13325-10-5 Archives - Alcohols-buliding-blocks

Zhu, Daqian’s team published research in RSC Advances in 2019 | CAS: 13325-10-5

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

The author of 《Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes》 were Zhu, Daqian; Wu, Zhouming; Liang, Liyun; Sun, Yameng; Luo, Bingling; Huang, Peng; Wen, Shijun. And the article was published in RSC Advances in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

In current work, unique iodoniums were employed to construct various complex polycyclic heteroarenes, e.g., I with structural diversity via tandem dual arylations. As a result, indole, thiophene and triphenylene motifs were fused into these heterocycles with high mol. quality, which might provide promising fragments in drug discovery. Moreover, these heterocycles could be diversified at a late stage.4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karlsson, Johan’s team published research in Nanoscale in 2019 | CAS: 13325-10-5

The author of 《Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours》 were Karlsson, Johan; Rui, Yuan; Kozielski, Kristen L.; Placone, Amanda L.; Choi, Olivia; Tzeng, Stephany Y.; Kim, Jayoung; Keyes, Jamal J.; Bogorad, Max I.; Gabrielson, Kathleen; Guerrero-Cazares, Hugo; Quinones-Hinojosa, Alfredo; Searson, Peter C.; Green, Jordan J.. And the article was published in Nanoscale in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

Improved delivery materials are needed to enable siRNA transport across biol. barriers, including the blood-brain barrier (BBB), to treat diseases like brain cancer. We engineered bioreducible nanoparticles for systemic siRNA delivery to patient-derived glioblastoma cells in an orthotopic mouse tumor model. We first utilized a newly developed biomimetic in vitro model to evaluate and optimize the performance of the engineered bioreducible nanoparticles at crossing the brain microvascular endothelium. We performed transmission electron microscopy imaging which indicated that the engineered nanoparticles are able to cross the BBB endothelium via a vesicular mechanism. The nanoparticle formulation engineered to best cross the BBB model in vitro led to safe delivery across the BBB to the brain in vivo. The nanoparticles were internalized by human brain cancer cells, released siRNA to the cytosol via environmentally-triggered degradation, and gene silencing was obtained both in vitro and in vivo. This study opens new frontiers for the in vitro evaluation and engineering of nanomedicines for delivery to the brain, and reports a systemically administered biodegradable nanocarrier for oligonucleotide delivery to treat glioma.4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Blakney, Anna K.’s team published research in ACS Nano in 2020 | CAS: 13325-10-5

Safety of 4-Aminobutan-1-olIn 2020 ,ãBig Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymerã?was published in ACS Nano. The article was written by Blakney, Anna K.; Zhu, Yunqing; McKay, Paul F.; Bouton, Clement R.; Yeow, Jonathan; Tang, Jiaqing; Hu, Kai; Samnuan, Karnyart; Grigsby, Christopher L.; Shattock, Robin J.; Stevens, Molly M.. The article contains the following contents:

Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA, thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or mRNA and do not necessarily deliver saRNA efficiently due to structural differences of these RNAs, thus motivating the development of saRNA delivery platforms. Here, we engineer a bioreducible, linear, cationic polymer called “”pABOL”” for saRNA delivery and show that increasing its mol. weight enhances delivery both in vitro and in vivo. We demonstrate that pABOL enhances protein expression and cellular uptake via both i.m. and intradermal injection compared to com. available polymers in vivo and that i.m. injection confers complete protection against influenza challenge. Due to the scalability of polymer synthesis and ease of formulation preparation, we anticipate that this polymer is highly clin. translatable as a delivery vehicle for saRNA for both vaccines and therapeutics. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yadav, Mahesh B.’s team published research in ACS Omega in 2020 | CAS: 13325-10-5

ãChemoselective Ring Closure of 4-(3-Methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)butanal Leading to Pandalizine Aã?was written by Yadav, Mahesh B.; Pandhade, Kailas R.; Argade, Narshinha P.. Computed Properties of C4H11NO And the article was included in ACS Omega in 2020. The article conveys some information:

Starting from methylmaleic anhydride, a facile total synthesis of pandalizine A alkaloid is described via the regioselective reduction of methylmaleimide and acid-catalyzed enolization of 4-(3-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)butanal followed by chemoselective intramol. dehydrative cyclization as the key steps. It is noteworthy that the analogous model system with an addnl. β-Me group followed an alternative chemoselective intermol. aldol condensation pathway. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qin, Yuman’s team published research in Chemical Science in 2020 | CAS: 13325-10-5

Name: 4-Aminobutan-1-olIn 2020 ,ãA general method for site-selective Csp3-S bond formation via cooperative catalysisã?was published in Chemical Science. The article was written by Qin, Yuman; Han, Yujie; Tang, Yongzhen; Wei, Junfa; Yang, Mingyu. The article contains the following contents:

A copper-catalyzed site-selective thiolation of Csp3-H bonds of aliphatic amines to get thioaryl amines e.g., I. The method featured a broad substrate scope and good functional group compatibility. Primary, secondary and tertiary C-H bonds could be converted into C-S bonds with a high efficiency. The late-stage modification of biol. active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Chen’s team published research in Polymer Chemistry in 2019 | CAS: 13325-10-5

The author of ãA photo-selective chain-end modification of polyacrylate-iodide and its application in patterned polymer brush synthesisã?were Chen, Chen; Wang, Chen-Gang; Guan, Wenxun; Goto, Atsushi. And the article was published in Polymer Chemistry in 2019. Name: 4-Aminobutan-1-ol The author mentioned the following in the article:

A photo-selective chain-end modification of polyacrylate-iodide (polymer-I) was developed. In the presence of a functional primary amine (NH2-R-X with an X functionality) and formic acid, by simply switching the UV light on and off, polymer-I was selectively converted to hydrogen-terminated polymer-H and chain-end functionalized polymer-NH-R-X (polymer-X), resp. The scopes of the amenable functional X groups and polyacrylates are wide, and hence this method may serve as a general and versatile method for selective chain-end modification. As a useful application, this method was successfully used to fabricate chain-end patterned binary polymer brushes on surfaces. This method is free from metal, amenable to various functionalities, and useful for designing a range of chain-end functionalized polymers and surface-functionalized materials. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Casiraghi, Andrea’s team published research in ChemMedChem in 2020 | CAS: 13325-10-5

ãDesign and Synthesis of Fluorescent Methylphenidate Analogues for a FRET-Based Assay of Synapsin III Bindingã?was written by Casiraghi, Andrea; Longhena, Francesca; Straniero, Valentina; Faustini, Gaia; Newman, Amy H.; Bellucci, Arianna; Valoti, Ermanno. Category: alcohols-buliding-blocks And the article was included in ChemMedChem in 2020. The article conveys some information:

The authors previously described synapsin III (Syn III) as a synaptic phosphoprotein that controls dopamine release in cooperation with α-synuclein (aSyn). Moreover, in Parkinson’s disease (PD), Syn III also participates in aSyn aggregation and toxicity. The authors’ recent observations point to threo-methylphenidate (MPH), a monoamine re-uptake inhibitor that efficiently counteracts the freezing-gait characteristic of advanced PD, as a ligand for Syn III. The authors have designed and synthesized two different fluorescently labeled MPH derivatives, one with Rhodamine Red (RHOD) and one with 5-carboxytetramethylrhodamine (TAMRA), to be used for assessing MPH binding to Syn III by FRET. TAMRA-MPH exhibited the ideal characteristics to be used as a FRET acceptor, as it was able to enter into the SK-N-SH cells and could interact specifically with human green fluorescent protein (GFP)-tagged Syn III but not with GFP alone. Moreover, the uptake of TAMRA-MPH and co-localization with Syn III was also observed in primary mesencephalic neurons. These findings support that MPH is a Syn III ligand and that TAMRA-conjugated drug mols. might be valuable tools to study drug-ligand interactions by FRET or to detect Syn III in cytol. and histol. samples. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Yamin’s team published research in Nanoscale Advances in 2020 | CAS: 13325-10-5

ãThe 5-Ammoniumvaleric acid stabilized mixed-dimensional perovskite submicron platelets with white light emissionã?was published in Nanoscale Advances in 2020. These research results belong to Shi, Yamin; Hu, Jiarui; Chen, Jian; Xu, Yaxin; Yang, Wantian; Chen, Junnian; He, Yunbin. Formula: C4H11NO The article mentions the following:

