Category: 1310357-40-4

Zhang, H.-L. published the artcileEnantioselective synthesis of enantiopure chiral alcohols using carbonyl reductases screened from Yarrowia lipolytica, Recommanded Product: 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, the publication is Journal of Applied Microbiology (2019), 126(1), 127-137, database is CAplus and MEDLINE.

Aims : We aimed to explore Yarrowia lipolytica carbonyl reductases as effective biocatalysts and to develop efficient asym. reduction systems for chiral alc. synthesis. Methods and Results : Yarrowia lipolytica carbonyl reductase genes were obtained via homologous sequence amplification strategy. Two carbonyl reductases, YaCRI and YaCRII, were identified and characterized, and used to catalyze the conversion of 2-hydroxyacetophenone (2-HAP) to optically pure (S)-1-phenyl-1,2-ethanediol. Enzymic assays revealed that YaCRI and YaCRII exhibited specific activities of 6·96 U mg^-1 (99·8% e.e.) and 7·85 U mg^-1 (99·9% e.e.), resp., and showed moderate heat resistance at 40-50°C and acid tolerance at pH 5·0-6·0. An efficient whole-cell two-phase system was established using reductase-expressing recombinant Escherichia coli. The conversion of 2-HAP (20·0 g l^-1) conversion with the solvent of di-Bu phthalate was approx. 70-fold higher than in water. Furthermore, the two recombinant E. coli displayed biocatalyst activity and enantioselectivity towards several different carbonyl compounds, and E. coliBL21 (DE3)/pET-28a-yacrII showed a broad substrate spectrum. Conclusions : A new whole-cell recombinant E. coli-based bioreduction system for enantiopure alc. synthesis with high enantioselectivity at high substrate concentrations was developed. Significance and Impact of the Study : We proposed a promising approach for the efficient preparation of enantiopure chiral alcs.

Journal of Applied Microbiology published new progress about 1310357-40-4. 1310357-40-4 belongs to alcohols-buliding-blocks, auxiliary class Benzenes, name is 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, and the molecular formula is C24H12, Recommanded Product: 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Botubol-Ares, Jose Manuel published the artcileMethylene-Linked Bis-NHC Half-Sandwich Ruthenium Complexes: Binding of Small Molecules and Catalysis toward Ketone Transfer Hydrogenation, Formula: C10H12ClNO, the publication is Organometallics (2021), 40(6), 792-803, database is CAplus.

[Cp^*RuCl(COD)] reacts with LH₂Cl₂ (L = methanebis(3-methylimidazol-2-ylidene)) and LiBu in THF at 65° furnishing the bis-carbene derivative [Cp^*RuCl(L)] (2). This compound reacts with NaBPh₄ in MeOH under dinitrogen to yield the labile dinitrogen-bridged complex [{Cp^*Ru(L)}₂(μ-N₂)][BPh₄]₂ (4). The dinitrogen ligand in 4 is readily replaced by donor mols. leading to the corresponding cationic complexes [Cp^*Ru(X)(L)][BPh₄] (X = MeCN 3, H₂ (6), C₂H₄ (8a), CH₂CHCOOMe 8b, CHPh 9). Attempts to recrystallize 4 from MeNO₂/EtOH solutions gave the nitrosyl derivative [Cp^*Ru(NO)(L)][BPh₄]₂ (5), which was structurally characterized. The allenylidene complex [Cp^*Ru:C:C:CPh₂(L)][BPh₄] (10) was also obtained, and it was prepared by reaction of 2 with HCCC(OH)Ph₂ and NaBPh₄ in MeOH at 60°. 3, 4, And 6 are efficient catalyst precursors for the transfer hydrogenation of a broad range of ketones. The dihydrogen complex 6 proved particularly effective, reaching TOF values up to 455 h^-1 at catalyst loadings of 0.1% mol., with a high functional group tolerance on the reduction of a broad scope of aryl and aliphatic ketones to yield the corresponding alcs.

Organometallics published new progress about 1310357-40-4. 1310357-40-4 belongs to alcohols-buliding-blocks, auxiliary class Benzenes, name is 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, and the molecular formula is C10H12ClNO, Formula: C10H12ClNO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts