Category: 126456-43-7

《Multinuclear nickel(II) complexes with chiral schiff base ligand》 was written by Farwa, Ume; Pait, Moumita; Ryu, Ji Yeon; Byun, Yong Min; Lee, Seul Gi; Jeong, Seung Hoo; Singh, Ovender; Singh, Neetu; Park, Hyoung-Ryun; Lee, Junseong. Electric Literature of C9H11NO And the article was included in Inorganica Chimica Acta in 2020. The article conveys some information:

Herein we report three chiral, hierarchal mono-, tetra-, and hexa-nuclear nickel complexes that were formed via controlled self-aggregation based on ancillary ligands H3L1 (2,6-bis[(2,3-dihydro-1H-2-indenol)imine]-4-bromophenol) and H3L2 (2,6-bis[(2,3-dihydro-1H-2-indenol)imine]-4-tert-butylphenol). Stoichiometric control of the metal precursor and ligand strongly influenced the nuclearity of the complexes. Mononuclear [Ni(H2L1)2Na2]·2ClO4(1) complex was obtained in the stoichiometric reaction of ligand H3L1 with nickel perchlorate in the presence of sodium acetate. Tetranuclear [Ni4(L1)2(μ3-OMe)2(μ1,3-OAc)2]·2Na(2) and hexanuclear [Ni6(L2)3(μ6-CO3)(MeOH)5(H2O)]·ClO4 (3) were selectively assembled by the reaction of nickel perchlorate and the ligand in a molar ratio of 1:2 without or with carbonate ions, resp. The solid-state structures of the complexes were confirmed by single-crystal X-ray crystallog. The photophys. properties of the complexes were explored using UV-visible spectroscopy. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C9H11NO

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In 2019,Organic Letters included an article by Pezzetta, Cristofer; Bonifazi, Davide; Davidson, Robert W. M.. SDS of cas: 126456-43-7. The article was titled 《Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach》. The information in the text is summarized as follows:

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common com. material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 126456-43-7

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Category: alcohols-buliding-blocksIn 2022 ,《Advances in Stereoselective Iron(II)-Catalyzed Synthesis of Sulfilimines with N-Mesyloxycarbamates》 was published in Helvetica Chimica Acta. The article was written by Lai, Calvine; Lebel, Helene. The article contains the following contents:

A stereoselective amination of thioethers R1SR2 to access sulfilimines (R)-R1R2SNC(O)OR3 [R1 = Ph, naphthalen-2-yl, thiophen-2-yl, etc., R2 = Me, Et, R3 = (4-methylphenyl)methyl, diphenylmethyl, 2,2,2-trichloroethyl, etc.] using N-mesyloxycarbamates MsOHNC(O)OR3 in a catalytic system composed of iron(II) chloride and a pyridine oxazoline (PyOX) ligand, e.g., (S)-5,5-dimethyl-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole, has been developed. The reaction proceeds with modest to good yields and selectivities (up to 86:14 d.r. and 72:28 e.r.). Selectivity was controlled by both the structure of the chiral ligand and the amination reagent. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Category: alcohols-buliding-blocks

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Zhou, Zijun; Tan, Yuqi; Shen, Xiang; Ivlev, Sergei; Meggers, Eric published an article in 2021. The article was titled 《Catalytic enantioselective synthesis of β-amino alcohols by nitrene insertion》, and you may find the article in Science China: Chemistry.Electric Literature of C9H11NO The information in the text is summarized as follows:

Herein, a general intramol. C(sp3)-H nitrene insertion method for the synthesis of chiral oxazolidin-2-ones as precursors of chiral β-amino alcs was reported. Specifically, the ring-closing C(sp3)-H amination of N-benzoyloxycarbamates with 2 mol% of a chiral ruthenium catalyst provides cyclic carbamates in up to 99% yield and with up to 99% ee. The method was applicable to benzylic, allylic, and propargylic C-H bonds and can even be applied to completely non-activated C (sp3)-H bonds, although with somewhat reduced yields and stereoselectivities. The obtained cyclic carbamates was subsequently be hydrolyzed to obtain chiral β-amino alcs. The method was very practical as the catalyst was easily synthesized on a gram scale and was recycled after the reaction for further use. The synthetic value of the new method was demonstrated with the asym. synthesis of a chiral oxazolidin-2-one as intermediate for the synthesis of the natural product aurantioclavine and chiral β-amino alcs. that are intermediates for the synthesis of chiral amino acids, indane-derived chiral Box-ligands, and the natural products dihydrohamacanthin A and dragmacidin A. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C9H11NO

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Fergus, Claire; Al-qasem, Mashael; Cotter, Michelle; McDonnell, Ciara M.; Sorrentino, Emiliano; Chevot, Franciane; Hokamp, Karsten; Senge, Mathias O.; Southern, John M.; Connon, Stephen J.; Kelly, Vincent P. published an article in 2021. The article was titled 《The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity》, and you may find the article in Nucleic Acids Research.Synthetic Route of C9H11NO The information in the text is summarized as follows:

Base-modification can occur throughout a tRNA mol.; however, elaboration is particularly prevalent at position 34 of the anticodon loop (the wobble position), where it functions to influence protein translation. Previously, we demonstrated that the queuosine modification at position 34 can be substituted with an artificial analog via the queuine tRNA ribosyltransferase enzyme to induce disease recovery in an animal model of multiple sclerosis. Here, we demonstrate that the human enzyme can recognize a very broad range of artificial 7-deazaguanine derivatives for tRNA incorporation. By contrast, the enzyme displays strict specificity for tRNA species decoding the dual synonymous NAU/C codons, determined using a novel enzyme-RNA capture-release method. Our data highlight the broad scope and therapeutic potential of exploiting the queuosine incorporation pathway to intentionally engineer chem. diversity into the tRNA anticodon. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C9H11NO

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In 2017,Fan, Yang; Kass, Steven R. published 《Enantioselective Friedel-Crafts Alkylation between Nitroalkenes and Indoles Catalyzed by Charge Activated Thiourea Organocatalysts》.Journal of Organic Chemistry published the findings.Product Details of 126456-43-7 The information in the text is summarized as follows:

A series of methylated and octylated pyridinium and quinolinium containing thiourea salts with a chiral 2-indanol substituent are reported. These organocatalysts are pos. charged analogs of privileged bis(3,5-trifluoromethyl)phenyl substituted thioureas, and are found to be much more active catalysts despite the absence of an addnl. hydrogen bond donor or acceptor site (i.e., the presence of a heteroatom-hydrogen or heteroatom). Friedel-Crafts reactions of trans-β-nitorostyrenes with indoles are examined, and good yields and enantioselectivities are obtained. Mechanistic studies indicate that this is a second-order transformation under the employed conditions, and is consistent with the dimer of the thiourea being the active catalyst. Charged organocatalysts, consequently, represent an attractive design strategy for catalyst development. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Product Details of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Product Details of 126456-43-7

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The author of 《1,2-Amino alcohol-dependent Petasis allylboration for racemic and chiral homoallylamines》 were Lin, Zi-Wei; Zhou, Yang; Zhao, Zhen-Ni; Zhao, Yan; Liu, Jun; Huang, Yi-Yong. And the article was published in Organic Chemistry Frontiers in 2019. Application In Synthesis of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

Petasis allylboration among an aldehyde RCHO (R = hexyl, cyclohexyl, Ph, 6-methoxy-3-pyridinyl, etc.), 1,2-amino alcs. such as (2S)-2-amino-3-phenylpropan-1-ol, (2S)-2-amino-2-phenylethan-1-ol, (1S,2R)-1-amino-2,3-dihydro-1H-inden-2-ol, etc. and pinacolallylboronate has been successfully accomplished at room temperature without any catalysts. A proposed reaction pathway involving the allylboration of an in situ-generated imine through a six-membered chairlike transition state is suggested to understand the role of a positioned hydroxy group and the diastereoselective outcome I. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application In Synthesis of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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The author of 《Practical synthesis of polysubstituted unsymmetric 1,10-phenanthrolines by palladium catalyzed intramolecular oxidative cross coupling of C(sp2)-H and C(sp3)-H bonds of carboxamides》 were Sun, Wen-Wu; Liu, Ji-Kai; Wu, Bin. And the article was published in Organic Chemistry Frontiers in 2019. Recommanded Product: 126456-43-7 The author mentioned the following in the article:

A short sequence for the practical synthesis of polysubstituted unsym. 1,10-phenanthroline compounds was developed based on the palladium-catalyzed oxidative cross coupling reaction of C(sp2)-H/C(sp3)-H bonds of carboxamides. DMAP as a preferred ligand was crucial for the reaction to avoid β-hydride elimination, which may be controlled by the π-π stacking effect between the aryl group of the substrate and DMAP, demonstrated by primary mechanistic studies and X-ray data of the substrate-Pd-DMAP complex. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 126456-43-7

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In 2022,Gutierrez-Bonet, Alvaro; Popov, Stasik; Emmert, Marion H.; Hughes, Jonathan M. E.; Nolting, Andrew F.; Ruccolo, Serge; Wang, Yunyi published an article in Organic Letters. The title of the article was 《Asymmetric Synthesis of Tertiary and Secondary Cyclopropyl Boronates via Cyclopropanation of Enantioenriched Alkenyl Boronic Esters》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

The cyclopropanation of alkenyl boronates and subsequent derivatization of the boronate handle are a convenient strategy to quickly build mol. complexity and access diverse compounds with a high sp3 fraction. Herein, the authors describe the asym. cyclopropanation of enantioenriched hydrobenzoin-derived alkenyl boronic esters toward the synthesis of tertiary and secondary cyclopropyl boronates.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2019,Chemistry – A European Journal included an article by Zheng, Lu; Zhan, Yulin; Ye, Lin; Zheng, Dan; Wang, Ying; Zhang, Kun; Jiang, Hua. SDS of cas: 126456-43-7. The article was titled 《Chiral Induction and Remote Chiral Communication in Quinoline Oligoamide Foldamers for Determination of Enantiomeric Excess and Absolute Configuration of Chiral Amines and Their Derivatives》. The information in the text is summarized as follows:

Two pentameric foldamers, Q5 (I) and Q5C-S (II), containing a C-F bond were synthesized based on quinoline oligamide foldamers for the measurement of enantiomeric excess and for the determination of absolute configuration of chiral amines, diamines, amino alcs., and α-amino acid esters. Chiral induction of Q5 was triggered in situ when the chiral analytes reacted with the C-F bond in Q5 by a N-nucleophilic substitution reaction, leading to a linear correlation between the CD amplitude at the region of quinoline chromophores and the ee values of the chiral analytes, which can be used for the ee determination of chiral analytes. Furthermore, the CD intensity of Q5C-S containing a chiral motif at its C-terminus enhances via remote, favorable chiral communication when the chiral induction was triggered in situ by chiral analytes at the N-terminus matches the original helicity of Q5C-S, but decreases via remote, conflicted chiral communication when the chiral induction is triggered in situ by chiral mols. at the N-terminus mismatches the original one. The system can thus be used for determination of the absolute configuration of chiral analytes, given that the chirality of the chiral motif at the C-terminus of Q5C-S is known. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.SDS of cas: 126456-43-7

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