Category: 13325-10-5

Masson, Thibaut; Guetta, Corinne Landras; Laigre, Eugenie; Cucchiarini, Anne; Duchambon, Patricia; Teulade-Fichou, Marie-Paule; Verga, Daniela published their research in Nucleic Acids Research in 2021. The article was titled 《BrdU immuno-tagged G-quadruplex ligands: a new ligand-guided immunofluorescence approach for tracking G-quadruplexes in cells》.COA of Formula: C4H11NO The article contains the following contents:

G-quadruplexes (G4s) are secondary structures forming in G-rich nucleic acids. G4s are assumed to play critical roles in biol., nonetheless their detection in cells is still challenging. For tracking G4s, synthetic mols. (G4 ligands) can be used as reporters and have found wide application for this purpose through chem. functionalization with a fluorescent tag. However, this approach is limited by a low-labeling degree impeding precise visualization in specific subcellular regions. Herein, we present a new visualization strategy based on the immuno-recognition of 5-bromo-2′-deoxyuridine (5-BrdU) modified G4 ligands, functionalized prior- or post-G4-target binding by CuAAC. Remarkably, recognition of the tag by antibodies leads to the detection of the modified ligands exclusively when bound to a G4 target both in vitro, as shown by ELISA, and in cells, thereby providing a highly efficient G4-ligand Guided Immunofluorescence Staining (G4-GIS) approach. The obtained signal amplification revealed well-defined fluorescent foci located in the perinuclear space and RNase treatment revealed the preferential binding to G4-RNA. Furthermore, ligand treatment affected significantly BG4 foci formation in cells. Our work headed to the development of a new imaging approach combining the advantages of immunostaining and G4-recognition by G4 ligands leading to visualization of G4/ligands species in cells with unrivaled precision and sensitivity. The experimental part of the paper was very detailed, including the reaction process of 4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO)

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In 2022,Iqbal, Sajid; Martins, Alessandro F.; Sohail, Muhammad; Zhao, Jingjing; Deng, Qi; Li, Muhan; Zhao, Zhongxi published an article in Frontiers in Pharmacology. The title of the article was 《Synthesis and characterization of poly (β-amino Ester) and applied PEGylated and non-PEGylated poly (β-amino ester)/plasmid DNA nanoparticles for efficient gene delivery》.Quality Control of 4-Aminobutan-1-ol The author mentioned the following in the article:

Polymer-based nanocarriers require extensive knowledge of their chemistries to learn functionalization strategies and understand the nature of interactions that they establish with biol. entities. In this research, the poly (ss-amino ester) (PβAE-447) was synthesized and characterized, aimed to identify the influence of some key parameters in the formulation process. Initially; PβAE-447 was characterized for aqueous solubility, swelling capacity, proton buffering ability, and cytotoxicity study before nanoparticles formulation. Interestingly, the polymer-supported higher cell viability than the Polyethylenimine (PEI) at 100 μg/mL. PβAE-447 complexed with GFP encoded plasmid DNA (pGFP) generated nanocarriers of 184 nm hydrodynamic radius (+7.42 mV Zeta potential) for cell transfection. Transfection assays performed with PEGylated and lyophilized PβAE-447/pDNA complexes on HEK-293, BEAS-2B, and A549 cell lines showed better transfection than PEI. The outcomes toward A549 cells (above 66%) showed the highest transfection efficiency compared to the other cell lines. Altogether, these results suggested that characterizing physicochem. properties pave the way to design a new generation of PβAE-447 for gene delivery. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)

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Lee, Cayo; Lai, Joey; Epifanov, Maxim; Wang, Cindy Xinyun; Sammis, Glenn M. published their research in Journal of Fluorine Chemistry in 2021. The article was titled 《Efficient protocol for the SO2F2-mediated deoxyfluorination of aliphatic alcohols》.Product Details of 13325-10-5 The article contains the following contents:

Herein the sulfuryl fluoride-mediated deoxyfluorination of alcs. using room temperature reaction conditions in only an hour is reported. A wide range of primary aliphatic alcs. were efficiently converted to the corresponding fluoride in 46-70% isolated yields. Secondary alcs. were also effectively deoxyfluorinated in 50-92% yields. Chiral secondary alcs. were cleanly converted to the corresponding alkyl fluoride with only a minor deterioration of the enantioenrichment. A steroid derivative also underwent deoxyfluorination in 50% yield and 5.9:1 dr, with the major product resulting from net inversion of the stereocenter.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.

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《Cationic Heteropolymers with Various Functional Groups as Efficient and Biocompatible Nonviral Gene Vectors》 was published in ACS Applied Bio Materials in 2020. These research results belong to Zhang, Ju-Hui; He, Xi; Xiao, Ya-Ping; Zhang, Ji; Wu, Xiao-Ru; Yu, Xiao-Qi. Electric Literature of C4H11NO The article mentions the following:

With the rise and development of gene therapy, it is of great significance to develop highly efficient and biocompatible polymeric gene carriers. In this work, a series of heteropolymers from ring-opening polymerization of diepoxide compounds and various functional primary amines were synthesized. The feed dosage of amines was adjusted to obtain the polymers with different functional group contents, and the structure-activity relationships of these polymers as nonviral gene vectors were examined in detail. Results revealed that, although the amine with the fluorinated chain seemed to be less reactive in the polymerization, the relative content of each component in the target product was consistent with the feed dosage. Compared to the “”golden standard”” polyethylenimine (PEI) 25 kDa, these heteropolymers showed much lower cytotoxicity and higher gene transfection efficiency, especially in serum-containing medium, and up to 78 times of efficiency than PEI was obtained. Meanwhile, they exhibited much better serum resistance than PEI, compared with the transfection efficiency in serum-free experiments, and even higher efficiency could be achieved with serum in HeLa cells. Mechanism study results suggest that the content of fluorinated chain and histamine might distinctly influence their transfection. The fluorinated chains could enhance the serum tolerance and cellular uptake efficiency (with serum), while the imidazole group in the histamine chain would improve the endosome/lysosome escape. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

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In 2022,Farag, Ahmed Karam; Ahn, Byung Sun; Yoo, Je Sik; Karam, Reham; Roh, Eun Joo published an article in Bioorganic Chemistry. The title of the article was 《Design, synthesis, and biological evaluation of pseudo-bicyclic pyrimidine-based compounds as potential EGFR inhibitors》.Name: 4-Aminobutan-1-ol The author mentioned the following in the article:

Cancer is one of the most dangerous diseases harvesting millions of lives every year globally, which mandates the development of new therapies. In this report, we designed and synthesized a novel series of compounds based on the structure of lapatinib and AF8c, a compound we developed and reported previously, to target EGFR kinase. The series was assayed against a panel of 60 cancer cell lines at the National Cancer Institute (NCI). Compounds 4a, 4f, 4 g, and 4 l showed high efficacy against melanoma, colon, and blood cancers, with 4a being the most effective. The evaluation of the potency of 4a against the 60 cell lines in a five-dose assay revealed a significant potency compared to lapatinib against melanoma, colon, and blood cancers. In vitro enzyme assay over 30 kinases showed significant potency against EGFR and high selectivity to EGFR among the tested kinases. A mol. modeling study of 4a and lapatinib inside the pockets of EGFR revealed that both compounds bind strongly inside the ATP-binding pocket of the EGFR kinase domain. Therefore, we present 4a as a novel EGFR kinase inhibitor with potent in vitro cellular activity against diverse types of cancer cells. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol) was used in this study.

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Mattiassi, Sabrina; Rizwan, Muhammad; Grigsby, Christopher L.; Zaw, Aung Moe; Leong, Kam W.; Yim, Evelyn K. F. published an article in 2021. The article was titled 《Enhanced efficiency of nonviral direct neuronal reprogramming on topographical patterns》, and you may find the article in Biomaterials Science.Name: 4-Aminobutan-1-ol The information in the text is summarized as follows:

Nonviral direct neuronal reprogramming holds significant potential in the fields of tissue engineering and regenerative medicine. However, the issue of low reprogramming efficiency poses a major barrier to its application. We propose that topog. cues, which have been applied successfully to enhance lineage-directed differentiation and multipotent stem cell transdifferentiation, could improve nonviral direct neuronal reprogramming efficiency. To investigate, we used a polymer-BAM (Brn2, Ascl1, Myt1l) factor transfection polypex to reprogram primary mouse embryonic fibroblasts. Using a multiarchitecture chip, we screened for patterns that may improve transfection and/or subsequent induced neuron reprogramming efficiency. Selected patterns were then investigated further by analyzing β-tubulin III (TUJ1) and microtubule-associated protein 2 (MAP2) protein expression, cell morphol. and electrophysiol. function of induced neurons. Certain hierarchical topogs., with nanopatterns imprinted on micropatterns, significantly improved the percentage of TUJ1+ and MAP2+ cells. It is postulated that the microscale base pattern enhances initial BAM expression while the nanoscale sub-pattern promotes subsequent maturation. This is because the base pattern alone increased expression of TUJ1 and MAP2, while the nanoscale pattern was the only pattern yielding induced neurons capable of firing multiple action potentials. Nanoscale patterns also produced the highest fraction of cells showing spontaneous synaptic activity. Overall, reprogramming efficiency with one dose of polyplex on hierarchical patterns was comparable to that of five doses without topog. Thus, topog. can enhance nonviral direct reprogramming of fibroblasts into induced neurons. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

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The author of 《Differentially Branched Ester Amine Quadpolymers with Amphiphilic and pH-Sensitive Properties for Efficient Plasmid DNA Delivery》 were Wilson, David R.; Rui, Yuan; Siddiq, Kamran; Routkevitch, Denis; Green, Jordan J.. And the article was published in Molecular Pharmaceutics in 2019. Recommanded Product: 13325-10-5 The author mentioned the following in the article:

Development of highly effective nonviral gene delivery vectors for transfection of diverse cell populations remains a challenge despite utilization of both rational and combinatorial driven approaches to nanoparticle engineering. In this work, multifunctional polyesters are synthesized with well-defined branching structures via A2 + B2/B3 + C1 Michael addition reactions from small mol. acrylate and amine monomers and then end-capped with amine-containing small mols. to assess the influence of polymer branching structure on transfection. These Branched poly(Ester Amine) Quadpolymers (BEAQs) are highly effective for delivery of plasmid DNA to retinal pigment epithelial cells and demonstrate multiple improvements over previously reported leading linear poly(beta-amino ester)s, particularly for volume-limited applications where improved efficiency is required. BEAQs with moderate degrees of branching are demonstrated to be optimal for delivery under high serum conditions and low nanoparticle doses further relevant for therapeutic gene delivery applications. Defined structural properties of each polymer in the series, including tertiary amine content, correlated with cellular transfection efficacy and viability. Trends that can be applied to the rational design of future generations of biodegradable polymers are elucidated. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5) was used in this study.

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The author of 《Folate-conjugated chitosan-pluronic P123 nanogels: synthesis and characterizations towards dual drug delivery》 were Nguyen, Van Toan; Nguyen, Thi Huong; Dang, Le Hang; Vu-Quang, Hieu; Tran, Ngoc Quyen. And the article was published in Journal of Nanomaterials in 2019. Reference of 4-Aminobutan-1-ol The author mentioned the following in the article:

In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system. 1H-NMR and TGA proved that the fabricating method of CP-FA was successful. Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16.27 ± 2.01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate pos. potential value (39.43 ± 3.45 mV) and the lower critical micelle concentration (0.036 mg/mL). Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer. The high hydrophobicity of the segment induced a great loading efficacy of up to 98.63 ± 0.42 of PTX and 97.82 ± 0.48 of Cur. In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time. The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel. The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5.74 ± 0.23 nM which was higher than that of CP-FA/PTX (IC50 = 8.20 ± 1.41 nM) due to the synergistic effect of both PTX and Cur. Thereby, a dual-drug delivery-system-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.

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Shi, Jinfeng; Ren, Yali; Ma, Jiaqi; Luo, Xi; Li, Jiaxin; Wu, Yihan; Gu, Huan; Fu, Chaomei; Cao, Zhixing; Zhang, Jinming published their research in Journal of Nanobiotechnology in 2021. The article was titled 《Novel CD44-targeting and pH/redox-dual-stimuli-responsive core-shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis》.Synthetic Route of C4H11NO The article contains the following contents:

The toxicity and inefficient delivery of triptolide (TPL) in tumor therapy have greatly limited the clin. application. Thus, we fabricated a CD44-targeting and tumor microenvironment pH/redox-sensitive nanosystem composed of hyaluronic acid-vitamin E succinate and poly (β-amino esters) (PBAEss) polymers to enhance the TPL-mediated suppression of breast cancer proliferation and lung metastasis. The generated TPL nanoparticles (NPs) had high drug loading efficiency (94.93% ± 2.1%) and a desirable average size (191 nm). Mediated by the PBAEss core, TPL/NPs displayed a pH/redox-dual-stimuli-responsive drug release profile in vitro. Based on the hyaluronic acid coating, TPL/NPs exhibited selective tumor cellular uptake and high tumor tissue accumulation capacity by targeting CD44. Consequently, TPL/NPs induced higher suppression of cell proliferation, blockage of proapoptotic and cell cycle activities, and strong inhibition of cell migration and invasion than that induced by free TPL in MCF-7 and MDA-MB-231 cells. Importantly, TPL/NPs also showed higher efficacy in shrinking tumor size and blocking lung metastasis with decreased systemic toxicity in a 4T1 breast cancer mouse model at an equivalent or lower TPL dosage compared with that of free TPL. Histol. immunofluorescence and immunohistochem. analyses in tumor and lung tissue revealed that TPL/NPs induced a high level of apoptosis and suppressed expression of matrix metalloproteinases, which contributed to inhibiting tumor growth and pulmonary metastasis. Collectively, our results demonstrate that TPL/NPs, which combine tumor active targeting and pH/redox-responsive drug release with proapoptotic and antimobility effects, represent a promising candidate in halting breast cancer progression and metastasis while minimizing systemic toxicity. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Synthetic Route of C4H11NO)

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《Nanoparticle depots for controlled and sustained gene delivery》 was written by Li, Zhongyu; Ho, William; Bai, Xin; Li, Fengqiao; Chen, Yen-jui; Zhang, Xue-Qing; Xu, Xiaoyang. Safety of 4-Aminobutan-1-ol And the article was included in Journal of Controlled Release in 2020. The article conveys some information:

Gene therapy is one of the most promising medical fields which holds the potential to rapidly advance the treatment of difficult ailments such as cancer as well as inherited genetic diseases. However, clin. translation is limited by several drug delivery hurdles including renal clearance, phagocytosis, enzymic degradation, protein absorption, as well as cellular internalization barriers. Addnl., successful treatments require sustained release of drug payloads to maintain the effective therapeutic level. As such, controlled and sustained release is a significant concern as the localization and kinetics of nucleic acid therapeutics can significantly influence the therapeutic efficacy. This is an unmet need which calls for the development of controlled-release nanoparticle (NP) technologies to further improve the gene therapy efficacy by prolonging the release of nucleic acid drug payload for sustained, long-term gene expression or silencing. Herein, we present a polymeric NP system with sustained gene delivery properties, which can be synthesized using biodegradable and biocompatible polymers via self-assembly. The NP delivery system is composed of a polymeric NP which acts as a drug depot encapsulating cationic polymer/nucleic acid complexes, facilitating the enhanced retention and prolonged release of the gene payload. The NPs showed excellent cellular biocompatibility and gene delivery efficacy using the green fluorescent protein (GFP) encoded DNA plasmid (pGFP) as a reporter gene. Sustained release of the pGFP payload was shown over a period of 8 days. The physicochem. properties such as morphol., particle size, zeta potential, pGFP encapsulation efficiency and biol. properties such as pGFP release profile, in vitro cytotoxicity and transfection efficacy in Hek 293 cells were characterized and evaluated. Importantly, the NP-mediated sustained release of pGFP generates enhanced GFP expression over time. We expect this NP-mediated gene delivery system to provide safe and sustained release of various nucleic acid-based therapeutics with applications in both fundamental biol. studies and clin. translations. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol) was used in this study.

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