Category: 127-66-2

Related Products of 127-66-2, Adding some certain compound to certain chemical reactions, such as: 127-66-2, name is 2-Phenylbut-3-yn-2-ol,molecular formula is C10H10O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127-66-2.

General procedure: A 50-mL stainless steel autoclave equipped with a magnetic stir bar was charged with ZnCl2 (27.2 mg, 20 molpercent), DBU (76 mg, 50 molpercent), 2b (154.1 mg, 1 mmol), H2O (27 mg, 1.5 mmol) and CH3CN (2.0 mL) successively and sealed at r.t. Then, the pressure was adjusted to 1 MPa with CO2 at the preset temperature (80 °C) and the autoclave was heated at this temperature for 48 h. After the reaction was complete, the reactor was cooled in ice-water bath, and then excess CO2 was carefully vented. Then, the residue was obtained by removing the solvent under vacuum and further purified by column chromatography (petroleum ether/EtOAc 100:1-5:1) to obtain 6b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 127-66-2, 2-Phenylbut-3-yn-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Song, Qing-Wen; Zhao, Qing-Ning; Li, Jing-Yuan; Zhang, Kan; Liu, Ping; Synthesis; vol. 51; 3; (2019); p. 739 – 746;,
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Related Products of 127-66-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.127-66-2, name is 2-Phenylbut-3-yn-2-ol, molecular formula is C10H10O, molecular weight is 146.19, as common compound, the synthetic route is as follows.

(2-Ethoxybut-3-yn-2-yl)benzene (Table 2, entry 1) [39a]:2-phenyl-3-butyn-2-ol (0.106 g, 0.728 mmol) was added to a 5-mLscrew cap vial and dissolved in CH2Cl2(1 mL). Ethanol (0.036 g,0.897 mmol) was added followed by the addition of [Fc]PF6(0.007 g, 0.022 mmol). The vial was then sealed and heated at40C for 3 days. The solvent was removed and the residue waschromatographed on a neutral alumina oxide (Aluminar®) column(2.5 × 30 cm, hexane and then CH2Cl2) to give the product as a yel-low solid (0.085 g, 0.487 mmol, 67percent). NMR (, CDCl3)1H: 7.67?7.29(m, 7H, aromatic), 3.69 (doublet of quintets, 1 H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 3.22 (doublet of quintets, 1H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 2.74 (s, 1H, C CH), 1.78 (s, 3H, CH3), 1.24 (t,3H,2JHH= 7.2 Hz, OCH2CH3) ppm.13C{1H}: 143.3 (s, aromatic ipso),128.6 (s, aromatic), 128.5 (s, aromatic), 127.9 (s, aromatic), 127.6(s, aromatic*), 126.1 (s, aromatic), 84.7 (s, C CH), 75.9 (s, CC CH),75.2 (s, C CH), 60.6 (s, OCH2), 33.2 (s, CH3), 15.6 (s, OCH2CH3)ppm. IR (ATR, Neat): 3284 (m), 3055 (w), 2973 (m), 2926(w), 1714(s), 1670 (s), 1575 (s), 1491 (s), 1335 (s), 1264 (s), 1057 (s), 997 (s)

The chemical industry reduces the impact on the environment during synthesis 127-66-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Queensen, Matthew J.; Rabus, Jordan M.; Bauer, Eike B.; Journal of Molecular Catalysis A: Chemical; vol. 407; (2015); p. 221 – 229;,
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Electric Literature of 127-66-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 127-66-2 as follows.

