Category: 13325-10-5

Ubale, Akash S.; Shaikh, Moseen A.; Gnanaprakasam, Boopathy published an article in 2021. The article was titled 《Sequential Oxidative-Fragmentation and Skeletal Rearrangement of Peroxides for the Synthesis of Quinazolinone Derivatives》, and you may find the article in Journal of Organic Chemistry.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

For the first time, sequential reaction of peroxyindole that involves base promoted oxidative-fragmentation to isocyanate formation and primary amine or amino alcs. accelerated skeletal rearrangement to synthesize exo-olefinic substituted quinazolinone or oxazoloquinazolinone was reported. Advantage of this new reaction includes broad substrate scope, transition-metal-free and room temperature condition. The formation of the isocyanate as a key intermediate that accelerate oxidative-skeletal rearrangement was confirmed by trapping experiments and the spectroscopic evidence.4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5) was used in this study.

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Wu, Yi; Li, LinZhu; Yuan, WeiQiong; Hu, JianZhong; Lv, ZhaoLin published an article in 2021. The article was titled 《Application of GC × GC coupled with TOF-MS for the trace analysis of chemical components and exploration the characteristic aroma profile of essential oils obtained from two tree peony species (Paeonia rockii and Paeonia ostii)》, and you may find the article in European Food Research and Technology.Product Details of 13325-10-5 The information in the text is summarized as follows:

Tree peony essential oil (EO) is a critical material for flavor and function in the industrial fields of perfume, medicine and food. To conduct an overall anal. of different varieties of tree peony EOs, the composition, aroma characteristics and antioxidant activity of ZiBan and FengDan EOs were analyzed by two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC × GC-TOF/MS) and the odor activity value (OAV). A total of 151 and 123 compounds were identified in ZiBan and FengDan EOs, resp., in which ZiBan EO was characterized by alc., alkane and acid, and FengDan EO was represented by aldehyde, alc. and terpene. Nevertheless, there were great differences in the content of coexisting substances in the two kinds of EOs. The aroma result indicated that the characteristic aroma and intensity of the two kinds of tree peony EOs were completely different; the aroma of ZiBan EO was mainly composed of fruity and floral aromas, whereas that of FengDan EO primarily consisted of fruity, fatty, grass and floral odors. The antioxidant activities of ZiBan EO was better than that of FengDan EO. The total antioxidant activities of ZiBan and FengDan EOs were found to be 0.020 mg Vc/mL EO and 0.003 mg Vc/mL EO, while the DPPH radical scavenging abilities of ZiBan and FengDan EOs were 24.77% and 21.60%, resp.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.

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《Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches》 was written by Uno, Shinpei; Kimura, Hironori; Murai, Masatoshi; Miyoshi, Hideto. Application of 13325-10-5This research focused onubiquinone analog respiratory complex I quinone binding pocket inhibitor; Complex I; NADH–quinone oxidoreductase; amilorides; bioenergetics; chemical biology; enzyme inhibitor; mitochondria; photoaffinity labeling; ubiquinone. The article conveys some information:

NADH-quinone oxidoreductase (respiratory complex I) couples NADH-to-quinone electron transfer to the translocation of protons across the membrane. Even though the architecture of the quinone-access channel in the enzyme has been modeled by X-ray crystallog. and cryo-EM, conflicting findings raise the question whether the models fully reflect physiol. relevant states present throughout the catalytic cycle. To gain further insights into the structural features of the binding pocket for quinone/inhibitor, we performed chem. biol. experiments using bovine heart sub-mitochondrial particles. We synthesized ubiquinones (UQs) that are oversized ,(i.e., SF-UQs) or lipid-like (i.e., PC-UQs) and are highly unlikely to enter and transit the predicted narrow channel. We found that SF-UQs and PC-UQs can be catalytically reduced by complex I, albeit only at moderate or low rates. Moreover, quinone-site inhibitors completely blocked the catalytic reduction and the membrane potential formation coupled to this reduction Photoaffinity-labeling experiments revealed that amiloride-type inhibitors bind to the interfacial domain of multiple core subunits (49 kDa, ND1, and PSST) and the 39-kDa supernumerary subunit, although the latter does not make up the channel cavity in the current models. The binding of amilorides to the multiple target subunits was remarkably suppressed by other quinone-site inhibitors and SF-UQs. Taken together, the present results are difficult to reconcile with the current channel models. On the basis of comprehensive interpretations of the present results and of previous findings, we discuss the physiol. relevance of these models. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Application of 13325-10-5)

