Category: 133082-13-0

《Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles》 was written by Li, Chengxi; Zhang, Yuanyuan; Sun, Qi; Gu, Tongnian; Peng, Henian; Tang, Wenjun. Electric Literature of C8H9ClO2 And the article was included in Journal of the American Chemical Society on August 31 ,2016. The article conveys some information:

We herein report a transition-metal-free cross-coupling between secondary alkyl halides/mesylates and aryl/alkenylboronic acid, providing expedited access to a series of nonchiral/chiral coupling products in moderate to good yields. For example, reacting PhCH(Br)Me with (E)-4-MeC6H4CH:CHB(OH)2 in K3PO4/toluene under nitrogen at 80°C for 4 h gave (E)-4-MeC6H4CH:CHCH(Me)Ph in 73% yield. Stereospecific SN2-type coupling is developed for the first time with alkenylboronic acids as pure nucleophiles, offering an attractive alternative to the stereospecific transition-metal-catalyzed C(sp2)-C(sp3) cross-coupling. The experimental process involved the reaction of (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Electric Literature of C8H9ClO2)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Electric Literature of C8H9ClO2 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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《Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs》 was written by Mamidi, Rao N. V. S.; Mannens, Geert; Annaert, Pieter; Hendrickx, Jan; Goris, Ivo; Bockx, Mark; Janssen, Cor G. M.; Kao, Mark; Kelley, Michael F.; Meuldermans, Willem. HPLC of Formula: 133082-13-0 And the article was included in Drug Metabolism and Disposition on April 30 ,2007. The article conveys some information:

The in vivo metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-], a novel neuromodulator, were investigated in mice, rats, rabbits, and dogs after oral administration of 14C-RWJ-333369. Plasma, urine, and feces samples were collected, assayed for radioactivity, and profiled for metabolites. In almost all species, the administered radioactive dose was predominantly excreted in urine (>85%) with less than 10% in feces. Excretion of radioactivity was rapid and nearly complete at 96 h after dosing in all species. Unchanged drug excreted in urine was minimal (<2.3% of the administered dose) in all species. The primary metabolic pathways were O-glucuronidation (rabbit > mouse > dog > rat) of RWJ-333369 and hydrolysis of the carbamate ester followed by oxidation to 2-chloromandelic acid. The latter metabolite was subsequently metabolized in parallel to 2-chlorophenylglycine and 2-chlorobenzoic acid (combined hydrolytic and oxidative pathways: rat > dog > mouse > rabbit). Other metabolic pathways present in all species included chiral inversion in combination with O-glucuronidation and sulfate conjugation (directly and/or following hydroxylation of RWJ-333369). Species-specific pathways, including N-acetylation of 2-chlorophenylglycine (mice, rats, and dogs) and arene oxidation followed by glutathione conjugation of RWJ-333369 (mice and rats), were more predominant in rodents than in other species. Consistent with human metabolism, multiple metabolic pathways and renal excretion were mainly involved in the elimination of RWJ-333369 and its metabolites in animal species. Unchanged drug was the major plasma circulating drug-related substance in the preclin. species and humans. In the experimental materials used by the author, we found (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0HPLC of Formula: 133082-13-0)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.HPLC of Formula: 133082-13-0 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N. published an article on February 20 ,2002. The article was titled 《Highly Selective Hydrolytic Kinetic Resolution of Terminal Epoxides Catalyzed by Chiral (salen)CoIII Complexes. Practical Synthesis of Enantioenriched Terminal Epoxides and 1,2-Diols》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: (1S)-1-(2-chlorophenyl)ethane-1,2-diol The information in the text is summarized as follows:

The hydrolytic kinetic resolution (HKR) of terminal epoxides catalyzed by a chiral (salen)CoIII complex affords both recovered unreacted epoxide and 1,2-diol product in highly enantioenriched form. As such, the HKR provides general access to useful, highly enantioenriched chiral building blocks that are otherwise difficult to access, from inexpensive racemic materials. The reaction has several appealing features from a practical standpoint, including the use of H2O as a reactant and low loadings (0.2-2.0 mol %) of a recyclable, com. available catalyst. In addition, the HKR displays extraordinary scope, as a wide assortment of sterically and electronically varied epoxides can be resolved to ≥99% ee. The corresponding 1,2-diols were produced in good-to-high enantiomeric excess using 0.45 equiv of H2O. Useful and general protocols are provided for the isolation of highly enantioenriched epoxides and diols, as well as for catalyst recovery and recycling. Selectivity factors (krel) were determined for the HKR reactions by measuring the product ee at ca. 20% conversion. In nearly all cases, krel values for the HKR exceed 50, and in several cases are well in excess of 200. The experimental part of the paper was very detailed, including the reaction process of (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Recommanded Product: (1S)-1-(2-chlorophenyl)ethane-1,2-diol)