To a solution of alkynol 1b (2.41 g, 2.83 mmol) and azide 2 (1 equiv) in THF/H2O (1/1, 80 mL) were added sodium ascorbate (95.5 mg, 0.48 mmol) and CuSO4*5H2O (60.5 mg, 0.24 mmol). After stirring overnight at ambient temperature, the reaction mixture was diluted with CH2Cl2 and washed with water. The organic phase was dried with MgSO4 and concentrated in vacuo. The residue was purified (flash chromatography, silica gel, 20-50percent gradient EA/PE) to provide 1.11 g (92percent) of alcohol 3b as solid (mp 60-63 °C). 1H NMR (400 MHz, DMSO): delta ppm: 7.85 (s, 1H), 7.63 (dd, 1H, J=7.6, 1.6 Hz), 7.52 (ddd, 1H, J=8.0, 7.6, 2 Hz), 7.45 (m, 2H), 7.28 (m, 2H), 7.20 (m, 1H), 7.11 (d, 1H, J=8.0 Hz), 7.01 (td, 1H, J=7.6, 0.8 Hz), 5.82 (s, 1H), 4.39 (t, 2H, J=7.2 Hz), 4.30 (m, 2H), 4.04 (t, 2H, J=6.0 Hz), 3.57 (m, 2H), 3,.24 (s, 3H), 2.01 (m, 2H), 1.80 (s, 3H), 1.69 (m, 2H); 13C NMR (100 MHz, DMSO): delta ppm: 165.8, 157.5, 155.0, 148.4, 133.5, 130.7, 127.1, 126.1, 125.1, 121.4, 120.15, 120.05, 113.4, 70.9, 69.7, 67.5, 63.4, 58.0, 48.9, 30.8, 26.5, 25.6; HRMS (TOF MS ES+) calcd for [M+Na]+ C29H32N3O5Na: 462.2005, found 462.2000.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127-66-2, its application will become more common.

Reference:
Article; Delatouche, Regis; Mondon, Martine; Gil, Adri; Frapper, Gilles; Bachmann, Christian; Bertrand, Philippe; Tetrahedron; vol. 67; 2; (2011); p. 401 – 407;,
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Application of 127-66-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127-66-2, name is 2-Phenylbut-3-yn-2-ol, molecular formula is C10H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The mixture of the substrate (0.250 mmol), 0.5percent Pd/MS3A or 0.5percent Pd/MS5A (10 wt percent of the substrate) and MeOH (1 mL) was stirred under H2 atmosphere (balloon) at room temperature. After a given period, the reaction mixture was filtered through a membrane filter (Millipore, Millex.(R).-LH, 0.45 mm), and the filtrate was concentrated in vacuo to produce the corresponding reduced product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 127-66-2, 2-Phenylbut-3-yn-2-ol.

Reference:
Article; Takahashi, Tohru; Yoshimura, Masatoshi; Suzuka, Hiroyasu; Maegawa, Tomohiro; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 68; 39; (2012); p. 8293 – 8299;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 127-66-2 ,Some common heterocyclic compound, 127-66-2, molecular formula is C10H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Catalyst by about 5 mg, propargylic alcohols 4.95 mmol inwater 0.5-1 mL and secondary amines by around 5 mmolwere mixed with a Schlenk tube that equipped to a stir bar.After that the apparatus was clean with carbon dioxide formore than two times, the blend was stirred under the temperatureof 50 C and pressure of 1.5 bar for carbon dioxidefor the desired time. When the considered reaction finished,the mixture was adapted by diethyl ether (3-15 mL). Theupper layers were gathered and dried by vacuuming to obtainthe crude yields that might be purified using more column chromatography onto silica gel by petroleum ether/ethylacetate (100:1-20:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127-66-2, its application will become more common.

Reference:
Article; Fan, Liqun; Wang, Jinhu; Zhang, Xianman; Sadeghzadeh, Seyed Mohsen; Zhiani, Rahele; Shahroudi, Mina; Amarloo, Fatemeh; Catalysis Letters; vol. 149; 12; (2019); p. 3465 – 3475;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 127-66-2 ,Some common heterocyclic compound, 127-66-2, molecular formula is C10H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The reactions were performed in a 50 ml autoclave with a Teflon vessel inside equipped with magnetic stirring under 3.0 MPa CO2. After introducing DBU (60.8 mg, 0.4 mmol), propylene glycol (76.1 mg, 1 mmol), 2-methyl-3-butyn-2-ol (126.2 mg, 1.5 mmol), DMF (2 ml), the autoclave was sealed and filled with CO2 to keep thepressure of CO2 under 3.0 MPa. Then, the reaction mixture was stirred at 120 C for 10 h. When the reaction completed, the autoclave was cooled to ambient temperature and residual CO2 was carefully released. Subsequently, the mixture was flushed with DMF and analyzed by GC using biphenyl as an internal standard.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 127-66-2, 2-Phenylbut-3-yn-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Han, Li-Hua; Li, Jing-Yuan; Song, Qing-Wen; Zhang, Kan; Zhang, Qian-Xia; Sun, Xiao-Fang; Liu, Ping; Chinese Chemical Letters; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts