13325-10-5 Archives - Page 2 of 12 - Alcohols-buliding-blocks

Fang, Hua’s team published research in Bioorganic Chemistry in 2020 | CAS: 13325-10-5

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

《Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77》 was written by Fang, Hua; Zhang, Jianyu; Ao, Mingtao; He, Fengming; Chen, Weizhu; Qian, Yuqing; Zhang, Yuxiang; Xu, Yang; Fang, Meijuan. Related Products of 13325-10-5 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this work, three series of ω-3 polyunsaturated fatty acid-alkanolamine derivatives (PUFA-AAs) were synthesized, characterized and their anti-inflammatory activity in vivo was evaluated. Three compounds exhibited marked anti-inflammatory activity in LPS-stimulated RAW 264.7 cells. The most promising compound cis-7,10,13,16,19-docosapentaenoic acid 2-hydroxyethyl amide (I) dose-dependently suppressed the cytokines with IC50 values in the low micromolar range. Further, I exhibited potential in vitro Nur77-binding affinity (Kd = 6.99 x 10-6 M) which is consistent with the result of docking studies. Next, the anti-inflammatory mechanism of I was found to be through NF-κB signal pathway in a Nur77-dependent manner. Moreover, we also observed I significantly inhibited LPS-induced expression of cytokines (IL-6, TNF-α, and IL-1β) through suppressing NF-κB activation and attenuated LPS-induced inflammation in mouse acute lung injury (ALI) model. In conclusion, the study strongly suggests that the PUFA-AA derivatives can be particularly as new Nur77 mediators for further treatment in inflammatory diseases. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xiao’s team published research in Biomaterials Science in 2020 | CAS: 13325-10-5

《Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury》 was written by Wang, Xiao; Liang, Qiujun; Mao, Yiming; Zhang, Rujing; Deng, Qiurong; Chen, Yongbing; Zhu, Rongying; Duan, Shanzhou; Yin, Lichen. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Biomaterials Science in 2020. The article conveys some information:

SiRNA-mediated RNA interference (RNAi) against inflammation-related genes provides a promising modality for the treatment of myocardial ischemia reperfusion (IR) injury, and its success is critically dependent on the development of efficient yet safe siRNA delivery vehicles. Herein, we developed a bioreducible, branched poly(β-amino ester) with built-in redox-responsive domains (BPAE-SS) for the effective ICAM-1 siRNA delivery into injured rat cardiac microvascular endothelial cells (RCMECs). The branched BPAE-SS with a multivalent structure afforded potent siRNA binding affinity compared to its linear analog, while upon internalization into RCMECs it was instantaneously degraded by intracellular glutathione (GSH) into small segments to mediate “”on-demand”” siRNA release and diminish the toxicity of post-transfection materials. By synchronizingly overcoming these critical barriers, BPAE-SS mediated remarkable ICAM-1 knockdown in IR-injured rats at 400μg siRNA per kg via single i.v. injection, and subsequently suppressed myocardial inflammation, apoptosis, and fibrosis to recover the cardiac function. This study therefore provides a unique delivery system that can address the multiple critical challenges against non-viral siRNA delivery, and the potent therapeutic efficacy of BPAE-SS-mediated ICAM-1 silencing provides a promising strategy for the anti-inflammatory treatment of myocardial IR injury. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Ting-Ting’s team published research in Organic Letters in 2019 | CAS: 13325-10-5

The author of 《Chemoselective Synthesis of α-Amino-α-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides》 were Chen, Ting-Ting; Wang, Ai-E.; Huang, Pei-Qiang. And the article was published in Organic Letters in 2019. Related Products of 13325-10-5 The author mentioned the following in the article:

A novel approach to α-amino-α-cyanophosphonates was developed. The method features a Tf2O-mediated reductive geminal cyanation/phosphonylation of secondary amides. Mild reaction conditions, high bond-forming efficiency, inexpensive readily available starting materials, and good to excellent yields with wide functional group compatibility constitute the main advantages of this method. The protocol can be run on a gram scale. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Guoliang’s team published research in Organic Letters in 2022 | CAS: 13325-10-5