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Recommanded Product: (1S)-1-(2-chlorophenyl)ethane-1,2-diol

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Category: alcohols-buliding-blocksOn March 28, 2009, Xu, Yi; Jia, Xin; Panke, Sven; Li, Zhi published an article in Chemical Communications (Cambridge, United Kingdom). The article was 《Asymmetric dihydroxylation of aryl olefins by sequential enantioselective epoxidation and regioselective hydrolysis with tandem biocatalysts》. The article mentions the following:

Chiral aryl vicinal diols were obtained in high ee and yield by asym. dihydroxylation of aryl olefins with tandem biocatalysts, an enantioselective styrene monooxygenase, and a regioselective epoxide hydrolase.(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Category: alcohols-buliding-blocks) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Category: alcohols-buliding-blocks

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The author of 《Structurally Defined Molecular Hypervalent Iodine Catalysts for Intermolecular Enantioselective Reactions》 were Haubenreisser, Stefan; Woeste, Thorsten H.; Martinez, Claudio; Ishihara, Kazuaki; Muniz, Kilian. And the article was published in Angewandte Chemie, International Edition in 2016. Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol The author mentioned the following in the article:

Mol. structures of the most prominent chiral non-racemic hypervalent iodine(III) reagents to date have been elucidated for the first time. The formation of a chirally induced supramol. scaffold based on a selective hydrogen-bonding arrangement provides an explanation for the consistently high asym. induction with these reagents. As an exploratory example, their scope as chiral catalysts was extended to the enantioselective dioxygenation of alkenes. A series of terminal styrenes RCH:CH2 (R = Ph, 4-FC6H4, 4-MeO2CC6H4, 3,5-Me2C6H3, 2-naphthyl, etc.) were converted into the corresponding vicinal diacetoxylation products (S)-RCH(OAc)CH2OAc under mild conditions and provided the proof of principle for a truly intermol. asym. alkene oxidation under iodine(I/III) catalysis.(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Name: (1S)-1-(2-chlorophenyl)ethane-1,2-diol

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Alcohols – Chemistry LibreTexts

《RP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: Method development and validation》 was written by Nageswara Rao, Ramisetti; Ramakrishna, Kuntamukkala; Sravan, Bompelli; Santhakumar, Kondapalli. Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol And the article was included in Journal of Pharmaceutical and Biomedical Analysis on April 15 ,2013. The article conveys some information:

A stability indicating reversed phase HPLC method was developed and validated for determination of process related impurities and forced degradants of carisbamate (CRS) in bulk drugs. Carisbamate when subjected to acid/base hydrolysis, H2O2 oxidation, photolysis and thermal stress significant degradation was observed during acid/base hydrolysis and the degradants were isolated and characterized by ESI-MS, 1H and 13C NMR. MS/MS and 2D-NMR (COSY and HSQC) studies revealed the possible isomerization of CRS under stress conditions. The optimum separation was accomplished on Agilent XDB C18 column (150 mm × 4.6 mm; 5 μm) using 0.02 M KH2PO4 (pH = 3.5) and CH3CN as a mobile phase in a gradient elution mode at a flow rate of 1.0 mL/min. The eluents were monitored by PDA detector at 211 nm and quantitation limits were obtained in the range of 0.1-0.3 μg/mL for CRS, degradants and other impurities. The LC method was validated with respect to accuracy, precision, linearity, robustness and limits of detection and quantification as per ICH guidelines. In addition to this study using (1S)-1-(2-chlorophenyl)ethane-1,2-diol, there are many other studies that have used (1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Safety of (1S)-1-(2-chlorophenyl)ethane-1,2-diol

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Alcohol – Wikipedia,
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