13325-10-5 Archives - Page 3 of 12 - Alcohols-buliding-blocks

Fonte, Melanie’s team published research in Tetrahedron Letters in 2019 | CAS: 13325-10-5

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

In 2019,Tetrahedron Letters included an article by Fonte, Melanie; Fagundes, Natalia; Gomes, Ana; Ferraz, Ricardo; Prudencio, Cristina; Araujo, Maria Joao; Gomes, Paula; Teixeira, Catia. HPLC of Formula: 13325-10-5. The article was titled 《Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials》. The information in the text is summarized as follows:

This is the first multi-step synthetic route, which has been developed towards N4,N9-disubstituted 4,9-diaminoacridines I. The target structures I are likely to reveal interesting biol. activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Woojoo E.’s team published research in RSC Chemical Biology in 2022 | CAS: 13325-10-5

In 2022,Kim, Woojoo E.; Ishikawa, Fumihiro; Re, Rebecca N.; Suzuki, Takehiro; Dohmae, Naoshi; Kakeya, Hideaki; Tanabe, Genzoh; Burkart, Michael D. published an article in RSC Chemical Biology. The title of the article was 《Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Nonribosomal peptide synthetases (NRPSs) are complex multi-modular enzymes containing catalytic domains responsible for the loading and incorporation of amino acids into natural products. These unique mol. factories can produce peptides with nonproteinogenic D-amino acids in which the epimerization (E) domain catalyzes the conversion of L-amino acids to D-amino acids, but its mechanism remains not fully understood. Here, we describe the development of pantetheine crosslinking probes that mimic the natural substrate L-Phe of the initiation module of tyrocidine synthetase, TycA, to elucidate and study the catalytic residues of the E domain. Mechanism-based crosslinking assays and MALDI-TOF MS were used to identify both H743 and E882 as the crosslinking site residues, demonstrating their roles as catalytic bases. Mutagenesis studies further validated these results and allowed the comparison of reactivity between the catalytic residues, concluding that glutamate acts as the dominant nucleophile in the crosslinking reaction, resembling the deprotonation of the Cα-H of amino acids in the epimerization reaction. The crosslinking probes employed in these studies provide new tools for studying the mol. details of E domains, as well as the potential to study C domains. In particular, they would elucidate key information for how these domains function and interact with their substrates in nature, further enhancing the knowledge needed to assist combinatorial biosynthetic efforts of NRPS systems to produce novel compounds In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duan, Shanzhou’s team published research in Biomaterials Science in 2020 | CAS: 13325-10-5

《Topology-assisted, photo-strengthened DNA/siRNA delivery mediated by branched poly(β-amino ester)s via synchronized intracellular kinetics》 was published in Biomaterials Science in 2020. These research results belong to Duan, Shanzhou; Cao, Desheng; Li, Xudong; Zhu, Huifang; Lan, Min; Tan, Zhengzhong; Song, Ziyuan; Zhu, Rongying; Yin, Lichen; Chen, Yongbing. Recommanded Product: 13325-10-5 The article mentions the following:

The performance of non-viral gene delivery vehicles, especially cationic polymers, is often challenged by the multiple cellular barriers that pose inconsistent requirements for material properties. A most pronounced inconsistency is exemplified by the mol. weight (MW)-related transfection efficiency and cytotoxicity. In this study, we report the development of photo-degradable, branched poly(β-amino ester)s (BPAE-NB) to realize efficient and photo-controlled DNA and siRNA delivery. BPAE-NB possessing built-in light-responsive 2-nitrobenzene moieties in the polymer backbone was synthesized via the A2 (amine) + B3 (triacrylate) + C2 (diacrylate) polycondensation reaction from 4-amino-1-butanol (A2), trimethylolpropane triacrylate (B3), and (2-nitro-1,3-phenylene)bis(methylene) diacrylate (NPBMDA, C2). The highly branched BPAE-NB with the multivalent arrangement of cationic groups provides stronger nucleic acid binding capacity than its linear analog LPAE-NB, and thus features stronger trans-membrane gene delivery capabilities and higher transfection efficiencies. Upon UV light irradiation, the backbone of BPAE-NB can quickly degrade into low-MW fragments as a consequence of the cleavage of the light-responsive 2-nitrobenzene, thus promoting intracellular gene release and diminishing the toxicity of materials at the post-transfection state. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Qingchun’s team published research in Inorganic Chemistry in 2019 | CAS: 13325-10-5

The author of 《Hexadentate β-Dicarbonyl(bis-catecholamine) Ligands for Efficient Uranyl Cation Decorporation: Thermodynamic and Antioxidant Activity Studies》 were Zhang, Qingchun; Jin, Bo; Zheng, Tian; Tang, Xingyan; Guo, Zhicheng; Peng, Rufang. And the article was published in Inorganic Chemistry in 2019. Recommanded Product: 13325-10-5 The author mentioned the following in the article:

The special linear dioxo cation structure of the uranyl cation, which relegates ligand coordination to an equatorial plane perpendicular to the O:U:O vector, poses an unusual challenge for the rational design of efficient chelating agents. Therefore, the planar hexadentate ligand rational design employed in this work incorporates two bidentate catecholamine (CAM) chelating moieties and a flexible linker with a β-dicarbonyl chelating moiety (β-dicarbonyl(CAM)2 ligands). The solution thermodn. of β-dicarbonyl(CAM)2 with a uranyl cation was investigated by potentiometric and spectrophotometric titrations The results demonstrated that the pUO22+ values are significantly higher than for the previously reported TMA(2Li-1,2-HOPO)2, and efficient chelation of the uranyl cation was realized by the planar hexadentate β-dicarbonyl(CAM)2. The efficient chelating ability of β-dicarbonyl(CAM)2 was attributed to the presence of the more flexible β-dicarbonyl chelating linker and planar hexadentate structure, which favors the geometric arrangement between ligand and uranyl coordinative preference. Meanwhile, β-dicarbonyl(CAM)2 also exhibits higher antiradical efficiency in comparison to butylated hydroxyanisole. These results indicated that β-dicarbonyl(CAM)2 has potential application prospects as a chelating agent for efficient chelation of a uranyl cation. New planar hexadentate ligands (β-dicarbonyl(CAM)2 ligands) shaped like a headset were designed in this work, which incorporated two bidentate CAM chelating moieties and a flexible linker with a β-dicarbonyl chelating moiety, and realized efficient chelation of a uranyl cation. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Zhaoming’s team published research in Biomaterials Science in 2021 | CAS: 13325-10-5

《Zn(II)-Dipicolylamine analogues with amphiphilic side chains endow low molecular weight PEI with high transfection performance》 was written by Chen, Zhaoming; Wang, Xindong; Liu, Shuai; Li, Yumeng; Zhou, Hao; Guo, Tianying. Computed Properties of C4H11NOThis research focused onzinc dipicolylamine polyethylenimine DNA transfection cyctotoxicity. The article conveys some information:

To investigate the effect of amphiphilic balance of Zn(II)-dipicolylamine analogs on the transfection process, we fabricated a series of Zn(II)-dipicolylamine functional modules (DDAC-Rs) with different hydrophilic-phobic side chains to modify low mol. weight PEI (Zn-DP-Rs) by the Michael addition reaction. Zn-DP-Rs with hydrophilic terminal hydroxy group side chains demonstrate superior overall performance compared to those of hydrophobic alkyl side chains. In terms of the influence of the chain lengths in DDAC-Rs, from Zn-DP-A/OH-3 to Zn-DP-A/OH-5, the corresponding transfection efficiency shows an upward trend as the lengths increase. However, decreasing efficacy is observed with further increase in the length of side chains. In addition, the Zn-DP-Rs with amphiphilic side chains show prominent performance in every respect, highlighting the significance of balance in the amphipathy of side chains in DDAC-Rs. This work is of great significance for the development of polycationic gene carrier materials with excellent performance. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shangguan, Li’s team published research in Analytica Chimica Acta in 2019 | CAS: 13325-10-5

Name: 4-Aminobutan-1-olIn 2019 ,《Highly sensitive fluorescent bioassay of 2,3,7,8-tetrachloro-dibenzo-p-dioxin based on abnormal expression of cytochrome P450 1A2 in human cells》 was published in Analytica Chimica Acta. The article was written by Shangguan, Li; Wei, Yuanqing; Wang, Kan; Zhang, Yuanjian; Liu, Songqin. The article contains the following contents:

Current in vitro bioassays of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, a major threat carcinogen) are relied on murine cells and fluorescent probe 7-ethoxyresorufin (7-ER), in which TCDD mostly causes abnormal expression of cytochrome P 450 1A1 (CYP1A1). However, for human cells, TCDD mainly leads to a distinct abnormal expression of cytochrome P 450 1A2 (CYP1A2). The poor response of 7-ER to CYP1A2 limits the traditional bioassay for human cells. Herein, we report a fluorescent probe N-(3-hydroxybutyl)-4-methoxy-1,8-naphthalimide (HBMN) for in vitro bioassay of TCDD with human cells. HBMN had ca. 60 times higher affinity to CYP1A2 than 7-ER. As such, the sensing sensitivity increased by 10 times, and different expression of CYP1A2 by TCDD induction in different human cells was found. Besides, HBMN was also feasible in rapid screening of TCDD concentration by naked eye. It would open a new way to highly sensitive detect TCDD and understand the pathogenesis of TCDD in different human organs. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mothukuri, Ganesh K.’s team published research in Chemical Science in 2020 | CAS: 13325-10-5

《Macrocycle synthesis strategy based on step-wise “”adding and reacting”” three components enables screening of large combinatorial libraries》 was written by Mothukuri, Ganesh K.; Kale, Sangram S.; Stenbratt, Carl L.; Zorzi, Alessandro; Vesin, Jonathan; Bortoli Chapalay, Julien; Deyle, Kaycie; Turcatti, Gerardo; Cendron, Laura; Angelini, Alessandro; Heinis, Christian. Recommanded Product: 4-Aminobutan-1-ol And the article was included in Chemical Science in 2020. The article conveys some information:

Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three building blocks are coupled sequentially in efficient alkylation reactions that eliminate the need for product purification We demonstrate the power of the approach by combinatorially reacting 15 bromoacetamide-activated tripeptides, 42 amines, and 6 bis-electrophile cyclization linkers to generate a 3780-compound library with minimal effort. Screening against thrombin yielded a potent and selective inhibitor (Ki = 4.2 ± 0.8 nM) that efficiently blocked blood coagulation in human plasma. Structure-activity relationship and X-ray crystallog. anal. revealed that two of the three building blocks acted synergistically and underscored the importance of combinatorial screening in macrocycle development. The three-component library synthesis approach is general and offers a promising avenue to generate macrocycle ligands to other targets. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Elzes, M. Rachel’s team published research in ACS Symposium Series in 2019 | CAS: 13325-10-5

《Thiourea-functional bioreducible poly(amido amine)s in gene delivery》 was written by Elzes, M. Rachel; Si, Guoying; Engbersen, Johan F. J.; Paulusse, Jos M. J.. Formula: C4H11NOThis research focused onthiourea bioreducible polyamido amine gene delivery. The article conveys some information:

Successful gene therapy relies on gene delivery vectors with high transfection efficiency and minimal toxicity. Bioreducible cationic polymers were developed as nonviral gene delivery vectors due to their large capacity to carry genes and highly modular synthesis. Poly(amido amine)s (PAAs) with disulfide linkages along the backbone and varying amounts of thiourea moieties in the side-chains were prepared via Michael-type polyaddition of 1-(4-aminobutyl)-3-(pyridin-3-yl)thiourea to N,N’-cystamine bisacrylamide (CBA). The thiourea-containing PAAs are able to condensate plasmid DNA into nanosized polyplexes with pos. surface charge as determined by dynamic light scattering and zeta-potential measurements. The plasmid DNA is readily liberated from the polyplexes upon exposure to reducing environment, as confirmed by gel electrophoresis after treatment with the reducing agent dithiothreitol. Polyplexes of thiourea-functionalized PAAs show no discernible toxicity and markedly higher transfection efficiencies on COS-7 cells as compared to polyplexes of the frequently applied branched polyethylenimine (PEI, 25 kDa), as well as the PAA analog obtained via polyaddition of 1-amino-4-butanol (ABOL) to CBA (pABOL), at their optimal transfection conditions. The high transfection capacity of the thiourea-functionalized PAAs remains largely unaffected in the presence of 10% serum, while the transfection efficiencies of PEI and pABOL are considerably reduced under these conditions. The results demonstrate the potential of thiourea functionalization of PAAs in enhancing their transfection efficiencies while maintaining minimal toxicities. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kopecka, Katerina’s team published research in Dalton Transactions in 2020 | CAS: 13325-10-5

《Exfoliation of layered mixed zirconium 4-sulfophenylphosphonate phenylphosphonates》 was written by Kopecka, Katerina; Melanova, Klara; Benes, Ludvik; Knotek, Petr; Mazur, Michal; Zima, Vitezslav. Safety of 4-Aminobutan-1-olThis research focused onzirconium sulfophenylphosphonate phenylphosphonate preparation intercalation amino alc. The article conveys some information:

Mixed zirconium 4-sulfophenylphosphonate phenylphosphonates with formulas Zr(HO3SC6H4PO3)1.8(C6H5PO3)0.2·2.6H2O, Zr(HO3SC6H4PO3)1.3(C6H5PO3)0.7·2H2O, and Zr(HO3SC6H4PO3)0.7(C6H5PO3)1.3·3.6H2O (generally, ZrSPhP) were intercalated with a series of amino alcs., H2N(CH2)nOH, where n = 2 to 6, and triethylamine. It was found that in the case of amino alcs. the basal spacing of the intercalates increases linearly with n. The intercalates prepared can be exfoliated either by sonication or by the action of high-shear forces. The use of a high-shear force disperser is a more efficient exfoliation method, as it provides lamellas with larger lateral dimensions in a much shorter time. It was found that amino alcs. provide roughly the same results regardless of the length of their carbon chain. As follows from at. force microscopy measurements, triethylamine is the most appropriate exfoliation agent for ZrSPhP as it produces platelets with the largest lateral size and the lowest amount of defects. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Senadi, Gopal Chandru’s team published research in Green Chemistry in 2019 | CAS: 13325-10-5

Name: 4-Aminobutan-1-olIn 2019 ,《Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions》 appeared in Green Chemistry. The author of the article were Senadi, Gopal Chandru; Kudale, Vishal Suresh; Wang, Jeh-Jeng. The article conveys some information:

Alcs. and ethers were identified as sustainable methine sources for synthesizing quinazolinones I [R = H, 8-Me, 7-NO2, etc.; R1 = OMe, allyl, Ph, etc,] and benzimidazoles II [R2 = H, 5-Cl, 6,7-di-Me, etc.] using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone I [R = H; R1 = CH2CH2OH, 2-(1H-indol-3-yl)ethyl] (a common precursor of rutaecarpine and (±) evodiamine) and dimedazole II [R2 = 5,6-di-Me]. Notable features of this method included its low toxicity, use of com. feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts