Category: 126456-43-7

In 2018,Gardelli, Cristina; Wada, Hiroki; Ray, Asim; Caffrey, Moya; Llinas, Antonio; Shamovsky, Igor; Tholander, Joakim; Larsson, Joakim; Sivars, Ulf; Hultin, Leif; Andersson, Ulf; Sanganee, Hitesh J.; Stenvall, Kristina; Leidvik, Brith; Gedda, Karin; Jinton, Lisa; Ryden Landergren, Marie; Karabelas, Kostas published 《Identification and pharmacological profile of an indane-based series of Ghrelin receptor full agonists》.Journal of Medicinal Chemistry published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease, and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to increase of IGF-1 plasma levels. The activation of the GH/IGF-1 axis leads to an increase of muscle mass and functional capacity. Ghrelin further acts on inflammation, appetite, and adipogenesis and for this reason was considered an important target to address catabolic conditions. We report the synthesis and properties of an indane based series of ghrelin receptor full agonists; they have been shown to generate a sustained increase of IGF-1 levels in dog and have been thoroughly investigated with respect to their functional activity. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2020 ,《Ninhydrin Revisited: Quantitative Chirality Recognition of Amines and Amino Alcohols Based on Nondestructive Dynamic Covalent Chemistry》 appeared in Journal of Organic Chemistry. The author of the article were Pilicer, Samantha L.; Wolf, Christian. The article conveys some information:

A novel approach to chiral recognition of small mols. using the classical ninhydrin agent is introduced. Well-defined dynamic covalent chem. with amines and amino alcs. was developed and applied to quant. ee sensing with good accuracy using a straightforward mixing protocol and subsequent CD measurements. This chiroptical assay is fast, broadly useful, practical and repurposes an inexpensive reagent known for more than 100 years in a new application. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2018,Journal of the American Chemical Society included an article by Wang, Hao; Bai, Zibo; Jiao, Tangqian; Deng, Zhiqiang; Tong, Huarong; He, Gang; Peng, Qian; Chen, Gong. Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. The article was titled 《Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand》. The information in the text is summarized as follows:

A Pd-catalyzed amide-directed enantioselective hydrocarbofunctionalization of unactivated alkenes with C-H nucleophiles has been developed using a chiral monodentate oxazoline (MOXin) ligand. Various indoles react at C3 position with aminoquinoline-coupled 3-alkenamides to give γ addition products in good to excellent yield and enantioselectivity. This study represents an important advance of the development of chiral monodentate oxazoline ligands, which have been underexplored for asym. catalysis. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2019,Chemistry – An Asian Journal included an article by Chulakova, Dilyara R.; Pradipta, Ambara R.; Lodochnikova, Olga A.; Kuznetsov, Danil R.; Bulygina, Kseniya S.; Smirnov, Ivan S.; Usachev, Konstantin S.; Latypova, Liliya Z.; Kurbangalieva, Almira R.; Tanaka, Katsunori. Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol. The article was titled 《Facile Access to Optically Active 2,6-Dialkyl-1,5-Diazacyclooctanes》. The information in the text is summarized as follows:

Herein, the 1,5-diazacyclooctane (1,5-DACO) bearing a chiral auxiliary obtained from the formal [4+4] cycloaddition of N-alkyl-α,β-unsaturated imines was reported. 1,5-DACO could be further derivatized by nucleophilic alkylation to give various chiral substituted 1,5-DACO derivatives I [R = Me, vinyl, Ph, etc.]. The removal of the chiral auxiliary was effectively carried out using hydrogenation over Pearlman’s catalyst. This methodol. allows the production of a broad range of unprecedented optically active 2,6-dialkyl-1,5-DACO II, which could not be accessed by other methods. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles》 was written by Huo, Haohua; Gorsline, Bradley J.; Fu, Gregory C.. Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol And the article was included in Science (Washington, DC, United States) in 2020. The article conveys some information:

Stereochem. control in the construction of carbon-carbon bonds between an alkyl electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis. Classical substitution reactions via SN1 and SN2 pathways are limited in their ability to generate carbon-carbon bonds (inadequate scope, due to side reactions such as rearrangements and eliminations) and to control stereochem. when beginning with readily available racemic starting materials (racemic products). Here, we report a chiral nickel catalyst that couples racemic electrophiles (propargylic halides) with racemic nucleophiles (β-zincated amides) to form carbon-carbon bonds in doubly stereoconvergent processes, affording a single stereoisomer of the product from two stereochem. mixtures of reactants. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2019,Angewandte Chemie, International Edition included an article by Wang, Li-Ke; Zhou, Jing-Jing; Lan, Yu-Bao; Ding, San-Yuan; Yu, Wei; Wang, Wei. Category: alcohols-buliding-blocks. The article was titled 《Divergent Synthesis of Chiral Covalent Organic Frameworks》. The information in the text is summarized as follows:

Featuring the simultaneous generation of a library of compounds from a certain intermediate, divergent synthesis has found increasing applications in the construction of natural products and potential medicines. Inspired by this approach, presented herein is a general strategy to introduce functionality, in a divergent manner, into covalent organic frameworks (COFs). This modular protocol includes two stages of covalent assembly, through which functional COFs can be constructed by a three-step transformation of a key platform mol., such as 4,7-dibromo-2-chloro-1H-benzo[d]imidazole (DBCBI). Constructed herein are four types of chiral COFs (CCOFs) from DBCBI by nucleophilic substitution, Suzuki coupling, and imine formation. The unique array of eight isoframework CCOFs allowed investigation of their catalytic performance and structure-activity relationship in an asym. amination reaction.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Category: alcohols-buliding-blocks

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Qin, Haitao; Cai, Wangshui; Wang, Shuang; Guo, Ting; Li, Guigen; Lu, Hongjian published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《N-Atom Deletion in Nitrogen Heterocycles》.Recommanded Product: 126456-43-7 The article contains the following contents:

A versatile method of N-atom excision from N-heterocycles was reported. The process used readily available N-heterocycles as substrates, and proceeded by N-sulfonylazidonation followed by the rearrangement of sulfamoyl azide intermediates, which provided various cyclic products. Examples were provided for deletion of nitrogen from natural products, synthesis of chiral O-heterocycles from com. available chiral β-amino alcs., formal inert C-H functionalization through a sequence of N-directed C-H functionalization and N-atom deletion reactions where the N-atom served as a traceless directing group.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 126456-43-7

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In 2022,Yao, Qi-Jun; Chen, Jia-Hao; Song, Hong; Huang, Fan-Rui; Shi, Bing-Feng published an article in Angewandte Chemie, International Edition. The title of the article was 《Cobalt/Salox-Catalyzed Enantioselective C-H Functionalization of Arylphosphinamides》.COA of Formula: C9H11NO The author mentioned the following in the article:

Previous methods on Co(III)-catalyzed asym. C-H activation rely on the use of tailor-made cyclopentadienyl-ligated Co(III) complexes, which require lengthy steps for the preparation Herein, the authors report an unprecedented enantioselective C-H functionalization enabled by a simple Co/salicyloxazoline (Salox) catalysis. The chiral Salox ligands can be easily prepared in one step from salicylonitrile and chiral amino alcs. A broad range of P-stereogenic compounds were synthesized in high yields with excellent enantioselectivities (45 examples, up to 99% yield and >99% ee). The isolation and characterization of several intermediates provided insights into the generation of active catalytic Co species, the action of Salox, and the mode of stereocontrol. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7COA of Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.COA of Formula: C9H11NO

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《Thiourea Derivative of 2-[(1R)-1-Aminoethyl]phenol: A Flexible Pocket-like Chiral Solvating Agent (CSA) for the Enantiodifferentiation of Amino Acid Derivatives by NMR Spectroscopy》 was written by Recchimurzo, Alessandra; Micheletti, Cosimo; Uccello-Barretta, Gloria; Balzano, Federica. Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olThis research focused onthiourea derivative chiral solvating agent enantiodifferentiation amino acid NMR. The article conveys some information:

Thiourea derivatives of 2-[(1R)-1-aminoethyl]phenol, (1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol, (1R,2R)-(1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol, and (R)-1-phenylethanamine have been compared as chiral solvating agents (CSAs) for the enantiodiscrimination of derivatized amino acids using NMR (NMR) spectroscopy. Thiourea derivative, prepared by reacting 2-[(1R)-1-aminoethyl]phenol with benzoyl isothiocyanate, constitutes an effective CSA for the enantiodiscrimination of N-3,5-dinitrobenzoyl (DNB) derivatives of amino acids with free or derivatized carboxyl functions. A base additive 1,4-diazabicyclo[2.2.2]octane(DABCO)/N,N-dimethylpyridin-4-amine (DMAP)/(NBu4OH) is required both to solubilize amino acid derivatives with free carboxyl groups in CDCl3 and to mediate their interaction with the chiral auxiliary to attain efficient differentiation of the NMR signals of enantiomeric substrates. For ternary systems CSA/substrate/DABCO, the chiral discrimination mechanism has been ascertained through the NMR determination of complexation stoichiometry, association constants, and stereochem. features of the diastereomeric solvates. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2017,Tan, Qiuyuan; Wang, Xinqiao; Xiong, Yang; Zhao, Zimeng; Li, Lu; Tang, Pei; Zhang, Min published 《Chiral Amino Alcohol Accelerated and Stereocontrolled Allylboration of Iminoisatins: Highly Efficient Construction of Adjacent Quaternary Stereogenic Centers》.Angewandte Chemie, International Edition published the findings.Application of 126456-43-7 The information in the text is summarized as follows:

We have developed a highly efficient asym. allylboration of ketimines with nonchiral γ,γ-disubstituted allylboronic acids by using a chiral amino alc. as the directing group, which is otherwise challenging. The amino alc. not only serves as a cheap source of nitrogen and chirality, but also dramatically enhances the reactivity. The versatility of this method was demonstrated by its ability to access all four stereoisomers with adjacent quaternary carbon centers. A reaction model was proposed to explain the diastereoselectivity and the rate-accelerating effect. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application of 126456-43-7

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Alcohol – Wikipedia,
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