Category: 126456-43-7

Category: alcohols-buliding-blocksIn 2019 ,《Chemo- and Regioselective Ring Construction Driven by Visible-Light Photoredox Catalysis: an Access to Fluoroalkylated Oxazolidines Featuring an All-Substituted Carbon Stereocenter》 was published in Advanced Synthesis & Catalysis. The article was written by Chu, Xue-Qiang; Ge, Danhua; Wang, Mao-Lin; Rao, Weidong; Loh, Teck-Peng; Shen, Zhi-Liang. The article contains the following contents:

The unique advantages conferred by incorporation of all-substituted carbon stereocenters in organic mols. have gained widespread recognition. In this work, we describe a three-component cyclization to access C-2 fluoroalkylated oxazolidines by fragments assembly of readily available silyl enol ether, fluoroalkyl halide, and chiral amino alc. in a single reaction vessel, which provides an efficient strategy for expanding the pool of pharmaceutically important heterocycles featuring an all-substituted carbon stereocenter. This process proceeds efficiently in a chemo-, regio-, and stereoselective fashion under mild reaction conditions at room temperature and exhibits broad functional group tolerance. The successful realization of this controlled heteroannulation sequence relies on distinctive perfluoroalkylation, regio- and stereoselective radical cyclization through visible-light photoredox catalysis. Moreover, a one-pot procedure directly employing ketone as substrate has also been achieved. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Category: alcohols-buliding-blocks

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《N-Heterocyclic Carbene-Catalyzed Activation of Ynals for the Construction of Functional Pyridines》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Li, Jia-Hui; Duan, Xiao-Yong; Tian, Zhao-Hui; Zheng, Yi-Fan; Qi, Jing. Electric Literature of C9H11NO The article mentions the following:

N-heterocyclic carbene-catalyzed activation of ynals for rapid synthesis of pyridine derivatives with important utilities was reported. This successful strategy using NHC-bound alkynyl acyl azolium as the key intermediate further improved the application of N-Ts 2-aminoacrylate as a nucleophile. Importantly, this work introduced an ester substituent to pyridines that was easily transformed to other functional groups.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Electric Literature of C9H11NO

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《Helical supramolecular polymers with rationally designed binding sites for chiral guest recognition》 was written by Salikolimi, Krishnachary; Praveen, Vakayil K.; Sudhakar, Achalkumar Ammathnadu; Yamada, Kuniyo; Horimoto, Noriko Nishizawa; Ishida, Yasuhiro. Computed Properties of C9H11NO And the article was included in Nature Communications in 2020. The article conveys some information:

Since various helical supramol. polymers became available, their application to mol. chirality recognition have been anticipated but not extensively studied. So far, only a few examples of chiral reactions have been reported, but none for chiral separation Here, we report the application of a helical supramol. polymer to the enantio-separation of chiral guest mols. The monomer of this supramol. polymer is the salt-pair of a dendritic carboxylic acid with an enantiopure amino alc. In an apolar solvent, this salt-pair stacks via hydrogen bonds to form a helical polymer. In conjunction with this carboxylic acid, various amino alcs. afford supramol. polymers, whose helical handedness is determined by the stereochem. of the amino alcs. When two salts with the same chirality are mixed, they undergo copolymerization, while those with opposite chirality do not. Owing to this stereoselective copolymerizability, the helical supramol. polymer could bias the enantiomeric composition of chiral amino alcs. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Computed Properties of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Computed Properties of C9H11NO

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In 2017,Su, Bo; Zhou, Tai-Gang; Li, Xian-Wei; Shao, Xiao-Ru; Xu, Pei-Lin; Wu, Wen-Lian; Hartwig, John F.; Shi, Zhang-Jie published 《A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C-H Bonds》.Angewandte Chemie, International Edition published the findings.Synthetic Route of C9H11NO The information in the text is summarized as follows:

Iridium catalysts containing dative nitrogen ligands are highly active for the borylation and silylation of C-H bonds, but chiral analogs of these catalysts for enantioselective silylation reactions have not been developed. We report a new chiral pyridinyloxazoline ligand for enantioselective, intramol. silylation of sym. diarylmethoxy diethylsilanes. Regioselective and enantioselective silylation of unsym. substrates was also achieved in the presence of this newly developed system. Preliminary mechanistic studies imply that C-H bond cleavage is irreversible, but not the rate-determining step. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C9H11NO

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In 2018,Journal of Medicinal Chemistry included an article by Sellmer, Andreas; Stangl, Hubert; Beyer, Mandy; Gruenstein, Elisabeth; Leonhardt, Michel; Pongratz, Herwig; Eichhorn, Emerich; Elz, Sigurd; Striegl, Birgit; Jenei-Lanzl, Zsuzsa; Dove, Stefan; Straub, Rainer H.; Kraemer, Oliver H.; Mahboobi, Siavosh. Recommanded Product: 126456-43-7. The article was titled 《Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors》. The information in the text is summarized as follows:

Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising new drugs for the therapy of these diseases. Whereas pan-HDACi inhibit all 11 Zn2+-dependent histone deacetylases (HDACs) and cause a broad spectrum of side effects, specific inhibitors of histone deacetylase 6 (HDAC6i) are supposed to have less side effects. The authors present the synthesis and biol. evaluation of Marbostats, novel HDAC6i that contain the hydroxamic acid moiety linked to tetrahydro-β-carboline derivatives The lead compound Marbostat-100 is a more potent and more selective HDAC6i than previously established well-characterized compounds in vitro as well as in cells. Moreover, Marbostat-100 is well tolerated by mice and effective against collagen type II induced arthritis. Thus, Marbostat-100 represents a most selective known HDAC6i and the possibility for clin. evaluation of a HDAC isoform-specific drug.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 126456-43-7

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Tian, Jun; Yu, Shanshan; Guo, Hongyu; Zhu, Maoshuai; Lu, Kai; Jiang, Yixuan; Yang, Jiaqiao; Yu, Xiaoqi; Pu, Lin published an article in European Journal of Organic Chemistry. The title of the article was 《Enantioselective Fluorescent Recognition of β-Amino Alcohols by Stereoselective Cyclization》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

2,2′-Diformyl-1,1′-binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β-amino alcs. and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput anal. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β-amino alc. with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2018,Yang, Guo-Hui; Li, Yao; Li, Xin published 《Chirality Sensing of Molecules with Diverse Functional Groups by Using N-tert-Butyl Sulfinyl Squaramide》.Asian Journal of Organic Chemistry published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

The readily available bifunctional 3,5-[di(trifluoromethyl)]phenyl-substituted N-tert-Bu sulfinyl squaramide was used as a unique chiral solvating agent. The strong hydrogen-bonding donor ability of this chiral compound led to its effective use in the chiral recognition of multiple guest mols. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers》 was written by Qiu, Hui; Shuai, Bin; Wang, Yun-Zhao; Liu, Dong; Chen, Yue-Gang; Gao, Pei-Sen; Ma, Hong-Xing; Chen, Song; Mei, Tian-Sheng. SDS of cas: 126456-43-7 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

A scalable enantioselective nickel-catalyzed electrochem. reductive homocoupling of aryl bromides has been developed, affording enantioenriched axially chiral biaryls in good yield under mild conditions using electricity as a reductant in an undivided cell [e.g., 2-(benzyloxy)-1-bromonaphthalene → (R)-2,2′-bis(benzyloxy)-1,1′-binaphthyl (72% yield (65% isolated), 93% ee) using a chiral indan-fused oxazoline and NiCl2.glyme in presence of mol. sieves]. Common metal reductants such as Mn or Zn powder resulted in significantly lower yields in the absence of elec. current under otherwise identical conditions, underscoring the enhanced reactivity provided by the combination of transition metal catalysis and electrochem. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 126456-43-7

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《Binuclear chiral Ni(II) complex of tridentate OON chiral Schiff base ligand, 1-((E)-(((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)imino)methyl)naphthalen-2-ol》 was written by Maiti, Subir Kr; Bora, Aditi; Barman, Pranjit; Chandra, Asit K.; Baidya, Bidisha. HPLC of Formula: 126456-43-7 And the article was included in Journal of Coordination Chemistry in 2020. The article conveys some information:

Binuclear Ni(II) chelating complex with chiral Schiff base 1-((E)-(((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)imino)methyl)naphthalene-2-ol [Ni2L2] has been synthesized. The structure of [Ni2L2] was elucidated with single-crystal x-ray diffraction, spectroscopic (UV-vis, FTIR, mass) anal. and substantiated with computational (DFT) method. The crystal system of binuclear complex is monoclinic with space group P21/c. The asym. unit having two tridentate OON-donor sets are in slightly distorted square-planar geometry around each Ni(II) center. The distortion is due to strong coordination between two Ni(II) ions. The stabilization of complex [Ni2L2] occurs due to noncovalent interactions and hydrogen bonding (C-H…C and C-H…O), H…H, O…H, C…H, and C-H…π stacking interactions, and van der Waals interactions. DFT optimization, with little acceptable discrepancies, correlate with the x-ray diffraction data as well as TD DFT optimization for electronic transitions of the complex showing acceptable alignment with spectroscopic data. The complex displays appreciable inclination towards DNA-binding with calf-thymus DNA (CT DNA) and the DNA-binding studies were carried out by UV-visible spectroscopy, fluorescence spectroscopy, cyclic voltammetry, viscosity measurements, and CD spectroscopy. The DNA-binding study reveals that the order of binding constant value is in 105M1, supporting the effective efficiency of binding and the modes of binding are intercalation and groove.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7HPLC of Formula: 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 126456-43-7

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《A Novel Bisoxazoline-Imidazolium Salt in Ytterbium-Catalyzed Asymmetric Reduction of Ketone》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Zhai, Yujie; Xu, Wenhao; Wang, Dong; Zheng, Purui; Zhao, Xiaoming; Xu, Tao. Product Details of 126456-43-7 The article mentions the following:

Chiral N-heterocyclic carbene (NHC), a privileged ligand for transition metals, has had a profound impact on organometallic chem. The monodentate and bidentate chiral carbenes have been developed significantly, while the tridentate ones have been less exploited. Herein, we designed and synthesized a new bisoxazoline-imidazolium salt as a carbene precursor, which owns three chelating sites and two kinds of chiral information centers. A preliminary investigation on the asym. ketone reduction was also studied. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 126456-43-7

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