; Rui, Yuan; Kim, Jayoung; Gorelick, Noah; Wilson, David R.; Kozielski, Kristen; Mangraviti, Antonella; Sankey, Eric; Brem, Henry; Tyler, Betty; Green, Jordan J.; Jackson, Eric M.. Recommanded Product: 13325-10-5 The article mentions the following:

Together, medulloblastoma (MB) and atypical teratoid/rhabdoid tumors (AT/RT) represent two of the most prevalent pediatric brain malignancies. Current treatment involves radiation, which has high risks of developmental sequelae for patients under the age of three. New safer and more effective treatment modalities are needed. Cancer gene therapy is a promising alternative, but there are challenges with using viruses in pediatric patients. We developed a library of poly(beta-amino ester) (PBAE) nanoparticles and evaluated their efficacy for plasmid delivery of a suicide gene therapy to pediatric brain cancer models-specifically herpes simplex virus type I thymidine kinase (HSVtk), which results in controlled apoptosis of transfected cells. In vivo, PBAE-HSVtk treated groups had a greater median overall survival in mice implanted with AT/RT (P = 0.0083 vs. control) and MB (P < 0.0001 vs. control). Our data provide proof of principle for using biodegradable PBAE nanoparticles as a safe and effective nanomedicine for treating pediatric CNS malignancies. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5)

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《Mild and Chemoselective Thioacylation of Amines Enabled by the Nucleophilic Activation of Elemental Sulfur》 was written by Saito, Masato; Murakami, Sho; Nanjo, Takeshi; Kobayashi, Yusuke; Takemoto, Yoshiji. Reference of 4-Aminobutan-1-ol And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

A mild and chemoselective method for the thioacylation of amines using α-keto acids and elemental sulfur has been developed. The key to the success of this transformation is the nucleophilic activation of elemental sulfur by thiols such as 1-dodecanethiol. A variety of functional groups, including unprotected hydroxyl, carboxyl, amide, sulfide, and tertiary amine moieties, are tolerated under the applied reaction conditions. To demonstrate the advantages of this method compared with conventional O-S exchange reactions using Lawesson’s reagent or P2S5, thioamide moieties were introduced site-specifically into biol. active compounds After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

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The author of 《Color, texture and enzyme activities of Hypsizygus marmoreus as affected by heating combined with color protection and hardening》 were Zhang, Su-min; Bai, Jin-hao; Chang, Ming-chang; Meng, Jun-long; Liu, Jing-yu; Feng, Cui-ping. And the article was published in International Journal of Food Properties in 2019. Recommanded Product: 4-Aminobutan-1-ol The author mentioned the following in the article:

Different pretreatments can affect the quality of Hypsizygus marmoreus (HM). In this study, the effects of thermal treatment or combined with color protection and hardening on color, texture, microstructure, polyphenol oxidase (PPO) and Peroxidase (POD) C-1: Explain the first time activities, and the volatile components of HM were investigated. The results showed compared with the control group, both heating group (H group) and color protection, hardening and heating (CHH group) significantly enhanced the color difference, and reduced all texture parameters as well as PPO and POD activities. Addnl., in two treatment groups, the structure of HM became loose, the amounts of alcs., ketones, and aldehydes were changed significantly. Compared with the H group, the color difference and PPO activities in CHH group were significantly decreased, while all texture parameters were increased significantly, the fibers of HM showed regular arrangement. In conclusion, the combination of CHH performed better effects on hardness, chewiness, microstructure, and enzymes activities related to enzymic browning. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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