Category: 126456-43-7

Zhang, Hongpeng; Zhao, Dongbing published their research in ACS Catalysis in 2021. The article was titled 《Synthesis of Silicon-Stereogenic Silanols Involving Iridium-Catalyzed Enantioselective C-H Silylation Leading to a New Ligand Scaffold》.Related Products of 126456-43-7 The article contains the following contents:

Despite a growing focus on the construction of highly enantioenriched silicon-stereogenic organosilicon compounds, the enantioselective synthesis of silicon-stereogenic silanols through asym. catalysis remains a considerable challenge. Herein, we realized enantioselective construction of silicon-stereogenic diarylsilanols via an Ir-catalyzed C-H silylation of diarylsilanols along with stereospecific substitution or Tamao-Fleming oxidation This strategy gives rise to a class of chiral diol catalyst cores (PSiOLs). Transformation of PSiOLs led to the ligand possessing both Si and P-stereocenters, which is capable of inducing excellent enantioselectivity in the rhodium(I)-catalyzed conjugate 1,4-addition of aryl boronic acids to cyclohexenone. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 126456-43-7

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Alcohols – Chemistry LibreTexts

In 2022,Lee, Ju Young; Varshnaya, Rohit Kumar; Yoo, Eun Jeong published an article in Organic Letters. The title of the article was 《Synthesis of Chiral Diazocine Derivatives via a Copper-Catalyzed Dearomative [5+3] Cycloaddition》.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

Copper-catalyzed [5+3] cycloaddition of N-aromatic zwitterions and enol diazoacetates produced enantio-enriched diazocine derivatives A sterically encumbered BOX ligand and NaBArF additive played significant roles in driving the overall catalytic process via the unfavorable dearomatization to construct the desired eight-membered heterocyclic compounds The induced stereoselectivity was preserved after further modifications of the skeleton, which demonstrates the potential applications of the developed asym. catalysis. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《Twist to Boost: Circumventing Quantum Yield and Dissymmetry Factor Trade-Off in Circularly Polarized Luminescence》 was written by Lee, Sumin; Lee, Yongmoon; Kim, Kyungmin; Heo, Seunga; Jeong, Dong Yeun; Kim, Sangsub; Cho, Jaeheung; Kim, Changsoon; You, Youngmin. Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olThis research focused ontwist boost circumventing quantum yield dissymmetry factor trade off. The article conveys some information:

Circularly polarized luminescence (CPL) enables promising applications in asym. photonics. However, the performances of CPL mols. do not yet meet the requirements of these applications. The shortcoming originates from the trade-off in CPL between the photoluminescence quantum yield (PLQY) and the photoluminescence dissymmetry factor (gPL). In this study, we developed a mol. strategy to circumvent this trade-off. Our approach takes advantage of the strong propensity of [Pt(N^C^N)Cl], where the N^C^N ligand is 1-(2-oxazoline)-3-(2-pyridyl)phenylate, to form face-to-face stacks. We introduced chiral substituents, including (S)-Me, (R)- and (S)-iso-Pr, and (S)-indanyl groups, into the ligand framework. This asym. control induces torsional displacements that give homohelical stacks of the Pt(II) complexes. X-ray single-crystal structure analyses for the (S)-iso-Pr Pt(II) complex reveal the formation of a homohelical dimer with a Pt···Pt distance of 3.48 Å, which is less than the sum of the van der Waals radii of Pt. This helical stack elicits the metal-metal-to-ligand charge-transfer (MMLCT) transition that exhibits strong chiroptical activity due to the elec. transition moment making an acute angle to the magnetic transition moment. The PLQY and gPL values of the MMLCT phosphorescence emission of the (S)-iso-Pr Pt(II) complex are 0.49 and 8.4 x 10-4, which are improved by factors of ca. 6 and 4, resp., relative to the values of the unimol. emission (PLQY, 0.078; gPL, 2.4 x 10-4). Our photophys. measurements for the systematically controlled Pt(II) complexes reveal that the CPL amplifications depend on the chiral substituent. Our investigations also indicate that excimers are not responsible for the enhanced chiroptical activity. To demonstrate the effectiveness of our approach, organic electroluminescence devices were fabricated. The MMLCT emission devices were found to exhibit simultaneous enhancements in the external quantum efficiency (EQE, 9.7%) and the electroluminescence dissymmetry factor (gEL, 1.2 x 10-4) over the unimol. emission devices (EQE, 5.8%; gEL, 0.3 x 10-4). These results demonstrate the usefulness of using the chiroptically active MMLCT emission for achieving an amplified CPL. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2017,Han, Zhengxu S.; Wu, Hao; Xu, Yibo; Zhang, Yongda; Qu, Bo; Li, Zhibin; Caldwell, Donald R.; Fandrick, Keith R.; Zhang, Li; Roschangar, Frank; Song, Jinhua J.; Senanayake, Chris H. published 《General and stereoselective method for the synthesis of sterically congested and structurally diverse P-stereogenic secondary phosphine oxides》.Organic Letters published the findings.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

Reaction of dichlorophosphines RPCl2 (R = aryl, hetaryl, ferrocenyl, aralkyl) with chiral N-sulfonyl-β-aminoalc. auxiliaries R*OH produced phosphinate esters RPH(O)(OR*), which were then alkylated with tBuLi yielding phosphorus-chiral secondary phosphine oxides RPH(O)(tBu) (3a-k) with >97% ee. A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alc. templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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In 2018,Inorganic Chemistry included an article by Li, Changda; Tang, Haitong; Fang, Yu; Xiao, Zhifeng; Wang, Kunyu; Wu, Xiang; Niu, Helin; Zhu, Chengfeng; Zhou, Hong-cai. Recommanded Product: 126456-43-7. The article was titled 《Bottom-Up Assembly of a Highly Efficient Metal-Organic Framework for Cooperative Catalysis》. The information in the text is summarized as follows:

A bottom-up assembly of a monomeric Cu complex and a 2-dimensional (2-D) heterometallic metal-organic framework (MOF) from a carboxylate-functionalized tridentate Schiff base ligand and metal ions is demonstrated. The obtained 2-D MOF features a unique bimetallic Cu center which is different from its monometallic precursor and acts as an efficient heterogeneous catalyst for the Friedel-Crafts reaction and Henry reaction. The MOF catalyst shows a remarkably superior activity compared to its homogeneous counterparts in a wide range of substrates. It is presumably ascribed to the dual activation of the substrates by the active bimetallic Cu center confined in the MOF network, which is supported by the significant changes in catalytic activity at low catalyst/substrates ratios when using the 2-D MOF and its precursor as catalysts, resp. The MOF catalyst shows an excellent stability and recyclability. The work provides a stepwise strategy to design a heterogeneous cooperative catalyst, by taking advantage of the modulated structure of MOF and tunable functionality of the tridentate Schiff base, with high performance in a variety of organic synthesis. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 126456-43-7

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Le Barbu-Debus, Katia; Zehnacker, Anne published their research in Chirality in 2021. The article was titled 《Competition between inter and intramolecular hydrogen bond evidenced by vibrational circular dichroism spectroscopy: The case of (1S,2R)-(-)-cis-1-amino-2-indanol》.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The article contains the following contents:

The IR (IR) absorption and vibrational CD (VCD) spectra of an intramolecularly hydrogen-bonded chiral amino-alc., (1S,2R)-(-)-cis-1-amino-2-indanol, are studied in DMSO-d6. The spectra are simulated at the d. functional theory (DFT) level within the frame of the cluster-in-the-liquid model. Both IR and VCD spectra show a clear signature of the formation of intermol. hydrogen bonds at the detriment of the intramol. OH …N interaction present in the isolated mol. Two solvent mols. are necessary to reproduce the exptl. spectra. Whereas the first DMSO mol. captures the main spectral modifications due to hydrogen bond formation between the solute and the solvent, the second DMSO mol. is necessary for a good description of the Boltzmann contribution of the different complexes, based on their Gibbs free energy.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《A New Chirally Organized Trifluoromethylanthrylmethanol Derivative and Its Application as Chiral Solvating Agent》 was written by Monteagudo, Eva; de March, Pedro; Alvarez-Larena, Angel; Virgili, Albert. Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olThis research focused ontrifluoromethylanthrylmethanol chiral solvating agent. The article conveys some information:

The synthesis and structure of 1,1′-(((10,10′-(1,1′-binaphthalene)-2,2′-diylbis(oxy))bis(methylene))bis(anthracene-10,9-diyl))bis(2,2,2-trifluoroethanol), 4, is reported. This compound owns both axial and central chirality allowing its use as a chiral solvating agent (CSA) for the enantiomeric composition determination of several mixtures of chiral aromatic alcs. and amines using NMR. The study of the resulting diastereoisomeric complexes was carried out by determining its stoichiometry and association binding constants In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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《An organometallic route to chiroptically active ZnO nanocrystals》 was written by Chwojnowska, Elzbieta; Wolska-Pietkiewicz, Malgorzata; Grzonka, Justyna; Lewinski, Janusz. Related Products of 126456-43-7This research focused onzinc oxide nanocrystal chiroptical activity monoanionic aminoalcoholate ligand. The article conveys some information:

The unique optical properties of zinc oxide nanocrystals (ZnO NCs) are strongly dependent on both the properties and the composition of the inorganic core-organic ligand interface. Developing a novel organometallic self-supporting approach, we report on the synthesis and characterization of ZnO nanocrystals coated by chiral monoanionic aminoalcoholate ligands. The resulting ZnO NCs are both chiroptically active and possess size dependent optical properties. The size and in consequence the emission color of the ZnO NCs could be simply adjusted by the characteristic of the aminoalc. used. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Related Products of 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Kim, Dongwon; Seo, Kyeong-Deok; Shim, Yoon-Bo; Lee, Kyungsuh; Lee, Sang Hak; Lee, Young-A.; Jung, Ok-Sang published an article in Dalton Transactions. The title of the article was 《Pair of chiral 2D silver(I) enantiomers: chiral recognition of L- and D-histidine via differential pulse voltammetry》.Related Products of 126456-43-7 The author mentioned the following in the article:

Self-assembly of AgPF6 with a pair of chiral tridentate ligands (1S,1’S,1”S,2R,2’R,2”R) and (1R,1’R,1”R,2S,2’S,2”S)-(benzenetricarbonyltris(azanediyl))tris(2,3-dihydro-1H-indene-2,1-diyl)triisonicotinate (s,r-L) and (r,s-L) in a mixture of methanol and dioxane yields 2D sheets consisting of [Ag(s,r-L)](PF6)·3C4H8O2·0.5H2O and [Ag(r,s-L)](PF6)·3C4H8O2·0.5H2O, resp. The differential pulse voltammetric (DPV) technique using the pair of chiral 2D-sheet enantiomers was employed for chiral discrimination of amino acid enantiomers, and was an effective tool for enantio-recognition of L- and D-histidines. Both the size and the binding site of amino acids were strongly dependent on electrochem. enantio-recognition via the chiral 2D sheets. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 126456-43-7

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bera, Srikrishna; Mao, Runze; Hu, Xile published their research in Nature Chemistry in 2021. The article was titled 《Enantioselective C(sp3)-C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis》.Category: alcohols-buliding-blocks The article contains the following contents:

Cross-coupling of two alkyl fragments is an efficient method to produce organic mols. rich in sp3-hybridized carbon centers, which are attractive candidate compounds in drug discovery. Enantioselective C(sp3)-C(sp3) coupling is challenging, especially of alkyl electrophiles without an activating group (aryl, vinyl, carbonyl). Here, we report a strategy based on nickel hydride addition to internal olefins followed by nickel-catalyzed alkyl-alkyl coupling. This strategy enables the enantioselective cross-coupling of non-activated alkyl halides with alkenyl boronates to produce chiral alkyl boronates. Employing readily available and stable olefins as pro-chiral nucleophiles, the coupling proceeds under mild conditions and exhibits broad scope and high functional-group tolerance. Applications for the functionalization of natural products and drug mols., as well as the synthesis of chiral building blocks and a key intermediate to (S)-(+)-pregabalin, are demonstrated. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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