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Parayath, N. N.; Hao, S.; Stephan, S. B.; Koehne, A. L.; Watson, C. E.; Stephan, M. T. published an article in 2021. The article was titled 《Genetic in situ engineering of myeloid regulatory cells controls inflammation in autoimmunity》, and you may find the article in Journal of Controlled Release.Reference of 4-Aminobutan-1-ol The information in the text is summarized as follows:

The ability of myeloid regulatory cells (MRCs) to control immune responses and to promote tolerance has prompted enormous interest in exploiting them therapeutically to treat inflammation, autoimmunity, or to improve outcomes in transplantation. While immunomodulatory small-mol. compounds and antibodies have provided relief for some patients, the dosing entails high systemic drug exposures and thus increased risk of off-target adverse effects. More recently, MRC-based cell-therapy products have entered clin. testing for tolerance induction. However, the elaborate and expensive protocols currently required to manufacture engineered MRCs ex vivo put this approach beyond the reach of many patients who might benefit. A solution could be to directly program MRCs in vivo. Here we describe a targeted nanocarrier that delivers in vitro-transcribed mRNA encoding a key anti-inflammatory mediator. We demonstrate in models of systemic lupus erythematosus that infusions of nanoparticles formulated with mRNA encoding glucocorticoid-induced leucine zipper (GILZ) effectively control the disease. We further establish that these nanoreagents are safe for repeated dosing. Implemented in the clinic, this new therapy could enable physicians to treat autoimmune disease while avoiding systemic treatments that disrupt immune homeostasis. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.

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Karlsson, Johan; Tzeng, Stephany Y.; Hemmati, Shayan; Luly, Kathryn M.; Choi, Olivia; Rui, Yuan; Wilson, David R.; Kozielski, Kristen L.; Quinones-Hinojosa, Alfredo; Green, Jordan J. published an article in 2021. The article was titled 《Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy》, and you may find the article in Advanced Functional Materials.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Clin. translation of polymer-based nanocarriers for systemic delivery of RNA has been limited due to poor colloidal stability in the blood stream and intracellular delivery of the RNA to the cytosol. To address these limitations, this study reports a new strategy incorporating photocrosslinking of bioreducible nanoparticles for improved stability extracellularly and rapid release of RNA intracellularly. In this design, the polymeric nanocarriers contain ester bonds for hydrolytic degradation and disulfide bonds for environmentally triggered small interfering RNA (siRNA) release in the cytosol. These photocrosslinked bioreducible nanoparticles (XbNPs) have a shielded surface charge, reduced adsorption of serum proteins, and enable superior siRNA-mediated knockdown in both glioma and melanoma cells in high-serum conditions compared to non-crosslinked formulations. Mechanistically, XbNPs promote cellular uptake and the presence of secondary and tertiary amines enables efficient endosomal escape. Following systemic administration, XbNPs facilitate targeting of cancer cells and tissue-mediated siRNA delivery beyond the liver, unlike conventional nanoparticle-based delivery. These attributes of XbNPs facilitate robust siRNA-mediated knockdown in vivo in melanoma tumors colonized in the lungs following systemic administration. Thus, biodegradable polymeric nanoparticles, via photocrosslinking, demonstrate extended colloidal stability and efficient delivery of RNA therapeutics under physiol. conditions, and thereby potentially advance systemic delivery technologies for nucleic acid-based therapeutics.4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5) was used in this study.

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《Thiourea-Catalyzed C-F Bond Activation: Amination of Benzylic Fluorides》 was published in Chemistry – A European Journal in 2020. These research results belong to Houle, Camille; Savoie, Paul R.; Davies, Clotilde; Jardel, Damien; Champagne, Pier Alexandre; Bibal, Brigitte; Paquin, Jean-Francois. Related Products of 13325-10-5 The article mentions the following:

The first thiourea-catalyzed C-F bond activation was described. The use of a thiourea catalyst and Ti(OiPr)4 as a fluoride scavenger allowed the amination of benzylic fluorides to benzylic amines RC6H4CH2R1 [R = 2-Me, 3-Cl, 4-Ph, etc.; R1 = NHPh, morpholino, imidazol-1-yl, etc.] in moderate to excellent yields. Preliminary results with S- and O-based nucleophiles were also presented. DFT calculations revealed the importance of hydrogen bonds between the catalyst and the fluorine atom of the substrate to lower the activation energy during the transition state. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

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The author of 《Antibacterial activity of natural rubber based coatings containing a new guanidinium-monomer as active agent》 were Tran, Thi Nguyet; Nourry, Arnaud; Brotons, Guillaume; Pasetto, Pamela. And the article was published in Progress in Organic Coatings in 2019. Electric Literature of C4H11NO The author mentioned the following in the article:

This paper presents the synthesis and biol. activity of a new antimicrobial material based on natural rubber derived building blocks and an organic antibacterial monomer, covalently bound to the polymer network. This investigation focused on the synthesis of an original acrylate monomer bearing an organic biol. active moiety (a guanidinium group) and in its co-polymerization in presence of telechelic acrylate oligomers, prepared from polyisoprene. The cross-linked films obtained have been characterized by IR Spectroscopy, contact angle and thermal analyses. It was shown that no-leaching of the bioactive monomer occurred and that the material resisted to long water immersions. Polyisoprene coatings prepared from pure acrylate oligoisoprenes also showed a weak antimicrobial activity that was drastically increased by integrating the guanidinium monomer. Biol. tests carried out with three strains of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis) proved the strong activity of the coatings. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

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In 2022,Saadati, Fariba; Cammarone, Silvia; Ciufolini, Marco A. published an article in Chemistry – A European Journal. The title of the article was 《A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine》.Recommanded Product: 4-Aminobutan-1-ol The author mentioned the following in the article:

This paper described a synthesis of ALC-0315 I by a sequence that more than doubles the overall yield relative to the published one, and that employed much cleaner reactions, thereby facilitating purifications to a considerable extent.4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol) was used in this study.

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Verevkin, Sergey P.; Andreeva, Irina V.; Pimerzin, Aleksey A. published their research in Journal of Molecular Liquids in 2021. The article was titled 《Evaluation of vaporization thermodynamics of pure amino-alcohols》.Category: alcohols-buliding-blocks The article contains the following contents:

The absolute vapor pressures of three amino-alcs. were measured using the transpiration method. The consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. Correlation of vaporization enthalpies with normal boiling temperatures was established. Vaporization enthalpies of amino-alcs. obey the group-additivity rules. The averaged values of vaporization enthalpies were recommended as reliable benchmark properties for the heat management of CO2 capture technologies. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks)

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《Isoquinolinequinone N-oxides as anticancer agents effective against drug resistant cell lines》 was written by Kruschel, Ryan D.; Buzid, Alyah; Khandavilli, Udaya B. Rao; Lawrence, Simon E.; Glennon, Jeremy D.; McCarthy, Florence O.. Reference of 4-Aminobutan-1-ol And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

The structured development of isoquinolinequinones I [R = Me, (CH2)4OH, Bn; RR1 = (CH2)2OCH(Et)CH2; R2 = H, Br] and their N-oxides II anticancer framework which exhibited growth inhibition in the nM range across melanoma, ovarian and leukemia cancer cell lines was reported. A new lead compound Me 6-(benzylamino)-1,3-dimethyl-2-oxido-5,8-dioxo-isoquinolin-2-ium-4-carboxylate exhibited nM GI50 values against 31/57 human tumor cell lines screened as part of the NCI60 panel and showed activity against doxorubicin resistant tumor cell lines. An electrochem. study highlighted a correlation between electropositivity of the isoquinolinequinone N-oxide framework and cytotoxicity. Adduct binding to sulfur based biol. nucleophiles glutathione and cysteine was observed in vitro. This new framework possessed significant anticancer potential.4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.

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Referemce:
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