Computed Properties of C4H11NOIn 2022 ,《Synthesis of Tertiary Amines through Extrusive Alkylation of Carbamates》 was published in Organic Letters. The article was written by Zhang, Guoliang; Favela, David; Chow, Winston L.; Iyer, Rishab N.; Pell, Alexander J.; Olson, David E.. The article contains the following contents:

A step-economical approach was reported enabling the protection of secondary amines as carbamates prior to their conversion to tertiary amines via the formal extrusion of CO2. This method was applied to the synthesis of iboga alkaloids (±)-conodusine A and (±)-conodusine B. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rastelli, Ettore J.’s team published research in Tetrahedron in 2021 | CAS: 13325-10-5

Rastelli, Ettore J.; Yue, Doris; Millard, Caroline; Wipf, Peter published an article in 2021. The article was titled 《3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones》, and you may find the article in Tetrahedron.Computed Properties of C4H11NO The information in the text is summarized as follows:

3D-printed polypropylene (PP) continuous-photoflow cell based on a modular cartridge system was developed for the photo-oxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones I (R = Me, 4-(trifluoromethyl)phenyl, 4-(2-morpholinoethoxy)phenyl, etc.), using ambient air as the sole co-reactant. This strategy takes advantage of the versatility of 3D-printing to construct cost-effective meso-scale reactors. In addition to scalability, a short residence time (tR 2 min) in 100-W blue LED light which minimizes the formation of dark, insoluble decomposition Products, is a tangible benefit of this technol. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Zichen’s team published research in Applied Spectroscopy in 2021 | CAS: 13325-10-5

Yang, Zichen; Ma, Chaoqun; Gu, Jiao; Wu, Yamin; Zhu, Chun; Li, Lei; Gao, Hui; Zhang, Ye; Shang, Yunpeng; Wang, Chengwei; Chen, Guoqing published an article in 2021. The article was titled 《A Sensitive Surface-Enhanced Raman Spectroscopy Method for Detecting Tetracycline in Milk》, and you may find the article in Applied Spectroscopy.Recommanded Product: 4-Aminobutan-1-ol The information in the text is summarized as follows:

Tetracycline, an animal antibiotic, may remain in milk to cause harm to human health. For economic reasons, the abuse of antibiotics is becoming more and more common. Therefore, the abuse of tetracycline has alarmed the dairy industry and many countries such as New Zealand, China, and the USA have proposed strict standards Surface-enhanced Raman scattering (SERS) is an emerging detection method which has been applied in food detection with the advantages of no complex pretreatment, fast detection, and weak water environment interference. Considering the abuse of antibiotics in dairy industry, we used polydimethylsiloxane (PDMS) plasma cavity as SERS substrate to detect tetracycline in milk. We found that the enhancement ability of PDMS substrate is affected by addition of 4-amino-1-butanol and complex interplay in the milk–tetracycline system. The modified PDMS plasma cavity has high SERS sensitivity that allows us to achieve low detection limit of 0.28 μg/L. The correlation coefficient was 0.987. The detection of tetracycline in milk using PDMS substrate is quick (within 10 min) and it provides a possible method for in-site detection of tetracycline. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jie’s team published research in Science China: Chemistry in 2021 | CAS: 13325-10-5

Liu, Jie; Xiang, Haonan; Jiang, Lvqi; Yi, Wenbin published their research in Science China: Chemistry in 2021. The article was titled 《Chemoselective desulfurization-fluorination/bromination of carbonofluoridothioates for the O-trifluoromethylation and O-bromodifluoromethylation of alcohols》.Application of 13325-10-5 The article contains the following contents:

Herein, a method for synthesizing various alkyl trifluoromethyl e.g., C6H5(CH2)5OCF3 and alkyl bromodifluoromethyl ethers e.g., C6H5(CH2)5OCF2Br using carbonofluoridothioates e.g., C6H5(CH2)5OC(S)F as precursors has been described. Carbonofluoridothioates were obtained upon the reaction of an alc. e.g., C6H5(CH2)5OH and S=CF2 generated via the decomposition of an SCF3 anion, and then selectively transformed into their corresponding trifluoromethyl and bromodifluoromethyl ethers upon changing the reaction conditions. This transformation has also been extended to the one-pot, two-step conversion of alcs. into alkyl trifluoromethyl ethers. A series of alkyl bromodifluoromethyl ethers has also been synthesized. These compounds open up a new avenue for the synthesis of a wide range of useful fluorinated products. In addition, this method is suitable for the late-stage introduction of trifluoromethyl ethers in complex small mols. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Application of 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stateman, Leah M.’s team published research in Chemical Science in 2019 | CAS: 13325-10-5

In 2019,Chemical Science included an article by Stateman, Leah M.; Wappes, Ethan A.; Nakafuku, Kohki M.; Edwards, Kara M.; Nagib, David A.. HPLC of Formula: 13325-10-5. The article was titled 《Catalytic β C-H amination via an imidate radical relay》. The information in the text is summarized as follows:

The first catalytic strategy to harness imidate radicals for C-H functionalization has been developed. This iodine-catalyzed approach enables β C-H amination of alcs. e.g., 4-trichloroacetamidyl cholesterol by an imidate-mediated radical relay. In contrast to the first-generation, (super)stoichiometric protocol, this catalytic method enables faster and more efficient reactivity. Furthermore, lower oxidant concentration affords broader functional group tolerance, including alkenes (6-methyl-5-hepten-2-one, 3,7-dimethyl-2,6-octadienol), alkynes (isonicotinonitrile), alcs.(1-octanol), carbonyls (Me 2-(([(4-nitrobenzene)sulfonyl]oxy)amino)-3-phenylpropanoate) and heteroarenes (quinoline, benzofuran, benzo[b]thiophene, etc.). Mechanistic experiments interrogating the electronic nature of the key 1,5 H-atom transfer event are included, as well as probes for chemo-, regio-, and stereo-selectivity. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lagardere, Prisca’s team published research in Pharmaceuticals in 2022 | CAS: 13325-10-5

Quality Control of 4-Aminobutan-1-olIn 2022 ,《4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives》 was published in Pharmaceuticals. The article was written by Lagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Franetich, Jean-Francois; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent. The article contains the following contents:

Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Based on the structure of Gamhepathiopine, a 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hit, active on the sexual and asexual stages of the parasite and thanked for the introduction of various substituents at position 4 of the thienopyrimidine core e.g., I by nucleophilic aromatic substitution and pallado-catalyzed coupling reactions, a series of 4-substituted thieno[3,2-d]pyrimidines were identified as displaying in vitro activities against both the erythrocytic stage of P. falciparum and the hepatic stage of P. berghei. Among the 28 compounds evaluated, the chloro analog of Gamhepathiopine showed good activity against the erythrocytic stage of P. falciparum, moderate toxicity on HepG2, and better activity against hepatic P. berghei parasites, compared to Gamhepathiopine. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kozielski, Kristen L.’s team published research in Biomaterials in 2019 | CAS: 13325-10-5

The author of 《Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo》 were Kozielski, Kristen L.; Ruiz-Valls, Alejandro; Tzeng, Stephany Y.; Guerrero-Cazares, Hugo; Rui, Yuan; Li, Yuxin; Vaughan, Hannah J.; Gionet-Gonzales, Marissa; Vantucci, Casey; Kim, Jayoung; Schiapparelli, Paula; Al-Kharboosh, Rawan; Quinones-Hinojosa, Alfredo; Green, Jordan J.. And the article was published in Biomaterials in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and deliver hundreds of siRNA mols. into a single nanoparticle, facilitating combination therapy against multiple GBM-promoting targets. We demonstrate that siRNA delivery with these polymeric nanoparticles is cancer-selective, thereby avoiding potential side effects in healthy cells. We show that we can deliver siRNAs targeting several anti-GBM genes (Robo1, YAP1, NKCC1, EGFR, and survivin) simultaneously and within the same nanoparticles. Robo1 (roundabout homolog 1) siRNA delivery by biodegradable particles was found to trigger GBM cell death, as did non-viral delivery of NKCC1, EGFR, and survivin siRNA. Most importantly, combining several anti-GBM siRNAs into a nanoparticle formulation leads to high GBM cell death, reduces GBM migration in vitro, and reduces tumor burden over time following intratumoral administration. We show that certain genes, like survivin and EGFR, are important for GBM survival, while NKCC1, is more crucial for cancer cell migration. This represents a powerful platform technol. with the potential to serve as a multimodal therapeutic for cancer. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts