Category: 126456-43-7

Jonsson, Helgi Freyr; Orthaber, Andreas; Fiksdahl, Anne published their research in Dalton Transactions in 2021. The article was titled 《Studies on gold(I) and gold(III) alcohol functionalised NHC complexes》.Recommanded Product: 126456-43-7 The article contains the following contents:

Five pairs of novel chiral alc. functionalized gold(I) and gold(III) NHC complexes derived from chiral amino alcs., were synthesized and characterized (NMR, IR, HRMS). Single crystal x-ray diffraction data of gold(I) and gold(III) complexes are reported and discussed. The chiral imidazolium preligands were readily synthesized via the oxalamides, subsequent reduction and final orthoformate condensation. An improved method was used for generation of gold(I) NHC complexes (up to 92%) and further oxidation afforded the corresponding gold(III) NHC complexes (up to 99%). All the Au(I) and Au(III) NHC complexes proved far more catalytically active in a 1,6-enyne alkoxycyclization test reaction than our previously tested N,N- and P,N-ligated Au(III) complexes. Comparative gold(I) and gold(III) catalytic studies demonstrated different catalytic ability, depending on the NHC ligand flexibility and bulkiness. Excellent yields (92-99%) of target alkoxycyclization product were obtained with both gold(I) and gold(III) complexes with the bulky N1-Mes-N2-ethanol based NHC ligand. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 126456-43-7

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《Copper Bis(oxazoline)-Catalyzed Enantioselective Alkynylation of Benzopyrylium Ions》 was published in Chemistry – A European Journal in 2020. These research results belong to Guan, Yong; Attard, Jonathan W.; Mattson, Anita E.. Related Products of 126456-43-7 The article mentions the following:

The stereocontrolled construction of biol. relevant chromanones and tetrahydroxanthones were achieved through the addition of alkynes to benzopyrylium trilfates under the influence of copper bis(oxazoline) catalysis. Excellent levels of enantiocontrol (63-98% ee) were achieved in the addition of a variety of alkynes to an array of chromenones with a hydrogen in the 2-position. Promising levels of enantiocontrol (54-67% ee) were achieved in the alkynylation of chromenones with esters in the 2-position, generating tertiary ether stereocenters resembling those frequently found in naturally occurring metabolites.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Related Products of 126456-43-7

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Formula: C9H11NOIn 2018 ,《Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors》 was published in ACS Infectious Diseases. The article was written by Fraser, Andrew L.; Menzies, Stefanie K.; King, Elizabeth F. B.; Tulloch, Lindsay B.; Gould, Eoin R.; Zacharova, Marija K.; Smith, Terry K.; Florence, Gordon J.. The article contains the following contents:

Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern that have a devastating effect on the developing world due to their burden on human and animal health. In this work, we detail the preparation of a focused library of substituted-tetrahydropyran derivatives and their evaluation as selective chem. tools for trypanosomatid inhibition and the follow-on development of photoaffinity probes capable of labeling target protein(s) in vitro. Several of these functionalized compounds maintain low micromolar activity against Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, and Leishmania donovani. In addition, we demonstrate the utility of the photoaffinity probes for target identification through preliminary cellular localization studies. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Formula: C9H11NO

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In 2017,Yu, Jianfei; Duan, Meng; Wu, Weilong; Qi, Xiaotian; Xue, Peng; Lan, Yu; Dong, Xiu-Qin; Zhang, Xumu published 《Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones》.Chemistry – A European Journal published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

We have successfully developed a series of novel and modular ferrocene-based amino-phosphine-alc. (f-Amphol) ligands and applied them to iridium-catalyzed asym. hydrogenation of various simple ketones to afford the corresponding chiral alcs. with excellent enantioselectivities and conversions (98-99.9 % ee, >99 % conversion, turnover number up to 200,000). Control experiments and d. functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asym. hydrogenation. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Bora, Aditi; Maiti, Subir Kr; Singh, Anmol; Barman, Pranjit published an article in 2021. The article was titled 《Studies on the effect of remote substituents on the DNA binding activity of novel chiral Schiff bases》, and you may find the article in Journal of Molecular Structure.Formula: C9H11NO The information in the text is summarized as follows:

Three chiral Schiff Bases (1S,2R)-1-(((E)-2-hydroxy-4-methylbenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = R3 = H; R2 = Me), (1S,2R)-1-(((E)-3-bromo-5-chloro-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = Br; R2 = H; R3 = Cl) and (1S,2R)-1-(((E)-2-hydroxy-4-methoxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = R3 = H; R2 = MeO) were synthesized and characterized by 1H NMR, FT-IR, UV-Vis and elemental anal. (CHN). The crystal structures of I (R1 = R3 = H; R2 = Me) and I (R1 = Br; R2 = H; R3 = Cl) were determined by using single X-ray diffraction crystallog. technique also. It was shown that the remote substituents not only affect the structure of the Schiff bases but also affect the biol. activity. Under physiol. conditions, the interaction of Schiff bases with calf-thymus DNA (CT-DNA) was investigated using fluorescence quenching, UV-Vis spectroscopy and cyclic voltammetry. The order of DNA binding affinity (Kb) calculated from the absorption spectroscopy was: I (R1 = R3 = H; R2 = MeO) > I (R1 = R3 = H; R2 = Me) > I (R1 = Br; R2 = H; R3 = Cl). In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C9H11NO

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Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2017 ,《Sulfated cyclodextrins as water-soluble chiral NMR solvating agents for cationic compounds》 was published in Tetrahedron: Asymmetry. The article was written by Dalvano, Brielle E.; Wenzel, Thomas J.. The article contains the following contents:

The utility of sulfated cyclodextrins as water-soluble chiral NMR solvating agents for cationic substrates is described. Sulfated α-, β- and γ-cyclodextrin with degrees of substitution of 12, 13 and 14, resp., a sulfated β-cyclodextrin with a degree of substitution of 9 and a sulfobutyl ether β-cyclodextrin with a degree of substitution of 6.3 were examined Results with 33 water-soluble cationic organic salts are reported. Chiral differentiation with the sulfated cyclodextrins is compared to prior results obtained with anionic carboxymethylated and phosphated cyclodextrins. The highly sulfated cyclodextrins are often more effective at causing enantiomeric differentiation in 1H NMR spectra than the sulfobutyl ether, carboxymethylated and phosphated cyclodextrins, and are recommended as the 1st choice of a chiral solvating agent for the anal. of chiral cationic organic salts in aqueous solution After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2017,Li, Zhao; Tamura, Masamichi; Yazaki, Ryo; Ohshima, Takashi published 《Catalytic chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester: hydroxy group over amino group and conjugate addition over transesterification》.Chemical & Pharmaceutical Bulletin published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

A highly chemoselective conjugate addition of amino alcs. to α,β-unsaturated ester using a soft Lewis acid/hard Bronsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcs., including unprecedented cyclic β-amino alc., were applicable to the present catalysis. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: alcohols-buliding-blocks

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In 2018,Huang, Bing-Bing; Wu, Liang; Liu, Ren-Rong; Xing, Ling-Ling; Liang, Ren-Xiao; Jia, Yi-Xia published 《Enantioselective Friedel-Crafts C2-alkylation of 3-substituted indoles with trifluoropyruvates and cyclic N-sulfonyl α-ketiminoesters》.Organic Chemistry Frontiers published the findings.Synthetic Route of C9H11NO The information in the text is summarized as follows:

Enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles I (R1 = H, 5-MeO, 6-F, etc.; R2 = Me, Ph) with trifluoropyruvates F3CC(O)CO2R3 (R3 = Me, Et) and cyclic N-sulfonyl α-ketiminoesters II (R4 = H, 4-Cl, 4,7-F2, 6-Me, etc.; R5 = Me, Et, i-Pr) were developed by using the complexes of Cu(OTf)2 or Zn(OTf)2 with chiral bisoxazoline ligands. A range of chiral indole-containing trifluoromethylated α-hydroxy esters III and cyclic α-amino esters bearing quaternary stereogenic centers IV was prepared, resp., in good yields and with excellent enantioselectivities (up to 99% ee) under mild conditions. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Synthetic Route of C9H11NO

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Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olIn 2020 ,《Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst》 appeared in Journal of Organic Chemistry. The author of the article were Dinh, Andrew N.; Maddox, Sean M.; Vaidya, Sagar D.; Saputra, Mirza A.; Nalbandian, Christopher J.; Gustafson, Jeffrey L.. The article conveys some information:

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chem. to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approx. 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2018,Nitha, P. R.; Joseph, Manu M.; Gopalan, Greeshma; Maiti, Kaustabh Kumar; Radhakrishnan, K. V.; Das, Parthasarathi published 《Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines》.Organic & Biomolecular Chemistry published the findings.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biol. potent 2-amidoimidazopyridine I (R1, R2 = -(CH2)4-, -(CH2)5-, cyclohexyl, etc.) scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biol. evaluation of cytotoxicity on selected examples provides scope for future investigations. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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