Category: 126456-43-7

The author of 《Multifunctional isoquinoline-oxazoline ligands of chemical and biological importance》 were Li, Wei; Wang, Guotong; Lai, Jixing; Li, Shengkun. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application of 126456-43-7 The author mentioned the following in the article:

Multifunctional isoquinoline-oxazolines (MIQOXs) were conceived and synthesized from com. available chiral amino acids. The multifunctional role of MIQOXs was demonstrated by Pd-catalyzed highly enantioselective addition of arylboronic acids to nitrostyrenes, and by the discovery of novel antifungal candidates. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application of 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application of 126456-43-7

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The author of 《Efficient production of red Monascus pigments with single non-natural amine residue by in situ chemical modification》 were Huang, Yaolin; Liu, Lujie; Zheng, Gaowei; Zhang, Xuehong; Wang, Zhilong. And the article was published in World Journal of Microbiology & Biotechnology in 2019. Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

Filamentous fungi Monascus sp. has been utilized for fermentative production of food colorant (Red Yeast Rice) for more than 1000 years in China. The main colorant components of Red Yeast Rice are mixture of red Monascus pigments (RMPs) with various primary amine residues. In the present work, the non-natural primary amine p-aminobenzamide, exhibiting as non-involved in nitrogen microbial metabolism, nontoxicity to microbial cells, and chem. reactivity with orange Monascus pigments (OMPs), was screened. Based on the screened result, RMPs with the single p-aminobenzamide residue were produced by cell suspension culture in a nonionic surfactant micelle aqueous solution via in situ chem. modification of OMPs. Furthermore, in situ chem. modification of OMPs also provided a strategy for maintaining a relatively low OMP concentration and then efficient accumulation of high concentration of RMPs (3.3 g/l). The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation》 was written by Verzijl, Gerard K. M.; Hassfeld, Jorma; de Vries, Andre H. M.; Lefort, Laurent. Product Details of 126456-43-7 And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

Herein, we report the first example of the asym. hydrogenation of a prochiral benzodiazepine substrate as key transformation in a pilot-scale synthesis of BET inhibitor BAY 1238097 (I). High-throughput screening in a parallel reactor enabled us to identify an efficient catalyst based on Ir and a chiral bisphosphine. An additive screening allowed significant reduction of catalyst loading. Ultimately, the hydrogenation was performed on a kilogram scale leading to the production of 27 kg of the desired product with an enantiomeric excess of 99% after crystallization In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 126456-43-7

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《Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders》 was written by Espadinha, Margarida; Viejo, Lucia; Lopes, Ricardo M. R. M.; Herrera-Arozamena, Clara; Molins, Elies; dos Santos, Daniel J. V. A.; Goncalves, Lidia; Rodriguez-Franco, Maria Isabel; de los Rios, Cristobal; Santos, Maria M. M.. Product Details of 126456-43-7 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

The synthesis and pharmacol. evaluation of a new scaffold with antagonistic activity for NMDAR was reported. Specifically, a chem. library of eighteen 1-aminoindan-2-ol tetracyclic lactams was synthesized and screened as NMDAR antagonists. The compounds were obtained by chiral pool synthesis using enantiomerically pure 1-aminoindan-2-ols as chiral inductors, and their stereochem. was proven by X-ray crystallog. anal. of two target compounds Most compounds reveal NMDAR antagonism, and eleven compounds display IC50 values in a Ca2+ entry-sensitive fluo-4 assay in the same order of magnitude of memantine, a clin. approved NMDAR antagonist. Docking studies suggest that the novel compounds can act as NMDAR channel blockers since there is a compatible conformation with MK-801 co-crystallized with NMDAR channel. In addition, we show that the tetracyclic 1-aminoindan-2-ol derivatives are brain permeable and non-toxic, and we identify promising hits for further optimization as modulators of the NMDAR function. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 126456-43-7

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In 2017,Pilicer, Samantha L.; Bakhshi, Pegah R.; Bentley, Keith W.; Wolf, Christian published 《Biomimetic Chirality Sensing with Pyridoxal-5′-phosphate》.Journal of the American Chemical Society published the findings.Product Details of 126456-43-7 The information in the text is summarized as follows:

Pyridoxal-5′-phosphate (PLP) is introduced to a biomimetic indicator displacement assay for simultaneous determination of the absolute configuration, enantiomeric composition and concentration of unprotected amino acids, amino alcs. and amines. The chiroptical assay is based on fast imine metathesis with a PLP aryl imine probe to capture the target compound for CD and fluorescence sensing anal. The substrate binding yields characteristic Cotton effects that provide information about the target compound ee and the synchronous release of the indicator results in a nonenantioselective off-on fluorescence response that is independent of the enantiomeric sample composition and readily correlated to the total analyte concentration The experimental process involved the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Product Details of 126456-43-7

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In 2017,Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Ortiz-Frade, Luis; Klimova, Elena I. published 《Reactions of 2,3-diferrocenylcyclopropenylium salts with bis-1,4-N,O-nucleophiles: Novel synthesis, characterization, chemical and electrochemical properties of the 2-(Z-1,2-diferrocenylvinyl)- 4,5-dihydrooxazole derivatives》.Journal of Organometallic Chemistry published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

A new method of synthesis of 2-(Z-1,2-diferrocenylvinyl)-4-R-5-R1-4,5-dihydrooxazoles (3a-f, R, R1 = H, Me, Ph) and (5, R-R1 = 1,2-indano); 2-(Z-1,2-diferrocenylvinyl)-4-R-5-R1-4,5-dihydrooxazol-3-ium salts (4a-f, R, R1 = H, Me, Ph) 3-H-4-R2 oxazolinium salts (4g,h, R2 = iPr, Ph) and 3-R3-4-R-5-R1 oxazolinium salts (9h-j, R3 = Me, Et, using N-R3 aminoethanols) by reactions of 1-X-2,3-diferrocenylcyclopropenylium salts (1a,b, X = OEt, 4-morpholinyl) with 1,2-amino- and 1,2-N-alkylaminoalcs. in the presence of Et3N is described. The interactions of the salts 4a,d,f and 9h-j with morpholine and piperidine results in the corresponding (E)-2-[N-2′,3′-diferrocenylacryloyl-2-(N-alkyl)amino]ethylmorpholines and piperidines FcCH:CFcCONR3CHRCHR1X (X = 4-morpholinyl, 1-piperidinyl). The characterization of the new compounds was done by IR, 1H and 13C NMR spectroscopy, mass-spectrometry, elemental anal., and X-ray diffraction studies. Electrochem. properties of the compounds 3a-d and 4a-d were investigated using cyclic square voltammetry. One adsorption process and two electrochem. processes II and III, attributed to the oxidations of the ferrocene moieties, E0′(II), E0′(III), and comproportionation constant Kcom are reported. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Category: alcohols-buliding-blocks

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In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Pang, Huan; Xu, Pingping; Li, Chonglu; Zhan, Yibei; Zhang, Zengyuan; Zhang, Wanshu; Yang, Guangfu; Sun, Yao; Li, Haibing. Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. The article was titled 《A photo-responsive macroscopic switch constructed using a chiral azo-calix[4]arene functionalized silicon surface》. The information in the text is summarized as follows:

A photo-responsive macroscopic switch was fabricated using a chiral azo-calix[4]arene derivative (FC4AD) functionalized silicon surface and exhibited selective and reversible recognition of (1R,2S)-1-amino-2-indanol through the variation of wettability. This photo-responsive device may have wide applications in controlled release of chiral drugs and in biosensors. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《Tandem Use of Optical Sensing and Machine Learning for the Determination of Absolute Configuration, Enantiomeric and Diastereomeric Ratios, and Concentration of Chiral Samples》 was written by De los Santos, Zeus A.; MacAvaney, Sean; Russell, Katina; Wolf, Christian. SDS of cas: 126456-43-7 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

We have developed an optical method for accurate concentration, er, and dr anal. of amino alcs. based on a simple mix-and-measure workflow that is fully adaptable to multiwell plate technol. and microscale anal. The conversion of the four aminoindanol stereoisomers with salicylaldehyde to the corresponding Schiff base allows anal. of the dr based on a change in the UV maximum at 420 nm that is very different for the homo- and heterochiral diastereomers and of the concentration of the sample using a hypsochromic shift of another absorption band around 340 nm that is independent of the analyte stereochem. Subsequent in situ formation of CuII assemblies in the absence and presence of base enables quantification of the er values for each diastereomeric pair by CD anal. Applying a linear programming method and a parameter sweep algorithm, we determined the concentration and relative amounts of each of the four stereoisomers in 20 samples of vastly different stereoisomeric compositions with an averaged absolute percent error of 1.7%. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 126456-43-7

Referemce:
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Xie, Yi-Wen; Zhao, Zhen-Ni; Lin, Zi-Wei; Wang, Yu-Hao; Liu, Ya-Qun; Huang, Yi-Yong published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Asymmetric Petasis reaction for the synthesis of chiral α- and β-butadienyl amines》.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The article contains the following contents:

The Petasis reaction using (1S,2R)-1-amino-2-indanol as the substrate and an activator to construct α- and β-butadienyl amines in optically pure forms was realized; these are otherwise difficult to prepare The reactions feature a metal-free nature, broad substrate scope, complete regioselectivities (γ-selectivity of pinacol homoallenyl- and isoprenylboronates), and high to excellent chirality induction (up to >20:1 dr). The favored nucleophilic addition across the Si-face of the imine intermediate was explained using DFT calculations of the six-membered chair-like transition state. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Related Products of 126456-43-7In 2020 ,《Pyridine- and Quinoline-Based Gold(III) Complexes: Synthesis, Characterization, and Application》 appeared in European Journal of Organic Chemistry. The author of the article were Reiersolmoen, Ann Christin; Fiksdahl, Anne. The article conveys some information:

Studies on gold(III) coordination of a series of prepared polydentate pyridine and quinoline based ligands are reported. Characterization (1H, 13C, 15N NMR, and XRD) of the novel gold(III) complexes, prepared in 31-98% yield, revealed different coordination ability of the pyridine and quinoline nitrogen atoms. Testing of catalytic activity in cyclopropanation of propargyl ester and styrene demonstrated that all the new ligated gold(III) complexes were catalytically active and outperformed KAuCl4. The superior activity of the particular Au(III)-pyridine-oxazole complexes may indicate de-coordination of the pyridine-N ligand as a crucial step for efficient generation of catalytic activity. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 126456-43-7

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