Low-dimensional Pb-Br and Pb-Cl perovskite single crystals have aroused considerable attention due to their broadband white-light emission. But their synthesis involving halogenation of organic amines, dissolution of lead oxide and a slow cooling process is quite complicated. Herein, we report white light emission from mixed-dimensional AVAx(MAPbCl3) perovskite submicron platelets formed by one-step solution processing. It is found that the presence of 5-ammoniumvaleric acid (5-AVA) with a zwitterionic functional group is crucial for modulating the morphol. and structural dimensionality of perovskites. Importantly, AVAx(MAPbCl3) perovskites exhibit distinctive structural dimensionality dependent broadband emission, indicating the formation of self-trapped excited states. The AVA2(MAPbCl3) perovskite exhibits white-light emission with a color rendering index (CRI) of 85 and a correlated color temperature (CCT) of 8624 K, yielding “”cold”” white light. Moreover, the mixed-dimensional perovskite exhibits good stability for more than 30 days. With this report, we aim to provide a facile approach for synthesizing stable low-dimensional perovskite nanostructures for making advanced optoelectronic devices. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yao’s team published research in Bioactive Materials in 2022 | CAS: 13325-10-5

In 2022,Wang, Yao; Hou, Mengying; Duan, Shanzhou; Zhao, Ziyin; Wu, Xuejie; Chen, Yongbing; Yin, Lichen published an article in Bioactive Materials. The title of the article was ãMacrophage-targeting gene silencing orchestrates myocardial microenvironment remodeling toward the anti-inflammatory treatment of ischemia-reperfusion (IR) injuryã?Related Products of 13325-10-5 The author mentioned the following in the article:

Ischemia-reperfusion (IR) injury represents a major cause of myocardial dysfunction after infarction and thrombolytic therapy, and it is closely related to the free radical explosion and overwhelming inflammatory responses. Herein, macrophage-targeting nanocomplexes (NCs) are developed to mediate efficient co-delivery of siRNA against MOF (siMOF) and microRNA-21 (miR21) into myocardial macrophages, cooperatively orchestrating the myocardial microenvironment against IR injury. Bioreducible, branched poly(β-amino ester) (BPAE-SS) is designed to co-condense siMOF and miR21 into NCs in a multivalency-reinforced approach, and they are surface-decorated with carboxylated mannan (Man-COOH) to shield the pos. surface charges and enhance the serum stability. The final MBSsm NCs are efficiently internalized by myocardial macrophages after systemic administration, wherein BPAE-SS is degraded into small segments by intracellular glutathione to promote the siMOF/miR21 release, finally provoking efficient gene silencing. Thus, cardiomyocyte protection and macrophage modulation are realized via the combined effects of ROS scavenging, inflammation inhibition, and autophagy attenuation, which ameliorates the myocardial microenvironment and restores the cardiac function via pos. cellular crosstalk. This study renders promising solutions to address the multiple systemic barriers against in vivo nucleic acid delivery, and it also offers new options for IR injury by manipulating multiple reciprocal bio-reactions.4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al Mokhtar Lamsabhi’s team published research in Molecules in 2021 | CAS: 13325-10-5

Al Mokhtar Lamsabhi; Mo, Otilia; Yanez, Manuel published an article in 2021. The article was titled ãPerturbating intramolecular hydrogen bonds through substituent effects or non-covalent interactionsã? and you may find the article in Molecules.Computed Properties of C4H11NO The information in the text is summarized as follows:

An anal. of the effects induced by F, Cl, and Br-substituents at the α-position of both, the hydroxyl or the amino group for a series of amino-alcs., HOCH2(CH2)nCH2NH2 (n = 0-5) on the strength and characteristics of their OH···N or NH···O intramol. hydrogen bonds (IMHBs) was carried out through the use of high-level G4 ab initio calculations For the parent unsubstituted amino-alcs., it is found that the strength of the OH···N IMHB goes through a maximum for n = 2, as revealed by the use of appropriate isodesmic reactions, natural bond orbital (NBO) anal. and atoms in mols. (AIM), and non-covalent interaction (NCI) procedures. The corresponding IR (IR) spectra also reflect the same trends. When the α-position to the hydroxyl group is substituted by halogen atoms, the OH···N IMHB significantly reinforces following the trend H < F < Cl < Br. Conversely, when the substitution takes place at the α-position with respect to the amino group, the result is a weakening of the OH···N IMHB. A totally different scenario is found when the amino-alcs. HOCH2(CH2)nCH2NH2 (n = 0-3) interact with BeF2. Although the presence of the beryllium derivative dramatically increases the strength of the IMHBs, the possibility for the beryllium atom to interact simultaneously with the O and the N atoms of the amino-alc. leads to the global min. of the potential energy surface, with the result that the IMHBs are replaced by two beryllium bonds. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts