Category: 13325-10-5

Reference of 4-Aminobutan-1-olIn 2021 ,《High-throughput evaluation of polymeric nanoparticles for tissue-targeted gene expression using barcoded plasmid DNA》 appeared in Journal of Controlled Release. The author of the article were Kim, Jayoung; Vaughan, Hannah J.; Zamboni, Camila G.; Sunshine, Joel C.; Green, Jordan J.. The article conveys some information:

Successful systemic gene delivery requires specific tissue targeting as well as efficient intracellular transfection. Increasingly, research laboratories are fabricating libraries of novel nanoparticles, engineering both new biomaterial structures and composition ratios of multicomponent systems. Yet, methods for screening gene delivery vehicles directly in vivo are often low-throughout, limiting the number of candidate nanoparticles that can be investigated. Here, we report a comprehensive, high-throughput method to evaluate a library of polymeric nanoparticles in vivo for tissue-specific gene delivery. The method involves pairing each nanoparticle formulation with a plasmid DNA (pDNA) that harbors a unique nucleotide sequence serving as the identifying “”barcode””. Using real time quant. PCR (qPCR) for detection of the barcoded pDNA and quant. reverse transcription PCR (RT-qPCR) for transcribed barcoded mRNA, we can quantify accumulation and transfection in tissues of interest. The barcode pDNA and primers were designed with sufficient sensitivity and specificity to evaluate multiple nanoparticle formulations per mouse, improving screening efficiency. Using this platform, we evaluated the biodistribution and transfection of 8 i.v. administered poly(beta-amino ester; PBAE) nanoparticle formulations, each with a PBAE polymer of differential structure. Significant levels of nanoparticle accumulation and gene transfection were observed mainly in organs involved in clearance, including spleen, liver, and kidneys. Interestingly, higher levels of transfection of select organs did not necessarily correlate with higher levels of tissue accumulation, highlighting the importance of directly measuring in vivo transfection efficiency as the key barcoded parameter in gene delivery vector optimization. To validate this method, nanoparticle formulations were used individually for luciferase pDNA delivery in vivo. The distribution of luciferase expression in tissues matched the transfection anal. by the barcode qPCR method, confirming that this platform can be used to accurately evaluate systemic gene delivery. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

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In 2022,Wozny, M.; Trzybinski, D.; Dabrowa, K.; Narodowiec, J.; Wozniak, K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Monosulfonated dibenzo-24-crown-8 and its properties》.SDS of cas: 13325-10-5 The author mentioned the following in the article:

Authors describe a method for preparing a monosulfonated dibenzo-24-crown-8 ether, SDB24C8, by direct sulfonation of the parent crown (DB24C8). Since neutral DB24C8 readily interacts with cationic guests, permanently charged SDB24C8 is an advantageous candidate for future supramol. applications. SDB24C8 can be isolated as a sulfonic acid to be used as it is or converted to a salt of choice. The crystallog. anal. provides the first known host-guest assembly with a DB24C8-based scaffold complexing hydronium and potassium cations. Supramol. studies of the interactions of this anionic macrocycle with alkali cations were also performed. According to the expectations, the introduction of the sulfonic group into the DB24C8 scaffold increases the affinities of the receptor. An unusual selectivity of SDB24C8 towards a sodium cation was also observed and further studied with DFT calculations In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

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Liu, Fuqiang; Ma, Nan; Liu, Jun; Zhu, Qiongqiong; Yue, Ting; Ma, Junhui; Wang, Yuan; Qu, Wei; Chu, Paul K.; Tang, Yan; Zhang, Wei published an article in 2021. The article was titled 《A cationic alternating copolymer composed of ornithine and glycine with an ordered sequence for enhanced bacterial activity》, and you may find the article in Polymer Engineering & Science.Related Products of 13325-10-5 The information in the text is summarized as follows:

The chains and segments of unordered cationic polypeptides are complex and may produce unexpected biol. activities. Herein, the Ugi’s 4CC reaction is adopted to synthesize a cationic alternating copolymer comprising ornithine and glycine (poly(Orn-alter-Gly)) with an ordered sequence for enhanced bacterial resistance. In this technique, potassium isocyanate, 4-(N-carbobenzyloxyamino)-1-butyraldehyde and 1-(4-Methoxyphenyl)ethylamine react to produce MPE-substituted poly(Orn-alter-Gly) in one step without using a catalyst and then poly(Orn-alter-Gly) is obtained by removing the N-(1-p-methoxyphenethyl) (MPE) group. 1H NMR, Fourier transform IR spectroscopy, and automatic amino acid anal. confirm that ornithine and glycine are linked alternately in the poly(Orn-alter-Gly) chains. Both MPE-substituted poly(Orn-alter-Gly) and poly(Orn-alter-Gly) have excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa as well as excellent biocompatibility. The synthesis strategy and materials provide new information on how to obtain ordered sequence cationic polypeptides. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

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In 2019,Nature (London, United Kingdom) included an article by Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia. Electric Literature of C4H11NO. The article was titled 《Modular click chemistry libraries for functional screens using a diazotizing reagent》. The information in the text is summarized as follows:

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

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《Probing the Edges between Stability and Degradation of a Series of ZnSe-Based Layered Hybrid Semiconductors》 was written by Yan, Mengwen; Myers, Christopher A.; John, Gregory M.; Meyers, Vincent E.; Chen, Alan A.; Feldblyum, Jeremy I.. Name: 4-Aminobutan-1-olThis research focused onzinc selenium layered hybrid semiconductor degradation density functional theory. The article conveys some information:

The discovery of layered materials with potentially unique elec. and chem. properties has become a major focus of materials research in the past decade. 2D II-VI layered hybrids (LHs) are a family of ligand-protected layered materials capable of isolation in few-layer form and possess emissive and electronic properties of potential relevance to semiconductor device technologies. The authors showed previously that, akin to black phosphorus and transition metal dichalcogenides, 2D II-VI LHs are sensitive to ambient atm. conditions. However, the causes for degradation of these ligand-protected materials remain unclear. Using ZnSe-based LHs, it is shown herein that the stability of these materials is related to the length and chem. of the organic ligands coordinated to the LH surfaces. Furthermore, exposure to isotopically enriched H218O and 18O2 reveals that H2O and O2 are both reactants contributing to ZnSe-LH degradation An H2O-initiated degradation pathway is proposed and is supported by d. functional theory calculations The findings contribute to the discovery of protection strategies for layered materials and elucidate a degradation pathway that may also be applicable to other layered materials.4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol) was used in this study.

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Product Details of 13325-10-5In 2022 ,《Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer》 was published in Journal of Medicinal Chemistry. The article was written by Li, Jiacheng; Liu, Ting; Song, Yuanli; Wang, Mingyu; Liu, Liping; Zhu, Hongwen; Li, Qi; Lin, Jin; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Wang, Mingliang; Zhou, Hu; Lin, Hua; Luo, Cheng. The article contains the following contents:

Aberrant hyperactivation of cyclins results in carcinogenesis and therapy resistance in cancers. Direct degradation of the specific cyclin or cyclin-dependent kinase (CDK)-cyclin complex by small-mol. degraders remains a great challenge. Here, we applied the first application of hydrophobic tagging to induce degradation of CDK9-cyclin T1 heterodimer, which is required to keep productive transcription of oncogenes in cancers. LL-K9-3 (I) was identified as a potent small-mol. degrader of CDK9-cyclin T1. Quant. and time-resolved proteome profiling exhibited LL-K9-3-induced selective and synchronous degradation of CDK9 and cyclin T1. The expressions of androgen receptor (AR) and cMyc were reduced by LL-K9-3 (I) in 22RV1 cells. LL-K9-3 (I) exhibited enhanced anti-proliferative and pro-apoptotic effects compared with its parental CDK9 inhibitor SNS032 and suppressed downstream signaling of CDK9 and AR more effectively than SNS032. Moreover, LL-K9-3 (I) inhibited AR and Myc-driven oncogenic transcriptional programs and exerted stronger inhibitory effects on several intrinsic target genes of AR than the monomeric CDK9 PROTAC (Thal-SNS032). After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5)

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Referemce:
Alcohol – Wikipedia,
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Mutlu Balci, Ceylan; Palabiyik, Duygu; Besli, Serap published their research in Inorganica Chimica Acta in 2021. The article was titled 《Amino alcohol based cyclotriphosphazenes: Effects of chain length and base factor on product diversity》.Reference of 4-Aminobutan-1-ol The article contains the following contents:

The effects of chain length and base on product diversity in the reactions of hexachlorocyclotriphosphazene, N3P3Cl6 (1) with amino alcs. (2a and 2b) were reported. In this sense, two different amino alcs. (2a and 2b) and three different base solutions (Et3N, NaH and amino alc. itself) were selected. All reactions were performed at 1:1 mol ratio in THF solvent and under argon atm. These reactions led to formation of open chain (3a, 3b and 7b) and spiro (4a-6a and 4b) compounds The isolated compounds (3a-5a, 3b, 4b and 7b) were characterized by elemental anal., MALDI-TOF mass spectrometry, 1H, and 31P NMR spectroscopy. The mol. and crystal structures of 4a, 5a and 4b were illuminated by X-Ray crystallog. The product formations and their amounts were discussed in terms of two different aspects: chain length of the nucleophile and the role of base. In addition, the product varieties in the reactions of hexachlorocyclotriphosphazene with diols, diamines and amino alcs. were mentioned. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

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Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Epifanov, Maxim; Mo, Jia Yi; Dubois, Rudy; Yu, Hao; Sammis, Glenn M. published their research in Journal of Organic Chemistry in 2021. The article was titled 《One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride》.HPLC of Formula: 13325-10-5 The article contains the following contents:

Herein, the SO2F2-mediated alc. substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates was reported. This strategy allows the expansion of SO2F2-mediated one-pot processes to include radical reactions, where the alkyl halides was exploited in the one-pot deoxygenation of primary alcs. under mild conditions (52-95% yield). This strategy enhanced the scope of substitutions to nucleophiles that are previously incompatible with one-pot SO2F2-mediated alc. activation and enables substitution of primary and secondary alcs. in 54-95% yield. Chiral secondary alcs. underwent a highly stereospecific (90-98% ee) double nucleophilic displacement with an overall retention of configuration.4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5) was used in this study.

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Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Effects of Branching Strategy on the Gene Transfection of Highly Branched Poly(β-amino ester)s》 was written by Wang, Yao; Wang, Chen-Fei; Lie, Ming; Zhou, De-Zhong; Huang, Wei; Wang, Wen-Xin. Reference of 4-Aminobutan-1-ol And the article was included in Chinese Journal of Polymer Science in 2020. The article conveys some information:

Abstract: Highly branched poly(β-amino ester)s (HPAEs) have emerged as one type of the most viable non-viral gene delivery vectors, both in vitro and in vivo. However, the effects of different branching strategies on the gene transfection performance have not yet been explored. Here, using triacrylate (B3) and diamine (B4) as the branching monomers, a series of HPAEs were synthesized via the “”A2 + B3 + C2″” and “”A2 + B4 + C2″” strategies, resp. Results show that the branching strategy plays a pivotal role in dictating the physiol. properties of the HPAE/DNA polyplexes and thus leads to obviously different cell viability and transfection efficiency. Comparatively, HPAEs synthesized via the “”A2 + B3 + C2″” branching strategy are more favorable for DNA transfection than that synthesized via the “”A2 + B4 + C2″” strategy. This study may provide new insights into the development of HPAEs based non-viral DNA delivery system. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

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Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing》 were Rui, Yuan; Wilson, David R.; Sanders, Katie; Green, Jordan J.. And the article was published in ACS Applied Materials & Interfaces in 2019. HPLC of Formula: 13325-10-5 The author mentioned the following in the article:

Functional co-delivery of plasmid DNA and RNA oligonucleotides in the same nanoparticle system is challenging due to differences in their phys. properties as well as their intracellular locations of function. In this study, we synthesized a series of reducible branched ester-amine quadpolymers (rBEAQs) and investigated their ability to co-encapsulate and deliver DNA plasmids and RNA oligos. The rBEAQs are designed to leverage polymer branching, reducibility, and hydrophobicity to successfully co-complex DNA and RNA in nanoparticles at low polymer to nucleic acid weight/weight ratios and enable high delivery efficiency. We validate the synthesis of this new class of biodegradable polymers, characterize the self-assembled nanoparticles that these polymers form with diverse nucleic acids, and demonstrate that the nanoparticles enable safe, effective, and efficient DNA-siRNA co-delivery as well as non-viral CRISPR-mediated gene editing utilizing Cas9 DNA and sgRNA co-delivery. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

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Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts